Variant ID: 19-41512841-G-T

NM_000767.4(CYP2B6):c.516G>T;(p.Gln172His)

This variant was identified in 324 publications




Publications:


Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study.

Bmc Medicine
RM Turner, EM de Koning, V Fontana, A Thompson, M Pirmohamed
Publication Date: 2020-11-25

Variant appearance in text: rs3745274
PubMed Link: 33234119
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.

Journal Of Personalized Medicine
V Hlaváč, P Holý, P Souček
Publication Date: 2020-08-28

Variant appearance in text: rs3745274
PubMed Link: 32872162
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of Comprehensive Pharmacogenomic Profiling of VIP Variants Among the Genetically Isolated Chechen Subpopulation from Jordan.

Pharmacogenomics And Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32765042
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

International Journal Of Molecular Sciences
CM Hattinger, MP Patrizio, S Luppi, M Serra
Publication Date: 2020-06-30

Variant appearance in text: rs3745274
PubMed Link: 32629971
Variant Present in the following documents:
  • Main text
View BVdb publication page



The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial.

Scientific Reports
RBR León-Cachón, AD Bamford, I Meester, HA Barrera-Saldaña, M Gómez-Silva, MFG Bustos
Publication Date: 2020-06-01

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 32483134
Variant Present in the following documents:
  • Main text
View BVdb publication page



Minding the gap in HIV host genetics: opportunities and challenges.

Human Genetics
SN Gingras, D Tang, J Tuff, PJ McLaren
Publication Date: 2020-06

Variant appearance in text: rs3745274
PubMed Link: 32409920
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients.

Frontiers In Pharmacology
JH Ahmed, E Makonnen, RK Bisaso, JK Mukonzo, A Fotoohi, A Aseffa, R Howe, M Hassan, E Aklillu
Publication Date: 2020

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 32390827
Variant Present in the following documents:
  • Main text
View BVdb publication page



Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy.

Frontiers In Pharmacology
ZN Al-Mahayri, GP Patrinos, BR Ali
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32351390
Variant Present in the following documents:
  • Main text
View BVdb publication page



Toward precision prescribing for methadone: Determinants of methadone deposition.

Plos One
AH Talal, Y Ding, CS Venuto, LM Chakan, A McLeod, A Dharia, GD Morse, LS Brown, M Markatou, ED Kharasch
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 32302325
Variant Present in the following documents:
  • Main text
View BVdb publication page



Importance of genetic polymorphisms in liver transplantation outcomes.

World Journal Of Gastroenterology
T Kelava, P Turcic, A Markotic, A Ostojic, D Sisl, A Mrzljak
Publication Date: 2020-03-28

Variant appearance in text: rs3745274
PubMed Link: 32256016
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases.

Molecules (Basel, Switzerland)
P Hajdinák, M Szabó, E Kiss, L Veress, L Wunderlich, A Szarka
Publication Date: 2020-03-28

Variant appearance in text: N/A
PubMed Link: 32231024
Variant Present in the following documents:
View BVdb publication page



Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.

Molecular Genetics & Genomic Medicine
LL Yu, W Zhang, J Li, L Zhao
Publication Date: 2020-05

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274
PubMed Link: 32119768
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations.

Frontiers In Pharmacology
S Mugusi, A Habtewold, E Ngaimisi, W Amogne, G Yimer, O Minzi, E Makonnen, C Sudfeld, J Burhenne, E Aklillu
Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 32116703
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study.

Cancers
B Altieri, S Sbiera, S Herterich, S De Francia, S Della Casa, A Calabrese, A Pontecorvi, M Quinkler, T Kienitz, M Mannelli, L Canu, A Angelousi, V Chortis, M Kroiss, M Terzolo, M Fassnacht, CL Ronchi
Publication Date: 2020-02-04

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274
PubMed Link: 32033200
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration.

Ja Clinical Reports
A Fujita, K Hayamizu, T Yoshihara, M Zaitsu, F Shiraishi, H Arima, K Matsuo, K Shiokawa, H Setoguchi, T Sasaguri
Publication Date: 2018-08-13

Variant appearance in text: rs3745274
PubMed Link: 32025958
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children.

Pharmacogenomics And Personalized Medicine
D Pavlovic, I Budic, T Jevtovic Stoimenov, D Stokanovic, V Marjanovic, M Stevic, M Slavkovic, D Simic
Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274
PubMed Link: 32021384
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine.

Pharmacogenomics And Personalized Medicine
M Chamnanphon, A Gaedigk, A Puangpetch, E Pasomsub, W Chantratita, RJ Longley, J Sattabongkot, P Chariyavilaskul, C Sukasem
Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 32021383
Variant Present in the following documents:
  • Main text
View BVdb publication page



Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.

Plos One
T Ahsan, NJ Urmi, AA Sajib
Publication Date: 2020

Variant appearance in text: rs3745274
PubMed Link: 31971968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.

Journal Of Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020-01-06

Variant appearance in text: rs3745274
PubMed Link: 31935801
Variant Present in the following documents:
  • Main text
View BVdb publication page



Adverse Drug Reactions Associated with CYP 2B6 Polymorphisms in HIV/AIDS-Treated Patients in Yaoundé, Cameroon.

The Application Of Clinical Genetics
C Nguefeu Nkenfou, B Atogho Tiedeu, C Nguefeu Nkenfou, AM Nji, JP Chedjou, C Tah Fomboh, C Kouanfack, WF Mbacham
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31920362
Variant Present in the following documents:
  • Main text
View BVdb publication page



Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.

Antimicrobial Agents And Chemotherapy
ST Abdullahi, JO Soyinka, A Olagunju, RA Bolarinwa, OJ Olarewaju, MT Bakare-Odunola, M Winterberg, J Tarning, A Owen, S Khoo
Publication Date: 2020-02-21

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 31871092
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.

Scientific Reports
M Gómez-Silva, E Piñeyro-Garza, R Vargas-Zapata, ME Gamino-Peña, A León-García, MB de León, A Llerena, RBR León-Cachón
Publication Date: 2019-11-28

Variant appearance in text: rs3745274
PubMed Link: 31780765
Variant Present in the following documents:
  • 41598_2019_Article_54436.pdf
  • aaaaaMain text
View BVdb publication page



Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

Pharmaceutics
Y Cazaubon, Y Talineau, C Feliu, C Konecki, J Russello, O Mathieu, Z Djerada
Publication Date: 2019-10-31

Variant appearance in text: rs3745274
PubMed Link: 31683663
Variant Present in the following documents:
  • Main text
  • pharmaceutics-11-00566.pdf
View BVdb publication page



Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.

Frontiers In Pharmacology
V Gonzalez-Covarrubias, M Morales-Franco, OF Cruz-Correa, A Martínez-Hernández, H García-Ortíz, F Barajas-Olmos, AD Genis-Mendoza, JJ Martínez-Magaña, H Nicolini, L Orozco, X Soberón
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31649539
Variant Present in the following documents:
  • Main text
  • fphar-10-01169.pdf
View BVdb publication page



Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial.

Journal Of Translational Medicine
M Alunni-Fabbroni, K Rönsch, T Huber, CC Cyran, M Seidensticker, J Mayerle, M Pech, B Basu, C Verslype, J Benckert, P Malfertheiner, J Ricke
Publication Date: 2019-10-01

Variant appearance in text: CYP2B6: 516G>T; Q172H
PubMed Link: 31570105
Variant Present in the following documents:
  • 12967_2019_Article_2079.pdf
View BVdb publication page



CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.

International Journal Of Chronic Obstructive Pulmonary Disease
Y Ding, Q Li, Q Feng, D Xu, C Wu, J Zhao, X Zhou, Y Yang, H Niu, P He, L Xing
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31564857
Variant Present in the following documents:
  • Main text
View BVdb publication page



Feasibility of Integrating Panel-Based Pharmacogenomics Testing for Chemotherapy and Supportive Care in Patients With Colorectal Cancer.

Technology In Cancer Research & Treatment
PM Kasi, T Koep, E Schnettler, F Shahjehan, V Kamatham, C Baldeo, CL Hughes
Publication Date: 2019-01-01

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 31533552
Variant Present in the following documents:
  • OneOme_sample_comprehensive_report.pdf
View BVdb publication page



Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery.

Pharmacogenomics And Personalized Medicine
H Awad, A Ahmed, RD Urman, N Stoicea, SD Bergese
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31440074
Variant Present in the following documents:
  • pgpm-12-145.pdf
View BVdb publication page



Pharmacogenomic considerations for medications in the perioperative setting.

Pharmacogenomics
EH Jhun, JL Apfelbaum, DM Dickerson, S Shahul, R Knoebel, K Danahey, MJ Ratain, PH O'Donnell
Publication Date: 2019-07

Variant appearance in text: CYP2B6: Gln172His; rs3745274
PubMed Link: 31411557
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers.

Clinical And Translational Science
IF Metzger, N Dave, Y Kreutz, JBL Lu, RE Galinsky, Z Desta
Publication Date: 2019-11

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 31339646
Variant Present in the following documents:
  • Main text
  • CTS-12-657.pdf
View BVdb publication page



Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.

Antimicrobial Agents And Chemotherapy
A Enimil, S Antwi, H Yang, A Dompreh, WA Alghamdi, FS Gillani, A Orstin, D Bosomtwe, T Opoku, J Norman, L Wiesner, T Langaee, CA Peloquin, MH Court, DJ Greenblatt, A Kwara
Publication Date: 2019-10

Variant appearance in text: rs3745274
PubMed Link: 31332062
Variant Present in the following documents:
  • Main text
View BVdb publication page



Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals
PF Wang, A Neiner, ED Kharasch
Publication Date: 2019-10

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 31324697
Variant Present in the following documents:
  • Main text
View BVdb publication page



Use of Pharmacogenetic Drugs by the Dutch Population.

Frontiers In Genetics
MA Alshabeeb, VHM Deneer, A Khan, FW Asselbergs
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31312209
Variant Present in the following documents:
  • Main text
View BVdb publication page



A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.

Aids (London, England)
RC Patel, RM Stalter, KK Thomas, B Tamraz, SW Blue, DW Erikson, CJ Kim, EJ Kelly, K Nanda, AP Kourtis, JR Lingappa, N Mugo, JM Baeten, KK Scarsi,
Publication Date: 2019-11-01

Variant appearance in text: rs3745274
PubMed Link: 31306173
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.

The Journal Of Antimicrobial Chemotherapy
M Neary, CA Chappell, KK Scarsi, S Nakalema, J Matovu, SL Achilles, BA Chen, M Siccardi, A Owen, M Lamorde
Publication Date: 2019-10-01

Variant appearance in text: rs3745274
PubMed Link: 31299074
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.

The Journal Of Antimicrobial Chemotherapy
WA Alghamdi, S Antwi, A Enimil, H Yang, A Dompreh, L Wiesner, T Langaee, CA Peloquin, A Kwara
Publication Date: 2019-09-01

Variant appearance in text: rs3745274
PubMed Link: 31243456
Variant Present in the following documents:
  • Main text
View BVdb publication page



Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.

Journal Of Acquired Immune Deficiency Syndromes (1999)
M Bwakura Dangarembizi, P Samson, EV Capparelli, CB Moore, P Jean-Philippe, SA Spector, N Chakhtoura, A Benns, B Zimmer, L Purdue, C Jackson, C Wallis, JL Libous, EG Chadwick,
Publication Date: 2019-08-01

Variant appearance in text: rs3745274
PubMed Link: 31241542
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics of Nicotine Metabolism: Novel CYP2A6 and CYP2B6 Genetic Variation Patterns in Alaska Native and American Indian Populations.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
KG Claw, JA Beans, SB Lee, JP Avey, PA Stapleton, SE Scherer, A El-Boraie, RF Tyndale, DA Nickerson, DA Dillard, KE Thummel, RF Robinson
Publication Date: 2020-05-26

Variant appearance in text: rs3745274
PubMed Link: 31241144
Variant Present in the following documents:
  • Main text
View BVdb publication page



The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology
NA Helsby, M Yong, M van Kan, JR de Zoysa, KE Burns
Publication Date: 2019-09

Variant appearance in text: rs3745274
PubMed Link: 31218720
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.

Pharmacogenetics And Genomics
S Tshabalala, A Choudhury, N Beeton-Kempen, N Martinson, M Ramsay, D Mancama
Publication Date: 2019-09

Variant appearance in text: rs3745274
PubMed Link: 31162291
Variant Present in the following documents:
  • Main text
  • pgen-29-167-s003.xlsx
  • pgen-29-167.pdf
View BVdb publication page



Targeted next generation sequencing as a tool for precision medicine.

Bmc Medical Genomics
M Gulilat, T Lamb, WA Teft, J Wang, JS Dron, JF Robinson, RG Tirona, RA Hegele, RB Kim, UI Schwarz
Publication Date: 2019-06-03

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 31159795
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients.

Frontiers In Pharmacology
JH Ahmed, E Makonnen, G Yimer, D Seifu, A Bekele, M Assefa, A Aseffa, R Howe, A Fotoohi, M Hassan, E Aklillu
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31139078
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.

Genes
P Crocco, A Montesanto, S Dato, S Geracitano, F Iannone, G Passarino, G Rose
Publication Date: 2019-05-27

Variant appearance in text: rs3745274
PubMed Link: 31137904
Variant Present in the following documents:
  • Main text
View BVdb publication page



Between a rock and a hard place: a high-risk patient with resistance to multiple P2Y12 antagonists.

Pharmacogenomics
BH Davis, C Dillon, A Cai, LA Williams Iii, SV Pamboukian, NA Limdi
Publication Date: 2019-05

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 31124414
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy.

Molecular Genetics & Genomic Medicine
K Jay, A Mitra, T Harding, D Matthes, B Van Ness
Publication Date: 2019-07

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 31111659
Variant Present in the following documents:
  • MGG3-7-e00751-s001.docx
View BVdb publication page



Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population.

Scientific Reports
NA Afsar, H Bruckmueller, AN Werk, MK Nisar, HR Ahmad, I Cascorbi
Publication Date: 2019-05-13

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 31086207
Variant Present in the following documents:
  • Main text
View BVdb publication page



Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

Southern African Journal Of Hiv Medicine
J Johnston, L Wiesner, P Smith, G Maartens, C Orrell
Publication Date: 2019

Variant appearance in text: rs3745274
PubMed Link: 31061724
Variant Present in the following documents:
  • Main text
View BVdb publication page



Secondary actionable findings identified by exome sequencing: expected impact on the organisation of care from the study of 700 consecutive tests.

European Journal Of Human Genetics : Ejhg
C Thauvin-Robinet, J Thevenon, S Nambot, J Delanne, P Kuentz, AL Bruel, A Chassagne, E Cretin, A Pelissier, C Peyron, E Gautier, D Lehalle, N Jean-Marçais, P Callier, AL Mosca-Boidron, A Vitobello, A Sorlin, F Tran Mau-Them, C Philippe, P Vabres, L Demougeot, C Poé, T Jouan, M Chevarin, M Lefebvre, M Bardou, E Tisserant, M Luu, C Binquet, JF Deleuze, C Verstuyft, Y Duffourd, L Faivre
Publication Date: 2019-08

Variant appearance in text: rs3745274
PubMed Link: 31019283
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Clinical Pharmacology And Therapeutics
Z Desta, RS Gammal, L Gong, M Whirl-Carrillo, AH Gaur, C Sukasem, J Hockings, A Myers, M Swart, RF Tyndale, C Masimirembwa, OF Iwuchukwu, S Chirwa, J Lennox, A Gaedigk, TE Klein, DW Haas
Publication Date: 2019-10

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274
PubMed Link: 31006110
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.

Molecular Genetics & Genomic Medicine
C Zhang, W Guo, Y Cheng, Q Li, X Yang, R Dai, L Zhu, W Chen
Publication Date: 2019-05

Variant appearance in text: rs3745274
PubMed Link: 30955239
Variant Present in the following documents:
  • Main text
View BVdb publication page



Actionable Pharmacogenetic Variation in the Slovenian Genomic Database.

Frontiers In Pharmacology
K Hočevar, A Maver, B Peterlin
Publication Date: 2019

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274
PubMed Link: 30930780
Variant Present in the following documents:
  • Main text
View BVdb publication page



Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study.

British Journal Of Clinical Pharmacology
C Victorri-Vigneau, C Verstuyft, R Bouquié, EJ Laforgue, JB Hardouin, J Leboucher, B Le Geay, C Dano, G Challet-Bouju, M Grall-Bronnec
Publication Date: 2019-07

Variant appearance in text: rs3745274
PubMed Link: 30907440
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.

Pharmacology Research & Perspectives
AJ Bloom, PF Wang, ED Kharasch
Publication Date: 2019-04

Variant appearance in text: N/A
PubMed Link: 30906561
Variant Present in the following documents:
View BVdb publication page



A Lower Dose of Efavirenz Can Be Coadministered With Rifampicin and Isoniazid in Tuberculosis Patients.

Open Forum Infectious Diseases
JP Kaboggoza, X Wang, M Neary, P Ayuso, C Sekaggya-Wiltshire, S Nakalema, A Owen, M McClure, M Lamorde, M Boffito
Publication Date: 2019-02

Variant appearance in text: rs3745274
PubMed Link: 30815503
Variant Present in the following documents:
  • Main text
View BVdb publication page



No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.

Clinical Pharmacology And Therapeutics
C Zahner, E Kruttschnitt, J Uricher, M Lissy, M Hirsch, S Nicolussi, S Krähenbühl, J Drewe
Publication Date: 2019-08

Variant appearance in text: rs3745274
PubMed Link: 30739325
Variant Present in the following documents:
  • CPT-106-432-s003.docx
View BVdb publication page



Pain polymorphisms and opioids: An evidence based review.

Molecular Medicine Reports
CMP Vieira, RM Fragoso, D Pereira, R Medeiros
Publication Date: 2019-03

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 30592275
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

Frontiers In Pharmacology
S Zhou, DJ Skaar, PA Jacobson, RS Huang
Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 30564130
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

The Journal Of Antimicrobial Chemotherapy
EH Decloedt, PZ Sinxadi, GU van Zyl, L Wiesner, S Khoo, JA Joska, DW Haas, G Maartens
Publication Date: 2019-03-01

Variant appearance in text: rs3745274
PubMed Link: 30535366
Variant Present in the following documents:
  • Main text
  • dky481.pdf
View BVdb publication page



Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?

British Journal Of Clinical Pharmacology
ST Abdullahi, A Olagunju, JO Soyinka, RA Bolarinwa, OJ Olarewaju, MT Bakare-Odunola, A Owen, S Khoo
Publication Date: 2019-03

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 30471138
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.

Systematic Reviews
M Richardson, J Kirkham, K Dwan, DJ Sloan, G Davies, AL Jorgensen
Publication Date: 2018-11-20

Variant appearance in text: rs3745274
PubMed Link: 30458875
Variant Present in the following documents:
  • 13643_2018_861_MOESM8_ESM.docx
  • aaaaaMain text
View BVdb publication page



Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.

International Journal Of Molecular Sciences
IS Olivier, R Cacabelos, V Naidoo
Publication Date: 2018-11-14

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 30441796
Variant Present in the following documents:
  • Main text
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Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients receiving nevirapine-based antiretroviral therapy.

Bmc Infectious Diseases
A Giacomelli, A Riva, FS Falvella, ML Oreni, D Cattaneo, S Cheli, G Renisi, V Di Cristo, A Lupo, E Clementi, S Rusconi, M Galli, AL Ridolfo
Publication Date: 2018-11-12

Variant appearance in text: rs3745274
PubMed Link: 30419834
Variant Present in the following documents:
  • Main text
View BVdb publication page



K-variant BCHE and pesticide exposure: Gene-environment interactions in a case-control study of Parkinson's disease in Egypt.

Scientific Reports
TW Rösler, M Salama, AS Shalash, EM Khedr, A El-Tantawy, G Fawi, A El-Motayam, E El-Seidy, M El-Sherif, M El-Gamal, M Moharram, M El-Kattan, M Abdel-Naby, S Ashour, U Müller, A Dempfle, G Kuhlenbäumer, GU Höglinger
Publication Date: 2018-11-08

Variant appearance in text: rs3745274
PubMed Link: 30410011
Variant Present in the following documents:
  • 41598_2018_35003_MOESM1_ESM.pdf
  • aaaaaMain text
View BVdb publication page



Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports
SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj
Publication Date: 2018-11-08

Variant appearance in text: rs3745274
PubMed Link: 30409984
Variant Present in the following documents:
  • Main text
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Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype.

Scientific Reports
EN Kitabi, OMS Minzi, S Mugusi, P Sasi, M Janabi, F Mugusi, L Bertilsson, J Burhenne, E Aklillu
Publication Date: 2018-11-05

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 30397233
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, Japan November 16-19, 2018.

Pediatric Blood & Cancer
.
Publication Date: 2018-11

Variant appearance in text: rs3745274
PubMed Link: 30240102
Variant Present in the following documents:
  • Main text
View BVdb publication page



User considerations in assessing pharmacogenomic tests and their clinical support tools.

Npj Genomic Medicine
G Mukerjee, A Huston, B Kabakchiev, M Piquette-Miller, R van Schaik, R Dorfman
Publication Date: 2018

Variant appearance in text: rs3745274
PubMed Link: 30210808
Variant Present in the following documents:
  • 41525_2018_65_MOESM1_ESM.docx
View BVdb publication page



Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.

European Journal Of Drug Metabolism And Pharmacokinetics
J Torgersen, SL Bellamy, B Ratshaa, X Han, M Mosepele, AF Zuppa, M Vujkovic, AP Steenhoff, GP Bisson, R Gross
Publication Date: 2019-04

Variant appearance in text: rs3745274
PubMed Link: 30168000
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.

Osong Public Health And Research Perspectives
L Hananta, I Astuti, AH Sadewa, J Alice, J Hutagalung, Mustofa
Publication Date: 2018-08

Variant appearance in text: N/A
PubMed Link: 30159225
Variant Present in the following documents:
View BVdb publication page



Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark.

Bmj Open
LJ Collin, DP Cronin-Fenton, TP Ahern, PM Christiansen, P Damkier, B Ejlertsen, S Hamilton-Dutoit, A Kjærsgaard, RA Silliman, HT Sørensen, TL Lash
Publication Date: 2018-08-01

Variant appearance in text: rs3745274
PubMed Link: 30068618
Variant Present in the following documents:
  • Main text
View BVdb publication page



Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects.

Biomed Research International
RJ Dinis-Oliveira
Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 29992157
Variant Present in the following documents:
  • Main text
View BVdb publication page



Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.

Pharmacology Research & Perspectives
P Haage, R Kronstrand, M Josefsson, S Calistri, RHN van Schaik, H Green, FC Kugelberg
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29992026
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population.

Saudi Pharmaceutical Journal : Spj : The Official Publication Of The Saudi Pharmaceutical Society
O Filiptsova, M Kobets, J Kobets, O Naboka, O Koiro, A Ochkur, L Galiy
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29991909
Variant Present in the following documents:
  • Main text
View BVdb publication page



From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.

Pharmacogenomics
NC Salloum, ELF Buchalter, S Chanani, G Espejo, MS Ismail, RO Laine, M Nageeb, AB Srivastava, N Trapp, L Trillo, E Vance, M Wenzinger, SM Hartz, SP David, LS Chen
Publication Date: 2018-07-01

Variant appearance in text: rs3745274
PubMed Link: 29914292
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and genetic determinants of nevirapine plasma trough concentration.

Sage Open Medicine
A Giacomelli, S Rusconi, FS Falvella, ML Oreni, D Cattaneo, V Cozzi, G Renisi, E Monge, S Cheli, E Clementi, A Riva, M Galli, AL Ridolfo
Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T; rs3745274
PubMed Link: 29899984
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.

The Journal Of Antimicrobial Chemotherapy
TB de Almeida, MCVM de Azevedo, JFDC Pinto, FRA Ferry, GAR da Silva, IJ de Castro, P Baker, A Tanuri, DW Haas, CC Cardoso
Publication Date: 2018-09-01

Variant appearance in text: rs3745274
PubMed Link: 29868865
Variant Present in the following documents:
  • Main text
  • dky190_supplementary_data.docx
View BVdb publication page



Disease burden and the role of pharmacogenomics in African populations.

Global Health, Epidemiology And Genomics
KL Mpye, A Matimba, K Dzobo, S Chirikure, A Wonkam, C Dandara
Publication Date: 2017

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 29868213
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

The Pharmacogenomics Journal
M Vujkovic, SL Bellamy, AF Zuppa, MR Gastonguay, GS Moorthy, B Ratshaa, X Han, AP Steenhoff, M Mosepele, BL Strom, GP Bisson, R Aplenc, R Gross
Publication Date: 2018-09

Variant appearance in text: rs3745274
PubMed Link: 29855606
Variant Present in the following documents:
  • Main text
View BVdb publication page



Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events.

Pharmacogenetics And Genomics
DW Haas, Y Bradford, A Verma, SS Verma, JJ Eron, RM Gulick, SA Riddler, PE Sax, ES Daar, GD Morse, EP Acosta, MD Ritchie
Publication Date: 2018-07

Variant appearance in text: rs3745274
PubMed Link: 29847509
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.

Clinical Pharmacology And Therapeutics
ED Kharasch, A Crafford
Publication Date: 2019-01

Variant appearance in text: rs3745274
PubMed Link: 29756345
Variant Present in the following documents:
  • Main text
  • nihms-968353.pdf
View BVdb publication page



Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

American Journal Of Medical Genetics. Part A
AM Padula, W Yang, K Schultz, F Lurmann, SK Hammond, GM Shaw
Publication Date: 2018-05

Variant appearance in text: rs3745274
PubMed Link: 29681089
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
H Ma, W Zhang, X Yang, Y Zhang, S Wei, H Zhang, Y Ma, H Dang
Publication Date: 2018-04-11

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 29637923
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of Opioid Use Disorder Treatment.

Cns Drugs
RC Crist, TK Clarke, WH Berrettini
Publication Date: 2018-04

Variant appearance in text: rs3745274
PubMed Link: 29623639
Variant Present in the following documents:
  • Main text
View BVdb publication page



Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.

Scientific Reports
L Tawe, T Motshoge, P Ramatlho, N Mutukwa, CW Muthoga, GBD Dongho, A Martinelli, E Peloewetse, G Russo, IK Quaye, GM Paganotti
Publication Date: 2018-03-20

Variant appearance in text: rs3745274
PubMed Link: 29559695
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

Clinical Pharmacokinetics
S Schalkwijk, R Ter Heine, AC Colbers, ADR Huitema, P Denti, KE Dooley, E Capparelli, BM Best, TR Cressey, R Greupink, FGM Russel, M Mirochnick, DM Burger
Publication Date: 2018-11

Variant appearance in text: CYP2B6: 516G>T
PubMed Link: 29520730
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics.

Biochemical Pharmacology
T Ahmad, MA Valentovic, GO Rankin
Publication Date: 2018-07

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274
PubMed Link: 29458047
Variant Present in the following documents:
  • Main text
View BVdb publication page



P450 Pharmacogenetics in Indigenous North American Populations.

Journal Of Personalized Medicine
LM Henderson, KG Claw, EL Woodahl, RF Robinson, BB Boyer, W Burke, KE Thummel
Publication Date: 2018-02-01

Variant appearance in text: CYP2B6: Q172H; rs3745274
PubMed Link: 29389890
Variant Present in the following documents:
  • Main text
View BVdb publication page



Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.

Pharmacogenomics
WS Oetting, B Wu, DP Schladt, W Guan, RP Remmel, C Dorr, RB Mannon, AJ Matas, AK Israni, PA Jacobson
Publication Date: 2018-02

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274
PubMed Link: 29318894
Variant Present in the following documents:
  • Main text
View BVdb publication page



Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer.

Oncotarget
HI Woo, SK Lee, J Kim, SW Kim, J Yu, SY Bae, JE Lee, SJ Nam, SY Lee
Publication Date: 2017-11-21

Variant appearance in text: rs3745274
PubMed Link: 29245979
Variant Present in the following documents:
  • oncotarget-08-100296-s002.doc
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000324071.4 c.516G>T p.Gln172His missense_variant 4/9 -
ENST00000330446.5 c.364+2490G>T - intron_variant - 2/4
ENST00000593831.1 c.256+2490G>T - intron_variant - 2/4
ENST00000594187.1 n.100G>T - non_coding_transcript_exon_variant 2/2 -
ENST00000598834.1 n.418G>T - non_coding_transcript_exon_variant 4/5 -
NM_000767.5 c.516G>T p.Gln172His missense_variant 4/9 -