A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
Cell Metabolism
Sinnott-Armstrong, Nasa N; Sousa, Isabel S IS; Laber, Samantha S; Rendina-Ruedy, Elizabeth E; Nitter Dankel, Simon E SE; Ferreira, Teresa T; Mellgren, Gunnar G; Karasik, David D; Rivas, Manuel M; Pritchard, Jonathan J; Guntur, Anyonya R AR; Cox, Roger D RD; Lindgren, Cecilia M CM; Hauner, Hans H; Sallari, Richard R; Rosen, Clifford J CJ; Hsu, Yi-Hsiang YH; Lander, Eric S ES; Kiel, Douglas P DP; Claussnitzer, Melina M
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Aging Cell
Teumer, Alexander A; Qi, Qibin Q; Nethander, Maria M; Aschard, Hugues H; Bandinelli, Stefania S; Beekman, Marian M; Berndt, Sonja I SI; Bidlingmaier, Martin M; Broer, Linda L; , ; Cappola, Anne A; Ceda, Gian Paolo GP; Chanock, Stephen S; Chen, Ming-Huei MH; Chen, Tai C TC; Chen, Yii-Der Ida YD; Chung, Jonathan J; Del Greco Miglianico, Fabiola F; Eriksson, Joel J; Ferrucci, Luigi L; Friedrich, Nele N; Gnewuch, Carsten C; Goodarzi, Mark O MO; Grarup, Niels N; Guo, Tingwei T; Hammer, Elke E; Hayes, Richard B RB; Hicks, Andrew A AA; Hofman, Albert A; Houwing-Duistermaat, Jeanine J JJ; Hu, Frank F; Hunter, David J DJ; Husemoen, Lise L LL; Isaacs, Aaron A; Jacobs, Kevin B KB; Janssen, Joop A M J L JA; Jansson, John-Olov JO; Jehmlich, Nico N; Johnson, Simon S; Juul, Anders A; Karlsson, Magnus M; Kilpelainen, Tuomas O TO; Kovacs, Peter P; Kraft, Peter P; Li, Chao C; Linneberg, Allan A; Liu, Yongmei Y; Loos, Ruth J F RJ; , ; Lorentzon, Mattias M; Lu, Yingchang Y; Maggio, Marcello M; Magi, Reedik R; Meigs, James J; Mellström, Dan D; Nauck, Matthias M; Newman, Anne B AB; Pollak, Michael N MN; Pramstaller, Peter P PP; Prokopenko, Inga I; Psaty, Bruce M BM; Reincke, Martin M; Rimm, Eric B EB; Rotter, Jerome I JI; Saint Pierre, Aude A; Schurmann, Claudia C; Seshadri, Sudha S; Sjögren, Klara K; Slagboom, P Eline PE; Strickler, Howard D HD; Stumvoll, Michael M; Suh, Yousin Y; Sun, Qi Q; Zhang, Cuilin C; Svensson, Johan J; Tanaka, Toshiko T; Tare, Archana A; Tönjes, Anke A; Uh, Hae-Won HW; van Duijn, Cornelia M CM; van Heemst, Diana D; Vandenput, Liesbeth L; Vasan, Ramachandran S RS; Völker, Uwe U; Willems, Sara M SM; Ohlsson, Claes C; Wallaschofski, Henri H; Kaplan, Robert C RC
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Nature Communications
Kilpeläinen, Tuomas O TO; Carli, Jayne F Martin JF; Skowronski, Alicja A AA; Sun, Qi Q; Kriebel, Jennifer J; Feitosa, Mary F MF; Hedman, Åsa K ÅK; Drong, Alexander W AW; Hayes, James E JE; Zhao, Jinghua J; Pers, Tune H TH; Schick, Ursula U; Grarup, Niels N; Kutalik, Zoltán Z; Trompet, Stella S; Mangino, Massimo M; Kristiansson, Kati K; Beekman, Marian M; Lyytikäinen, Leo-Pekka LP; Eriksson, Joel J; Henneman, Peter P; Lahti, Jari J; Tanaka, Toshiko T; Luan, Jian'an J; Del Greco M, Fabiola F; Pasko, Dorota D; Renström, Frida F; Willems, Sara M SM; Mahajan, Anubha A; Rose, Lynda M LM; Guo, Xiuqing X; Liu, Yongmei Y; Kleber, Marcus E ME; Pérusse, Louis L; Gaunt, Tom T; Ahluwalia, Tarunveer S TS; Ju Sung, Yun Y; Ramos, Yolande F YF; Amin, Najaf N; Amuzu, Antoinette A; Barroso, Inês I; Bellis, Claire C; Blangero, John J; Buckley, Brendan M BM; Böhringer, Stefan S; I Chen, Yii-Der YD; de Craen, Anton J N AJ; Crosslin, David R DR; Dale, Caroline E CE; Dastani, Zari Z; Day, Felix R FR; Deelen, Joris J; Delgado, Graciela E GE; Demirkan, Ayse A; Finucane, Francis M FM; Ford, Ian I; Garcia, Melissa E ME; Gieger, Christian C; Gustafsson, Stefan S; Hallmans, Göran G; Hankinson, Susan E SE; Havulinna, Aki S AS; Herder, Christian C; Hernandez, Dena D; Hicks, Andrew A AA; Hunter, David J DJ; Illig, Thomas T; Ingelsson, Erik E; Ioan-Facsinay, Andreea A; Jansson, John-Olov JO; Jenny, Nancy S NS; Jørgensen, Marit E ME; Jørgensen, Torben T; Karlsson, Magnus M; Koenig, Wolfgang W; Kraft, Peter P; Kwekkeboom, Joanneke J; Laatikainen, Tiina T; Ladwig, Karl-Heinz KH; LeDuc, Charles A CA; Lowe, Gordon G; Lu, Yingchang Y; Marques-Vidal, Pedro P; Meisinger, Christa C; Menni, Cristina C; Morris, Andrew P AP; Myers, Richard H RH; Männistö, Satu S; Nalls, Mike A MA; Paternoster, Lavinia L; Peters, Annette A; Pradhan, Aruna D AD; Rankinen, Tuomo T; Rasmussen-Torvik, Laura J LJ; Rathmann, Wolfgang W; Rice, Treva K TK; Brent Richards, J J; Ridker, Paul M PM; Sattar, Naveed N; Savage, David B DB; Söderberg, Stefan S; Timpson, Nicholas J NJ; Vandenput, Liesbeth L; van Heemst, Diana D; Uh, Hae-Won HW; Vohl, Marie-Claude MC; Walker, Mark M; Wichmann, Heinz-Erich HE; Widén, Elisabeth E; Wood, Andrew R AR; Yao, Jie J; Zeller, Tanja T; Zhang, Yiying Y; Meulenbelt, Ingrid I; Kloppenburg, Margreet M; Astrup, Arne A; Sørensen, Thorkild I A TI; Sarzynski, Mark A MA; Rao, D C DC; Jousilahti, Pekka P; Vartiainen, Erkki E; Hofman, Albert A; Rivadeneira, Fernando F; Uitterlinden, André G AG; Kajantie, Eero E; Osmond, Clive C; Palotie, Aarno A; Eriksson, Johan G JG; Heliövaara, Markku M; Knekt, Paul B PB; Koskinen, Seppo S; Jula, Antti A; Perola, Markus M; Huupponen, Risto K RK; Viikari, Jorma S JS; Kähönen, Mika M; Lehtimäki, Terho T; Raitakari, Olli T OT; Mellström, Dan D; Lorentzon, Mattias M; Casas, Juan P JP; Bandinelli, Stefanie S; März, Winfried W; Isaacs, Aaron A; van Dijk, Ko W KW; van Duijn, Cornelia M CM; Harris, Tamara B TB; Bouchard, Claude C; Allison, Matthew A MA; Chasman, Daniel I DI; Ohlsson, Claes C; Lind, Lars L; Scott, Robert A RA; Langenberg, Claudia C; Wareham, Nicholas J NJ; Ferrucci, Luigi L; Frayling, Timothy M TM; Pramstaller, Peter P PP; Borecki, Ingrid B IB; Waterworth, Dawn M DM; Bergmann, Sven S; Waeber, Gérard G; Vollenweider, Peter P; Vestergaard, Henrik H; Hansen, Torben T; Pedersen, Oluf O; Hu, Frank B FB; Eline Slagboom, P P; Grallert, Harald H; Spector, Tim D TD; Jukema, J W JW; Klein, Robert J RJ; Schadt, Erik E EE; Franks, Paul W PW; Lindgren, Cecilia M CM; Leibel, Rudolph L RL; Loos, Ruth J F RJ
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
American Journal Of Human Genetics
Andreassen, Ole A OA; Djurovic, Srdjan S; Thompson, Wesley K WK; Schork, Andrew J AJ; Kendler, Kenneth S KS; O'Donovan, Michael C MC; Rujescu, Dan D; Werge, Thomas T; van de Bunt, Martijn M; Morris, Andrew P AP; McCarthy, Mark I MI; , ; , ; , ; Roddey, J Cooper JC; McEvoy, Linda K LK; Desikan, Rahul S RS; Dale, Anders M AM