Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers.
Molecules (Basel, Switzerland)
Thamim, Masthan M; Agrahari, Ashish Kumar AK; Gupta, Pawan P; Thirumoorthy, Krishnan K
Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics.
Molecular Diagnosis & Therapy
Śledzińska, Paulina P; Bebyn, Marek M; Szczerba, Ewelina E; Furtak, Jacek J; Harat, Maciej M; Olszewska, Natalia N; Kamińska, Katarzyna K; Kowalewski, Janusz J; Lewandowska, Marzena A MA
Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities.
Journal Of Personalized Medicine
Scheiter, Alexander A; Hierl, Frederik F; Winkel, Ingrid I; Keil, Felix F; Klier-Richter, Margit M; Coulouarn, Cédric C; Lüke, Florian F; Kandulski, Arne A; Evert, Matthias M; Dietmaier, Wolfgang W; Calvisi, Diego F DF; Utpatel, Kirsten K
An activating germline IDH1 variant associated with a tumor entity characterized by unilateral and bilateral chondrosarcoma of the mastoid.
Hgg Advances
Blackburn, Patrick R PR; Carter, Jodi M JM; Oglesbee, Devin D; Westendorf, Jennifer J JJ; Neff, Brian A BA; Stichel, Damian D; Tsen, David W DW; Gavrilova, Ralitza H RH; Wesseling, Pieter P; von Deimling, Andreas A; Caulfield, Thomas R TR; Klee, Eric W EW; Pusch, Stefan S; Inwards, Carrie Y CY
Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain.
Cancer Discovery
Ganz, Javier J; Maury, Eduardo A EA; Becerra, Basheer B; Bizzotto, Sara S; Doan, Ryan N RN; Kenny, Connor J CJ; Shin, Taehwan T; Kim, Junho J; Zhou, Zinan Z; Ligon, Keith L KL; Lee, Eunjung Alice EA; Walsh, Christopher A CA
Rates and patterns of clonal oncogenic mutations in the normal human brain.
Cancer Discovery
Ganz, Javier J; Maury, Eduardo A EA; Becerra, Basheer B; Bizzotto, Sara S; Doan, Ryan N RN; Kenny, Connor J CJ; Shin, Taehwan T; Kim, Junho J; Zhou, Zinan Z; Ligon, Keith L KL; Lee, Eunjung Alice EA; Walsh, Christopher A CA
Mohan, Aditya A AA; Tomaszewski, William H WH; Haskell-Mendoza, Aden P AP; Hotchkiss, Kelly M KM; Singh, Kirit K; Reedy, Jessica L JL; Fecci, Peter E PE; Sampson, John H JH; Khasraw, Mustafa M
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
O6-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma.
Annals Of Saudi Medicine
Alassiri, Ali H AH; Alkhaibary, Ali A; Al-Sarheed, Saud S; Alsufani, Fahd F; Alharbi, Mohammed M; Alkhani, Ahmed A; Aloraidi, Ahmed A
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
The Journal Of Biological Chemistry
Avellaneda Matteo, Diego D; Grunseth, Adam J AJ; Gonzalez, Eric R ER; Anselmo, Stacy L SL; Kennedy, Madison A MA; Moman, Precious P; Scott, David A DA; Hoang, An A; Sohl, Christal D CD
Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Molecular Cancer
Kovaleva, Valentina V; Geissler, Anna-Lena AL; Lutz, Lisa L; Fritsch, Ralph R; Makowiec, Frank F; Wiesemann, Sebastian S; Hopt, Ulrich T UT; Passlick, Bernward B; Werner, Martin M; Lassmann, Silke S
Publication Date: 2016-10-18
Variant appearance in text: IDH1: 299G>A; Arg100Gln
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.
Cell Reports
Giannakis, Marios M; Mu, Xinmeng Jasmine XJ; Shukla, Sachet A SA; Qian, Zhi Rong ZR; Cohen, Ofir O; Nishihara, Reiko R; Bahl, Samira S; Cao, Yin Y; Amin-Mansour, Ali A; Yamauchi, Mai M; Sukawa, Yasutaka Y; Stewart, Chip C; Rosenberg, Mara M; Mima, Kosuke K; Inamura, Kentaro K; Nosho, Katsuhiko K; Nowak, Jonathan A JA; Lawrence, Michael S MS; Giovannucci, Edward L EL; Chan, Andrew T AT; Ng, Kimmie K; Meyerhardt, Jeffrey A JA; Van Allen, Eliezer M EM; Getz, Gad G; Gabriel, Stacey B SB; Lander, Eric S ES; Wu, Catherine J CJ; Fuchs, Charles S CS; Ogino, Shuji S; Garraway, Levi A LA
Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.
British Journal Of Cancer
Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB
Publication Date: 2015-04-14
Variant appearance in text: IDH1: 299G>A; Arg100Gln
D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.
Acta Neuropathologica Communications
Pusch, Stefan S; Schweizer, Leonille L; Beck, Ann-Christin AC; Lehmler, Johanna-Marie JM; Weissert, Susanne S; Balss, Jörg J; Miller, Aubry K AK; von Deimling, Andreas A