Genetic predisposition in the 2'-5'A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity.
Diabetologia
Pedersen, Kristina K; Haupt-Jorgensen, Martin M; Krogvold, Lars L; Kaur, Simranjeet S; Gerling, Ivan C IC; Pociot, Flemming F; Dahl-Jørgensen, Knut K; Buschard, Karsten K
Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.
Plos One
Munroe, Melissa E ME; Pezant, Nathan N; Brown, Michael A MA; Fife, Dustin A DA; Guthridge, Joel M JM; Kelly, Jennifer A JA; Wiley, Graham G; Gaffney, Patrick M PM; James, Judith A JA; Montgomery, Courtney G CG
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.
Plos Genetics
Molineros, Julio E JE; Maiti, Amit K AK; Sun, Celi C; Looger, Loren L LL; Han, Shizhong S; Kim-Howard, Xana X; Glenn, Stuart S; Adler, Adam A; Kelly, Jennifer A JA; Niewold, Timothy B TB; Gilkeson, Gary S GS; Brown, Elizabeth E EE; Alarcón, Graciela S GS; Edberg, Jeffrey C JC; Petri, Michelle M; Ramsey-Goldman, Rosalind R; Reveille, John D JD; Vilá, Luis M LM; Freedman, Barry I BI; Tsao, Betty P BP; Criswell, Lindsey A LA; Jacob, Chaim O CO; Moore, Jason H JH; Vyse, Timothy J TJ; Langefeld, Carl L CL; Guthridge, Joel M JM; Gaffney, Patrick M PM; Moser, Kathy L KL; Scofield, R Hal RH; Alarcón-Riquelme, Marta E ME; , ; Williams, Scott M SM; Merrill, Joan T JT; James, Judith A JA; Kaufman, Kenneth M KM; Kimberly, Robert P RP; Harley, John B JB; Nath, Swapan K SK
Reduced expression of IFIH1 is protective for type 1 diabetes.
Plos One
Downes, Kate K; Pekalski, Marcin M; Angus, Karen L KL; Hardy, Matthew M; Nutland, Sarah S; Smyth, Deborah J DJ; Walker, Neil M NM; Wallace, Chris C; Todd, John A JA