The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population.
Diabetologia
Wedekind, Lauren E LE; Mahajan, Anubha A; Hsueh, Wen-Chi WC; Chen, Peng P; Olaiya, Muideen T MT; Kobes, Sayuko S; Sinha, Madhumita M; Baier, Leslie J LJ; Knowler, William C WC; McCarthy, Mark I MI; Hanson, Robert L RL
Constructing a polygenic risk score for childhood obesity using functional data analysis.
Econometrics And Statistics
Craig, Sarah J C SJC; Kenney, Ana M AM; Lin, Junli J; Paul, Ian M IM; Birch, Leann L LL; Savage, Jennifer S JS; Marini, Michele E ME; Chiaromonte, Francesca F; Reimherr, Matthew L ML; Makova, Kateryna D KD
A Genome-Wide Association Study Reveals a BDNF-Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures.
Biomedicines
Levchenko, Anastasia A; Malov, Sergey S; Antonik, Alexey A; Protsvetkina, Anastasia A; Rybakova, Kseniya V KV; Kanapin, Alexander A; Yakovlev, Alexey N AN; Nenasteva, Anna Y AY; Nikolishin, Anton E AE; Cherkasov, Nikolay N; Chuprova, Natalia A NA; Blagonravova, Anna S AS; Sergeeva, Angelica V AV; Zhilyaeva, Tatyana V TV; Denisenko, Maria K MK; Gainetdinov, Raul R RR; Kibitov, Alexander O AO; Krupitsky, Evgeny M EM
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.
Journal Of The National Cancer Institute
Murphy, Neil N; Song, Mingyang M; Papadimitriou, Nikos N; Carreras-Torres, Robert R; Langenberg, Claudia C; Martin, Richard M RM; Tsilidis, Konstantinos K KK; Barroso, Inês I; Chen, Ji J; Frayling, Timothy M TM; Bull, Caroline J CJ; Vincent, Emma E EE; Cotterchio, Michelle M; Gruber, Stephen B SB; Pai, Rish K RK; Newcomb, Polly A PA; Perez-Cornago, Aurora A; van Duijnhoven, Franzel J B FJB; Van Guelpen, Bethany B; Vodicka, Pavel P; Wolk, Alicja A; Wu, Anna H AH; Peters, Ulrike U; Chan, Andrew T AT; Gunter, Marc J MJ
Hoskins, Jason W JW; Chung, Charles C CC; O'Brien, Aidan A; Zhong, Jun J; Connelly, Katelyn K; Collins, Irene I; Shi, Jianxin J; Amundadottir, Laufey T LT
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.
Diabetes
Bowker, Nicholas N; Hansford, Robert R; Burgess, Stephen S; Foley, Christopher N CN; Auyeung, Victoria P W VPW; Erzurumluoglu, A Mesut AM; Stewart, Isobel D ID; Wheeler, Eleanor E; Pietzner, Maik M; Gribble, Fiona F; Reimann, Frank F; Bhatnagar, Pallav P; Coghlan, Matthew P MP; Wareham, Nicholas J NJ; Langenberg, Claudia C
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.
Diabetes
Bowker, Nicholas N; Hansford, Robert R; Burgess, Stephen S; Foley, Christopher N CN; Auyeung, Victoria P W VPW; Erzurumluoglu, A Mesut AM; Stewart, Isobel D ID; Wheeler, Eleanor E; Pietzner, Maik M; Gribble, Fiona F; Reimann, Frank F; Bhatnagar, Pallav P; Coghlan, Matthew P MP; Wareham, Nicholas J NJ; Langenberg, Claudia C
Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.
Diabetologia
Tremblay, Johanne J; Haloui, Mounsif M; Attaoua, Redha R; Tahir, Ramzan R; Hishmih, Camil C; Harvey, François F; Marois-Blanchet, François-Christophe FC; Long, Carole C; Simon, Paul P; Santucci, Lara L; Hizel, Candan C; Chalmers, John J; Marre, Michel M; Harrap, Stephen S; Cífková, Renata R; Krajčoviechová, Alena A; Matthews, David R DR; Williams, Bryan B; Poulter, Neil N; Zoungas, Sophia S; Colagiuri, Stephen S; Mancia, Giuseppe G; Grobbee, Diederick E DE; Rodgers, Anthony A; Liu, Liusheng L; Agbessi, Mawussé M; Bruat, Vanessa V; Favé, Marie-Julie MJ; Harwood, Michelle P MP; Awadalla, Philip P; Woodward, Mark M; Hussin, Julie G JG; Hamet, Pavel P
Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.
Bmc Cancer
Heft Neal, Molly E ME; Birkeland, Andrew C AC; Bhangale, Apurva D AD; Zhai, Jingyi J; Kulkarni, Aditi A; Foltin, Susan K SK; Jewell, Brittany M BM; Ludwig, Megan L ML; Pinatti, Lisa L; Jiang, Hui H; McHugh, Jonathan B JB; Marentette, Lawence L; McKean, Erin L EL; Brenner, J Chad JC
Coffee consumption and risk of breast cancer: A Mendelian randomization study.
Plos One
Ellingjord-Dale, Merete M; Papadimitriou, Nikos N; Katsoulis, Michail M; Yee, Chew C; Dimou, Niki N; Gill, Dipender D; Aune, Dagfinn D; Ong, Jue-Sheng JS; MacGregor, Stuart S; Elsworth, Benjamin B; Lewis, Sarah J SJ; Martin, Richard M RM; Riboli, Elio E; Tsilidis, Konstantinos K KK
Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes.
Scientific Reports
Liu, Qian Q; Pan, Jianxin J; Berzuini, Carlo C; Rutter, Martin K MK; Guo, Hui H
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses.
Bmj (Clinical Research Ed.)
Sun, Yi-Qian YQ; Burgess, Stephen S; Staley, James R JR; Wood, Angela M AM; Bell, Steven S; Kaptoge, Stephen K SK; Guo, Qi Q; Bolton, Thomas R TR; Mason, Amy M AM; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Vie, Gunnhild Å GÅ; Bjørngaard, Johan H JH; Kinge, Jonas Minet JM; Chen, Yue Y; Mai, Xiao-Mei XM
Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.
Bmj (Clinical Research Ed.)
Wootton, Robyn E RE; Lawn, Rebecca B RB; Millard, Louise A C LAC; Davies, Neil M NM; Taylor, Amy E AE; Munafò, Marcus R MR; Timpson, Nicholas J NJ; Davis, Oliver S P OSP; Davey Smith, George G; Haworth, Claire M A CMA
Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL).
Bmj Open
Hjelmesæth, Jøran J; Åsberg, Anders A; Andersson, Shalini S; Sandbu, Rune R; Robertsen, Ida I; Johnson, Line Kristin LK; Angeles, Philip Carlo PC; Hertel, Jens Kristoffer JK; Skovlund, Eva E; Heijer, Maria M; Ek, Anna-Lena AL; Krogstad, Veronica V; Karlsen, Tor-Ivar TI; Christensen, Hege H; Andersson, Tommy B TB; Karlsson, Cecilia C
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses.
Plos Genetics
Baranski, Thomas J TJ; Kraja, Aldi T AT; Fink, Jill L JL; Feitosa, Mary M; Lenzini, Petra A PA; Borecki, Ingrid B IB; Liu, Ching-Ti CT; Cupples, L Adrienne LA; North, Kari E KE; Province, Michael A MA
Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.
Plos Genetics
Rask-Andersen, Mathias M; Karlsson, Torgny T; Ek, Weronica E WE; Johansson, Åsa Å
BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.
International Journal Of Obesity (2005)
Graff, M M; North, K E KE; Richardson, A S AS; Young, K L KL; Mazul, A L AL; Highland, H M HM; Mohlke, K L KL; Lange, L A LA; Lange, E M EM; Mullan Harris, K K; Gordon-Larsen, P P
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
Plos Medicine
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Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study.
Annals Of Human Genetics
Lange, Leslie A LA; Graff, Mariaelisa M; Lange, Ethan M EM; Young, Kristin L KL; Richardson, Andrea S AS; Mohlke, Karen L KL; North, Kari E KE; Harris, Kathleen M KM; Gordon-Larsen, Penny P
A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery.
Obesity Surgery
Bandstein, Marcus M; Voisin, Sarah S; Nilsson, Emil K EK; Schultes, Bernd B; Ernst, Barbara B; Thurnheer, Martin M; Benedict, Christian C; Mwinyi, Jessica J; Schiöth, Helgi B HB
Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study.
Bmc Medical Genetics
Wang, Hai-Jun HJ; Hinney, Anke A; Song, Jie-Yun JY; Scherag, André A; Meng, Xiang-Rui XR; Grallert, Harald H; Illig, Thomas T; Hebebrand, Johannes J; Wang, Yan Y; Ma, Jun J
Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age.
International Journal Of Obesity (2005)
Rukh, G G; Ahmad, S S; Ericson, U U; Hindy, G G; Stocks, T T; Renström, F F; Almgren, P P; Nilsson, P M PM; Melander, O O; Franks, P W PW; Orho-Melander, M M
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
Alzheimer'S & Dementia : The Journal Of The Alzheimer'S Association
Mukherjee, Shubhabrata S; Walter, Stefan S; Kauwe, John S K JSK; Saykin, Andrew J AJ; Bennett, David A DA; Larson, Eric B EB; Crane, Paul K PK; Glymour, M Maria MM; , ; , ; ,
Influence of SNP*SNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health.
Pediatric Obesity
Young, K L KL; Graff, M M; North, K E KE; Richardson, A S AS; Bradfield, J P JP; Grant, S F A SF; Lange, L A LA; Lange, E M EM; Harris, K M KM; Gordon-Larsen, P P
Genetic studies of body mass index yield new insights for obesity biology.
Nature
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Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.
Plos Medicine
Würtz, Peter P; Wang, Qin Q; Kangas, Antti J AJ; Richmond, Rebecca C RC; Skarp, Joni J; Tiainen, Mika M; Tynkkynen, Tuulia T; Soininen, Pasi P; Havulinna, Aki S AS; Kaakinen, Marika M; Viikari, Jorma S JS; Savolainen, Markku J MJ; Kähönen, Mika M; Lehtimäki, Terho T; Männistö, Satu S; Blankenberg, Stefan S; Zeller, Tanja T; Laitinen, Jaana J; Pouta, Anneli A; Mäntyselkä, Pekka P; Vanhala, Mauno M; Elliott, Paul P; Pietiläinen, Kirsi H KH; Ripatti, Samuli S; Salomaa, Veikko V; Raitakari, Olli T OT; Järvelin, Marjo-Riitta MR; Smith, George Davey GD; Ala-Korpela, Mika M
Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study.
Journal Of The National Cancer Institute
Thrift, Aaron P AP; Shaheen, Nicholas J NJ; Gammon, Marilie D MD; Bernstein, Leslie L; Reid, Brian J BJ; Onstad, Lynn L; Risch, Harvey A HA; Liu, Geoffrey G; Bird, Nigel C NC; Wu, Anna H AH; Corley, Douglas A DA; Romero, Yvonne Y; Chanock, Stephen J SJ; Chow, Wong-Ho WH; Casson, Alan G AG; Levine, David M DM; Zhang, Rui R; Ek, Weronica E WE; MacGregor, Stuart S; Ye, Weimin W; Hardie, Laura J LJ; Vaughan, Thomas L TL; Whiteman, David C DC
Do genetic risk scores for body mass index predict risk of phobic anxiety? Evidence for a shared genetic risk factor.
Psychological Medicine
Walter, S S; Glymour, M M MM; Koenen, K K; Liang, L L; Tchetgen Tchetgen, E J EJ; Cornelis, M M; Chang, S-C SC; Rewak, M M; Rimm, E E; Kawachi, I I; Kubzansky, L D LD
Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity.
Genes & Nutrition
Tanisawa, Kumpei K; Ito, Tomoko T; Sun, Xiaomin X; Ise, Ryuken R; Oshima, Satomi S; Cao, Zhen-Bo ZB; Sakamoto, Shizuo S; Tanaka, Masashi M; Higuchi, Mitsuru M
Association of a body mass index genetic risk score with growth throughout childhood and adolescence.
Plos One
Warrington, Nicole M NM; Howe, Laura D LD; Wu, Yan Yan YY; Timpson, Nicholas J NJ; Tilling, Kate K; Pennell, Craig E CE; Newnham, John J; Davey-Smith, George G; Palmer, Lyle J LJ; Beilin, Lawrence J LJ; Lye, Stephen J SJ; Lawlor, Debbie A DA; Briollais, Laurent L
Fine Mapping and Identification of BMI Loci in African Americans.
American Journal Of Human Genetics
Gong, Jian J; Schumacher, Fredrick F; Lim, Unhee U; Hindorff, Lucia A LA; Haessler, Jeff J; Buyske, Steven S; Carlson, Christopher S CS; Rosse, Stephanie S; Bůžková, Petra P; Fornage, Myriam M; Gross, Myron M; Pankratz, Nathan N; Pankow, James S JS; Schreiner, Pamela J PJ; Cooper, Richard R; Ehret, Georg G; Gu, C Charles CC; Houston, Denise D; Irvin, Marguerite R MR; Jackson, Rebecca R; Kuller, Lew L; Henderson, Brian B; Cheng, Iona I; Wilkens, Lynne L; Leppert, Mark M; Lewis, Cora E CE; Li, Rongling R; Nguyen, Khanh-Dung H KD; Goodloe, Robert R; Farber-Eger, Eric E; Boston, Jonathan J; Dilks, Holli H HH; Ritchie, Marylyn D MD; Fowke, Jay J; Pooler, Loreall L; Graff, Misa M; Fernandez-Rhodes, Lindsay L; Cochrane, Barbara B; Boerwinkle, Eric E; Kooperberg, Charles C; Matise, Tara C TC; Le Marchand, Loic L; Crawford, Dana C DC; Haiman, Christopher A CA; North, Kari E KE; Peters, Ulrike U
Generalization of adiposity genetic loci to US Hispanic women.
Nutrition & Diabetes
Graff, M M; Fernández-Rhodes, L L; Liu, S S; Carlson, C C; Wassertheil-Smoller, S S; Neuhouser, M M; Reiner, A A; Kooperberg, C C; Rampersaud, E E; Manson, J E JE; Kuller, L H LH; Howard, B V BV; Ochs-Balcom, H M HM; Johnson, K C KC; Vitolins, M Z MZ; Sucheston, L L; Monda, K K; North, K E KE
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
Human Molecular Genetics
Graff, Mariaelisa M; Ngwa, Julius S JS; Workalemahu, Tsegaselassie T; Homuth, Georg G; Schipf, Sabine S; Teumer, Alexander A; Völzke, Henry H; Wallaschofski, Henri H; Abecasis, Goncalo R GR; Edward, Lakatta L; Francesco, Cucca C; Sanna, Serena S; Scheet, Paul P; Schlessinger, David D; Sidore, Carlo C; Xiao, Xiangjun X; Wang, Zhaoming Z; Chanock, Stephen J SJ; Jacobs, Kevin B KB; Hayes, Richard B RB; Hu, Frank F; Van Dam, Rob M RM; , ; Crout, Richard J RJ; Marazita, Mary L ML; Shaffer, John R JR; Atwood, Larry D LD; Fox, Caroline S CS; Heard-Costa, Nancy L NL; White, Charles C; Choh, Audrey C AC; Czerwinski, Stefan A SA; Demerath, Ellen W EW; Dyer, Thomas D TD; Towne, Bradford B; Amin, Najaf N; Oostra, Ben A BA; Van Duijn, Cornelia M CM; Zillikens, M Carola MC; Esko, Tõnu T; Nelis, Mari M; Nikopensius, Tit T; Metspalu, Andres A; Strachan, David P DP; Monda, Keri K; Qi, Lu L; North, Kari E KE; Cupples, L Adrienne LA; Gordon-Larsen, Penny P; Berndt, Sonja I SI