Variant ID: 19-45412079-C-T

NM_000041.2(APOE):c.526C>T;(p.Arg176Cys)

This variant was identified in 1366 publications




Publications:


Increased prediction value of biomarker combinations for the conversion of mild cognitive impairment to Alzheimer's dementia.

Translational Neurodegeneration
A Zhao, Y Li, Y Yan, Y Qiu, B Li, W Xu, Y Wang, J Liu, Y Deng
Publication Date: 2020-08-03

Variant appearance in text: rs7412
PMID: 32741361
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Mediterranean Diet and Endothelial Function: A Review of its Effects at Different Vascular Bed Levels.

Nutrients
JD Torres-Peña, OA Rangel-Zuñiga, JF Alcala-Diaz, J Lopez-Miranda, J Delgado-Lista
Publication Date: 2020-07-24

Variant appearance in text: rs7412
PMID: 32722321
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Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.

Bmc Medical Genomics
OJ Veatch, CR Bauer, BT Keenan, NS Josyula, DR Mazzotti, K Bagai, BA Malow, JD Robishaw, AI Pack, SA Pendergrass
Publication Date: 2020-07-25

Variant appearance in text: rs7412
PMID: 32711518
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Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer's disease.

Scientific Reports
N Kobayashi, S Shinagawa, H Niimura, H Kida, T Nagata, K Tagai, K Shimada, N Oka, R Shikimoto, Y Noda, S Nakajima, M Mimura, M Shigeta, K Kondo
Publication Date: 2020-07-22

Variant appearance in text: rs7412
PMID: 32699290
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Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins.

Elife
MW Wong, A Thalamuthu, N Braidy, KA Mather, Y Liu, L Ciobanu, BT Baune, NJ Armstrong, J Kwok, P Schofield, MJ Wright, D Ames, R Pickford, T Lee, A Poljak, PS Sachdev
Publication Date: 2020-07-22

Variant appearance in text: rs7412
PMID: 32697195
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Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.

Frontiers In Aging Neuroscience
Q Zhang, L Wu, C Du, K Xu, J Sun, J Zhang, H Li, X Li
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32694990
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Apolipoprotein E expression pattern in human induced pluripotent stem cells during in vitro neural induction.

F1000Research
H Lee, P Nowosiad, LM Dutan Polit, J Price, DP Srivastava, S Thuret
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32685135
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The role of interleukin-33 in patients with mild cognitive impairment and Alzheimer's disease.

Alzheimer'S Research & Therapy
CS Liang, KP Su, CL Tsai, JT Lee, CS Chu, TC Yeh, MW Su, GY Lin, YK Lin, HT Chu, CK Tsai, FC Yang
Publication Date: 2020-07-16

Variant appearance in text: rs7412
PMID: 32678011
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Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
RL Henson, E Doran, BT Christian, BL Handen, WE Klunk, F Lai, JH Lee, HD Rosas, N Schupf, SH Zaman, IT Lott, AM Fagan
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32671183
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Interactive Effects of Apolipoprotein E ε4 and Triiodothyronine on Memory Performance in Patients With Subjective Cognitive Decline.

Frontiers In Medicine
JS Lee, Y Soh, HG Kim, KM Lee, YN Kwon, SS Yoon, KC Park, HY Rhee
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32671080
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Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy.

Frontiers In Cell And Developmental Biology
PA Richmond, F van der Kloet, FM Vaz, D Lin, A Uzozie, E Graham, M Kobor, S Mostafavi, PD Moerland, PF Lange, AHC van Kampen, WW Wasserman, M Engelen, S Kemp, CDM van Karnebeek
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32671069
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Apolipoprotein E ε-4 as a genetic determinant of Alzheimer's disease heterogeneity.

Degenerative Neurological And Neuromuscular Disease
MJ Kotze, HK Lückhoff, T Brand, J Pretorius, SJ van Rensburg
Publication Date: 2015

Variant appearance in text: rs7412
PMID: 32669910
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Relationship between the Presence of the ApoE ε4 Allele and EEG Complexity along the Alzheimer's Disease Continuum.

Sensors (Basel, Switzerland)
V Gutiérrez-de Pablo, C Gómez, J Poza, A Maturana-Candelas, S Martins, I Gomes, AM Lopes, N Pinto, R Hornero
Publication Date: 2020-07-10

Variant appearance in text: rs7412
PMID: 32664228
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Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification.

Bioinformatics (Oxford, England)
L Du, F Liu, K Liu, X Yao, SL Risacher, J Han, L Guo, AJ Saykin, L Shen,
Publication Date: 2020-07-01

Variant appearance in text: rs7412
PMID: 32657360
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A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.

Research In Developmental Disabilities
MSC Thomas, O Ojinaga Alfageme, H D'Souza, PA Patkee, MA Rutherford, KY Mok, J Hardy, A Karmiloff-Smith,
Publication Date: 2020-07-09

Variant appearance in text: rs7412
PMID: 32653761
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Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers.

Journal Of Alzheimer'S Disease : Jad
KH Fan, E Feingold, SL Rosenthal, FY Demirci, M Ganguli, OL Lopez, MI Kamboh
Publication Date: 2020-07-08

Variant appearance in text: rs7412
PMID: 32651314
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Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease.

Annals Of Clinical And Translational Neurology
JA Pillai, J Bena, G Bebek, LM Bekris, A Bonner-Jackson, L Kou, A Pai, L Sørensen, M Neilsen, SM Rao, M Chance, BT Lamb, JB Leverenz,
Publication Date: 2020-07-07

Variant appearance in text: rs7412
PMID: 32634865
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Recent Caffeine Drinking Associates with Cognitive Function in the UK Biobank.

Nutrients
MC Cornelis, S Weintraub, MC Morris
Publication Date: 2020-07-02

Variant appearance in text: rs7412
PMID: 32630669
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Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

International Journal Of Molecular Sciences
A Urbizu, K Beyer
Publication Date: 2020-07-02

Variant appearance in text: rs7412
PMID: 32630630
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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
ME Petersen, F Zhang, N Schupf, SJ Krinsky-McHale, J Hall, M Mapstone, A Cheema, W Silverman, I Lott, MS Rafii, B Handen, W Klunk, E Head, B Christian, T Foroud, F Lai, HD Rosas, S Zaman, BM Ances, MC Wang, B Tycko, JH Lee, S O'Bryant,
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32626817
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Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.

Investigative Ophthalmology & Visual Science
MA Margeta, SM Letcher, RP Igo, JN Cooke Bailey, LR Pasquale, JL Haines, O Butovsky, JL Wiggs,
Publication Date: 2020-07-01

Variant appearance in text: rs7412
PMID: 32614373
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Plasma proteomic signatures predict dementia and cognitive impairment.

Alzheimer'S & Dementia (New York, N. Y.)
T Tanaka, R Lavery, V Varma, G Fantoni, M Colpo, M Thambisetty, J Candia, SM Resnick, DA Bennett, A Biancotto, S Bandinelli, L Ferrucci
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32607407
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Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Scientific Reports
F Röhr, N Bucholtz, S Toepfer, K Norman, D Spira, E Steinhagen-Thiessen, CM Lill, L Bertram, I Demuth, N Buchmann, S Düzel
Publication Date: 2020-06-30

Variant appearance in text: rs7412
PMID: 32606300
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Work Hours and Cognitive Function: The Multi-Ethnic Study of Atherosclerosis.

Safety And Health At Work
LE Charles, D Fekedulegn, CM Burchfiel, K Fujishiro, AZ Al Hazzouri, AL Fitzpatrick, SR Rapp
Publication Date: 2020-06

Variant appearance in text: rs7412
PMID: 32596013
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Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.

Lancet (London, England)
J Fortea, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernández, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, D Alcolea, J Clarimón, SH Zaman, R Blesa, A Lleó
Publication Date: 2020-06-27

Variant appearance in text: rs7412
PMID: 32593336
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APOE Alleles and Diet in Brain Aging and Alzheimer's Disease.

Frontiers In Aging Neuroscience
HN Yassine, CE Finch
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32587511
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TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer's Disease.

Frontiers In Aging Neuroscience
N Zhang, D Gu, M Meng, ML Gordon
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32581773
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Telmisartan and Rosuvastatin Synergistically Ameliorate Dementia and Cognitive Impairment in Older Hypertensive Patients With Apolipoprotein E Genotype.

Frontiers In Aging Neuroscience
W Hu, Y Li, Y Zhao, Y Dong, Y Cui, S Sun, G Gong, H Zhang, Q Chai, J Wang, Z Liu
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32581766
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APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.

Aging
J Sun, Z Zhu, K Chen, D Wei, X Li, H Li, J Zhang, X Chen, Y Chen, Z Zhang
Publication Date: 2020-06-22

Variant appearance in text: rs7412
PMID: 32572010
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Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Hakka postmenopausal women in southern China.

Lipids In Health And Disease
J Hou, Q Deng, X Guo, X Deng, W Zhong, Z Zhong
Publication Date: 2020-06-16

Variant appearance in text: rs7412
PMID: 32546237
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ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.

Lipids In Health And Disease
J Shi, Z Cheng, S Qiu, H Cui, Y Gu, Q Zhao, Y Ren, H Zhang, H Sun, Y Liu, Y Li, Y Qiao, Y Hu, Y Liu, Y Cheng
Publication Date: 2020-06-13

Variant appearance in text: rs7412
PMID: 32534589
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Clinical and pathologic features of cognitive-predominant corticobasal degeneration.

Neurology
N Sakae, OA Santos, O Pedraza, I Litvan, ME Murray, R Duara, RJ Uitti, ZK Wszolek, NR Graff-Radford, KA Josephs, DW Dickson
Publication Date: 2020-06-09

Variant appearance in text: rs7412
PMID: 32518146
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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.

Aging
CL Kuo, LC Pilling, JL Atkins, GA Kuchel, D Melzer
Publication Date: 2020-06-08

Variant appearance in text: rs7412
PMID: 32511104
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Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease.

Oxidative Medicine And Cellular Longevity
AA Mamun, MS Uddin, MF Bin Bashar, S Zaman, Y Begum, IJ Bulbul, MS Islam, MS Sarwar, B Mathew, MS Amran, G Md Ashraf, MN Bin-Jumah, SA Mousa, MM Abdel-Daim
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32509144
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Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer's Disease: An OCT Study.

Journal Of Clinical Medicine
I López-Cuenca, R de Hoz, E Salobrar-García, L Elvira-Hurtado, P Rojas, JA Fernández-Albarral, A Barabash, JJ Salazar, AI Ramírez, JM Ramírez
Publication Date: 2020-06-03

Variant appearance in text: rs7412
PMID: 32503282
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MetaPhat: Detecting and Decomposing Multivariate Associations From Univariate Genome-Wide Association Statistics.

Frontiers In Genetics
J Lin, R Tabassum, S Ripatti, M Pirinen
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32499813
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Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study.

Trials
M Shamloo, MJ Granger, EA Trautwein, JD House, D MacKay
Publication Date: 2020-06-01

Variant appearance in text: rs7412
PMID: 32487131
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Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study.

Bmc Psychiatry
Y Yoshino, T Yoshida, H Morino, M Nakamura, M Abe, H Omachi, S Inoue, Y Miyoshi, Y Tachibana, N Yamauchi, N Takeda, M Mizobuchi, Y Ozaki, S Ochi, J Iga, SI Ueno
Publication Date: 2020-06-01

Variant appearance in text: rs7412
PMID: 32487126
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Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.

Journal Of Personalized Medicine
V Bessi, J Balestrini, S Bagnoli, S Mazzeo, G Giacomucci, S Padiglioni, I Piaceri, M Carraro, C Ferrari, L Bracco, S Sorbi, B Nacmias
Publication Date: 2020-05-29

Variant appearance in text: rs7412
PMID: 32485802
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Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
WLF Lim, K Huynh, P Chatterjee, I Martins, KS Jayawardana, C Giles, NA Mellett, SM Laws, AI Bush, CC Rowe, VL Villemagne, D Ames, BG Drew, CL Masters, PJ Meikle, RN Martins,
Publication Date: 2020-05-26

Variant appearance in text: rs7412
PMID: 32474467
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A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.

Molecular Genetics & Genomic Medicine
SM Soyal, M Kwik, O Kalev, S Lenz, G Zara, P Strasser, W Patsch, S Weis
Publication Date: 2020-05-30

Variant appearance in text: rs7412
PMID: 32472747
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Age-dependent effect of APOE and polygenic component on Alzheimer's disease.

Neurobiology Of Aging
E Bellou, E Baker, G Leonenko, M Bracher-Smith, P Daunt, G Menzies, J Williams, V Escott-Price,
Publication Date: 2020-04-30

Variant appearance in text: rs7412
PMID: 32464432
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APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.

Alzheimer'S Research & Therapy
E Konijnenberg, BM Tijms, J Gobom, V Dobricic, I Bos, S Vos, M Tsolaki, F Verhey, J Popp, P Martinez-Lage, R Vandenberghe, A Lleó, L Frölich, S Lovestone, J Streffer, L Bertram, K Blennow, CE Teunissen, R Veerhuis, AB Smit, P Scheltens, H Zetterberg, PJ Visser
Publication Date: 2020-05-27

Variant appearance in text: rs7412
PMID: 32460813
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APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort.

The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences
CL Kuo, LC Pilling, JL Atkins, JAH Masoli, J Delgado, GA Kuchel, D Melzer
Publication Date: 2020-05-26

Variant appearance in text: rs7412
PMID: 32451547
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Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolaemia: A Propensity Score Analysis.

Life (Basel, Switzerland)
A Mickiewicz, M Futema, A Ćwiklinska, A Kuchta, M Jankowski, M Kaszubowski, M Chmara, B Wasąg, M Fijałkowski, M Jaguszewski, SE Humphries, M Gruchała
Publication Date: 2020-05-20

Variant appearance in text: rs7412
PMID: 32443900
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High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil.

Brazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
AP Batista, KF Barbosa, CZ Masioli, EM Queiroz, CC Marinho, APC Cândido, GLL Machado-Coelho
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32401924
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The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Frontiers In Pharmacology
JJ Martínez-Magaña, AD Genis-Mendoza, JA Villatoro Velázquez, B Camarena, R Martín Del Campo Sanchez, C Fleiz Bautista, M Bustos Gamiño, E Reséndiz, A Aguilar, ME Medina-Mora, H Nicolini
Publication Date: 2020

Variant appearance in text: APOE: R176C; rs7412
PMID: 32390825
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Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep.

Plos Biology
SM Ulv Larsen, HP Landolt, W Berger, M Nedergaard, GM Knudsen, SC Holst
Publication Date: 2020-05

Variant appearance in text: rs7412
PMID: 32369477
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Is APOE ε4 associated with cognitive performance in early MS?

Neurology(R) Neuroimmunology & Neuroinflammation
S Engel, C Graetz, A Salmen, M Muthuraman, G Toenges, B Ambrosius, A Bayas, A Berthele, C Heesen, L Klotz, T Kümpfel, RA Linker, SG Meuth, F Paul, M Stangel, B Tackenberg, F Then Bergh, H Tumani, F Weber, B Wildemann, UK Zettl, G Antony, S Bittner, S Groppa, B Hemmer, H Wiendl, R Gold, F Zipp, CM Lill, F Luessi,
Publication Date: 2020-07

Variant appearance in text: rs7412
PMID: 32358224
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Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

International Journal Of Molecular Sciences
R Cacabelos
Publication Date: 2020-04-26

Variant appearance in text: rs7412
PMID: 32357528
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DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health.

Alzheimer'S & Dementia (New York, N. Y.)
J Mur, DL McCartney, RM Walker, A Campbell, ML Bermingham, SW Morris, DJ Porteous, AM McIntosh, IJ Deary, KL Evans, RE Marioni
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32346601
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The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health.

Alzheimer'S Research & Therapy
J de Frutos-Lucas, P Cuesta, D López-Sanz, Á Peral-Suárez, E Cuadrado-Soto, F Ramírez-Toraño, BM Brown, JM Serrano, SM Laws, IC Rodríguez-Rojo, J Verdejo-Román, R Bruña, ML Delgado-Losada, A Barabash, AM López-Sobaler, R López-Higes, A Marcos, F Maestú
Publication Date: 2020-04-24

Variant appearance in text: rs7412
PMID: 32331531
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A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study.

Frontiers In Pharmacology
A Roco, E Nieto, M Suárez, M Rojo, MP Bertoglia, G Verón, F Tamayo, A Arredondo, D Cruz, J Muñoz, G Bravo, P Salas, F Mejías, G Godoy, P Véliz, LA Quiñones
Publication Date: 2020

Variant appearance in text: APOE: Arg176Cys
PMID: 32327994
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A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2-73) Phase 2a clinical study.

Alzheimer'S & Dementia (New York, N. Y.)
H Hampel, C Williams, A Etcheto, F Goodsaid, F Parmentier, J Sallantin, WE Kaufmann, CU Missling, M Afshar
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32318621
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A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin.

Molecular Genetics & Genomic Medicine
LG Leal, C Hoggart, MR Jarvelin, KH Herzig, MJE Sternberg, A David
Publication Date: 2020-04-19

Variant appearance in text: rs7412
PMID: 32307928
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Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

Molecular Neurodegeneration
LZ Ma, L Tan, YL Bi, XN Shen, W Xu, YH Ma, HQ Li, Q Dong, JT Yu
Publication Date: 2020-04-10

Variant appearance in text: rs7412
PMID: 32276587
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THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.

The Quarterly Review Of Biology
BC Trumble, CE Finch
Publication Date: 2019-12

Variant appearance in text: rs7412
PMID: 32269391
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Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
M Mapstone, TJ Gross, F Macciardi, AK Cheema, M Petersen, E Head, BL Handen, WE Klunk, BT Christian, W Silverman, IT Lott, N Schupf,
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32258359
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Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

Brain Pathology (Zurich, Switzerland)
S Koga, F Li, N Zhao, SF Roemer, TJ Ferman, AI Wernick, RL Walton, AH Faroqi, NR Graff-Radford, WP Cheshire, OA Ross, DW Dickson
Publication Date: 2020-03-30

Variant appearance in text: rs7412
PMID: 32232888
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Genome-wide analyses disclose the distinctive HLA architecture and the pharmacogenetic landscape of the Somali population.

Scientific Reports
AA Ali, M Aalto, J Jonasson, A Osman
Publication Date: 2020-03-27

Variant appearance in text: rs7412
PMID: 32221414
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Patient with frontal-variant syndrome in early-onset Alzheimer's disease.

General Psychiatry
H Cai, S Ning, W Li, X Li, S Xiao, L Sun
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32215362
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Genetic and regulatory architecture of Alzheimer's disease in the APOE region.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
AM Kulminski, L Shu, Y Loika, L He, A Nazarian, K Arbeev, S Ukraintseva, A Yashin, I Culminskaya
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32211503
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Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis.

Journal Of The American Heart Association
CL Schaich, D Malaver, H Chen, HA Shaltout, A Zeki Al Hazzouri, DM Herrington, TM Hughes
Publication Date: 2020-04-07

Variant appearance in text: rs7412
PMID: 32200711
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DNA methylation QTL analysis identifies new regulators of human longevity.

Human Molecular Genetics
S Szymczak, J Dose, GG Torres, FA Heinsen, G Venkatesh, P Datlinger, M Nygaard, J Mengel-From, F Flachsbart, W Klapper, K Christensen, W Lieb, S Schreiber, R Häsler, C Bock, A Franke, A Nebel
Publication Date: 2020-03-11

Variant appearance in text: rs7412
PMID: 32160291
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Personality Factors and Subjective Cognitive Decline: The FACEHBI Cohort.

Behavioural Neurology
N Muñoz, M Gomà-I-Freixanet, S Valero, O Rodríguez-Gómez, A Sanabria, A Pérez-Cordón, I Hernández, M Marquié, I Mir, E Martín, A Benaque, A Ruiz, L Tarraga, M Boada, M Alegret, On Behalf Of The Facehbi Study
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32148563
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Molecular diagnosis methods in familial hypercholesterolemia.

Anatolian Journal Of Cardiology
V Moldovan, C Banescu, M Dobreanu
Publication Date: 2020-02

Variant appearance in text: rs7412
PMID: 32120369
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Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition.

Frontiers In Psychiatry
S Lamballais, RL Muetzel, MA Ikram, H Tiemeier, MW Vernooij, T White, HHH Adams
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32116848
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Genetic Association of FERMT2, HLA-DRB1, CD2AP, and PTK2B Polymorphisms With Alzheimer's Disease Risk in the Southern Chinese Population.

Frontiers In Aging Neuroscience
Y Yan, A Zhao, Y Qui, Y Li, R Yan, Y Wang, W Xu, Y Deng
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 32116649
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Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment.

Scientific Reports
R Sussams, W Schlotz, Z Clough, J Amin, S Simpson, A Abbott, R Beardmore, R Sharples, R Raybould, K Brookes, K Morgan, D Culliford, C Holmes
Publication Date: 2020-02-27

Variant appearance in text: rs7412
PMID: 32108148
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Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene.

Jci Insight
X Liao, F Cai, Z Sun, Y Zhang, J Wang, B Jiao, J Guo, J Li, X Liu, L Guo, Y Zhou, J Wang, X Yan, H Jiang, K Xia, J Li, B Tang, L Shen, W Song
Publication Date: 2020-02-27

Variant appearance in text: rs7412
PMID: 32102983
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Risk factors for progression of age-related macular degeneration.

Ophthalmic & Physiological Optics : The Journal Of The British College Of Ophthalmic Opticians (Optometrists)
TJ Heesterbeek, L Lorés-Motta, CB Hoyng, YTE Lechanteur, AI den Hollander
Publication Date: 2020-02-25

Variant appearance in text: rs7412
PMID: 32100327
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GenEpi: gene-based epistasis discovery using machine learning.

Bmc Bioinformatics
YC Chang, JT Wu, MY Hong, YA Tung, PH Hsieh, SW Yee, KM Giacomini, YJ Oyang, CY Chen,
Publication Date: 2020-02-24

Variant appearance in text: rs7412
PMID: 32093643
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Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation.

Brain : A Journal Of Neurology
S Skouras, J Torner, P Andersson, Y Koush, C Falcon, C Minguillon, K Fauria, F Alpiste, K Blenow, H Zetterberg, JD Gispert, JL Molinuevo,
Publication Date: 2020-02-24

Variant appearance in text: rs7412
PMID: 32091109
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Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.

Scientific Reports
SL Evans, NG Dowell, F Prowse, N Tabet, SL King, JM Rusted
Publication Date: 2020-02-20

Variant appearance in text: rs7412
PMID: 32080211
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Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype.

Scientific Reports
JS Friedberg, N Aytan, JD Cherry, W Xia, OJ Standring, VE Alvarez, R Nicks, S Svirsky, G Meng, G Jun, H Ryu, R Au, TD Stein
Publication Date: 2020-02-19

Variant appearance in text: rs7412
PMID: 32076055
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APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.

Stroke
ST Pendlebury, D Poole, A Burgess, J Duerden, PM Rothwell,
Publication Date: 2020-02-18

Variant appearance in text: rs7412
PMID: 32070224
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Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study.

Scientific Reports
LCK Wong, MYZ Wong, CS Tan, H Vrooman, N Venketasubramanian, CY Cheng, C Chen, S Hilal
Publication Date: 2020-02-14

Variant appearance in text: rs7412
PMID: 32060376
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Impaired Innate Immunity Mechanisms in the Brain of Alzheimer's Disease.

International Journal Of Molecular Sciences
M Romagnoli, E Porcellini, I Carbone, R Veerhuis, F Licastro
Publication Date: 2020-02-08

Variant appearance in text: rs7412
PMID: 32046242
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Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial.

Bmj Open
DP Devanand, H Andrews, WC Kreisl, Q Razlighi, A Gershon, Y Stern, A Mintz, T Wisniewski, E Acosta, J Pollina, M Katsikoumbas, KL Bell, GH Pelton, D Deliyannides, KM Prasad, ED Huey
Publication Date: 2020-02-06

Variant appearance in text: rs7412
PMID: 32034019
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Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

Journal Of Alzheimer'S Disease : Jad
S Westwood, AL Baird, SN Anand, AJ Nevado-Holgado, A Kormilitzin, L Shi, A Hye, NJ Ashton, AR Morgan, I Bos, SJB Vos, S Baker, NJ Buckley, M Ten Kate, P Scheltens, CE Teunissen, R Vandenberghe, S Gabel, K Meersmans, S Engelborghs, EE De Roeck, K Sleegers, GB Frisoni, O Blin, JC Richardson, R Bordet, JL Molinuevo, L Rami, A Wallin, P Kettunen, M Tsolaki, F Verhey, A Lléo, I Sala, J Popp, G Peyratout, P Martinez-Lage, M Tainta, P Johannsen, Y Freund-Levi, L Frölich, V Dobricic, C Legido-Quigley, L Bertram, F Barkhof, H Zetterberg, BP Morgan, J Streffer, PJ Visser, S Lovestone
Publication Date: 2020-01-22

Variant appearance in text: rs7412
PMID: 31985466
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Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children.

Wellcome Open Research
R Korologou-Linden, L O'Keeffe, LD Howe, G Davey-Smith, HJ Jones, EL Anderson, E Stergiakouli
Publication Date: 2019

Variant appearance in text: rs7412
PMID: 31984241
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Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.

Plos One
EG Lee, J Tulloch, S Chen, L Leong, AD Saxton, B Kraemer, M Darvas, CD Keene, A Shutes-David, K Todd, S Millard, CE Yu
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 31978088
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Accuracy of Imputation for Apolipoprotein E ε Alleles in Genome-Wide Genotyping Data.

Jama Network Open
E Vuoksimaa, T Palviainen, N Lindgren, JO Rinne, J Kaprio
Publication Date: 2020-01-03

Variant appearance in text: rs7412
PMID: 31977056
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The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Npj Genomic Medicine
A Oni-Orisan, T Haldar, DK Ranatunga, MW Medina, C Schaefer, RM Krauss, C Iribarren, N Risch, TJ Hoffmann
Publication Date: 2020

Variant appearance in text: rs7412
PMID: 31969989
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Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players.

Frontiers In Aging Neuroscience
R Corpas, E Solana, A De la Rosa, S Sarroca, C Griñán-Ferré, M Oriol, E Corbella, E Rodríguez-Farré, J Vina, M Pallàs, D Bartrés-Faz, MC Gomez-Cabrera, C Sanfeliu
Publication Date: 2019

Variant appearance in text: rs7412
PMID: 31956305
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Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders.

Annals Of Translational Medicine
LD Niu, W Xu, JQ Li, CC Tan, XP Cao, J Yu, L Tan,
Publication Date: 2019-11

Variant appearance in text: rs7412
PMID: 31930058
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APOE ε4 Modifies Effect of Residential Greenness on Cognitive Function among Older Adults: A Longitudinal Analysis in China.

Scientific Reports
A Zhu, L Yan, C Shu, Y Zeng, JS Ji
Publication Date: 2020-01-09

Variant appearance in text: rs7412
PMID: 31919381
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Longitudinal basal forebrain degeneration interacts with TREM2/C3 biomarkers of inflammation in pre-symptomatic Alzheimer's disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
TW Schmitz, H Soreq, J Poirier, RN Spreng,
Publication Date: 2020-01-08

Variant appearance in text: rs7412
PMID: 31915256
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Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men.

Neurology
C Benedict, K Blennow, H Zetterberg, J Cedernaes
Publication Date: 2020-01-08

Variant appearance in text: rs7412
PMID: 31915189
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000252486.4 c.526C>T p.Arg176Cys missense_variant 4/4 -
ENST00000425718.1 c.526C>T p.Arg176Cys missense_variant 3/3 -
ENST00000434152.1 c.604C>T p.Arg202Cys missense_variant 4/4 -
ENST00000446996.1 c.526C>T p.Arg176Cys missense_variant 4/4 -
NM_000041.4 c.526C>T p.Arg176Cys missense_variant 4/4 -
NM_001302688.2 c.604C>T p.Arg202Cys missense_variant 4/4 -
NM_001302689.2 c.526C>T p.Arg176Cys missense_variant 4/4 -
NM_001302690.1 c.526C>T p.Arg176Cys missense_variant 4/4 -
NM_001302691.2 c.526C>T p.Arg176Cys missense_variant 4/4 -