Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.
Nature Genetics
Schlosser, Pascal P; Scherer, Nora N; Grundner-Culemann, Franziska F; Monteiro-Martins, Sara S; Haug, Stefan S; Steinbrenner, Inga I; Uluvar, Burulça B; Wuttke, Matthias M; Cheng, Yurong Y; Ekici, Arif B AB; Gyimesi, Gergely G; Karoly, Edward D ED; Kotsis, Fruzsina F; Mielke, Johanna J; Gomez, Maria F MF; Yu, Bing B; Grams, Morgan E ME; Coresh, Josef J; Boerwinkle, Eric E; Köttgen, Michael M; Kronenberg, Florian F; Meiselbach, Heike H; Mohney, Robert P RP; Akilesh, Shreeram S; , ; Schmidts, Miriam M; Hediger, Matthias A MA; Schultheiss, Ulla T UT; Eckardt, Kai-Uwe KU; Oefner, Peter J PJ; Sekula, Peggy P; Li, Yong Y; Köttgen, Anna A
Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group.
Journal Of Experimental & Clinical Cancer Research : Cr
Junk, Stefanie V SV; Schaeffeler, Elke E; Zimmermann, Martin M; Möricke, Anja A; Beier, Rita R; Schütte, Peter P; Fedders, Birthe B; Alten, Julia J; Hinze, Laura L; Klein, Norman N; Kulozik, Andreas A; Muckenthaler, Martina U MU; Koehler, Rolf R; Borkhardt, Arndt A; Vijayakrishnan, Jayaram J; Ellinghaus, David D; Forster, Michael M; Franke, Andre A; Wintering, Astrid A; Kratz, Christian P CP; Schrappe, Martin M; Schwab, Matthias M; Houlston, Richard S RS; Cario, Gunnar G; Stanulla, Martin M
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia.
Jama Network Open
Yang, Wenjian W; Karol, Seth E SE; Hoshitsuki, Keito K; Lee, Shawn S; Larsen, Eric C EC; Winick, Naomi N; Carroll, William L WL; Loh, Mignon L ML; Raetz, Elizabeth A EA; Hunger, Stephen P SP; Winter, Stuart S SS; Dunsmore, Kimberly P KP; Devidas, Meenakshi M; Relling, Mary V MV; Yang, Jun J JJ
Crosstalk between Host Genome and Metabolome among People with HIV in South Africa.
Metabolites
Liu, Chang C; Wang, Zicheng Z; Hui, Qin Q; Chiang, Yiyun Y; Chen, Junyu J; Brijkumar, Jaysingh J; Edwards, Johnathan A JA; Ordonez, Claudia E CE; Dudgeon, Mathew R MR; Sunpath, Henry H; Pillay, Selvan S; Moodley, Pravi P; Kuritzkes, Daniel R DR; Moosa, Mohamed Y S MYS; Jones, Dean P DP; Marconi, Vincent C VC; Sun, Yan V YV
UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.
The Pharmacogenomics Journal
Lin, Nan N; Damask, Amy A; Boyapati, Anita A; Hamilton, Jennifer D JD; Hamon, Sara S; Ternes, Nils N; Nivens, Michael C MC; Penn, John J; Lopez, Alexander A; Reid, Jeffrey G JG; Overton, John J; Shuldiner, Alan R AR; Abecasis, Goncalo G; Baras, Aris A; Paulding, Charles C
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.
Nutrients
Coltell, Oscar O; Asensio, Eva M EM; Sorlí, José V JV; Barragán, Rocio R; Fernández-Carrión, Rebeca R; Portolés, Olga O; Ortega-Azorín, Carolina C; Martínez-LaCruz, Raul R; González, José I JI; Zanón-Moreno, Vicente V; Gimenez-Alba, Ignacio I; Fitó, Montserrat M; Ros, Emilio E; Ordovas, Jose M JM; Corella, Dolores D
Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate.
Bmc Genetics
Benton, M C MC; Lea, R A RA; Macartney-Coxson, D D; Bellis, C C; Carless, M A MA; Curran, J E JE; Hanna, M M; Eccles, D D; Chambers, G K GK; Blangero, J J; Griffiths, L R LR
A GWAS Study on Liver Function Test Using eMERGE Network Participants.
Plos One
Namjou, Bahram B; Marsolo, Keith K; Lingren, Todd T; Ritchie, Marylyn D MD; Verma, Shefali S SS; Cobb, Beth L BL; Perry, Cassandra C; Kitchner, Terrie E TE; Brilliant, Murray H MH; Peissig, Peggy L PL; Borthwick, Kenneth M KM; Williams, Marc S MS; Grafton, Jane J; Jarvik, Gail P GP; Holm, Ingrid A IA; Harley, John B JB
Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article.
Medicine
Oussalah, Abderrahim A; Bosco, Paolo P; Anello, Guido G; Spada, Rosario R; Guéant-Rodriguez, Rosa-Maria RM; Chery, Céline C; Rouyer, Pierre P; Josse, Thomas T; Romano, Antonino A; Elia, Maurizzio M; Bronowicki, Jean-Pierre JP; Guéant, Jean-Louis JL
Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols.
Open Forum Infectious Diseases
Moore, Carrie B CB; Verma, Anurag A; Pendergrass, Sarah S; Verma, Shefali S SS; Johnson, Daniel H DH; Daar, Eric S ES; Gulick, Roy M RM; Haubrich, Richard R; Robbins, Gregory K GK; Ritchie, Marylyn D MD; Haas, David W DW
Genome-wide analysis of hepatic lipid content in extreme obesity.
Acta Diabetologica
DiStefano, Johanna K JK; Kingsley, Christopher C; Craig Wood, G G; Chu, Xin X; Argyropoulos, George G; Still, Christopher D CD; Doné, Stefania Cotta SC; Legendre, Christophe C; Tembe, Waibhav W; Gerhard, Glenn S GS
A genome-wide association study of the human metabolome in a community-based cohort.
Cell Metabolism
Rhee, Eugene P EP; Ho, Jennifer E JE; Chen, Ming-Huei MH; Shen, Dongxiao D; Cheng, Susan S; Larson, Martin G MG; Ghorbani, Anahita A; Shi, Xu X; Helenius, Iiro T IT; O'Donnell, Christopher J CJ; Souza, Amanda L AL; Deik, Amy A; Pierce, Kerry A KA; Bullock, Kevin K; Walford, Geoffrey A GA; Vasan, Ramachandran S RS; Florez, Jose C JC; Clish, Clary C; Yeh, J-R Joanna JR; Wang, Thomas J TJ; Gerszten, Robert E RE
Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.
Atherosclerosis
Cox, Amanda J AJ; Ng, Maggie C-Y MC; Xu, Jianzhao J; Langefeld, Carl D CD; Koch, Kenneth L KL; Dawson, Paul A PA; Carr, J Jeffrey JJ; Freedman, Barry I BI; Hsu, Fang-Chi FC; Bowden, Donald W DW
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
Plos One
Milton, Jacqueline N JN; Sebastiani, Paola P; Solovieff, Nadia N; Hartley, Stephen W SW; Bhatnagar, Pallav P; Arking, Dan E DE; Dworkis, Daniel A DA; Casella, James F JF; Barron-Casella, Emily E; Bean, Christopher J CJ; Hooper, W Craig WC; DeBaun, Michael R MR; Garrett, Melanie E ME; Soldano, Karen K; Telen, Marilyn J MJ; Ashley-Koch, Allison A; Gladwin, Mark T MT; Baldwin, Clinton T CT; Steinberg, Martin H MH; Klings, Elizabeth S ES
A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.
Plos One
Jylhävä, Juulia J; Lyytikäinen, Leo-Pekka LP; Kähönen, Mika M; Hutri-Kähönen, Nina N; Kettunen, Johannes J; Viikari, Jorma J; Raitakari, Olli T OT; Lehtimäki, Terho T; Hurme, Mikko M
Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
Mayo Clinic Proceedings
Bielinski, Suzette J SJ; Chai, High Seng HS; Pathak, Jyotishman J; Talwalkar, Jayant A JA; Limburg, Paul J PJ; Gullerud, Rachel E RE; Sicotte, Hugues H; Klee, Eric W EW; Ross, Jason L JL; Kocher, Jean-Pierre A JP; Kullo, Iftikhar J IJ; Heit, John A JA; Petersen, Gloria M GM; de Andrade, Mariza M; Chute, Christopher G CG
Genome-wide association meta-analysis for total serum bilirubin levels.
Human Molecular Genetics
Johnson, Andrew D AD; Kavousi, Maryam M; Smith, Albert V AV; Chen, Ming-Huei MH; Dehghan, Abbas A; Aspelund, Thor T; Lin, Jing-Ping JP; van Duijn, Cornelia M CM; Harris, Tamara B TB; Cupples, L Adrienne LA; Uitterlinden, Andre G AG; Launer, Lenore L; Hofman, Albert A; Rivadeneira, Fernando F; Stricker, Bruno B; Yang, Qiong Q; O'Donnell, Christopher J CJ; Gudnason, Vilmundur V; Witteman, Jacqueline C JC
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans.
Breast Cancer Research And Treatment
Huo, Dezheng D; Kim, Hee-Jin HJ; Adebamowo, Clement A CA; Ogundiran, Temidayo O TO; Akang, Effiong E EE; Campbell, Oladapo O; Adenipekun, Adeniyi A; Niu, Qun Q; Sveen, Lise L; Fackenthal, James D JD; Fackenthal, Donna Lee DL; Das, Soma S; Cox, Nancy N; Di Rienzo, Anna A; Olopade, Olufunmilayo I OI