Publications:

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Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations.

Frontiers In Pharmacology

Parada-Márquez, Juan Fernando JF; Maldonado-Rodriguez, Nicolás David ND; Triana-Fonseca, Paula P; Contreras-Bravo, Nora Constanza NC; Calderón-Ospina, Carlos Alberto CA; Restrepo, Carlos M CM; Morel, Adrien A; Ortega-Recalde, Oscar Javier OJ; Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Fonseca-Mendoza, Dora Janeth DJ

Publication Date: 2023

Variant appearance in text: rs45482602

PubMed Link: 37021041

Variant Present in the following documents:

• Table2.xlsx, sheet 1

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Variations in the Frequencies of Polymorphisms in the CYP450s Genes in Eight Major Ethnicities of Iran: A Review of the Human Data.

Journal Of Personalized Medicine

Neyshaburinezhad, Navid N; Ghasim, Hengameh H; Rouini, Mohammadreza M; Daali, Youssef Y; Ardakani, Yalda H YH

Publication Date: 2022-11-05

Variant appearance in text: rs45482602

PubMed Link: 36579562

Variant Present in the following documents:

• jpm-12-01848.pdf

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Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.

Npj Genomic Medicine

Lanillos, Javier J; Carcajona, Marta M; Maietta, Paolo P; Alvarez, Sara S; Rodriguez-Antona, Cristina C

Publication Date: 2022-02-18

Variant appearance in text: CYP2B6: 777C>A; Ser259Arg; rs45482602

PubMed Link: 35181665

Variant Present in the following documents:

• 41525_2022_283_MOESM4_ESM.xlsx, sheet 1
• 41525_2022_283_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review.

Heliyon

Harahap, Yahdiana Y; Nurahman, Farhan F; Purwanto, Denni Joko DJ; Yanuar, Arry A

Publication Date: 2021-10

Variant appearance in text: CYP2B6: S259R

PubMed Link: 34746455

Variant Present in the following documents:

• Main text
• main.pdf

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 34621706

Variant Present in the following documents:

• Main text
• tcp-29-135.pdf
• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

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Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.

Journal Of Personalized Medicine

Neyshaburinezhad, Navid N; Ghasim, Hengameh H; Rouini, Mohammadreza M; Daali, Youssef Y; Ardakani, Yalda H YH

Publication Date: 2021-08-18

Variant appearance in text: rs45482602

PubMed Link: 34442448

Variant Present in the following documents:

• Main text
• jpm-11-00804.pdf

View BVdb publication page

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Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population.

Molecular Genetics & Genomic Medicine

Ahmed, Sagheer S; Khan, Saeed S; Janjua, Kholood K; Imran, Imran I; Khan, Arif Ullah AU

Publication Date: 2021-03

Variant appearance in text: rs45482602

PubMed Link: 33599403

Variant Present in the following documents:

• Main text
• MGG3-9-e1527.pdf

View BVdb publication page

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Variation in 100 relevant pharmacogenes among emiratis with insights from understudied populations.

Scientific Reports

Al-Mahayri, Zeina N ZN; Patrinos, George P GP; Wattanapokayakit, Sukanya S; Iemwimangsa, Nareenart N; Fukunaga, Koya K; Mushiroda, Taisei T; Chantratita, Wasun W; Ali, Bassam R BR

Publication Date: 2020-12-04

Variant appearance in text: rs45482602

PubMed Link: 33277594

Variant Present in the following documents:

• 41598_2020_78231_MOESM1_ESM.pdf

View BVdb publication page

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Exome Sequencing in BRCA1- and BRCA2-Negative Greek Families Identifies MDM1 and NBEAL1 as Candidate Risk Genes for Hereditary Breast Cancer.

Frontiers In Genetics

Glentis, Stavros S; Dimopoulos, Alexandros C AC; Rouskas, Konstantinos K; Ntritsos, George G; Evangelou, Evangelos E; Narod, Steven A SA; Mes-Masson, Anne-Marie AM; Foulkes, William D WD; Rivera, Barbara B; Tonin, Patricia N PN; Ragoussis, Jiannis J; Dimas, Antigone S AS

Publication Date: 2019

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 31681433

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 10

View BVdb publication page

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The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology

Helsby, N A NA; Yong, M M; van Kan, M M; de Zoysa, J R JR; Burns, K E KE

Publication Date: 2019-09

Variant appearance in text: rs45482602

PubMed Link: 31218720

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs45482602

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia.

Scientific Reports

Zakerska-Banaszak, Oliwia O; Skrzypczak-Zielinska, Marzena M; Tamowicz, Barbara B; Mikstacki, Adam A; Walczak, Michal M; Prendecki, Michal M; Dorszewska, Jolanta J; Pollak, Agnieszka A; Lechowicz, Urszula U; Oldak, Monika M; Huminska-Lisowska, Kinga K; Molinska-Glura, Marta M; Szalata, Marlena M; Slomski, Ryszard R

Publication Date: 2017-11-13

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 29133890

Variant Present in the following documents:

• Main text
• 41598_2017_Article_15657.pdf

View BVdb publication page

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The genetic epidemiology of substance use disorder: A review.

Drug And Alcohol Dependence

Prom-Wormley, Elizabeth C EC; Ebejer, Jane J; Dick, Danielle M DM; Bowers, M Scott MS

Publication Date: 2017-11-01

Variant appearance in text: rs45482602

PubMed Link: 28938182

Variant Present in the following documents:

• Main text

View BVdb publication page

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Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics

Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM

Publication Date: 2017-10

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 28378927

Variant Present in the following documents:

• Main text
• CPT-102-688.pdf

View BVdb publication page

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

View BVdb publication page

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Insights into CYP2B6-mediated drug-drug interactions.

Acta Pharmaceutica Sinica. B

Hedrich, William D WD; Hassan, Hazem E HE; Wang, Hongbing H

Publication Date: 2016-09

Variant appearance in text: CYP2B6: Ser259Arg

PubMed Link: 27709010

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco

Richmond-Rakerd, Leah S LS; Otto, Jacqueline M JM; Slutske, Wendy S WS; Ehlers, Cindy L CL; Wilhelmsen, Kirk C KC; Gizer, Ian R IR

Publication Date: 2017-04-01

Variant appearance in text: rs45482602

PubMed Link: 27663783

Variant Present in the following documents:

• Main text

View BVdb publication page

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The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine.

Genome Medicine

Garofalo, Andrea A; Sholl, Lynette L; Reardon, Brendan B; Taylor-Weiner, Amaro A; Amin-Mansour, Ali A; Miao, Diana D; Liu, David D; Oliver, Nelly N; MacConaill, Laura L; Ducar, Matthew M; Rojas-Rudilla, Vanesa V; Giannakis, Marios M; Ghazani, Arezou A; Gray, Stacy S; Janne, Pasi P; Garber, Judy J; Joffe, Steve S; Lindeman, Neal N; Wagle, Nikhil N; Garraway, Levi A LA; Van Allen, Eliezer M EM

Publication Date: 2016-07-26

Variant appearance in text: CYP2B6: 777C>A; S259R; rs45482602

PubMed Link: 27460824

Variant Present in the following documents:

• 13073_2016_333_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs45482602

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

View BVdb publication page

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Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals

Pearce, Robin E RE; Gaedigk, Roger R; Twist, Greyson P GP; Dai, Hongying H; Riffel, Amanda K AK; Leeder, J Steven JS; Gaedigk, Andrea A

Publication Date: 2016-07

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 26608082

Variant Present in the following documents:

• Main text

View BVdb publication page

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Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in Children.

International Journal Of Molecular Sciences

Franca, Raffaella R; Stocco, Gabriele G; Favretto, Diego D; Giurici, Nagua N; Decorti, Giuliana G; Rabusin, Marco M

Publication Date: 2015-08-10

Variant appearance in text: CYP2B6: Ser259Arg

PubMed Link: 26266406

Variant Present in the following documents:

• Main text

View BVdb publication page

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: N/A

PubMed Link: 26206375

Variant Present in the following documents:

View BVdb publication page

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs45482602

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs45482602

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

View BVdb publication page

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Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population.

The Malaysian Journal Of Medical Sciences : Mjms

Arnaldo, Paulo P; Thompson, Ricardo Estevão RE; Lopes, Márcia Quinhones MQ; Suffys, Philip Noel PN; Santos, Adalberto Rezende AR

Publication Date: 2013-07

Variant appearance in text: CYP2B6: 777C>A

PubMed Link: 24043992

Variant Present in the following documents:

• Main text

View BVdb publication page

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High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Pharmacogenomics

Twist, Greyson P GP; Gaedigk, Roger R; Leeder, J Steven JS; Gaedigk, Andrea A

Publication Date: 2013-06

Variant appearance in text: rs45482602

PubMed Link: 23746185

Variant Present in the following documents:

• Main text

View BVdb publication page

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Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.

Pharmacogenomics

Li, Jing J; Menard, Vincent V; Benish, Rebekah L RL; Jurevic, Richard J RJ; Guillemette, Chantal C; Stoneking, Mark M; Zimmerman, Peter A PA; Mehlotra, Rajeev K RK

Publication Date: 2012-04

Variant appearance in text: CYP2B6: Ser259Arg; rs45482602

PubMed Link: 22462748

Variant Present in the following documents:

• Main text

View BVdb publication page

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CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Addiction Biology

Levran, Orna O; Peles, Einat E; Hamon, Sara S; Randesi, Matthew M; Adelson, Miriam M; Kreek, Mary Jeanne MJ

Publication Date: 2013-07

Variant appearance in text: CYP2B6: S259R; rs45482602

PubMed Link: 21790905

Variant Present in the following documents:

• Main text

View BVdb publication page

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Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

British Journal Of Cancer

Bray, J J; Sludden, J J; Griffin, M J MJ; Cole, M M; Verrill, M M; Jamieson, D D; Boddy, A V AV

Publication Date: 2010-03-16

Variant appearance in text: CYP2B6: Ser259Arg

PubMed Link: 20179710

Variant Present in the following documents:

• Main text
• 6605587a.pdf

View BVdb publication page

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Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco

David, Sean P SP; Brown, Richard A RA; Papandonatos, George D GD; Kahler, Christopher W CW; Lloyd-Richardson, Elizabeth E EE; Munafò, Marcus R MR; Shields, Peter G PG; Lerman, Caryn C; Strong, David D; McCaffery, Jeanne J; Niaura, Raymond R

Publication Date: 2007-08

Variant appearance in text: N/A

PubMed Link: 17654295

Variant Present in the following documents:

View BVdb publication page

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Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea.

European Journal Of Clinical Pharmacology

Mehlotra, Rajeev K RK; Ziats, Mark N MN; Bockarie, Moses J MJ; Zimmerman, Peter A PA

Publication Date: 2006-04

Variant appearance in text: N/A

PubMed Link: 16506047

Variant Present in the following documents:

View BVdb publication page

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