Publications:

---

Molecularly Targeted Therapy in Acute Myeloid Leukemia: Current Treatment Landscape and Mechanisms of Response and Resistance.

Cancers

Lachowiez, Curtis A CA; DiNardo, Courtney D CD; Loghavi, Sanam S

Publication Date: 2023-03-06

Variant appearance in text: IDH1: S280F

PubMed Link: 36900407

Variant Present in the following documents:

• Main text
• cancers-15-01617.pdf

View BVdb publication page

---

Resistance to targeted therapies in acute myeloid leukemia.

Clinical & Experimental Metastasis

Mecklenbrauck, Rabea R; Heuser, Michael M

Publication Date: 2022-11-01

Variant appearance in text: IDH1: S280F

PubMed Link: 36318439

Variant Present in the following documents:

• Main text
• 10585_2022_Article_10189.pdf

View BVdb publication page

---

Small molecule inhibitors targeting the cancers.

Medcomm

Liu, Gui-Hong GH; Chen, Tao T; Zhang, Xin X; Ma, Xue-Lei XL; Shi, Hua-Shan HS

Publication Date: 2022-12

Variant appearance in text: IDH1: S280F

PubMed Link: 36254250

Variant Present in the following documents:

• Main text
• MCO2-3-e181.pdf

View BVdb publication page

---

Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.

Cancer Discovery

Lyu, Junhua J; Liu, Yuxuan Y; Gong, Lihu L; Chen, Mingyi M; Madanat, Yazan F YF; Zhang, Yuannyu Y; Cai, Feng F; Gu, Zhimin Z; Cao, Hui H; Kaphle, Pranita P; Kim, Yoon Jung YJ; Kalkan, Fatma N FN; Stephens, Helen H; Dickerson, Kathryn E KE; Ni, Min M; Chen, Weina W; Patel, Prapti P; Mims, Alice S AS; Borate, Uma U; Burd, Amy A; Cai, Sheng F SF; Yin, C Cameron CC; You, M James MJ; Chung, Stephen S SS; Collins, Robert H RH; DeBerardinis, Ralph J RJ; Liu, Xin X; Xu, Jian J

Publication Date: 2022-10-12

Variant appearance in text: IDH1: S280F

PubMed Link: 36222845

Variant Present in the following documents:

• Main text
• cd-21-1661_supp1.pdf
• 170.pdf

View BVdb publication page

---

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma.

Npj Precision Oncology

Cleary, James M JM; Rouaisnel, Betty B; Daina, Antoine A; Raghavan, Srivatsan S; Roller, Lauren A LA; Huffman, Brandon M BM; Singh, Harshabad H; Wen, Patrick Y PY; Bardeesy, Nabeel N; Zoete, Vincent V; Wolpin, Brian M BM; Losman, Julie-Aurore JA

Publication Date: 2022-09-02

Variant appearance in text: IDH1: S280F

PubMed Link: 36056177

Variant Present in the following documents:

• Main text
• 41698_2022_Article_304.pdf

View BVdb publication page

---

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.

Nature Communications

Reinbold, Raphael R; Hvinden, Ingvild C IC; Rabe, Patrick P; Herold, Ryan A RA; Finch, Alina A; Wood, James J; Morgan, Melissa M; Staudt, Maximillian M; Clifton, Ian J IJ; Armstrong, Fraser A FA; McCullagh, James S O JSO; Redmond, Jo J; Bardella, Chiara C; Abboud, Martine I MI; Schofield, Christopher J CJ

Publication Date: 2022-08-15

Variant appearance in text: IDH1: S280F

PubMed Link: 35970853

Variant Present in the following documents:

• Main text
• 41467_2022_Article_32436.pdf
• 41467_2022_32436_MOESM1_ESM.pdf
• 41467_2022_32436_MOESM2_ESM.xlsx, sheet 5

View BVdb publication page

---

The Molecular Mechanisms of Resistance to IDH Inhibitors in Acute Myeloid Leukemia.

Frontiers In Oncology

Zhuang, Xiaomei X; Pei, Han Zhong HZ; Li, Tianwen T; Huang, Junbin J; Guo, Yao Y; Zhao, Yuming Y; Yang, Ming M; Zhang, Dengyang D; Chang, Zhiguang Z; Zhang, Qi Q; Yu, Liuting L; He, Chunxiao C; Zhang, Liqing L; Pan, Yihang Y; Chen, Chun C; Chen, Yun Y

Publication Date: 2022

Variant appearance in text: IDH1: S280F

PubMed Link: 35814406

Variant Present in the following documents:

• Main text
• fonc-12-931462.pdf

View BVdb publication page

---

Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies.

Cancer Science

Fukuhara, Suguru S; Oshikawa-Kumade, Yuji Y; Kogure, Yasunori Y; Shingaki, Sumito S; Kariyazono, Hirokazu H; Kikukawa, Yoshiya Y; Koya, Junji J; Saito, Yuki Y; Tabata, Mariko M; Yoshifuji, Kota K; Mizuno, Kota K; Miyagi-Maeshima, Akiko A; Matsushita, Hiromichi H; Sugiyama, Masanaka M; Ogawa, Chitose C; Inamoto, Yoshihiro Y; Fukuda, Takahiro T; Sugano, Masato M; Yamauchi, Nobuhiko N; Minami, Yosuke Y; Hirata, Makoto M; Yoshida, Teruhiko T; Kohno, Takashi T; Kohsaka, Shinji S; Mano, Hiroyuki H; Shiraishi, Yuichi Y; Ogawa, Seishi S; Izutsu, Koji K; Kataoka, Keisuke K

Publication Date: 2022-08

Variant appearance in text: IDH1: S280F

PubMed Link: 35579198

Variant Present in the following documents:

• CAS-113-2763-s003.xlsx, sheet 6

View BVdb publication page

---

Refining AML Treatment: The Role of Genetics in Response and Resistance Evaluation to New Agents.

Cancers

Halik, Adriane A; Arends, Christopher Maximilian CM; Bullinger, Lars L; Damm, Frederik F; Frick, Mareike M

Publication Date: 2022-03-26

Variant appearance in text: IDH1: S280F

PubMed Link: 35406464

Variant Present in the following documents:

• Main text
• cancers-14-01689.pdf

View BVdb publication page

---

Recent Research Progress of Chiral Small Molecular Antitumor-Targeted Drugs Approved by the FDA From 2011 to 2019.

Frontiers In Oncology

Chu, Xuetong X; Bu, Yizhi Y; Yang, Xiaoping X

Publication Date: 2021

Variant appearance in text: IDH1: S280F

PubMed Link: 34976824

Variant Present in the following documents:

• Main text
• fonc-11-785855.pdf

View BVdb publication page

---

Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia.

Cancers

Ribeiro, Sara S; Eiring, Anna M AM; Khorashad, Jamshid S JS

Publication Date: 2021-10-09

Variant appearance in text: IDH1: S280F

PubMed Link: 34680203

Variant Present in the following documents:

• Main text
• cancers-13-05055.pdf

View BVdb publication page

---

Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm.

Blood Cancer Journal

Issa, Ghayas C GC; DiNardo, Courtney D CD

Publication Date: 2021-06-03

Variant appearance in text: IDH1: S280F

PubMed Link: 34083508

Variant Present in the following documents:

• Main text
• 41408_2021_Article_497.pdf

View BVdb publication page

---

Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm.

Blood Cancer Journal

Issa, Ghayas C GC; DiNardo, Courtney D CD

Publication Date: 2021-06-03

Variant appearance in text: IDH1: S280F

PubMed Link: 34083508

Variant Present in the following documents:

• Main text
• 41408_2021_Article_497.pdf

View BVdb publication page

---

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia.

Nature Communications

Wang, Feng F; Morita, Kiyomi K; DiNardo, Courtney D CD; Furudate, Ken K; Tanaka, Tomoyuki T; Yan, Yuanqing Y; Patel, Keyur P KP; MacBeth, Kyle J KJ; Wu, Bin B; Liu, Guowen G; Frattini, Mark M; Matthews, Jairo A JA; Little, Latasha D LD; Gumbs, Curtis C; Song, Xingzhi X; Zhang, Jianhua J; Thompson, Erika J EJ; Kadia, Tapan M TM; Garcia-Manero, Guillermo G; Jabbour, Elias E; Ravandi, Farhad F; Bhalla, Kapil N KN; Konopleva, Marina M; Kantarjian, Hagop M HM; Andrew Futreal, P P; Takahashi, Koichi K

Publication Date: 2021-05-10

Variant appearance in text: IDH1: S280F

PubMed Link: 33972549

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Assessing acquired resistance to IDH1 inhibitor therapy by full-exon IDH1 sequencing and structural modeling.

Cold Spring Harbor Molecular Case Studies

Oltvai, Zoltán N ZN; Harley, Susan E SE; Koes, David D; Michel, Stephen S; Warlick, Erica D ED; Nelson, Andrew C AC; Yohe, Sophia S; Mroz, Pawel P

Publication Date: 2021-04

Variant appearance in text: IDH1: 839C>T; S280F; rs757389021

PubMed Link: 33832922

Variant Present in the following documents:

• Main text
• supp_mcs.a006007_Supplemental_Figures.pdf
• MCS006007Olt.pdf

View BVdb publication page

---

Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML.

Blood Advances

Choe, Sung S; Wang, Hongfang H; DiNardo, Courtney D CD; Stein, Eytan M EM; de Botton, Stéphane S; Roboz, Gail J GJ; Altman, Jessica K JK; Mims, Alice S AS; Watts, Justin M JM; Pollyea, Daniel A DA; Fathi, Amir T AT; Tallman, Martin S MS; Kantarjian, Hagop M HM; Stone, Richard M RM; Quek, Lynn L; Konteatis, Zenon Z; Dang, Lenny L; Nicolay, Brandon B; Nejad, Parham P; Liu, Guowen G; Zhang, Vickie V; Liu, Hua H; Goldwasser, Meredith M; Liu, Wei W; Marks, Kevin K; Bowden, Chris C; Biller, Scott A SA; Attar, Eyal C EC; Wu, Bin B

Publication Date: 2020-05-12

Variant appearance in text: IDH1: S280F

PubMed Link: 32380538

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Evaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy.

Oncotargets And Therapy

Nassereddine, Samah S; Lap, Coen J CJ; Tabbara, Imad A IA

Publication Date: 2019

Variant appearance in text: IDH1: S280F

PubMed Link: 30643428

Variant Present in the following documents:

• Main text
• ott-12-303.pdf

View BVdb publication page

---

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.

Nature

Intlekofer, Andrew M AM; Shih, Alan H AH; Wang, Bo B; Nazir, Abbas A; Rustenburg, Ariën S AS; Albanese, Steven K SK; Patel, Minal M; Famulare, Christopher C; Correa, Fabian M FM; Takemoto, Naofumi N; Durani, Vidushi V; Liu, Hui H; Taylor, Justin J; Farnoud, Noushin N; Papaemmanuil, Elli E; Cross, Justin R JR; Tallman, Martin S MS; Arcila, Maria E ME; Roshal, Mikhail M; Petsko, Gregory A GA; Wu, Bin B; Choe, Sung S; Konteatis, Zenon D ZD; Biller, Scott A SA; Chodera, John D JD; Thompson, Craig B CB; Levine, Ross L RL; Stein, Eytan M EM

Publication Date: 2018-07

Variant appearance in text: IDH1: S280F

PubMed Link: 29950729

Variant Present in the following documents:

• Main text
• nihms964938.pdf
• NIHMS964938-supplement-Supp_Tables_1-5.xlsx, sheet 3

View BVdb publication page

---