Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: BMPR2: 2695C>T; Arg899Ter

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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The Role of Bone Morphogenetic Protein Receptor Type 2 (BMPR2) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling.

Cells

Devendran, Anichavezhi A; Kar, Sumanta S; Bailey, Rasheed R; Trivieri, Maria Giovanna MG

Publication Date: 2022-11-29

Variant appearance in text: BMPR2: R899X

PubMed Link: 36497082

Variant Present in the following documents:

• cells-11-03823.pdf

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Hypoxia-induced pulmonary hypertension upregulates eNOS and TGF-β contributing to sex-linked differences in BMPR2 mutant mice.

Pulmonary Circulation

Erewele, Ejehi O EO; Castellon, Maricela M; Loya, Omar O; Marshboom, Glenn G; Schwartz, Andrew A; Yerlioglu, Kayla K; Callahan, Christopher C; Chen, Jiwang J; Minshall, Richard D RD; Oliveira, Suellen D SD

Publication Date: 2022-10

Variant appearance in text: BMPR2: R899X

PubMed Link: 36484056

Variant Present in the following documents:

• Main text
• PUL2-12-e12163.pdf

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l-Carnitine therapy improves right heart dysfunction through Cpt1-dependent fatty acid oxidation.

Pulmonary Circulation

Agrawal, Vineet V; Hemnes, Anna R AR; Shelburne, Nicholas J NJ; Fortune, Niki N; Fuentes, Julio L JL; Colvin, Dan D; Calcutt, Marion W MW; Talati, Megha M; Poovey, Emily E; West, James D JD; Brittain, Evan L EL

Publication Date: 2022-07

Variant appearance in text: BMPR2: R899X

PubMed Link: 35911183

Variant Present in the following documents:

• Main text
• PUL2-12-e12107.pdf

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Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.

Scientific Reports

Joshi, Sachindra R SR; Liu, Jun J; Bloom, Troy T; Karaca Atabay, Elif E; Kuo, Tzu-Hsing TH; Lee, Michael M; Belcheva, Elitza E; Spaits, Matthew M; Grenha, Rosa R; Maguire, Michelle C MC; Frost, Jeffrey L JL; Wang, Kathryn K; Briscoe, Steven D SD; Alexander, Mark J MJ; Herrin, Brantley R BR; Castonguay, Roselyne R; Pearsall, R Scott RS; Andre, Patrick P; Yu, Paul B PB; Kumar, Ravindra R; Li, Gang G

Publication Date: 2022-05-12

Variant appearance in text: BMPR2: R899X

PubMed Link: 35551212

Variant Present in the following documents:

• Main text
• 41598_2022_Article_11435.pdf
• 41598_2022_11435_MOESM1_ESM.pdf

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Experimental animal models of pulmonary hypertension: Development and challenges.

Animal Models And Experimental Medicine

Wu, Xiao-Han XH; Ma, Jie-Ling JL; Ding, Dong D; Ma, Yue-Jiao YJ; Wei, Yun-Peng YP; Jing, Zhi-Cheng ZC

Publication Date: 2022-09

Variant appearance in text: BMPR2: R899X

PubMed Link: 35333455

Variant Present in the following documents:

• Main text

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Case Report: BMPR2-Targeted MinION Sequencing as a Tool for Genetic Analysis in Patients With Pulmonary Arterial Hypertension.

Frontiers In Cardiovascular Medicine

Takashima, Tomoya T; Brisset, Sophie S; Furukawa, Asuka A; Taniguchi, Hirohisa H; Takeyasu, Rika R; Kawamura, Akio A; Tamura, Yuichi Y

Publication Date: 2021

Variant appearance in text: BMPR2: 2695C>T; Arg899X

PubMed Link: 34589526

Variant Present in the following documents:

• Main text
• fcvm-08-711694.pdf

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Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension.

Journal Of Experimental Pharmacology

Zolty, Ronald R

Publication Date: 2021

Variant appearance in text: BMPR2: R899X

PubMed Link: 34429666

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• Main text
• jep-13-817.pdf

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Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling.

American Journal Of Respiratory Cell And Molecular Biology

Lee, Michael H MH; Mickael, Claudia C; Graham, Brian B BB

Publication Date: 2021-09

Variant appearance in text: BMPR2: R899X

PubMed Link: 34029508

Variant Present in the following documents:

• Main text
• rcmb.2021-0143ED.pdf

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Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.

International Journal Of Molecular Sciences

van Uden, Denise D; Koudstaal, Thomas T; van Hulst, Jennifer A C JAC; Bergen, Ingrid M IM; Gootjes, Chelsea C; Morrell, Nicholas W NW; van Loo, Geert G; von der Thüsen, Jan H JH; van den Bosch, Thierry P P TPP; Ghigna, Maria-Rosa MR; Perros, Frédéric F; Montani, David D; Kool, Mirjam M; Boomars, Karin A KA; Hendriks, Rudi W RW

Publication Date: 2021-02-10

Variant appearance in text: BMPR2: R899X

PubMed Link: 33578743

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• Main text

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Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde.

Journal Of Occupational Medicine And Toxicology (London, England)

Ghelli, Federica F; Bellisario, Valeria V; Squillacioti, Giulia G; Grignani, Elena E; Garzaro, Giacomo G; Buglisi, Martina M; Bergamaschi, Enrico E; Bono, Roberto R

Publication Date: 2021-02-09

Variant appearance in text: BMPR2: R899X

PubMed Link: 33563312

Variant Present in the following documents:

• 12995_2021_Article_293.pdf

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Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus.

Cardiovascular Research

Dunmore, Benjamin J BJ; Jones, Rowena J RJ; Toshner, Mark R MR; Upton, Paul D PD; Morrell, Nicholas W NW

Publication Date: 2021-09-28

Variant appearance in text: BMPR2: R899X

PubMed Link: 33399862

Variant Present in the following documents:

• Main text

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Emerging therapies for right ventricular dysfunction and failure.

Cardiovascular Diagnosis And Therapy

Klinke, Anna A; Schubert, Torben T; Müller, Marion M; Legchenko, Ekaterina E; Zelt, Jason G E JGE; Shimauchi, Tsukasa T; Napp, L Christian LC; Rothman, Alexander M K AMK; Bonnet, Sébastien S; Stewart, Duncan J DJ; Hansmann, Georg G; Rudolph, Volker V

Publication Date: 2020-10

Variant appearance in text: BMPR2: R899X

PubMed Link: 33224787

Variant Present in the following documents:

• Main text

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The role of genomics and genetics in pulmonary arterial hypertension.

Global Cardiology Science & Practice

Swietlik, Emilia M EM; Gräf, Stefan S; Morrell, Nicholas W NW

Publication Date: 2020-04-30

Variant appearance in text: BMPR2: R899X

PubMed Link: 33150157

Variant Present in the following documents:

• Main text

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DNA Damage and Repair in Pulmonary Arterial Hypertension.

Genes

Sharma, Samantha S; Aldred, Micheala A MA

Publication Date: 2020-10-19

Variant appearance in text: BMPR2: R899X

PubMed Link: 33086628

Variant Present in the following documents:

• Main text

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BMPR2 Promoter Variants Effect Gene Expression in Pulmonary Arterial Hypertension Patients.

Genes

Song, Jie J; Hinderhofer, Katrin K; Kaufmann, Lilian T LT; Benjamin, Nicola N; Fischer, Christine C; Grünig, Ekkehard E; Eichstaedt, Christina A CA

Publication Date: 2020-10-06

Variant appearance in text: BMPR2: 2695C>T; Arg899*

PubMed Link: 33036198

Variant Present in the following documents:

• Main text

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Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.

Arteriosclerosis, Thrombosis, And Vascular Biology

Theilmann, Anne L AL; Hawke, Lindsey G LG; Hilton, L Rhiannon LR; Whitford, Mara K M MKM; Cole, Devon V DV; Mackeil, Jodi L JL; Dunham-Snary, Kimberly J KJ; Mewburn, Jeffrey J; James, Paula D PD; Maurice, Donald H DH; Archer, Stephen L SL; Ormiston, Mark L ML

Publication Date: 2020-11

Variant appearance in text: BMPR-II: R899X

PubMed Link: 32998516

Variant Present in the following documents:

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Prevalence and clinical features of bone morphogenetic protein receptor type 2 mutation in Korean idiopathic pulmonary arterial hypertension patients: The PILGRIM explorative cohort.

Plos One

Jang, Albert Youngwoo AY; Kim, Bo-Gyeong BG; Kwon, Sunkoo S; Seo, Jiyoung J; Kim, Hyung Kwan HK; Chang, Hyuk-Jae HJ; Chang, Sung-A SA; Cho, Goo-Yeong GY; Rhee, Sang Jae SJ; Jung, Hae Ok HO; Kim, Kyung-Hee KH; Seo, Hye Sun HS; Kim, Kye Hun KH; Shin, Jinho J; Lee, Jun Soo JS; Kim, Minsu M; Lee, Young Jae YJ; Chung, Wook-Jin WJ

Publication Date: 2020

Variant appearance in text: BMPR2: 2695C>T; Arg899X

PubMed Link: 32966279

Variant Present in the following documents:

• Main text
• pone.0238698.pdf

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Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension.

Pulmonary Circulation

Long, Lu L; Yang, Xudong X; Southwood, Mark M; Moore, Stephen S; Crosby, Alexi A; Upton, Paul D PD; Dunmore, Benjamin J BJ; Morrell, Nicholas W NW

Publication Date: 2020

Variant appearance in text: BMPR2: R899X

PubMed Link: 32733669

Variant Present in the following documents:

• Main text
• sj-pdf-1-pul-10.1177_2045894020935783.pdf
• 10.1177_2045894020935783.pdf

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Current and emerging therapeutic approaches to pulmonary hypertension.

Reviews In Cardiovascular Medicine

Bisserier, Malik M; Pradhan, Natasha N; Hadri, Lahouaria L

Publication Date: 2020-06-30

Variant appearance in text: BMPR-II: R899X

PubMed Link: 32706206

Variant Present in the following documents:

• Main text

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications

Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U

Publication Date: 2020-07-20

Variant appearance in text: BMPR2: R899X

PubMed Link: 32686686

Variant Present in the following documents:

• 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1

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Anaemia, iron homeostasis and pulmonary hypertension: a review.

Internal And Emergency Medicine

Sonnweber, Thomas T; Pizzini, Alex A; Tancevski, Ivan I; Löffler-Ragg, Judith J; Weiss, Günter G

Publication Date: 2020-06

Variant appearance in text: BMPR2: R899X

PubMed Link: 32040829

Variant Present in the following documents:

• Main text
• 11739_2020_Article_2288.pdf

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Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.

American Journal Of Physiology. Lung Cellular And Molecular Physiology

Hashimoto, Ryota R; Lanier, Gregg M GM; Dhagia, Vidhi V; Joshi, Sachindra R SR; Jordan, Allan A; Waddell, Ian I; Tuder, Rubin R; Stenmark, Kurt R KR; Wolin, Michael S MS; McMurtry, Ivan F IF; Gupte, Sachin A SA

Publication Date: 2020-02-01

Variant appearance in text: BMPR2: R899X

PubMed Link: 31913656

Variant Present in the following documents:

• Main text

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Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension.

British Journal Of Pharmacology

Maron, Bradley A BA; Leopold, Jane A JA; Hemnes, Anna R AR

Publication Date: 2020-04

Variant appearance in text: BMPR2: R899X

PubMed Link: 31881099

Variant Present in the following documents:

• Main text

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BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.

American Journal Of Physiology. Lung Cellular And Molecular Physiology

Hemnes, Anna R AR; Fessel, Joshua P JP; Chen, Xinping X; Zhu, Shijun S; Fortune, Niki L NL; Jetter, Christopher C; Freeman, Michael M; Newman, John H JH; West, James D JD; Talati, Megha H MH

Publication Date: 2020-02-01

Variant appearance in text: BMPR2: R899X

PubMed Link: 31850803

Variant Present in the following documents:

• Main text

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The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.

Science Signaling

Morikawa, Masato M; Mitani, Yoshihide Y; Holmborn, Katarina K; Kato, Taichi T; Koinuma, Daizo D; Maruyama, Junko J; Vasilaki, Eleftheria E; Sawada, Hirofumi H; Kobayashi, Mai M; Ozawa, Takayuki T; Morishita, Yasuyuki Y; Bessho, Yasumasa Y; Maeda, Shingo S; Ledin, Johan J; Aburatani, Hiroyuki H; Kageyama, Ryoichiro R; Maruyama, Kazuo K; Heldin, Carl-Henrik CH; Miyazono, Kohei K

Publication Date: 2019-11-12

Variant appearance in text: BMPR2: R899X

PubMed Link: 31719172

Variant Present in the following documents:

• Main text

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Metabolic Remodeling in the Pressure-Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism-A Systematic Review and Meta-Analysis.

Journal Of The American Heart Association

Koop, Anne-Marie C AC; Bossers, Guido P L GPL; Ploegstra, Mark-Jan MJ; Hagdorn, Quint A J QAJ; Berger, Rolf M F RMF; Silljé, Herman H W HHW; Bartelds, Beatrijs B

Publication Date: 2019-11-05

Variant appearance in text: BMPR2: R899X

PubMed Link: 31657265

Variant Present in the following documents:

• JAH3-8-e012086-s001.pdf
• JAH3-8-e012086.pdf

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Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Lakhal-Littleton, Samira S; Crosby, Alexi A; Frise, Matthew C MC; Mohammad, Goran G; Carr, Carolyn A CA; Loick, Paul A M PAM; Robbins, Peter A PA

Publication Date: 2019-06-25

Variant appearance in text: BMPR2: R899X

PubMed Link: 31152133

Variant Present in the following documents:

• Main text
• pnas.201822010.pdf
• pnas.1822010116.sapp.pdf

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Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.

The European Respiratory Journal

Mair, Kirsty M KM; Harvey, Katie Y KY; Henry, Alasdair D AD; Hillyard, Dianne Z DZ; Nilsen, Margaret M; MacLean, Margaret R MR

Publication Date: 2019-06

Variant appearance in text: BMPR2: R899X

PubMed Link: 30923189

Variant Present in the following documents:

• Main text

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The Search for Disease-Modifying Therapies in Pulmonary Hypertension.

Journal Of Cardiovascular Pharmacology And Therapeutics

Woodcock, Chen-Shan Chen CC; Chan, Stephen Y SY

Publication Date: 2019-07

Variant appearance in text: BMPR2: R899X

PubMed Link: 30773044

Variant Present in the following documents:

• Main text

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A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial Hypertension.

Scientific Reports

Barozzi, Chiara C; Galletti, Margherita M; Tomasi, Luciana L; De Fanti, Sara S; Palazzini, Massimiliano M; Manes, Alessandra A; Sazzini, Marco M; Galiè, Nazzareno N

Publication Date: 2019-01-24

Variant appearance in text: BMPR2: R899X

PubMed Link: 30679663

Variant Present in the following documents:

• Main text
• 41598_2018_Article_37277.pdf

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Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again.

Journal Of The American Heart Association

Prins, Kurt W KW; Thenappan, Thenappan T; Weir, E Kenneth EK; Kalra, Rajat R; Pritzker, Marc M; Archer, Stephen L SL

Publication Date: 2019-01-08

Variant appearance in text: BMPR2: R899X

PubMed Link: 30590974

Variant Present in the following documents:

• Main text
• JAH3-8-e011343.pdf

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Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.

Communications Biology

Vattulainen-Collanus, Sanna S; Southwood, Mark M; Yang, Xu Dong XD; Moore, Stephen S; Ghatpande, Prajakta P; Morrell, Nicholas W NW; Lagna, Giorgio G; Hata, Akiko A

Publication Date: 2018

Variant appearance in text: BMPR2: R899X

PubMed Link: 30272025

Variant Present in the following documents:

• Main text

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Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension.

International Journal Of Molecular Sciences

D'Amico, Reid W RW; Faley, Shannon S; Shim, Ha-Na HN; Prosser, Joanna R JR; Agrawal, Vineet V; Bellan, Leon M LM; West, James D JD

Publication Date: 2018-08-29

Variant appearance in text: BMPR2: R899X

PubMed Link: 30158434

Variant Present in the following documents:

• Main text

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The role of endothelial leak in pulmonary hypertension (2017 Grover Conference Series).

Pulmonary Circulation

Zhou, Chun C; Francis, C Michael CM; Xu, Ningyong N; Stevens, Troy T

Publication Date: 2018

Variant appearance in text: BMPR2: R899X

PubMed Link: 30124139

Variant Present in the following documents:

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Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension.

Molecular Genetics & Genomic Medicine

Abbasi, Yeganeh Y; Jabbari, Javad J; Jabbari, Reza R; Glinge, Charlotte C; Izadyar, Seyed Bahador SB; Spiekerkoetter, Edda E; Zamanian, Roham T RT; Carlsen, Jørn J; Tfelt-Hansen, Jacob J

Publication Date: 2018-09

Variant appearance in text: BMPR2: R899*

PubMed Link: 30084161

Variant Present in the following documents:

• Main text
• MGG3-6-835.pdf

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BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series).

Pulmonary Circulation

Frump, Andrea A; Prewitt, Allison A; de Caestecker, Mark P MP

Publication Date: 2018

Variant appearance in text: BMPR2: R899X

PubMed Link: 29521190

Variant Present in the following documents:

• Main text

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The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series).

Pulmonary Circulation

MacLean, Margaret Mandy R MMR

Publication Date: 2018

Variant appearance in text: BMPR2: R899X

PubMed Link: 29468941

Variant Present in the following documents:

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Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Nucleic Acids Research

Wauchope, Orrette R OR; Mitchener, Michelle M MM; Beavers, William N WN; Galligan, James J JJ; Camarillo, Jeannie M JM; Sanders, William D WD; Kingsley, Philip J PJ; Shim, Ha-Na HN; Blackwell, Thomas T; Luong, Thong T; deCaestecker, Mark M; Fessel, Joshua P JP; Marnett, Lawrence J LJ

Publication Date: 2018-04-20

Variant appearance in text: BMPR2: R899X

PubMed Link: 29438559

Variant Present in the following documents:

• Main text
• gky089.pdf

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Emerging therapeutics in pulmonary hypertension.

American Journal Of Physiology. Lung Cellular And Molecular Physiology

Hensley, Matthew K MK; Levine, Andrea A; Gladwin, Mark T MT; Lai, Yen-Chun YC

Publication Date: 2018-05-01

Variant appearance in text: BMPR2: R899X

PubMed Link: 29388467

Variant Present in the following documents:

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Pulmonary Vascular Research Institute World Congress 2017 Scientific Abstracts.

Pulmonary Circulation

Publication Date: 2017

Variant appearance in text: BMPR-II: R899X

PubMed Link: 29040048

Variant Present in the following documents:

• 10.1177_2045893217730218.pdf

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Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling.

Pulmonary Circulation

Pickworth, Josephine J; Rothman, Alexander A; Iremonger, James J; Casbolt, Helen H; Hopkinson, Kay K; Hickey, Peter M PM; Gladson, Santhi S; Shay, Sheila S; Morrell, Nicholas W NW; Francis, Sheila E SE; West, James D JD; Lawrie, Allan A

Publication Date: 2017

Variant appearance in text: BMPR2: R899X

PubMed Link: 28828907

Variant Present in the following documents:

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The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

British Journal Of Pharmacology

Ayme-Dietrich, Estelle E; Lawson, Roland R; Côté, Francine F; de Tapia, Claudia C; Da Silva, Sylvia S; Ebel, Claudine C; Hechler, Béatrice B; Gachet, Christian C; Guyonnet, Jérome J; Rouillard, Hélène H; Stoltz, Jordane J; Quentin, Emily E; Banas, Sophie S; Daubeuf, François F; Frossard, Nelly N; Gasser, Bernard B; Mazzucotelli, Jean-Philippe JP; Hermine, Olivier O; Maroteaux, Luc L; Monassier, Laurent L

Publication Date: 2017-11

Variant appearance in text: BMPR2: R899X

PubMed Link: 28806488

Variant Present in the following documents:

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Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.

The European Respiratory Journal

Chen, Xinping X; Austin, Eric D ED; Talati, Megha M; Fessel, Joshua P JP; Farber-Eger, Eric H EH; Brittain, Evan L EL; Hemnes, Anna R AR; Loyd, James E JE; West, James J

Publication Date: 2017-08

Variant appearance in text: BMPR2: R899X

PubMed Link: 28775043

Variant Present in the following documents:

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Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension.

Pulmonary Circulation

Trammell, Aaron W AW; Talati, Megha M; Blackwell, Thomas R TR; Fortune, Niki L NL; Niswender, Kevin D KD; Fessel, Joshua P JP; Newman, John H JH; West, James D JD; Hemnes, Anna R AR

Publication Date: 2017

Variant appearance in text: BMPR2: R899X

PubMed Link: 28704134

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Pulmonary extra-medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series.

Pulmonary Circulation

Singh, Inderjit I; Mikita, Geoffrey G; Green, Daniel D; Risquez, Cristobal C; Sanders, Abraham A

Publication Date: 2017-03

Variant appearance in text: BMPR2: R899X

PubMed Link: 28680586

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Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension.

Pulmonary Circulation

Egnatchik, Robert A RA; Brittain, Evan L EL; Shah, Amy T AT; Fares, Wassim H WH; Ford, H James HJ; Monahan, Ken K; Kang, Christie J CJ; Kocurek, Emily G EG; Zhu, Shijun S; Luong, Thong T; Nguyen, Thuy T TT; Hysinger, Erik E; Austin, Eric D ED; Skala, Melissa C MC; Young, Jamey D JD; Roberts, L Jackson LJ; Hemnes, Anna R AR; West, James J; Fessel, Joshua P JP

Publication Date: 2017-03

Variant appearance in text: BMPR2: R899X

PubMed Link: 28680578

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BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.

Cellular And Molecular Life Sciences : Cmls

Orriols, Mar M; Gomez-Puerto, Maria Catalina MC; Ten Dijke, Peter P

Publication Date: 2017-08

Variant appearance in text: BMPR2: R899X

PubMed Link: 28447104

Variant Present in the following documents:

• Main text
• 18_2017_Article_2510.pdf

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Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.

Bmb Reports

Kim, Myung-Jin MJ; Park, Seon Young SY; Chang, Hae Ryung HR; Jung, Eun Young EY; Munkhjargal, Anudari A; Lim, Jong-Seok JS; Lee, Myeong-Sok MS; Kim, Yonghwan Y

Publication Date: 2017-06

Variant appearance in text: BMPR2: 2695C>T

PubMed Link: 28391780

Variant Present in the following documents:

• Main text

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Bone Morphogenetic Proteins in Vascular Homeostasis and Disease.

Cold Spring Harbor Perspectives In Biology

Goumans, Marie-José MJ; Zwijsen, An A; Ten Dijke, Peter P; Bailly, Sabine S

Publication Date: 2018-02-01

Variant appearance in text: BMPR2: R899X

PubMed Link: 28348038

Variant Present in the following documents:

• Main text

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MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9).

Plos One

Yuan, Huijuan H; Sehgal, Pravin B PB

Publication Date: 2016

Variant appearance in text: BMPR2: R899X

PubMed Link: 27875556

Variant Present in the following documents:

• pone.0166382.pdf

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