Publications:

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Increased prediction value of biomarker combinations for the conversion of mild cognitive impairment to Alzheimer's dementia.

Translational Neurodegeneration

A Zhao, Y Li, Y Yan, Y Qiu, B Li, W Xu, Y Wang, J Liu, Y Deng

Publication Date: 2020-08-03

Variant appearance in text: rs429358

PMID: 32741361

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Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.

Bmc Medical Genomics

OJ Veatch, CR Bauer, BT Keenan, NS Josyula, DR Mazzotti, K Bagai, BA Malow, JD Robishaw, AI Pack, SA Pendergrass

Publication Date: 2020-07-25

Variant appearance in text: rs429358

PMID: 32711518

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Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer's disease.

Scientific Reports

N Kobayashi, S Shinagawa, H Niimura, H Kida, T Nagata, K Tagai, K Shimada, N Oka, R Shikimoto, Y Noda, S Nakajima, M Mimura, M Shigeta, K Kondo

Publication Date: 2020-07-22

Variant appearance in text: rs429358

PMID: 32699290

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Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins.

Elife

MW Wong, A Thalamuthu, N Braidy, KA Mather, Y Liu, L Ciobanu, BT Baune, NJ Armstrong, J Kwok, P Schofield, MJ Wright, D Ames, R Pickford, T Lee, A Poljak, PS Sachdev

Publication Date: 2020-07-22

Variant appearance in text: rs429358

PMID: 32697195

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Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.

Frontiers In Aging Neuroscience

Q Zhang, L Wu, C Du, K Xu, J Sun, J Zhang, H Li, X Li

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32694990

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Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems.

Alzheimer'S & Dementia (New York, N. Y.)

L Sargent, M Nalls, EJ Amella, PW Slattum, M Mueller, S Bandinelli, Q Tian, T Swift-Scanlan, SK Lageman, A Singleton

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32685657

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Apolipoprotein E expression pattern in human induced pluripotent stem cells during in vitro neural induction.

F1000Research

H Lee, P Nowosiad, LM Dutan Polit, J Price, DP Srivastava, S Thuret

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32685135

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Multivariate genomic scan implicates novel loci and haem metabolism in human ageing.

Nature Communications

PRHJ Timmers, JF Wilson, PK Joshi, J Deelen

Publication Date: 2020-07-16

Variant appearance in text: rs429358

PMID: 32678081

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The role of interleukin-33 in patients with mild cognitive impairment and Alzheimer's disease.

Alzheimer'S Research & Therapy

CS Liang, KP Su, CL Tsai, JT Lee, CS Chu, TC Yeh, MW Su, GY Lin, YK Lin, HT Chu, CK Tsai, FC Yang

Publication Date: 2020-07-16

Variant appearance in text: rs429358

PMID: 32678011

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Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome.

Alzheimer'S & Dementia (Amsterdam, Netherlands)

RL Henson, E Doran, BT Christian, BL Handen, WE Klunk, F Lai, JH Lee, HD Rosas, N Schupf, SH Zaman, IT Lott, AM Fagan

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32671183

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Interactive Effects of Apolipoprotein E ε4 and Triiodothyronine on Memory Performance in Patients With Subjective Cognitive Decline.

Frontiers In Medicine

JS Lee, Y Soh, HG Kim, KM Lee, YN Kwon, SS Yoon, KC Park, HY Rhee

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32671080

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Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy.

Frontiers In Cell And Developmental Biology

PA Richmond, F van der Kloet, FM Vaz, D Lin, A Uzozie, E Graham, M Kobor, S Mostafavi, PD Moerland, PF Lange, AHC van Kampen, WW Wasserman, M Engelen, S Kemp, CDM van Karnebeek

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32671069

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Apolipoprotein E ε-4 as a genetic determinant of Alzheimer's disease heterogeneity.

Degenerative Neurological And Neuromuscular Disease

MJ Kotze, HK Lückhoff, T Brand, J Pretorius, SJ van Rensburg

Publication Date: 2015

Variant appearance in text: rs429358

PMID: 32669910

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Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification.

Bioinformatics (Oxford, England)

L Du, F Liu, K Liu, X Yao, SL Risacher, J Han, L Guo, AJ Saykin, L Shen,

Publication Date: 2020-07-01

Variant appearance in text: rs429358

PMID: 32657360

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A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.

Research In Developmental Disabilities

MSC Thomas, O Ojinaga Alfageme, H D'Souza, PA Patkee, MA Rutherford, KY Mok, J Hardy, A Karmiloff-Smith,

Publication Date: 2020-07-09

Variant appearance in text: rs429358

PMID: 32653761

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Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease.

Annals Of Clinical And Translational Neurology

JA Pillai, J Bena, G Bebek, LM Bekris, A Bonner-Jackson, L Kou, A Pai, L Sørensen, M Neilsen, SM Rao, M Chance, BT Lamb, JB Leverenz,

Publication Date: 2020-07-07

Variant appearance in text: rs429358

PMID: 32634865

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Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.

Bmc Medical Genomics

AR Waksmunski, M Grunin, TG Kinzy, RP Igo, JL Haines, JN Cooke Bailey

Publication Date: 2020-07-06

Variant appearance in text: rs429358

PMID: 32631374

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Recent Caffeine Drinking Associates with Cognitive Function in the UK Biobank.

Nutrients

MC Cornelis, S Weintraub, MC Morris

Publication Date: 2020-07-02

Variant appearance in text: rs429358

PMID: 32630669

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Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

International Journal Of Molecular Sciences

A Urbizu, K Beyer

Publication Date: 2020-07-02

Variant appearance in text: rs429358

PMID: 32630630

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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.

Alzheimer'S & Dementia (Amsterdam, Netherlands)

ME Petersen, F Zhang, N Schupf, SJ Krinsky-McHale, J Hall, M Mapstone, A Cheema, W Silverman, I Lott, MS Rafii, B Handen, W Klunk, E Head, B Christian, T Foroud, F Lai, HD Rosas, S Zaman, BM Ances, MC Wang, B Tycko, JH Lee, S O'Bryant,

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32626817

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Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.

Investigative Ophthalmology & Visual Science

MA Margeta, SM Letcher, RP Igo, JN Cooke Bailey, LR Pasquale, JL Haines, O Butovsky, JL Wiggs,

Publication Date: 2020-07-01

Variant appearance in text: rs429358

PMID: 32614373

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Plasma proteomic signatures predict dementia and cognitive impairment.

Alzheimer'S & Dementia (New York, N. Y.)

T Tanaka, R Lavery, V Varma, G Fantoni, M Colpo, M Thambisetty, J Candia, SM Resnick, DA Bennett, A Biancotto, S Bandinelli, L Ferrucci

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32607407

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Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Scientific Reports

F Röhr, N Bucholtz, S Toepfer, K Norman, D Spira, E Steinhagen-Thiessen, CM Lill, L Bertram, I Demuth, N Buchmann, S Düzel

Publication Date: 2020-06-30

Variant appearance in text: rs429358

PMID: 32606300

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Work Hours and Cognitive Function: The Multi-Ethnic Study of Atherosclerosis.

Safety And Health At Work

LE Charles, D Fekedulegn, CM Burchfiel, K Fujishiro, AZ Al Hazzouri, AL Fitzpatrick, SR Rapp

Publication Date: 2020-06

Variant appearance in text: rs429358

PMID: 32596013

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Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.

Lancet (London, England)

J Fortea, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernández, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, D Alcolea, J Clarimón, SH Zaman, R Blesa, A Lleó

Publication Date: 2020-06-27

Variant appearance in text: rs429358

PMID: 32593336

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APOE Alleles and Diet in Brain Aging and Alzheimer's Disease.

Frontiers In Aging Neuroscience

HN Yassine, CE Finch

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32587511

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TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer's Disease.

Frontiers In Aging Neuroscience

N Zhang, D Gu, M Meng, ML Gordon

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32581773

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Telmisartan and Rosuvastatin Synergistically Ameliorate Dementia and Cognitive Impairment in Older Hypertensive Patients With Apolipoprotein E Genotype.

Frontiers In Aging Neuroscience

W Hu, Y Li, Y Zhao, Y Dong, Y Cui, S Sun, G Gong, H Zhang, Q Chai, J Wang, Z Liu

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32581766

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APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.

Aging

J Sun, Z Zhu, K Chen, D Wei, X Li, H Li, J Zhang, X Chen, Y Chen, Z Zhang

Publication Date: 2020-06-22

Variant appearance in text: rs429358

PMID: 32572010

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Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Hakka postmenopausal women in southern China.

Lipids In Health And Disease

J Hou, Q Deng, X Guo, X Deng, W Zhong, Z Zhong

Publication Date: 2020-06-16

Variant appearance in text: rs429358

PMID: 32546237

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ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.

Lipids In Health And Disease

J Shi, Z Cheng, S Qiu, H Cui, Y Gu, Q Zhao, Y Ren, H Zhang, H Sun, Y Liu, Y Li, Y Qiao, Y Hu, Y Liu, Y Cheng

Publication Date: 2020-06-13

Variant appearance in text: rs429358

PMID: 32534589

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Clinical and pathologic features of cognitive-predominant corticobasal degeneration.

Neurology

N Sakae, OA Santos, O Pedraza, I Litvan, ME Murray, R Duara, RJ Uitti, ZK Wszolek, NR Graff-Radford, KA Josephs, DW Dickson

Publication Date: 2020-06-09

Variant appearance in text: rs429358

PMID: 32518146

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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.

Aging

CL Kuo, LC Pilling, JL Atkins, GA Kuchel, D Melzer

Publication Date: 2020-06-08

Variant appearance in text: rs429358

PMID: 32511104

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Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease.

Oxidative Medicine And Cellular Longevity

AA Mamun, MS Uddin, MF Bin Bashar, S Zaman, Y Begum, IJ Bulbul, MS Islam, MS Sarwar, B Mathew, MS Amran, G Md Ashraf, MN Bin-Jumah, SA Mousa, MM Abdel-Daim

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32509144

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Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer's Disease: An OCT Study.

Journal Of Clinical Medicine

I López-Cuenca, R de Hoz, E Salobrar-García, L Elvira-Hurtado, P Rojas, JA Fernández-Albarral, A Barabash, JJ Salazar, AI Ramírez, JM Ramírez

Publication Date: 2020-06-03

Variant appearance in text: rs429358

PMID: 32503282

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Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study.

Trials

M Shamloo, MJ Granger, EA Trautwein, JD House, D MacKay

Publication Date: 2020-06-01

Variant appearance in text: rs429358

PMID: 32487131

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Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study.

Bmc Psychiatry

Y Yoshino, T Yoshida, H Morino, M Nakamura, M Abe, H Omachi, S Inoue, Y Miyoshi, Y Tachibana, N Yamauchi, N Takeda, M Mizobuchi, Y Ozaki, S Ochi, J Iga, SI Ueno

Publication Date: 2020-06-01

Variant appearance in text: rs429358

PMID: 32487126

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Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.

Journal Of Personalized Medicine

V Bessi, J Balestrini, S Bagnoli, S Mazzeo, G Giacomucci, S Padiglioni, I Piaceri, M Carraro, C Ferrari, L Bracco, S Sorbi, B Nacmias

Publication Date: 2020-05-29

Variant appearance in text: rs429358

PMID: 32485802

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Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad

WLF Lim, K Huynh, P Chatterjee, I Martins, KS Jayawardana, C Giles, NA Mellett, SM Laws, AI Bush, CC Rowe, VL Villemagne, D Ames, BG Drew, CL Masters, PJ Meikle, RN Martins,

Publication Date: 2020-05-26

Variant appearance in text: rs429358

PMID: 32474467

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A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.

Molecular Genetics & Genomic Medicine

SM Soyal, M Kwik, O Kalev, S Lenz, G Zara, P Strasser, W Patsch, S Weis

Publication Date: 2020-05-30

Variant appearance in text: rs429358

PMID: 32472747

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Age-dependent effect of APOE and polygenic component on Alzheimer's disease.

Neurobiology Of Aging

E Bellou, E Baker, G Leonenko, M Bracher-Smith, P Daunt, G Menzies, J Williams, V Escott-Price,

Publication Date: 2020-04-30

Variant appearance in text: rs429358

PMID: 32464432

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The effect of LRRK2 loss-of-function variants in humans.

Nature Medicine

N Whiffin, IM Armean, A Kleinman, JL Marshall, EV Minikel, JK Goodrich, NM Quaife, JB Cole, Q Wang, KJ Karczewski, BB Cummings, L Francioli, K Laricchia, A Guan, B Alipanahi, P Morrison, MAS Baptista, KM Merchant, , , JS Ware, AS Havulinna, B Iliadou, JJ Lee, GN Nadkarni, C Whiteman, , M Daly, T Esko, C Hultman, RJF Loos, L Milani, A Palotie, C Pato, M Pato, D Saleheen, PF Sullivan, J Alföldi, P Cannon, DG MacArthur

Publication Date: 2020-05-27

Variant appearance in text: rs429358

PMID: 32461697

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APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.

Alzheimer'S Research & Therapy

E Konijnenberg, BM Tijms, J Gobom, V Dobricic, I Bos, S Vos, M Tsolaki, F Verhey, J Popp, P Martinez-Lage, R Vandenberghe, A Lleó, L Frölich, S Lovestone, J Streffer, L Bertram, K Blennow, CE Teunissen, R Veerhuis, AB Smit, P Scheltens, H Zetterberg, PJ Visser

Publication Date: 2020-05-27

Variant appearance in text: rs429358

PMID: 32460813

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APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort.

The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences

CL Kuo, LC Pilling, JL Atkins, JAH Masoli, J Delgado, GA Kuchel, D Melzer

Publication Date: 2020-05-26

Variant appearance in text: rs429358

PMID: 32451547

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Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolaemia: A Propensity Score Analysis.

Life (Basel, Switzerland)

A Mickiewicz, M Futema, A Ćwiklinska, A Kuchta, M Jankowski, M Kaszubowski, M Chmara, B Wasąg, M Fijałkowski, M Jaguszewski, SE Humphries, M Gruchała

Publication Date: 2020-05-20

Variant appearance in text: rs429358

PMID: 32443900

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High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil.

Brazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas

AP Batista, KF Barbosa, CZ Masioli, EM Queiroz, CC Marinho, APC Cândido, GLL Machado-Coelho

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32401924

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Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis.

Lipids In Health And Disease

Z Zhuang, M Gao, R Yang, N Li, Z Liu, W Cao, T Huang

Publication Date: 2020-05-08

Variant appearance in text: rs429358

PMID: 32384904

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Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.

Plos Biology

SM Ulv Larsen, HP Landolt, W Berger, M Nedergaard, GM Knudsen, SC Holst

Publication Date: 2020-05

Variant appearance in text: rs429358

PMID: 32369477

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Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.

Nature Communications

E Persyn, KB Hanscombe, JMM Howson, CM Lewis, M Traylor, HS Markus

Publication Date: 2020-05-01

Variant appearance in text: rs429358

PMID: 32358547

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Is APOE ε4 associated with cognitive performance in early MS?

Neurology(R) Neuroimmunology & Neuroinflammation

S Engel, C Graetz, A Salmen, M Muthuraman, G Toenges, B Ambrosius, A Bayas, A Berthele, C Heesen, L Klotz, T Kümpfel, RA Linker, SG Meuth, F Paul, M Stangel, B Tackenberg, F Then Bergh, H Tumani, F Weber, B Wildemann, UK Zettl, G Antony, S Bittner, S Groppa, B Hemmer, H Wiendl, R Gold, F Zipp, CM Lill, F Luessi,

Publication Date: 2020-07

Variant appearance in text: rs429358

PMID: 32358224

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Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

International Journal Of Molecular Sciences

R Cacabelos

Publication Date: 2020-04-26

Variant appearance in text: rs429358

PMID: 32357528

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DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health.

Alzheimer'S & Dementia (New York, N. Y.)

J Mur, DL McCartney, RM Walker, A Campbell, ML Bermingham, SW Morris, DJ Porteous, AM McIntosh, IJ Deary, KL Evans, RE Marioni

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32346601

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The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health.

Alzheimer'S Research & Therapy

J de Frutos-Lucas, P Cuesta, D López-Sanz, Á Peral-Suárez, E Cuadrado-Soto, F Ramírez-Toraño, BM Brown, JM Serrano, SM Laws, IC Rodríguez-Rojo, J Verdejo-Román, R Bruña, ML Delgado-Losada, A Barabash, AM López-Sobaler, R López-Higes, A Marcos, F Maestú

Publication Date: 2020-04-24

Variant appearance in text: rs429358

PMID: 32331531

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A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study.

Frontiers In Pharmacology

A Roco, E Nieto, M Suárez, M Rojo, MP Bertoglia, G Verón, F Tamayo, A Arredondo, D Cruz, J Muñoz, G Bravo, P Salas, F Mejías, G Godoy, P Véliz, LA Quiñones

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32327994

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A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2-73) Phase 2a clinical study.

Alzheimer'S & Dementia (New York, N. Y.)

H Hampel, C Williams, A Etcheto, F Goodsaid, F Parmentier, J Sallantin, WE Kaufmann, CU Missling, M Afshar

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32318621

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A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin.

Molecular Genetics & Genomic Medicine

LG Leal, C Hoggart, MR Jarvelin, KH Herzig, MJE Sternberg, A David

Publication Date: 2020-04-19

Variant appearance in text: rs429358

PMID: 32307928

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Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

Molecular Neurodegeneration

LZ Ma, L Tan, YL Bi, XN Shen, W Xu, YH Ma, HQ Li, Q Dong, JT Yu

Publication Date: 2020-04-10

Variant appearance in text: rs429358

PMID: 32276587

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Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome.

Alzheimer'S & Dementia (Amsterdam, Netherlands)

M Mapstone, TJ Gross, F Macciardi, AK Cheema, M Petersen, E Head, BL Handen, WE Klunk, BT Christian, W Silverman, IT Lott, N Schupf,

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32258359

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Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Journal Of Hepatology

CA Parisinos, HR Wilman, EL Thomas, M Kelly, RC Nicholls, J McGonigle, S Neubauer, AD Hingorani, RS Patel, H Hemingway, JD Bell, R Banerjee, H Yaghootkar

Publication Date: 2020-04-02

Variant appearance in text: rs429358

PMID: 32247823

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Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

Brain Pathology (Zurich, Switzerland)

S Koga, F Li, N Zhao, SF Roemer, TJ Ferman, AI Wernick, RL Walton, AH Faroqi, NR Graff-Radford, WP Cheshire, OA Ross, DW Dickson

Publication Date: 2020-03-30

Variant appearance in text: rs429358

PMID: 32232888

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Genome-wide analyses disclose the distinctive HLA architecture and the pharmacogenetic landscape of the Somali population.

Scientific Reports

AA Ali, M Aalto, J Jonasson, A Osman

Publication Date: 2020-03-27

Variant appearance in text: rs429358

PMID: 32221414

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Patient with frontal-variant syndrome in early-onset Alzheimer's disease.

General Psychiatry

H Cai, S Ning, W Li, X Li, S Xiao, L Sun

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32215362

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Genetic and regulatory architecture of Alzheimer's disease in the APOE region.

Alzheimer'S & Dementia (Amsterdam, Netherlands)

AM Kulminski, L Shu, Y Loika, L He, A Nazarian, K Arbeev, S Ukraintseva, A Yashin, I Culminskaya

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32211503

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Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients.

Disease Markers

Y Hu, T Ling, M Yu, Y Bai, T Feng, P Zhang, Y Wang

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32211081

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Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis.

Journal Of The American Heart Association

CL Schaich, D Malaver, H Chen, HA Shaltout, A Zeki Al Hazzouri, DM Herrington, TM Hughes

Publication Date: 2020-04-07

Variant appearance in text: rs429358

PMID: 32200711

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Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.

Nature Communications

JB Cole, JC Florez, JN Hirschhorn

Publication Date: 2020-03-19

Variant appearance in text: rs429358

PMID: 32193382

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DNA methylation QTL analysis identifies new regulators of human longevity.

Human Molecular Genetics

S Szymczak, J Dose, GG Torres, FA Heinsen, G Venkatesh, P Datlinger, M Nygaard, J Mengel-From, F Flachsbart, W Klapper, K Christensen, W Lieb, S Schreiber, R Häsler, C Bock, A Franke, A Nebel

Publication Date: 2020-03-11

Variant appearance in text: rs429358

PMID: 32160291

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Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations.

Elife

SM Smith, LT Elliott, F Alfaro-Almagro, P McCarthy, TE Nichols, G Douaud, KL Miller

Publication Date: 2020-03-05

Variant appearance in text: rs429358

PMID: 32134384

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Molecular diagnosis methods in familial hypercholesterolemia.

Anatolian Journal Of Cardiology

V Moldovan, C Banescu, M Dobreanu

Publication Date: 2020-02

Variant appearance in text: rs429358

PMID: 32120369

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Genetic Association of FERMT2, HLA-DRB1, CD2AP, and PTK2B Polymorphisms With Alzheimer's Disease Risk in the Southern Chinese Population.

Frontiers In Aging Neuroscience

Y Yan, A Zhao, Y Qui, Y Li, R Yan, Y Wang, W Xu, Y Deng

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 32116649

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Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment.

Scientific Reports

R Sussams, W Schlotz, Z Clough, J Amin, S Simpson, A Abbott, R Beardmore, R Sharples, R Raybould, K Brookes, K Morgan, D Culliford, C Holmes

Publication Date: 2020-02-27

Variant appearance in text: rs429358

PMID: 32108148

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Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene.

Jci Insight

X Liao, F Cai, Z Sun, Y Zhang, J Wang, B Jiao, J Guo, J Li, X Liu, L Guo, Y Zhou, J Wang, X Yan, H Jiang, K Xia, J Li, B Tang, L Shen, W Song

Publication Date: 2020-02-27

Variant appearance in text: rs429358

PMID: 32102983

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Risk factors for progression of age-related macular degeneration.

Ophthalmic & Physiological Optics : The Journal Of The British College Of Ophthalmic Opticians (Optometrists)

TJ Heesterbeek, L Lorés-Motta, CB Hoyng, YTE Lechanteur, AI den Hollander

Publication Date: 2020-02-25

Variant appearance in text: rs429358

PMID: 32100327

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GenEpi: gene-based epistasis discovery using machine learning.

Bmc Bioinformatics

YC Chang, JT Wu, MY Hong, YA Tung, PH Hsieh, SW Yee, KM Giacomini, YJ Oyang, CY Chen,

Publication Date: 2020-02-24

Variant appearance in text: rs429358

PMID: 32093643

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Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation.

Brain : A Journal Of Neurology

S Skouras, J Torner, P Andersson, Y Koush, C Falcon, C Minguillon, K Fauria, F Alpiste, K Blenow, H Zetterberg, JD Gispert, JL Molinuevo,

Publication Date: 2020-02-24

Variant appearance in text: rs429358

PMID: 32091109

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Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.

Scientific Reports

SL Evans, NG Dowell, F Prowse, N Tabet, SL King, JM Rusted

Publication Date: 2020-02-20

Variant appearance in text: rs429358

PMID: 32080211

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Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype.

Scientific Reports

JS Friedberg, N Aytan, JD Cherry, W Xia, OJ Standring, VE Alvarez, R Nicks, S Svirsky, G Meng, G Jun, H Ryu, R Au, TD Stein

Publication Date: 2020-02-19

Variant appearance in text: rs429358

PMID: 32076055

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APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.

Stroke

ST Pendlebury, D Poole, A Burgess, J Duerden, PM Rothwell,

Publication Date: 2020-02-18

Variant appearance in text: rs429358

PMID: 32070224

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Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study.

Scientific Reports

LCK Wong, MYZ Wong, CS Tan, H Vrooman, N Venketasubramanian, CY Cheng, C Chen, S Hilal

Publication Date: 2020-02-14

Variant appearance in text: rs429358

PMID: 32060376

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Impaired Innate Immunity Mechanisms in the Brain of Alzheimer's Disease.

International Journal Of Molecular Sciences

M Romagnoli, E Porcellini, I Carbone, R Veerhuis, F Licastro

Publication Date: 2020-02-08

Variant appearance in text: rs429358

PMID: 32046242

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Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial.

Bmj Open

DP Devanand, H Andrews, WC Kreisl, Q Razlighi, A Gershon, Y Stern, A Mintz, T Wisniewski, E Acosta, J Pollina, M Katsikoumbas, KL Bell, GH Pelton, D Deliyannides, KM Prasad, ED Huey

Publication Date: 2020-02-06

Variant appearance in text: rs429358

PMID: 32034019

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Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

Journal Of Alzheimer'S Disease : Jad

S Westwood, AL Baird, SN Anand, AJ Nevado-Holgado, A Kormilitzin, L Shi, A Hye, NJ Ashton, AR Morgan, I Bos, SJB Vos, S Baker, NJ Buckley, M Ten Kate, P Scheltens, CE Teunissen, R Vandenberghe, S Gabel, K Meersmans, S Engelborghs, EE De Roeck, K Sleegers, GB Frisoni, O Blin, JC Richardson, R Bordet, JL Molinuevo, L Rami, A Wallin, P Kettunen, M Tsolaki, F Verhey, A Lléo, I Sala, J Popp, G Peyratout, P Martinez-Lage, M Tainta, P Johannsen, Y Freund-Levi, L Frölich, V Dobricic, C Legido-Quigley, L Bertram, F Barkhof, H Zetterberg, BP Morgan, J Streffer, PJ Visser, S Lovestone

Publication Date: 2020-01-22

Variant appearance in text: rs429358

PMID: 31985466

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Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children.

Wellcome Open Research

R Korologou-Linden, L O'Keeffe, LD Howe, G Davey-Smith, HJ Jones, EL Anderson, E Stergiakouli

Publication Date: 2019

Variant appearance in text: rs429358

PMID: 31984241

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Mixed evidence for the relationship between periodontitis and Alzheimer's disease: A bidirectional Mendelian randomization study.

Plos One

YQ Sun, RC Richmond, Y Chen, XM Mai

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 31978120

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Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.

Plos One

EG Lee, J Tulloch, S Chen, L Leong, AD Saxton, B Kraemer, M Darvas, CD Keene, A Shutes-David, K Todd, S Millard, CE Yu

Publication Date: 2020

Variant appearance in text: rs429358

PMID: 31978088

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Accuracy of Imputation for Apolipoprotein E ε Alleles in Genome-Wide Genotyping Data.

Jama Network Open

E Vuoksimaa, T Palviainen, N Lindgren, JO Rinne, J Kaprio

Publication Date: 2020-01-03

Variant appearance in text: rs429358

PMID: 31977056

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The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.

Nature Communications

M Pinese, P Lacaze, EM Rath, A Stone, MJ Brion, A Ameur, S Nagpal, C Puttick, S Husson, D Degrave, TN Cristina, VFS Kahl, AL Statham, RL Woods, JJ McNeil, M Riaz, M Barr, MR Nelson, CM Reid, AM Murray, RC Shah, R Wolfe, JR Atkins, C Fitzsimmons, HM Cairns, MJ Green, VJ Carr, MJ Cowley, HA Pickett, PA James, JE Powell, W Kaplan, G Gibson, U Gyllensten, MJ Cairns, M McNamara, ME Dinger, DM Thomas

Publication Date: 2020-01-23

Variant appearance in text: rs429358

PMID: 31974348

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FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.

Nature Communications

T Yan, J Liang, J Gao, L Wang, H Fujioka, , X Zhu, X Wang

Publication Date: 2020-01-21

Variant appearance in text: rs429358

PMID: 31964863

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Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players.

Frontiers In Aging Neuroscience

R Corpas, E Solana, A De la Rosa, S Sarroca, C Griñán-Ferré, M Oriol, E Corbella, E Rodríguez-Farré, J Vina, M Pallàs, D Bartrés-Faz, MC Gomez-Cabrera, C Sanfeliu

Publication Date: 2019

Variant appearance in text: rs429358

PMID: 31956305

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Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders.

Annals Of Translational Medicine

LD Niu, W Xu, JQ Li, CC Tan, XP Cao, J Yu, L Tan,

Publication Date: 2019-11

Variant appearance in text: rs429358

PMID: 31930058

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000252486.4	c.388T>C	p.Cys130Arg	missense_variant	4/4	-
ENST00000425718.1	c.388T>C	p.Cys130Arg	missense_variant	3/3	-
ENST00000434152.1	c.466T>C	p.Cys156Arg	missense_variant	4/4	-
ENST00000446996.1	c.388T>C	p.Cys130Arg	missense_variant	4/4	-
NM_000041.4	c.388T>C	p.Cys130Arg	missense_variant	4/4	-
NM_001302688.2	c.466T>C	p.Cys156Arg	missense_variant	4/4	-
NM_001302689.2	c.388T>C	p.Cys130Arg	missense_variant	4/4	-
NM_001302690.1	c.388T>C	p.Cys130Arg	missense_variant	4/4	-
NM_001302691.2	c.388T>C	p.Cys130Arg	missense_variant	4/4	-