Publications:

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Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study.

Bmc Medicine

RM Turner, EM de Koning, V Fontana, A Thompson, M Pirmohamed

Publication Date: 2020-11-25

Variant appearance in text: rs3745274

PubMed Link: 33234119

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.

Journal Of Personalized Medicine

V Hlaváč, P Holý, P Souček

Publication Date: 2020-08-28

Variant appearance in text: rs3745274

PubMed Link: 32872162

Variant Present in the following documents:

• Main text

View BVdb publication page

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Analysis of Comprehensive Pharmacogenomic Profiling of VIP Variants Among the Genetically Isolated Chechen Subpopulation from Jordan.

Pharmacogenomics And Personalized Medicine

LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani

Publication Date: 2020

Variant appearance in text: rs3745274

PubMed Link: 32765042

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

International Journal Of Molecular Sciences

CM Hattinger, MP Patrizio, S Luppi, M Serra

Publication Date: 2020-06-30

Variant appearance in text: rs3745274

PubMed Link: 32629971

Variant Present in the following documents:

• Main text

View BVdb publication page

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The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial.

Scientific Reports

RBR León-Cachón, AD Bamford, I Meester, HA Barrera-Saldaña, M Gómez-Silva, MFG Bustos

Publication Date: 2020-06-01

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 32483134

Variant Present in the following documents:

• Main text

View BVdb publication page

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Minding the gap in HIV host genetics: opportunities and challenges.

Human Genetics

SN Gingras, D Tang, J Tuff, PJ McLaren

Publication Date: 2020-06

Variant appearance in text: rs3745274

PubMed Link: 32409920

Variant Present in the following documents:

• Main text

View BVdb publication page

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Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients.

Frontiers In Pharmacology

JH Ahmed, E Makonnen, RK Bisaso, JK Mukonzo, A Fotoohi, A Aseffa, R Howe, M Hassan, E Aklillu

Publication Date: 2020

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 32390827

Variant Present in the following documents:

• Main text

View BVdb publication page

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Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy.

Frontiers In Pharmacology

ZN Al-Mahayri, GP Patrinos, BR Ali

Publication Date: 2020

Variant appearance in text: rs3745274

PubMed Link: 32351390

Variant Present in the following documents:

• Main text

View BVdb publication page

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Toward precision prescribing for methadone: Determinants of methadone deposition.

Plos One

AH Talal, Y Ding, CS Venuto, LM Chakan, A McLeod, A Dharia, GD Morse, LS Brown, M Markatou, ED Kharasch

Publication Date: 2020

Variant appearance in text: rs3745274

PubMed Link: 32302325

Variant Present in the following documents:

• Main text

View BVdb publication page

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Importance of genetic polymorphisms in liver transplantation outcomes.

World Journal Of Gastroenterology

T Kelava, P Turcic, A Markotic, A Ostojic, D Sisl, A Mrzljak

Publication Date: 2020-03-28

Variant appearance in text: rs3745274

PubMed Link: 32256016

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases.

Molecules (Basel, Switzerland)

P Hajdinák, M Szabó, E Kiss, L Veress, L Wunderlich, A Szarka

Publication Date: 2020-03-28

Variant appearance in text: N/A

PubMed Link: 32231024

Variant Present in the following documents:

View BVdb publication page

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Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.

Molecular Genetics & Genomic Medicine

LL Yu, W Zhang, J Li, L Zhao

Publication Date: 2020-05

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274

PubMed Link: 32119768

Variant Present in the following documents:

• Main text

View BVdb publication page

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Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations.

Frontiers In Pharmacology

S Mugusi, A Habtewold, E Ngaimisi, W Amogne, G Yimer, O Minzi, E Makonnen, C Sudfeld, J Burhenne, E Aklillu

Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 32116703

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study.

Cancers

B Altieri, S Sbiera, S Herterich, S De Francia, S Della Casa, A Calabrese, A Pontecorvi, M Quinkler, T Kienitz, M Mannelli, L Canu, A Angelousi, V Chortis, M Kroiss, M Terzolo, M Fassnacht, CL Ronchi

Publication Date: 2020-02-04

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274

PubMed Link: 32033200

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration.

Ja Clinical Reports

A Fujita, K Hayamizu, T Yoshihara, M Zaitsu, F Shiraishi, H Arima, K Matsuo, K Shiokawa, H Setoguchi, T Sasaguri

Publication Date: 2018-08-13

Variant appearance in text: rs3745274

PubMed Link: 32025958

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children.

Pharmacogenomics And Personalized Medicine

D Pavlovic, I Budic, T Jevtovic Stoimenov, D Stokanovic, V Marjanovic, M Stevic, M Slavkovic, D Simic

Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274

PubMed Link: 32021384

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine.

Pharmacogenomics And Personalized Medicine

M Chamnanphon, A Gaedigk, A Puangpetch, E Pasomsub, W Chantratita, RJ Longley, J Sattabongkot, P Chariyavilaskul, C Sukasem

Publication Date: 2020

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 32021383

Variant Present in the following documents:

• Main text

View BVdb publication page

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Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.

Plos One

T Ahsan, NJ Urmi, AA Sajib

Publication Date: 2020

Variant appearance in text: rs3745274

PubMed Link: 31971968

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.

Journal Of Personalized Medicine

LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani

Publication Date: 2020-01-06

Variant appearance in text: rs3745274

PubMed Link: 31935801

Variant Present in the following documents:

• Main text

View BVdb publication page

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Adverse Drug Reactions Associated with CYP 2B6 Polymorphisms in HIV/AIDS-Treated Patients in Yaoundé, Cameroon.

The Application Of Clinical Genetics

C Nguefeu Nkenfou, B Atogho Tiedeu, C Nguefeu Nkenfou, AM Nji, JP Chedjou, C Tah Fomboh, C Kouanfack, WF Mbacham

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31920362

Variant Present in the following documents:

• Main text

View BVdb publication page

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Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.

Antimicrobial Agents And Chemotherapy

ST Abdullahi, JO Soyinka, A Olagunju, RA Bolarinwa, OJ Olarewaju, MT Bakare-Odunola, M Winterberg, J Tarning, A Owen, S Khoo

Publication Date: 2020-02-21

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 31871092

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.

Scientific Reports

M Gómez-Silva, E Piñeyro-Garza, R Vargas-Zapata, ME Gamino-Peña, A León-García, MB de León, A Llerena, RBR León-Cachón

Publication Date: 2019-11-28

Variant appearance in text: rs3745274

PubMed Link: 31780765

Variant Present in the following documents:

• 41598_2019_Article_54436.pdf
• aaaaaMain text

View BVdb publication page

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Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

Pharmaceutics

Y Cazaubon, Y Talineau, C Feliu, C Konecki, J Russello, O Mathieu, Z Djerada

Publication Date: 2019-10-31

Variant appearance in text: rs3745274

PubMed Link: 31683663

Variant Present in the following documents:

• Main text
• pharmaceutics-11-00566.pdf

View BVdb publication page

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Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.

Frontiers In Pharmacology

V Gonzalez-Covarrubias, M Morales-Franco, OF Cruz-Correa, A Martínez-Hernández, H García-Ortíz, F Barajas-Olmos, AD Genis-Mendoza, JJ Martínez-Magaña, H Nicolini, L Orozco, X Soberón

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31649539

Variant Present in the following documents:

• Main text
• fphar-10-01169.pdf

View BVdb publication page

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Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial.

Journal Of Translational Medicine

M Alunni-Fabbroni, K Rönsch, T Huber, CC Cyran, M Seidensticker, J Mayerle, M Pech, B Basu, C Verslype, J Benckert, P Malfertheiner, J Ricke

Publication Date: 2019-10-01

Variant appearance in text: CYP2B6: 516G>T; Q172H

PubMed Link: 31570105

Variant Present in the following documents:

• 12967_2019_Article_2079.pdf

View BVdb publication page

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CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.

International Journal Of Chronic Obstructive Pulmonary Disease

Y Ding, Q Li, Q Feng, D Xu, C Wu, J Zhao, X Zhou, Y Yang, H Niu, P He, L Xing

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31564857

Variant Present in the following documents:

• Main text

View BVdb publication page

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Feasibility of Integrating Panel-Based Pharmacogenomics Testing for Chemotherapy and Supportive Care in Patients With Colorectal Cancer.

Technology In Cancer Research & Treatment

PM Kasi, T Koep, E Schnettler, F Shahjehan, V Kamatham, C Baldeo, CL Hughes

Publication Date: 2019-01-01

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 31533552

Variant Present in the following documents:

• OneOme_sample_comprehensive_report.pdf

View BVdb publication page

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Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery.

Pharmacogenomics And Personalized Medicine

H Awad, A Ahmed, RD Urman, N Stoicea, SD Bergese

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31440074

Variant Present in the following documents:

• pgpm-12-145.pdf

View BVdb publication page

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Pharmacogenomic considerations for medications in the perioperative setting.

Pharmacogenomics

EH Jhun, JL Apfelbaum, DM Dickerson, S Shahul, R Knoebel, K Danahey, MJ Ratain, PH O'Donnell

Publication Date: 2019-07

Variant appearance in text: CYP2B6: Gln172His; rs3745274

PubMed Link: 31411557

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers.

Clinical And Translational Science

IF Metzger, N Dave, Y Kreutz, JBL Lu, RE Galinsky, Z Desta

Publication Date: 2019-11

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 31339646

Variant Present in the following documents:

• Main text
• CTS-12-657.pdf

View BVdb publication page

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Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.

Antimicrobial Agents And Chemotherapy

A Enimil, S Antwi, H Yang, A Dompreh, WA Alghamdi, FS Gillani, A Orstin, D Bosomtwe, T Opoku, J Norman, L Wiesner, T Langaee, CA Peloquin, MH Court, DJ Greenblatt, A Kwara

Publication Date: 2019-10

Variant appearance in text: rs3745274

PubMed Link: 31332062

Variant Present in the following documents:

• Main text

View BVdb publication page

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Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals

PF Wang, A Neiner, ED Kharasch

Publication Date: 2019-10

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 31324697

Variant Present in the following documents:

• Main text

View BVdb publication page

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Use of Pharmacogenetic Drugs by the Dutch Population.

Frontiers In Genetics

MA Alshabeeb, VHM Deneer, A Khan, FW Asselbergs

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31312209

Variant Present in the following documents:

• Main text

View BVdb publication page

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A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.

Aids (London, England)

RC Patel, RM Stalter, KK Thomas, B Tamraz, SW Blue, DW Erikson, CJ Kim, EJ Kelly, K Nanda, AP Kourtis, JR Lingappa, N Mugo, JM Baeten, KK Scarsi,

Publication Date: 2019-11-01

Variant appearance in text: rs3745274

PubMed Link: 31306173

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.

The Journal Of Antimicrobial Chemotherapy

M Neary, CA Chappell, KK Scarsi, S Nakalema, J Matovu, SL Achilles, BA Chen, M Siccardi, A Owen, M Lamorde

Publication Date: 2019-10-01

Variant appearance in text: rs3745274

PubMed Link: 31299074

Variant Present in the following documents:

• Main text

View BVdb publication page

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Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.

The Journal Of Antimicrobial Chemotherapy

WA Alghamdi, S Antwi, A Enimil, H Yang, A Dompreh, L Wiesner, T Langaee, CA Peloquin, A Kwara

Publication Date: 2019-09-01

Variant appearance in text: rs3745274

PubMed Link: 31243456

Variant Present in the following documents:

• Main text

View BVdb publication page

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Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.

Journal Of Acquired Immune Deficiency Syndromes (1999)

M Bwakura Dangarembizi, P Samson, EV Capparelli, CB Moore, P Jean-Philippe, SA Spector, N Chakhtoura, A Benns, B Zimmer, L Purdue, C Jackson, C Wallis, JL Libous, EG Chadwick,

Publication Date: 2019-08-01

Variant appearance in text: rs3745274

PubMed Link: 31241542

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenomics of Nicotine Metabolism: Novel CYP2A6 and CYP2B6 Genetic Variation Patterns in Alaska Native and American Indian Populations.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco

KG Claw, JA Beans, SB Lee, JP Avey, PA Stapleton, SE Scherer, A El-Boraie, RF Tyndale, DA Nickerson, DA Dillard, KE Thummel, RF Robinson

Publication Date: 2020-05-26

Variant appearance in text: rs3745274

PubMed Link: 31241144

Variant Present in the following documents:

• Main text

View BVdb publication page

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The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology

NA Helsby, M Yong, M van Kan, JR de Zoysa, KE Burns

Publication Date: 2019-09

Variant appearance in text: rs3745274

PubMed Link: 31218720

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.

Pharmacogenetics And Genomics

S Tshabalala, A Choudhury, N Beeton-Kempen, N Martinson, M Ramsay, D Mancama

Publication Date: 2019-09

Variant appearance in text: rs3745274

PubMed Link: 31162291

Variant Present in the following documents:

• Main text
• pgen-29-167-s003.xlsx
• pgen-29-167.pdf

View BVdb publication page

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Targeted next generation sequencing as a tool for precision medicine.

Bmc Medical Genomics

M Gulilat, T Lamb, WA Teft, J Wang, JS Dron, JF Robinson, RG Tirona, RA Hegele, RB Kim, UI Schwarz

Publication Date: 2019-06-03

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 31159795

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients.

Frontiers In Pharmacology

JH Ahmed, E Makonnen, G Yimer, D Seifu, A Bekele, M Assefa, A Aseffa, R Howe, A Fotoohi, M Hassan, E Aklillu

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31139078

Variant Present in the following documents:

• Main text

View BVdb publication page

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Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.

Genes

P Crocco, A Montesanto, S Dato, S Geracitano, F Iannone, G Passarino, G Rose

Publication Date: 2019-05-27

Variant appearance in text: rs3745274

PubMed Link: 31137904

Variant Present in the following documents:

• Main text

View BVdb publication page

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Between a rock and a hard place: a high-risk patient with resistance to multiple P2Y12 antagonists.

Pharmacogenomics

BH Davis, C Dillon, A Cai, LA Williams Iii, SV Pamboukian, NA Limdi

Publication Date: 2019-05

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 31124414

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy.

Molecular Genetics & Genomic Medicine

K Jay, A Mitra, T Harding, D Matthes, B Van Ness

Publication Date: 2019-07

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 31111659

Variant Present in the following documents:

• MGG3-7-e00751-s001.docx

View BVdb publication page

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Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population.

Scientific Reports

NA Afsar, H Bruckmueller, AN Werk, MK Nisar, HR Ahmad, I Cascorbi

Publication Date: 2019-05-13

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 31086207

Variant Present in the following documents:

• Main text

View BVdb publication page

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Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

Southern African Journal Of Hiv Medicine

J Johnston, L Wiesner, P Smith, G Maartens, C Orrell

Publication Date: 2019

Variant appearance in text: rs3745274

PubMed Link: 31061724

Variant Present in the following documents:

• Main text

View BVdb publication page

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Secondary actionable findings identified by exome sequencing: expected impact on the organisation of care from the study of 700 consecutive tests.

European Journal Of Human Genetics : Ejhg

C Thauvin-Robinet, J Thevenon, S Nambot, J Delanne, P Kuentz, AL Bruel, A Chassagne, E Cretin, A Pelissier, C Peyron, E Gautier, D Lehalle, N Jean-Marçais, P Callier, AL Mosca-Boidron, A Vitobello, A Sorlin, F Tran Mau-Them, C Philippe, P Vabres, L Demougeot, C Poé, T Jouan, M Chevarin, M Lefebvre, M Bardou, E Tisserant, M Luu, C Binquet, JF Deleuze, C Verstuyft, Y Duffourd, L Faivre

Publication Date: 2019-08

Variant appearance in text: rs3745274

PubMed Link: 31019283

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Clinical Pharmacology And Therapeutics

Z Desta, RS Gammal, L Gong, M Whirl-Carrillo, AH Gaur, C Sukasem, J Hockings, A Myers, M Swart, RF Tyndale, C Masimirembwa, OF Iwuchukwu, S Chirwa, J Lennox, A Gaedigk, TE Klein, DW Haas

Publication Date: 2019-10

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274

PubMed Link: 31006110

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.

Molecular Genetics & Genomic Medicine

C Zhang, W Guo, Y Cheng, Q Li, X Yang, R Dai, L Zhu, W Chen

Publication Date: 2019-05

Variant appearance in text: rs3745274

PubMed Link: 30955239

Variant Present in the following documents:

• Main text

View BVdb publication page

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Actionable Pharmacogenetic Variation in the Slovenian Genomic Database.

Frontiers In Pharmacology

K Hočevar, A Maver, B Peterlin

Publication Date: 2019

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274

PubMed Link: 30930780

Variant Present in the following documents:

• Main text

View BVdb publication page

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Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study.

British Journal Of Clinical Pharmacology

C Victorri-Vigneau, C Verstuyft, R Bouquié, EJ Laforgue, JB Hardouin, J Leboucher, B Le Geay, C Dano, G Challet-Bouju, M Grall-Bronnec

Publication Date: 2019-07

Variant appearance in text: rs3745274

PubMed Link: 30907440

Variant Present in the following documents:

• Main text

View BVdb publication page

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Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.

Pharmacology Research & Perspectives

AJ Bloom, PF Wang, ED Kharasch

Publication Date: 2019-04

Variant appearance in text: N/A

PubMed Link: 30906561

Variant Present in the following documents:

View BVdb publication page

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A Lower Dose of Efavirenz Can Be Coadministered With Rifampicin and Isoniazid in Tuberculosis Patients.

Open Forum Infectious Diseases

JP Kaboggoza, X Wang, M Neary, P Ayuso, C Sekaggya-Wiltshire, S Nakalema, A Owen, M McClure, M Lamorde, M Boffito

Publication Date: 2019-02

Variant appearance in text: rs3745274

PubMed Link: 30815503

Variant Present in the following documents:

• Main text

View BVdb publication page

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No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.

Clinical Pharmacology And Therapeutics

C Zahner, E Kruttschnitt, J Uricher, M Lissy, M Hirsch, S Nicolussi, S Krähenbühl, J Drewe

Publication Date: 2019-08

Variant appearance in text: rs3745274

PubMed Link: 30739325

Variant Present in the following documents:

• CPT-106-432-s003.docx

View BVdb publication page

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Pain polymorphisms and opioids: An evidence based review.

Molecular Medicine Reports

CMP Vieira, RM Fragoso, D Pereira, R Medeiros

Publication Date: 2019-03

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 30592275

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

Frontiers In Pharmacology

S Zhou, DJ Skaar, PA Jacobson, RS Huang

Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 30564130

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

The Journal Of Antimicrobial Chemotherapy

EH Decloedt, PZ Sinxadi, GU van Zyl, L Wiesner, S Khoo, JA Joska, DW Haas, G Maartens

Publication Date: 2019-03-01

Variant appearance in text: rs3745274

PubMed Link: 30535366

Variant Present in the following documents:

• Main text
• dky481.pdf

View BVdb publication page

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Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?

British Journal Of Clinical Pharmacology

ST Abdullahi, A Olagunju, JO Soyinka, RA Bolarinwa, OJ Olarewaju, MT Bakare-Odunola, A Owen, S Khoo

Publication Date: 2019-03

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 30471138

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.

Systematic Reviews

M Richardson, J Kirkham, K Dwan, DJ Sloan, G Davies, AL Jorgensen

Publication Date: 2018-11-20

Variant appearance in text: rs3745274

PubMed Link: 30458875

Variant Present in the following documents:

• 13643_2018_861_MOESM8_ESM.docx
• aaaaaMain text

View BVdb publication page

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Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.

International Journal Of Molecular Sciences

IS Olivier, R Cacabelos, V Naidoo

Publication Date: 2018-11-14

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 30441796

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients receiving nevirapine-based antiretroviral therapy.

Bmc Infectious Diseases

A Giacomelli, A Riva, FS Falvella, ML Oreni, D Cattaneo, S Cheli, G Renisi, V Di Cristo, A Lupo, E Clementi, S Rusconi, M Galli, AL Ridolfo

Publication Date: 2018-11-12

Variant appearance in text: rs3745274

PubMed Link: 30419834

Variant Present in the following documents:

• Main text

View BVdb publication page

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K-variant BCHE and pesticide exposure: Gene-environment interactions in a case-control study of Parkinson's disease in Egypt.

Scientific Reports

TW Rösler, M Salama, AS Shalash, EM Khedr, A El-Tantawy, G Fawi, A El-Motayam, E El-Seidy, M El-Sherif, M El-Gamal, M Moharram, M El-Kattan, M Abdel-Naby, S Ashour, U Müller, A Dempfle, G Kuhlenbäumer, GU Höglinger

Publication Date: 2018-11-08

Variant appearance in text: rs3745274

PubMed Link: 30410011

Variant Present in the following documents:

• 41598_2018_35003_MOESM1_ESM.pdf
• aaaaaMain text

View BVdb publication page

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Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports

SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj

Publication Date: 2018-11-08

Variant appearance in text: rs3745274

PubMed Link: 30409984

Variant Present in the following documents:

• Main text

View BVdb publication page

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Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype.

Scientific Reports

EN Kitabi, OMS Minzi, S Mugusi, P Sasi, M Janabi, F Mugusi, L Bertilsson, J Burhenne, E Aklillu

Publication Date: 2018-11-05

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 30397233

Variant Present in the following documents:

• Main text

View BVdb publication page

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Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, Japan November 16-19, 2018.

Pediatric Blood & Cancer

.

Publication Date: 2018-11

Variant appearance in text: rs3745274

PubMed Link: 30240102

Variant Present in the following documents:

• Main text

View BVdb publication page

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User considerations in assessing pharmacogenomic tests and their clinical support tools.

Npj Genomic Medicine

G Mukerjee, A Huston, B Kabakchiev, M Piquette-Miller, R van Schaik, R Dorfman

Publication Date: 2018

Variant appearance in text: rs3745274

PubMed Link: 30210808

Variant Present in the following documents:

• 41525_2018_65_MOESM1_ESM.docx

View BVdb publication page

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Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.

European Journal Of Drug Metabolism And Pharmacokinetics

J Torgersen, SL Bellamy, B Ratshaa, X Han, M Mosepele, AF Zuppa, M Vujkovic, AP Steenhoff, GP Bisson, R Gross

Publication Date: 2019-04

Variant appearance in text: rs3745274

PubMed Link: 30168000

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.

Osong Public Health And Research Perspectives

L Hananta, I Astuti, AH Sadewa, J Alice, J Hutagalung, Mustofa

Publication Date: 2018-08

Variant appearance in text: N/A

PubMed Link: 30159225

Variant Present in the following documents:

View BVdb publication page

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Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark.

Bmj Open

LJ Collin, DP Cronin-Fenton, TP Ahern, PM Christiansen, P Damkier, B Ejlertsen, S Hamilton-Dutoit, A Kjærsgaard, RA Silliman, HT Sørensen, TL Lash

Publication Date: 2018-08-01

Variant appearance in text: rs3745274

PubMed Link: 30068618

Variant Present in the following documents:

• Main text

View BVdb publication page

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Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects.

Biomed Research International

RJ Dinis-Oliveira

Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 29992157

Variant Present in the following documents:

• Main text

View BVdb publication page

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Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.

Pharmacology Research & Perspectives

P Haage, R Kronstrand, M Josefsson, S Calistri, RHN van Schaik, H Green, FC Kugelberg

Publication Date: 2018-07

Variant appearance in text: rs3745274

PubMed Link: 29992026

Variant Present in the following documents:

• Main text

View BVdb publication page

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Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population.

Saudi Pharmaceutical Journal : Spj : The Official Publication Of The Saudi Pharmaceutical Society

O Filiptsova, M Kobets, J Kobets, O Naboka, O Koiro, A Ochkur, L Galiy

Publication Date: 2018-07

Variant appearance in text: rs3745274

PubMed Link: 29991909

Variant Present in the following documents:

• Main text

View BVdb publication page

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From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.

Pharmacogenomics

NC Salloum, ELF Buchalter, S Chanani, G Espejo, MS Ismail, RO Laine, M Nageeb, AB Srivastava, N Trapp, L Trillo, E Vance, M Wenzinger, SM Hartz, SP David, LS Chen

Publication Date: 2018-07-01

Variant appearance in text: rs3745274

PubMed Link: 29914292

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical and genetic determinants of nevirapine plasma trough concentration.

Sage Open Medicine

A Giacomelli, S Rusconi, FS Falvella, ML Oreni, D Cattaneo, V Cozzi, G Renisi, E Monge, S Cheli, E Clementi, A Riva, M Galli, AL Ridolfo

Publication Date: 2018

Variant appearance in text: CYP2B6: 516G>T; rs3745274

PubMed Link: 29899984

Variant Present in the following documents:

• Main text

View BVdb publication page

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Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.

The Journal Of Antimicrobial Chemotherapy

TB de Almeida, MCVM de Azevedo, JFDC Pinto, FRA Ferry, GAR da Silva, IJ de Castro, P Baker, A Tanuri, DW Haas, CC Cardoso

Publication Date: 2018-09-01

Variant appearance in text: rs3745274

PubMed Link: 29868865

Variant Present in the following documents:

• Main text
• dky190_supplementary_data.docx

View BVdb publication page

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Disease burden and the role of pharmacogenomics in African populations.

Global Health, Epidemiology And Genomics

KL Mpye, A Matimba, K Dzobo, S Chirikure, A Wonkam, C Dandara

Publication Date: 2017

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 29868213

Variant Present in the following documents:

• Main text

View BVdb publication page

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Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

The Pharmacogenomics Journal

M Vujkovic, SL Bellamy, AF Zuppa, MR Gastonguay, GS Moorthy, B Ratshaa, X Han, AP Steenhoff, M Mosepele, BL Strom, GP Bisson, R Aplenc, R Gross

Publication Date: 2018-09

Variant appearance in text: rs3745274

PubMed Link: 29855606

Variant Present in the following documents:

• Main text

View BVdb publication page

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Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events.

Pharmacogenetics And Genomics

DW Haas, Y Bradford, A Verma, SS Verma, JJ Eron, RM Gulick, SA Riddler, PE Sax, ES Daar, GD Morse, EP Acosta, MD Ritchie

Publication Date: 2018-07

Variant appearance in text: rs3745274

PubMed Link: 29847509

Variant Present in the following documents:

• Main text

View BVdb publication page

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Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.

Clinical Pharmacology And Therapeutics

ED Kharasch, A Crafford

Publication Date: 2019-01

Variant appearance in text: rs3745274

PubMed Link: 29756345

Variant Present in the following documents:

• Main text
• nihms-968353.pdf

View BVdb publication page

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Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

American Journal Of Medical Genetics. Part A

AM Padula, W Yang, K Schultz, F Lurmann, SK Hammond, GM Shaw

Publication Date: 2018-05

Variant appearance in text: rs3745274

PubMed Link: 29681089

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research

H Ma, W Zhang, X Yang, Y Zhang, S Wei, H Zhang, Y Ma, H Dang

Publication Date: 2018-04-11

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 29637923

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pharmacogenetics of Opioid Use Disorder Treatment.

Cns Drugs

RC Crist, TK Clarke, WH Berrettini

Publication Date: 2018-04

Variant appearance in text: rs3745274

PubMed Link: 29623639

Variant Present in the following documents:

• Main text

View BVdb publication page

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Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.

Scientific Reports

L Tawe, T Motshoge, P Ramatlho, N Mutukwa, CW Muthoga, GBD Dongho, A Martinelli, E Peloewetse, G Russo, IK Quaye, GM Paganotti

Publication Date: 2018-03-20

Variant appearance in text: rs3745274

PubMed Link: 29559695

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

Clinical Pharmacokinetics

S Schalkwijk, R Ter Heine, AC Colbers, ADR Huitema, P Denti, KE Dooley, E Capparelli, BM Best, TR Cressey, R Greupink, FGM Russel, M Mirochnick, DM Burger

Publication Date: 2018-11

Variant appearance in text: CYP2B6: 516G>T

PubMed Link: 29520730

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics.

Biochemical Pharmacology

T Ahmad, MA Valentovic, GO Rankin

Publication Date: 2018-07

Variant appearance in text: CYP2B6: 516G>T; Q172H; rs3745274

PubMed Link: 29458047

Variant Present in the following documents:

• Main text

View BVdb publication page

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P450 Pharmacogenetics in Indigenous North American Populations.

Journal Of Personalized Medicine

LM Henderson, KG Claw, EL Woodahl, RF Robinson, BB Boyer, W Burke, KE Thummel

Publication Date: 2018-02-01

Variant appearance in text: CYP2B6: Q172H; rs3745274

PubMed Link: 29389890

Variant Present in the following documents:

• Main text

View BVdb publication page

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Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.

Pharmacogenomics

WS Oetting, B Wu, DP Schladt, W Guan, RP Remmel, C Dorr, RB Mannon, AJ Matas, AK Israni, PA Jacobson

Publication Date: 2018-02

Variant appearance in text: CYP2B6: 516G>T; Gln172His; rs3745274

PubMed Link: 29318894

Variant Present in the following documents:

• Main text

View BVdb publication page

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Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer.

Oncotarget

HI Woo, SK Lee, J Kim, SW Kim, J Yu, SY Bae, JE Lee, SJ Nam, SY Lee

Publication Date: 2017-11-21

Variant appearance in text: rs3745274

PubMed Link: 29245979

Variant Present in the following documents:

• oncotarget-08-100296-s002.doc

View BVdb publication page

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000324071.4	c.516G>T	p.Gln172His	missense_variant	4/9	-
ENST00000330446.5	c.364+2490G>T	-	intron_variant	-	2/4
ENST00000593831.1	c.256+2490G>T	-	intron_variant	-	2/4
ENST00000594187.1	n.100G>T	-	non_coding_transcript_exon_variant	2/2	-
ENST00000598834.1	n.418G>T	-	non_coding_transcript_exon_variant	4/5	-
NM_000767.5	c.516G>T	p.Gln172His	missense_variant	4/9	-