APOE c.860T>A ;(p.V287E)

Variant ID: 19-45412413-T-A

NM_000041.2(APOE):c.860T>A;(p.V287E)

This variant was identified in 13 publications

View GRCh38 version.




Publications:


The LDL receptor binding domain of apolipoprotein E directs the relative orientation of its C-terminal segment in reconstituted nascent HDL.

Biochimica Et Biophysica Acta. Biomembranes
Kothari, S S; Bala, N N; Patel, A B AB; Donovan, A A; Narayanaswami, V V
Publication Date: 2021-07-01

Variant appearance in text: APOE: V287E
PubMed Link: 33831404
Variant Present in the following documents:
  • Main text
  • nihms-1706340.pdf
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Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.

Neuron
Chen, Yun Y; Strickland, Michael R MR; Soranno, Andrea A; Holtzman, David M DM
Publication Date: 2021-01-20

Variant appearance in text: APOE: V287E
PubMed Link: 33176118
Variant Present in the following documents:
  • Main text
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Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E.

Biophysical Journal
Ray, Angana A; Ahalawat, Navjeet N; Mondal, Jagannath J
Publication Date: 2017-12-19

Variant appearance in text: APOE: V287E
PubMed Link: 29262361
Variant Present in the following documents:
  • Main text
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Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship.

Plos One
Lek, Mark T MT; Cruz, Siobanth S; Ibe, Nnejiuwa U NU; Beck, Wendy H J WHJ; Bielicki, John K JK; Weers, Paul M M PMM; Narayanaswami, Vasanthy V
Publication Date: 2017

Variant appearance in text: APOE: V287E
PubMed Link: 28644829
Variant Present in the following documents:
  • Main text
  • pone.0178346.pdf
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In silico analyses of deleterious missense SNPs of human apolipoprotein E3.

Scientific Reports
Pires, Allan S AS; Porto, William F WF; Franco, Octavio L OL; Alencar, Sérgio A SA
Publication Date: 2017-05-30

Variant appearance in text: APOE: V287E
PubMed Link: 28559539
Variant Present in the following documents:
  • Main text
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Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Chetty, Palaniappan S PS; Mayne, Leland L; Lund-Katz, Sissel S; Englander, S Walter SW; Phillips, Michael C MC
Publication Date: 2017-01-31

Variant appearance in text: APOE: V287E
PubMed Link: 28096372
Variant Present in the following documents:
  • Main text
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The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.

Biochemistry
Garai, Kanchan K; Verghese, Philip B PB; Baban, Berevan B; Holtzman, David M DM; Frieden, Carl C
Publication Date: 2014-10-14

Variant appearance in text: APOE: V287E
PubMed Link: 25207746
Variant Present in the following documents:
  • Main text
  • bi5008172.pdf
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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.

Alzheimer'S Research & Therapy
Wolf, Andrew B AB; Valla, Jon J; Bu, Guojun G; Kim, Jungsu J; LaDu, Mary Jo MJ; Reiman, Eric M EM; Caselli, Richard J RJ
Publication Date: 2013

Variant appearance in text: APOE: V287E
PubMed Link: 23998393
Variant Present in the following documents:
  • Main text
  • alzrt204.pdf
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Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3.

Archives Of Biochemistry And Biophysics
Tran, Tuyen N TN; Kim, Sea H SH; Gallo, Carlos C; Amaya, Max M; Kyees, Jessica J; Narayanaswami, Vasanthy V
Publication Date: 2013-01-01

Variant appearance in text: APOE: V287E
PubMed Link: 23103361
Variant Present in the following documents:
  • Main text
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Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Frieden, Carl C; Garai, Kanchan K
Publication Date: 2012-06-05

Variant appearance in text: APOE: Val287Glu
PubMed Link: 22615372
Variant Present in the following documents:
  • Main text
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Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Chen, Jianglei J; Li, Qianqian Q; Wang, Jianjun J
Publication Date: 2011-09-06

Variant appearance in text: APOE: V287E
PubMed Link: 21873229
Variant Present in the following documents:
  • Main text
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Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR.

Protein Science : A Publication Of The Protein Society
Garai, Kanchan K; Mustafi, Sourajit M SM; Baban, Berevan B; Frieden, Carl C
Publication Date: 2010-01

Variant appearance in text: APOE: V287E
PubMed Link: 19904741
Variant Present in the following documents:
  • Main text
View BVdb publication page