A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Jang, H Josh HJ; Hostetter, Galen G; MacFarlane, Alexander W AW; Madaj, Zachary Z; Ross, Eric A EA; Hinoue, Toshinori T; Kulchycki, Justin R JR; Burgos, Ryan S RS; Tafseer, Mahvish M; Alpaugh, R Katherine RK; Schwebel, Candice L CL; Kokate, Rutika R; Geynisman, Daniel M DM; Zibelman, Matthew R MR; Ghatalia, Pooja P; Nichols, Peter W PW; Chung, Woonbok W; Madzo, Jozef J; Hahn, Noah M NM; Quinn, David I DI; Issa, Jean-Pierre J JJ; Topper, Michael J MJ; Baylin, Stephen B SB; Shen, Hui H; Campbell, Kerry S KS; Jones, Peter A PA; Plimack, Elizabeth R ER
Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group.
Journal Of Experimental & Clinical Cancer Research : Cr
Junk, Stefanie V SV; Schaeffeler, Elke E; Zimmermann, Martin M; Möricke, Anja A; Beier, Rita R; Schütte, Peter P; Fedders, Birthe B; Alten, Julia J; Hinze, Laura L; Klein, Norman N; Kulozik, Andreas A; Muckenthaler, Martina U MU; Koehler, Rolf R; Borkhardt, Arndt A; Vijayakrishnan, Jayaram J; Ellinghaus, David D; Forster, Michael M; Franke, Andre A; Wintering, Astrid A; Kratz, Christian P CP; Schrappe, Martin M; Schwab, Matthias M; Houlston, Richard S RS; Cario, Gunnar G; Stanulla, Martin M
Publication Date: 2023-01-13
Variant appearance in text: UGT1A7: N129K; rs17868323
The UGT1A9*22 genotype identifies a high-risk group for irinotecan toxicity among gastric cancer patients.
Genomics & Informatics
Lee, Choong-Kun CK; Chon, Hong Jae HJ; Kwon, Woo Sun WS; Ban, Hyo-Jeong HJ; Kim, Sang Cheol SC; Kim, Hyunwook H; Jeung, Hei-Cheul HC; Chung, Jimyung J; Rha, Sun Young SY
Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells.
Npj Systems Biology And Applications
Immanuel, Selva Rupa Christinal SRC; Ghanate, Avinash D AD; Parmar, Dharmeshkumar S DS; Yadav, Ritu R; Uthup, Riya R; Panchagnula, Venkateswarlu V; Raghunathan, Anu A
Publication Date: 2021-01-08
Variant appearance in text: UGT1A7: N129K; rs17868323
Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations.
Journal Of Medical Biochemistry
Stanković, Biljana B; Kotur, Nikola N; Gašić, Vladimir V; Klaassen, Kristel K; Ristivojević, Bojan B; Stojiljković, Maja M; Pavlović, Sonja S; Zukić, Branka B
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.
Scientific Reports
Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA
Publication Date: 2019-10-09
Variant appearance in text: UGT1A7: N129K; rs17868323
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell Death & Disease
Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D
X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family.
Scientific Reports
Khan, Muhammad Jaseem MJ; Pollock, Nijole N; Jiang, Huaiyang H; Castro, Carlos C; Nazli, Rubina R; Ahmed, Jawad J; Basit, Sulman S; Rajkovic, Aleksandar A; Yatsenko, Alexander N AN
Publication Date: 2018-11-02
Variant appearance in text: UGT1A7: N129K; rs17868323
Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma.
Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
Nature Communications
Chia, Shumei S; Low, Joo-Leng JL; Zhang, Xiaoqian X; Kwang, Xue-Lin XL; Chong, Fui-Teen FT; Sharma, Ankur A; Bertrand, Denis D; Toh, Shen Yon SY; Leong, Hui-Sun HS; Thangavelu, Matan T MT; Hwang, Jacqueline S G JSG; Lim, Kok-Hing KH; Skanthakumar, Thakshayeni T; Tan, Hiang-Khoon HK; Su, Yan Y; Hui Choo, Siang S; Hentze, Hannes H; Tan, Iain B H IBH; Lezhava, Alexander A; Tan, Patrick P; Tan, Daniel S W DSW; Periyasamy, Giridharan G; Koh, Judice L Y JLY; Gopalakrishna Iyer, N N; DasGupta, Ramanuj R
UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens.
Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans.
Plos One
Aarts, Jac M M J G JM; Alink, Gerrit M GM; Scherjon, Fulco F; MacDonald, Katharine K; Smith, Alison C AC; Nijveen, Harm H; Roebroeks, Wil W
Publication Date: 2016
Variant appearance in text: UGT1A7: Asn129Lys; rs17868323
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.
Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
Publication Date: 2015-12-08
Variant appearance in text: UGT1A7: N129K; rs17868323
Whole-genome sequencing of the world's oldest people.
Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Publication Date: 2014
Variant appearance in text: UGT1A7: N129K; rs17868323
Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy.
Genome Medicine
Lupski, James R JR; Gonzaga-Jauregui, Claudia C; Yang, Yaping Y; Bainbridge, Matthew N MN; Jhangiani, Shalini S; Buhay, Christian J CJ; Kovar, Christie L CL; Wang, Min M; Hawes, Alicia C AC; Reid, Jeffrey G JG; Eng, Christine C; Muzny, Donna M DM; Gibbs, Richard A RA
Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study.
Frontiers In Oncology
Heck, Julia E JE; Moore, Lee E LE; Lee, Yuan-Chin A YC; McKay, James D JD; Hung, Rayjean J RJ; Karami, Sara S; Gaborieau, Valérie V; Szeszenia-Dabrowska, Neonila N; Zaridze, David G DG; Mukeriya, Anush A; Mates, Dana D; Foretova, Lenka L; Janout, Vladimir V; Kollárová, Helena H; Bencko, Vladimir V; Rothman, Nathaniel N; Brennan, Paul P; Chow, Wong-Ho WH; Boffetta, Paolo P
Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer.
Human Molecular Genetics
Tang, Wei W; Fu, Yi-Ping YP; Figueroa, Jonine D JD; Malats, Núria N; Garcia-Closas, Montserrat M; Chatterjee, Nilanjan N; Kogevinas, Manolis M; Baris, Dalsu D; Thun, Michael M; Hall, Jennifer L JL; De Vivo, Immaculata I; Albanes, Demetrius D; Porter-Gill, Patricia P; Purdue, Mark P MP; Burdett, Laurie L; Liu, Luyang L; Hutchinson, Amy A; Myers, Timothy T; Tardón, Adonina A; Serra, Consol C; Carrato, Alfredo A; Garcia-Closas, Reina R; Lloreta, Josep J; Johnson, Alison A; Schwenn, Molly M; Karagas, Margaret R MR; Schned, Alan A; Black, Amanda A; Jacobs, Eric J EJ; Diver, W Ryan WR; Gapstur, Susan M SM; Virtamo, Jarmo J; Hunter, David J DJ; Fraumeni, Joseph F JF; Chanock, Stephen J SJ; Silverman, Debra T DT; Rothman, Nathaniel N; Prokunina-Olsson, Ludmila L
UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.
British Journal Of Cancer
Martinez-Balibrea, E E; Abad, A A; Martínez-Cardús, A A; Ginés, A A; Valladares, M M; Navarro, M M; Aranda, E E; Marcuello, E E; Benavides, M M; Massutí, B B; Carrato, A A; Layos, L L; Manzano, J L JL; Moreno, V V
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Innocenti, Federico F; Kroetz, Deanna L DL; Schuetz, Erin E; Dolan, M Eileen ME; Ramírez, Jacqueline J; Relling, Mary M; Chen, Peixian P; Das, Soma S; Rosner, Gary L GL; Ratain, Mark J MJ
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Cotterchio, Michelle M; Boucher, Beatrice A BA; Manno, Michael M; Gallinger, Steven S; Okey, Allan B AB; Harper, Patricia A PA
Publication Date: 2008-11
Variant appearance in text: UGT1A7: N129K; rs17868323
UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
Bmc Cancer
Stücker, I I; Loriot, M A MA; N'koutchou, G G; Cénée, S S; Bodin, L L; Mulot, C C; Gelu-Simeon, M M; Pelletier, L L; Bronowicki, J P JP; Degos, F F; Beaune, P P; Laurent-Puig, P P; Hémon, D D; Trinchet, J C JC; Pelletier, G G
Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.
American Journal Of Human Genetics
Shi, Min M; Christensen, Kaare K; Weinberg, Clarice R CR; Romitti, Paul P; Bathum, Lise L; Lozada, Anthony A; Morris, Richard W RW; Lovett, Michael M; Murray, Jeffrey C JC
Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.
World Journal Of Gastroenterology
Piepoli, Ada A; Gentile, Annamaria A; Valvano, Maria Rosa MR; Barana, Daniela D; Oliani, Cristina C; Cotugno, Rosa R; Quitadamo, Michele M; Andriulli, Angelo A; Perri, Francesco F