Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: ANGPTL4: 118G>A; Glu40Lys
ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation.
Experimental & Molecular Medicine
Cho, Dong Im DI; Ahn, Min Joo MJ; Cho, Hyang Hee HH; Cho, Meeyoung M; Jun, Ju Hee JH; Kang, Bo Gyeong BG; Lim, Soo Yeon SY; Yoo, Soo Ji SJ; Kim, Mi Ra MR; Kim, Hyung-Seok HS; Lee, Su-Jin SJ; Dat, Le Thanh LT; Lee, Changho C; Kim, Yong Sook YS; Ahn, Youngkeun Y
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Genome Biology
Kanoni, Stavroula S; Graham, Sarah E SE; Wang, Yuxuan Y; Surakka, Ida I; Ramdas, Shweta S; Zhu, Xiang X; Clarke, Shoa L SL; Bhatti, Konain Fatima KF; Vedantam, Sailaja S; Winkler, Thomas W TW; Locke, Adam E AE; Marouli, Eirini E; Zajac, Greg J M GJM; Wu, Kuan-Han H KH; Ntalla, Ioanna I; Hui, Qin Q; Klarin, Derek D; Hilliard, Austin T AT; Wang, Zeyuan Z; Xue, Chao C; Thorleifsson, Gudmar G; Helgadottir, Anna A; Gudbjartsson, Daniel F DF; Holm, Hilma H; Olafsson, Isleifur I; Hwang, Mi Yeong MY; Han, Sohee S; Akiyama, Masato M; Sakaue, Saori S; Terao, Chikashi C; Kanai, Masahiro M; Zhou, Wei W; Brumpton, Ben M BM; Rasheed, Humaira H; Havulinna, Aki S AS; Veturi, Yogasudha Y; Pacheco, Jennifer Allen JA; Rosenthal, Elisabeth A EA; Lingren, Todd T; Feng, QiPing Q; Kullo, Iftikhar J IJ; Narita, Akira A; Takayama, Jun J; Martin, Hilary C HC; Hunt, Karen A KA; Trivedi, Bhavi B; Haessler, Jeffrey J; Giulianini, Franco F; Bradford, Yuki Y; Miller, Jason E JE; Campbell, Archie A; Lin, Kuang K; Millwood, Iona Y IY; 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Namjou, Bahram B; Hayes, M Geoffrey MG; Ritchie, Marylyn D MD; Jousilahti, Pekka P; Salomaa, Veikko V; Hveem, Kristian K; Åsvold, Bjørn Olav BO; Kubo, Michiaki M; Kamatani, Yoichiro Y; Okada, Yukinori Y; Murakami, Yoshinori Y; Kim, Bong-Jo BJ; Thorsteinsdottir, Unnur U; Stefansson, Kari K; Zhang, Jifeng J; Chen, YEugene Y; Ho, Yuk-Lam YL; Lynch, Julie A JA; Rader, Daniel J DJ; Tsao, Philip S PS; Chang, Kyong-Mi KM; Cho, Kelly K; O'Donnell, Christopher J CJ; Gaziano, John M JM; Wilson, Peter W F PWF; Frayling, Timothy M TM; Hirschhorn, Joel N JN; Kathiresan, Sekar S; Mohlke, Karen L KL; Sun, Yan V YV; Morris, Andrew P AP; Boehnke, Michael M; Brown, Christopher D CD; Natarajan, Pradeep P; Deloukas, Panos P; Willer, Cristen J CJ; Assimes, Themistocles L TL; Peloso, Gina M GM
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Nature Genetics
Aragam, Krishna G KG; Jiang, Tao T; Goel, Anuj A; Kanoni, Stavroula S; Wolford, Brooke N BN; Atri, Deepak S DS; Weeks, Elle M EM; Wang, Minxian M; Hindy, George G; Zhou, Wei W; Grace, Christopher C; Roselli, Carolina C; Marston, Nicholas A NA; Kamanu, Frederick K FK; Surakka, Ida I; Venegas, Loreto Muñoz LM; Sherliker, Paul P; Koyama, Satoshi S; Ishigaki, Kazuyoshi K; Åsvold, Bjørn O BO; Brown, Michael R MR; Brumpton, Ben B; de Vries, Paul S PS; Giannakopoulou, Olga O; Giardoglou, Panagiota P; Gudbjartsson, Daniel F DF; Güldener, Ulrich U; Haider, Syed M Ijlal SMI; Helgadottir, Anna A; Ibrahim, Maysson M; Kastrati, Adnan A; Kessler, Thorsten T; Kyriakou, Theodosios T; Konopka, Tomasz T; Li, Ling L; Ma, Lijiang L; Meitinger, Thomas T; Mucha, Sören S; Munz, Matthias M; Murgia, Federico F; Nielsen, Jonas B JB; Nöthen, Markus M MM; Pang, Shichao S; Reinberger, Tobias T; Schnitzler, Gavin G; Smedley, Damian D; Thorleifsson, Gudmar G; von Scheidt, Moritz M; Ulirsch, Jacob C JC; , ; , ; Arnar, David O DO; Burtt, Noël P NP; Costanzo, Maria C MC; Flannick, Jason J; Ito, Kaoru K; Jang, Dong-Keun DK; Kamatani, Yoichiro Y; Khera, Amit V AV; Komuro, Issei I; Kullo, Iftikhar J IJ; Lotta, Luca A LA; Nelson, Christopher P CP; Roberts, Robert R; Thorgeirsson, Gudmundur G; Thorsteinsdottir, Unnur U; Webb, Thomas R TR; Baras, Aris A; Björkegren, Johan L M JLM; Boerwinkle, Eric E; Dedoussis, George G; Holm, Hilma H; Hveem, Kristian K; Melander, Olle O; Morrison, Alanna C AC; Orho-Melander, Marju M; Rallidis, Loukianos S LS; Ruusalepp, Arno A; Sabatine, Marc S MS; Stefansson, Kari K; Zalloua, Pierre P; Ellinor, Patrick T PT; Farrall, Martin M; Danesh, John J; Ruff, Christian T CT; Finucane, Hilary K HK; Hopewell, Jemma C JC; Clarke, Robert R; Gupta, Rajat M RM; Erdmann, Jeanette J; Samani, Nilesh J NJ; Schunkert, Heribert H; Watkins, Hugh H; Willer, Cristen J CJ; Deloukas, Panos P; Kathiresan, Sekar S; Butterworth, Adam S AS; ,
Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies.
Diagnostics (Basel, Switzerland)
Zarkasi, Khairul Anwar KA; Abdullah, Noraidatulakma N; Abdul Murad, Nor Azian NA; Ahmad, Norfazilah N; Jamal, Rahman R
GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity.
Frontiers In Cell And Developmental Biology
Kristensen, Kristian Kølby KK; Leth-Espensen, Katrine Zinck KZ; Kumari, Anni A; Grønnemose, Anne Louise AL; Lund-Winther, Anne-Marie AM; Young, Stephen G SG; Ploug, Michael M
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
Nature Communications
Natarajan, Pradeep P; Pampana, Akhil A; Graham, Sarah E SE; Ruotsalainen, Sanni E SE; Perry, James A JA; de Vries, Paul S PS; Broome, Jai G JG; Pirruccello, James P JP; Honigberg, Michael C MC; Aragam, Krishna K; Wolford, Brooke B; Brody, Jennifer A JA; Antonacci-Fulton, Lucinda L; Arden, Moscati M; Aslibekyan, Stella S; Assimes, Themistocles L TL; Ballantyne, Christie M CM; Bielak, Lawrence F LF; Bis, Joshua C JC; Cade, Brian E BE; Do, Ron R; Doddapaneni, Harsha H; Emery, Leslie S LS; Hung, Yi-Jen YJ; Irvin, Marguerite R MR; Khan, Alyna T AT; Lange, Leslie L; Lee, Jiwon J; Lemaitre, Rozenn N RN; Martin, Lisa W LW; Metcalf, Ginger G; Montasser, May E ME; Moon, Jee-Young JY; Muzny, Donna D; O'Connell, Jeffrey R JR; Palmer, Nicholette D ND; Peralta, Juan M JM; Peyser, Patricia A PA; Stilp, Adrienne M AM; Tsai, Michael M; Wang, Fei Fei FF; Weeks, Daniel E DE; Yanek, Lisa R LR; Wilson, James G JG; Abecasis, Goncalo G; Arnett, Donna K DK; Becker, Lewis C LC; Blangero, John J; Boerwinkle, Eric E; Bowden, Donald W DW; Chang, Yi-Cheng YC; Chen, Yii-Der I YI; Choi, Won Jung WJ; Correa, Adolfo A; Curran, Joanne E JE; Daly, Mark J MJ; Dutcher, Susan K SK; Ellinor, Patrick T PT; Fornage, Myriam M; Freedman, Barry I BI; Gabriel, Stacey S; Germer, Soren S; Gibbs, Richard A RA; He, Jiang J; Hveem, Kristian K; Jarvik, Gail P GP; Kaplan, Robert C RC; Kardia, Sharon L R SLR; Kenny, Eimear E; Kim, Ryan W RW; Kooperberg, Charles C; Laurie, Cathy C CC; Lee, Seonwook S; Lloyd-Jones, Don M DM; Loos, Ruth J F RJF; Lubitz, Steven A SA; Mathias, Rasika A RA; Martinez, Karine A Viaud KAV; McGarvey, Stephen T ST; Mitchell, Braxton D BD; Nickerson, Deborah A DA; North, Kari E KE; Palotie, Aarno A; Park, Cheol Joo CJ; Psaty, Bruce M BM; Rao, D C DC; Redline, Susan S; Reiner, Alexander P AP; Seo, Daekwan D; Seo, Jeong-Sun JS; Smith, Albert V AV; Tracy, Russell P RP; Vasan, Ramachandran S RS; Kathiresan, Sekar S; Cupples, L Adrienne LA; Rotter, Jerome I JI; Morrison, Alanna C AC; Rich, Stephen S SS; Ripatti, Samuli S; Willer, Cristen C; , ; , ; Peloso, Gina M GM
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis.
European Heart Journal
Wang, Qin Q; Oliver-Williams, Clare C; Raitakari, Olli T OT; Viikari, Jorma J; Lehtimäki, Terho T; Kähönen, Mika M; Järvelin, Marjo-Riitta MR; Salomaa, Veikko V; Perola, Markus M; Danesh, John J; Kettunen, Johannes J; Butterworth, Adam S AS; Holmes, Michael V MV; Ala-Korpela, Mika M
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Plos One
Hahn, Julie J; Fu, Yi-Ping YP; Brown, Michael R MR; Bis, Joshua C JC; de Vries, Paul S PS; Feitosa, Mary F MF; Yanek, Lisa R LR; Weiss, Stefan S; Giulianini, Franco F; Smith, Albert Vernon AV; Guo, Xiuqing X; Bartz, Traci M TM; Becker, Diane M DM; Becker, Lewis C LC; Boerwinkle, Eric E; Brody, Jennifer A JA; Chen, Yii-Der Ida YI; Franco, Oscar H OH; Grove, Megan M; Harris, Tamara B TB; Hofman, Albert A; Hwang, Shih-Jen SJ; Kral, Brian G BG; Launer, Lenore J LJ; Markus, Marcello R P MRP; Rice, Kenneth M KM; Rich, Stephen S SS; Ridker, Paul M PM; Rivadeneira, Fernando F; Rotter, Jerome I JI; Sotoodehnia, Nona N; Taylor, Kent D KD; Uitterlinden, André G AG; Völker, Uwe U; Völzke, Henry H; Yao, Jie J; Chasman, Daniel I DI; Dörr, Marcus M; Gudnason, Vilmundur V; Mathias, Rasika A RA; Post, Wendy W; Psaty, Bruce M BM; Dehghan, Abbas A; O'Donnell, Christopher J CJ; Morrison, Alanna C AC
Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase.
International Journal Of Molecular Sciences
Barchetta, Ilaria I; Chiappetta, Caterina C; Ceccarelli, Valentina V; Cimini, Flavia Agata FA; Bertoccini, Laura L; Gaggini, Melania M; Cristofano, Claudio Di CD; Silecchia, Gianfranco G; Lenzi, Andrea A; Leonetti, Frida F; Baroni, Marco Giorgio MG; Gastaldelli, Amalia A; Cavallo, Maria Gisella MG
Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.
Circulation. Genomic And Precision Medicine
Wang, Zhe Z; Chen, Han H; Bartz, Traci M TM; Bielak, Lawrence F LF; Chasman, Daniel I DI; Feitosa, Mary F MF; Franceschini, Nora N; Guo, Xiuqing X; Lim, Elise E; Noordam, Raymond R; Richard, Melissa A MA; Wang, Heming H; Cade, Brian B; Cupples, L Adrienne LA; de Vries, Paul S PS; Giulanini, Franco F; Lee, Jiwon J; Lemaitre, Rozenn N RN; Martin, Lisa W LW; Reiner, Alex P AP; Rich, Stephen S SS; Schreiner, Pamela J PJ; Sidney, Stephen S; Sitlani, Colleen M CM; Smith, Jennifer A JA; Willems van Dijk, Ko K; Yao, Jie J; Zhao, Wei W; Fornage, Myriam M; Kardia, Sharon L R SLR; Kooperberg, Charles C; Liu, Ching-Ti CT; Mook-Kanamori, Dennis O DO; Province, Michael A MA; Psaty, Bruce M BM; Redline, Susan S; Ridker, Paul M PM; Rotter, Jerome I JI; Boerwinkle, Eric E; Morrison, Alanna C AC; ,
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue.
Molecular Metabolism
Ruppert, Philip M M PMM; Michielsen, Charlotte C J R CCJR; Hazebroek, Eric J EJ; Pirayesh, Ali A; Olivecrona, Gunilla G; Afman, Lydia A LA; Kersten, Sander S
Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids.
Journal Of Lipid Research
Chen, Yan Q YQ; Pottanat, Thomas G TG; Siegel, Robert W RW; Ehsani, Mariam M; Qian, Yue-Wei YW; Zhen, Eugene Y EY; Regmi, Ajit A; Roell, William C WC; Guo, Haihong H; Luo, M Jane MJ; Gimeno, Ruth E RE; Van't Hooft, Ferdinand F; Konrad, Robert J RJ