Publications:

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Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.

Nature Communications

Kumar, Arvind A; Kindig, Kayla K; Rao, Shanlin S; Zaki, Afroditi-Maria AM; Basak, Sandip S; Sansom, Mark S P MSP; Biggin, Philip C PC; Chakrapani, Sudha S

Publication Date: 2022-08-18

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PubMed Link: 35982060

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• 41467_2022_Article_32594.pdf

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Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations.

Frontiers In Molecular Biosciences

Mhashal, Anil Ranu AR; Yoluk, Ozge O; Orellana, Laura L

Publication Date: 2022

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PubMed Link: 35836931

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• Main text
• fmolb-09-890851.pdf

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Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.

Elife

Lefebvre, Solène N SN; Taly, Antoine A; Menny, Anaïs A; Medjebeur, Karima K; Corringer, Pierre-Jean PJ

Publication Date: 2021-09-30

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PubMed Link: 34590583

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• Main text
• elife-60682.pdf

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Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.

Nature Communications

Kumar, Arvind A; Basak, Sandip S; Rao, Shanlin S; Gicheru, Yvonne Y; Mayer, Megan L ML; Sansom, Mark S P MSP; Chakrapani, Sudha S

Publication Date: 2020-07-27

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PubMed Link: 32719334

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• 41467_2020_Article_17364.pdf

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Impaired Glycine Receptor Trafficking in Neurological Diseases.

Frontiers In Molecular Neuroscience

Schaefer, Natascha N; Roemer, Vera V; Janzen, Dieter D; Villmann, Carmen C

Publication Date: 2018

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PubMed Link: 30186111

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• Main text
• fnmol-11-00291.pdf

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The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.

The Journal Of Physiology

Gielen, Marc M; Corringer, Pierre-Jean PJ

Publication Date: 2018-05-15

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PubMed Link: 29484660

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• Main text

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Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.

Elife

Basak, Sandip S; Schmandt, Nicolaus N; Gicheru, Yvonne Y; Chakrapani, Sudha S

Publication Date: 2017-03-06

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PubMed Link: 28262093

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• Main text

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The Intracellular Loop of the Glycine Receptor: It's not all about the Size.

Frontiers In Molecular Neuroscience

Langlhofer, Georg G; Villmann, Carmen C

Publication Date: 2016

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PubMed Link: 27330534

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• Main text
• fnmol-09-00041.pdf

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Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Moraga-Cid, Gustavo G; Sauguet, Ludovic L; Huon, Christèle C; Malherbe, Laurie L; Girard-Blanc, Christine C; Petres, Stéphane S; Murail, Samuel S; Taly, Antoine A; Baaden, Marc M; Delarue, Marc M; Corringer, Pierre-Jean PJ

Publication Date: 2015-03-03

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PubMed Link: 25730860

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• Main text

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The impact of human hyperekplexia mutations on glycine receptor structure and function.

Molecular Brain

Bode, Anna A; Lynch, Joseph W JW

Publication Date: 2014-01-09

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PubMed Link: 24405574

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• 1756-6606-7-2.pdf

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β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia.

Plos One

Shan, Qiang Q; Han, Lu L; Lynch, Joseph W JW

Publication Date: 2011

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PubMed Link: 22132222

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• Main text
• pone.0028105.pdf

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