SIRT6 c.438-151A>G

Variant ID: 19-4176085-T-C

NM_016539.2(SIRT6):c.438-151A>G

This variant was identified in 24 publications

View GRCh38 version.




Publications:


Characteristics of circulating small noncoding RNAs in plasma and serum during human aging.

Aging Medicine (Milton (N.S.W))
Xiao, Ping P; Shi, Zhangyue Z; Liu, Chenang C; Hagen, Darren E DE
Publication Date: 2023-03

Variant appearance in text: rs107251
PubMed Link: 36911092
Variant Present in the following documents:
  • AGM2-6-35-s002.xlsx, sheet 3
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Genetic regulation of newborn telomere length is mediated and modified by DNA methylation.

Frontiers In Genetics
Wang, Congrong C; Alfano, Rossella R; Reimann, Brigitte B; Hogervorst, Janneke J; Bustamante, Mariona M; De Vivo, Immaculata I; Plusquin, Michelle M; Nawrot, Tim S TS; Martens, Dries S DS
Publication Date: 2022

Variant appearance in text: rs107251
PubMed Link: 36267401
Variant Present in the following documents:
  • Main text
  • fgene-13-934277.pdf
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Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population.

Biomed Research International
Song, Xingfa X; Wang, Haidong H; Wang, Chao C; Ji, Guangquan G; Jiang, Pei P; Liang, Donglou D; Wang, Xiaojing X
Publication Date: 2022

Variant appearance in text: rs107251
PubMed Link: 35224092
Variant Present in the following documents:
  • BMRI2022-4294008.pdf
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Genetics Is of the Essence to Face NAFLD.

Biomedicines
Meroni, Marica M; Longo, Miriam M; Tria, Giada G; Dongiovanni, Paola P
Publication Date: 2021-09-30

Variant appearance in text: rs107251
PubMed Link: 34680476
Variant Present in the following documents:
  • Main text
  • biomedicines-09-01359.pdf
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Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.

Scientific Reports
Maszlag-Török, Rita R; Boros, Fanni A FA; Vécsei, László L; Klivényi, Péter P
Publication Date: 2021-05-21

Variant appearance in text: rs107251
PubMed Link: 34021216
Variant Present in the following documents:
  • Main text
  • 41598_2021_Article_90059.pdf
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Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC.

International Journal Of Molecular Sciences
Longo, Miriam M; Paolini, Erika E; Meroni, Marica M; Dongiovanni, Paola P
Publication Date: 2021-04-17

Variant appearance in text: rs107251
PubMed Link: 33920670
Variant Present in the following documents:
  • Main text
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The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.

Life (Basel, Switzerland)
Izzo, Carmine C; Vitillo, Paolo P; Di Pietro, Paola P; Visco, Valeria V; Strianese, Andrea A; Virtuoso, Nicola N; Ciccarelli, Michele M; Galasso, Gennaro G; Carrizzo, Albino A; Vecchione, Carmine C
Publication Date: 2021-01-15

Variant appearance in text: rs107251
PubMed Link: 33467601
Variant Present in the following documents:
  • Main text
  • life-11-00060.pdf
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Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section.

Neuropsychiatric Disease And Treatment
Luo, Shi-Chao SC; Duan, Kai-Ming KM; Fang, Chao C; Li, Dan-Yang DY; Zheng, Shan-Shan SS; Yang, Si-Qi SQ; Yang, Shu-Ting ST; Yang, Mi M; Zhang, Liang-Bin LB; Wang, Sai-Ying SY
Publication Date: 2020

Variant appearance in text: rs107251
PubMed Link: 33380799
Variant Present in the following documents:
  • Main text
  • ndt-16-3225.pdf
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Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells.

Epigenetics
Owczarz, Magdalena M; Połosak, Jacek J; Domaszewska-Szostek, Anna A; Kołodziej, Paulina P; Kuryłowicz, Alina A; Puzianowska-Kuźnicka, Monika M
Publication Date: 2020-12

Variant appearance in text: rs107251
PubMed Link: 32573339
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.

Acta Neuropathologica Communications
Nicholatos, Justin W JW; Francisco, Adam B AB; Bender, Carolyn A CA; Yeh, Tiffany T; Lugay, Fraz J FJ; Salazar, Jairo E JE; Glorioso, Christin C; Libert, Sergiy S
Publication Date: 2018-11-08

Variant appearance in text: rs107251
PubMed Link: 30409187
Variant Present in the following documents:
  • Main text
  • 40478_2018_Article_625.pdf
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Whole-exome sequencing analysis of Waardenburg syndrome in a Chinese family.

Human Genome Variation
Chen, Dezhong D; Zhao, Na N; Wang, Jing J; Li, Zhuoyu Z; Wu, Changxin C; Fu, Jie J; Xiao, Han H
Publication Date: 2017

Variant appearance in text: rs107251
PubMed Link: 28690861
Variant Present in the following documents:
  • hgv201727-s1.xls, sheet 1
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The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.

Antioxidants & Redox Signaling
Khoury, Nathalie N; Koronowski, Kevin B KB; Young, Juan I JI; Perez-Pinzon, Miguel A MA
Publication Date: 2018-03-10

Variant appearance in text: rs107251
PubMed Link: 28683567
Variant Present in the following documents:
  • Main text
View BVdb publication page



SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men.

Bmc Medical Genetics
Hirvonen, Katariina K; Laivuori, Hannele H; Lahti, Jari J; Strandberg, Timo T; Eriksson, Johan G JG; Hackman, Peter P
Publication Date: 2017-04-11

Variant appearance in text: rs107251
PubMed Link: 28399814
Variant Present in the following documents:
  • Main text
  • 12881_2017_Article_401.pdf
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Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension.

Scientific Reports
Liu, Xin X; Hu, Cheng C; Bao, Minghui M; Li, Jing J; Liu, Xiaoyan X; Tan, Xuerui X; Zhou, Yong Y; Chen, Yequn Y; Wu, Shouling S; Chen, Shuohua S; Zhang, Rong R; Jiang, Feng F; Jia, Weiping W; Wang, Xingyu X; Yang, Xinchun X; Cai, Jun J
Publication Date: 2016-08-02

Variant appearance in text: rs107251
PubMed Link: 27480026
Variant Present in the following documents:
  • srep30811-s1.pdf
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SIRT6 protects against endothelial dysfunction and atherosclerosis in mice.

Aging
Xu, Suowen S; Yin, Meimei M; Koroleva, Marina M; Mastrangelo, Michael A MA; Zhang, Wenbo W; Bai, Peter P; Little, Peter J PJ; Jin, Zheng Gen ZG
Publication Date: 2016-05

Variant appearance in text: rs107251
PubMed Link: 27249230
Variant Present in the following documents:
  • Main text
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Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.

Disease Markers
Tang, Sai-sai SS; Xu, Shun S; Cheng, Jie J; Cai, Meng-yun MY; Chen, Lin L; Liang, Li-li LL; Yang, Xi-li XL; Chen, Can C; Liu, Xin-guang XG; Xiong, Xing-dong XD
Publication Date: 2016

Variant appearance in text: rs107251
PubMed Link: 27118880
Variant Present in the following documents:
  • Main text
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In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins.

International Journal Of Molecular Sciences
Kurylowicz, Alina A
Publication Date: 2016-04-19

Variant appearance in text: rs107251
PubMed Link: 27104517
Variant Present in the following documents:
  • Main text
  • ijms-17-00572.pdf
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Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
Publication Date: 2015-12-08

Variant appearance in text: rs107251
PubMed Link: 26549847
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
  • mmc3.xlsx, sheet 1
  • mmc3.xlsx, sheet 2
View BVdb publication page



Sirtuin/uncoupling protein gene variants and carotid plaque area and morphology.

International Journal Of Stroke : Official Journal Of The International Stroke Society
Dong, Chuanhui C; Della-Morte, David D; Cabral, Digna D; Wang, Liyong L; Blanton, Susan H SH; Seemant, Chaturvedi C; Sacco, Ralph L RL; Rundek, Tatjana T
Publication Date: 2015-12

Variant appearance in text: rs107251
PubMed Link: 26332421
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.

International Journal Of Molecular Sciences
Sun, Kexin K; Xiang, Xiao X; Li, Na N; Huang, Shaoping S; Qin, Xueying X; Wu, Yiqun Y; Tang, Xun X; Gao, Pei P; Li, Jing J; Wu, Tao T; Chen, Dafang D; Hu, Yonghua Y
Publication Date: 2015-06-24

Variant appearance in text: rs107251
PubMed Link: 26114387
Variant Present in the following documents:
  • Main text
View BVdb publication page



SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

Plos One
TenNapel, Mindi J MJ; Lynch, Charles F CF; Burns, Trudy L TL; Wallace, Robert R; Smith, Brian J BJ; Button, Anna A; Domann, Frederick E FE
Publication Date: 2014

Variant appearance in text: rs107251
PubMed Link: 25541994
Variant Present in the following documents:
  • Main text
  • pone.0115616.pdf
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Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Age (Dordrecht, Netherlands)
Soerensen, Mette M; Dato, Serena S; Tan, Qihua Q; Thinggaard, Mikael M; Kleindorp, Rabea R; Beekman, Marian M; Suchiman, H Eka D HE; Jacobsen, Rune R; McGue, Matt M; Stevnsner, Tinna T; Bohr, Vilhelm A VA; de Craen, Anton J M AJ; Westendorp, Rudi G J RG; Schreiber, Stefan S; Slagboom, P Eline PE; Nebel, Almut A; Vaupel, James W JW; Christensen, Kaare K; Christiansen, Lene L
Publication Date: 2013-04

Variant appearance in text: rs107251
PubMed Link: 22234866
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque.

Plos One
Dong, Chuanhui C; Della-Morte, David D; Wang, Liyong L; Cabral, Digna D; Beecham, Ashley A; McClendon, Mark S MS; Luca, Corneliu C CC; Blanton, Susan H SH; Sacco, Ralph L RL; Rundek, Tatjana T
Publication Date: 2011

Variant appearance in text: rs107251
PubMed Link: 22087257
Variant Present in the following documents:
  • Main text
  • pone.0027157.pdf
View BVdb publication page



Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.

Clinical And Experimental Nephrology
Maeda, Shiro S; Koya, Daisuke D; Araki, Shin-Ichi SI; Babazono, Tetsuya T; Umezono, Tomoya T; Toyoda, Masao M; Kawai, Koichi K; Imanishi, Masahito M; Uzu, Takashi T; Suzuki, Daisuke D; Maegawa, Hiroshi H; Kashiwagi, Atsunori A; Iwamoto, Yasuhiko Y; Nakamura, Yusuke Y
Publication Date: 2011-06

Variant appearance in text: rs107251
PubMed Link: 21331741
Variant Present in the following documents:
  • Main text
  • 10157_2011_Article_418.pdf
View BVdb publication page