Publications:

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

The Biochemical Journal

Luna, Lucas A LA; Lesecq, Zachary Z; White, Katharine A KA; Hoang, An A; Scott, David A DA; Zagnitko, Olga O; Bobkov, Andrey A AA; Barber, Diane L DL; Schiffer, Jamie M JM; Isom, Daniel G DG; Sohl, Christal D CD

Publication Date: 2020-08-28

Variant appearance in text: IDH1: T77A

PubMed Link: 32729927

Variant Present in the following documents:

• Main text

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Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle.

Cell Research

Liu, Jing J; Peng, Yunhua Y; Shi, Le L; Wan, Lixin L; Inuzuka, Hiroyuki H; Long, Jiangang J; Guo, Jianping J; Zhang, Jinfang J; Yuan, Min M; Zhang, Shuangxi S; Wang, Xun X; Gao, Jing J; Dai, Xiangpeng X; Furumoto, Shozo S; Jia, Lijun L; Pandolfi, Pier Paolo PP; Asara, John M JM; Kaelin, William G WG; Liu, Jiankang J; Wei, Wenyi W

Publication Date: 2021-01

Variant appearance in text: IDH1: T77A

PubMed Link: 32669607

Variant Present in the following documents:

• Main text

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IDH1 fine-tunes cap-dependent translation initiation.

Journal Of Molecular Cell Biology

Liu, Lichao L; Lu, J Yuyang JY; Li, Fajin F; Xing, Xudong X; Li, Tong T; Yang, Xuerui X; Shen, Xiaohua X

Publication Date: 2019-10-25

Variant appearance in text: IDH1: T77A

PubMed Link: 31408165

Variant Present in the following documents:

• Main text
• mjz082.pdf

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Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.

Cell Reports

Badur, Mehmet G MG; Muthusamy, Thangaselvam T; Parker, Seth J SJ; Ma, Shenghong S; McBrayer, Samuel K SK; Cordes, Thekla T; Magana, Jose H JH; Guan, Kun-Liang KL; Metallo, Christian M CM

Publication Date: 2018-10-23

Variant appearance in text: IDH1: T77A

PubMed Link: 30355481

Variant Present in the following documents:

• Main text
• NIHMS1511532-supplement-2.pdf
• nihms-1511532.pdf
• NIHMS1511532-supplement-1.pdf

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D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.

Oncotarget

Ma, Shenghong S; Jiang, Bowen B; Deng, Wanglong W; Gu, Zhong-Kai ZK; Wu, Fei-Zhen FZ; Li, Tingting T; Xia, Yukun Y; Yang, Hui H; Ye, Dan D; Xiong, Yue Y; Guan, Kun-Liang KL

Publication Date: 2015-04-20

Variant appearance in text: IDH1: T77A

PubMed Link: 25825982

Variant Present in the following documents:

• oncotarget-06-8606.pdf

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