ALK c.4219G>A ;(p.E1407K)

Variant ID: 2-29416734-C-T

NM_004304.4(ALK):c.4219G>A;(p.E1407K)

This variant was identified in 7 publications

View GRCh38 version.




Publications:


Rare GCC2-ALK fusion G13:A20 detected by next generation sequencing in non-small cell lung cancer patients and treatment response.

Translational Cancer Research
Qin, Jing J; Zeng, Daxiong D; Xie, Fajun F; Yu, Ruoying R; Wu, Xue X; Liu, Kaihua K; Shao, Yang W YW; Lu, Hongyang H; Jiang, Junhong J
Publication Date: 2019-09

Variant appearance in text: ALK: E1407K
PubMed Link: 35116968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Final efficacy and safety data, and exploratory molecular profiling from the phase III ALUR study of alectinib versus chemotherapy in crizotinib-pretreated ALK-positive non-small-cell lung cancer.

Esmo Open
Wolf, J J; Helland, Å Å; Oh, I-J IJ; Migliorino, M R MR; Dziadziuszko, R R; Wrona, A A; de Castro, J J; Mazieres, J J; Griesinger, F F; Chlistalla, M M; Cardona, A A; Ruf, T T; Trunzer, K K; Smoljanovic, V V; Novello, S S
Publication Date: 2022-01-15

Variant appearance in text: ALK: E1407K
PubMed Link: 35042152
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Final efficacy and safety data, and exploratory molecular profiling from the phase III ALUR study of alectinib versus chemotherapy in crizotinib-pretreated ALK-positive non-small-cell lung cancer.

Esmo Open
Wolf, J J; Helland, Å Å; Oh, I-J IJ; Migliorino, M R MR; Dziadziuszko, R R; Wrona, A A; de Castro, J J; Mazieres, J J; Griesinger, F F; Chlistalla, M M; Cardona, A A; Ruf, T T; Trunzer, K K; Smoljanovic, V V; Novello, S S
Publication Date: 2022-02

Variant appearance in text: ALK: E1407K
PubMed Link: 35042152
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology
Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F
Publication Date: 2021

Variant appearance in text: ALK: E1407K
PubMed Link: 34660278
Variant Present in the following documents:
  • Main text
View BVdb publication page



Case report: 16-yr life history and genomic evolution of an ER+ HER2- breast cancer.

Cold Spring Harbor Molecular Case Studies
Xu, Bing B; Amallraja, Anu A; Swaminathan, Padmapriya P; Elsey, Rachel R; Davis, Christel C; Theel, Stephanie S; Viet, Sarah S; Petersen, Jason J; Krie, Amy A; Davies, Gareth G; Williams, Casey B CB; Ehli, Erik E; Meißner, Tobias T
Publication Date: 2020-12

Variant appearance in text: ALK: 4219G>A; E1407K
PubMed Link: 33008833
Variant Present in the following documents:
  • MCS005629Xu.pdf
  • supp_mcs.a005629_Supplemental_Files_1-5.pdf
View BVdb publication page



Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types.

Genome Research
Boot, Arnoud A; Ng, Alvin W T AWT; Chong, Fui Teen FT; Ho, Szu-Chi SC; Yu, Willie W; Tan, Daniel S W DSW; Iyer, N Gopalakrishna NG; Rozen, Steven G SG
Publication Date: 2020-06

Variant appearance in text: ALK: E1407K
PubMed Link: 32661091
Variant Present in the following documents:
  • supp_gr.255620.119_Supplemental_Table_S2.xlsx, sheet 1
View BVdb publication page



mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Publication Date: 2020-06-23

Variant appearance in text: ALK: E1407K
PubMed Link: 32579932
Variant Present in the following documents:
  • mmc5.xlsx, sheet 3
View BVdb publication page



Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Publication Date: 2018-04-03

Variant appearance in text: ALK: Glu1407Lys
PubMed Link: 29617658
Variant Present in the following documents:
  • NIHMS958974-supplement-6.xlsx, sheet 1
View BVdb publication page