Genomic ALK alterations in primary and relapsed neuroblastoma.
British Journal Of Cancer
Rosswog, Carolina C; Fassunke, Jana J; Ernst, Angela A; Schömig-Markiefka, Birgid B; Merkelbach-Bruse, Sabine S; Bartenhagen, Christoph C; Cartolano, Maria M; Ackermann, Sandra S; Theissen, Jessica J; Blattner-Johnson, Mirjam M; Jones, Barbara B; Schramm, Kathrin K; Altmüller, Janine J; Nürnberg, Peter P; Ortmann, Monika M; Berthold, Frank F; Peifer, Martin M; Büttner, Reinhard R; Westermann, Frank F; Schulte, Johannes H JH; Simon, Thorsten T; Hero, Barbara B; Fischer, Matthias M
ATR inhibition enables complete tumour regression in ALK-driven NB mouse models.
Nature Communications
Szydzik, Joanna J; Lind, Dan E DE; Arefin, Badrul B; Kurhe, Yeshwant Y; Umapathy, Ganesh G; Siaw, Joachim Tetteh JT; Claeys, Arne A; Gabre, Jonatan L JL; Van den Eynden, Jimmy J; Hallberg, Bengt B; Palmer, Ruth H RH
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma.
Proceedings Of The National Academy Of Sciences Of The United States Of America
van den Boogaard, Marlinde L ML; Oka, Rurika R; Hakkert, Anne A; Schild, Linda L; Ebus, Marli E ME; van Gerven, Michael R MR; Zwijnenburg, Danny A DA; Molenaar, Piet P; Hoyng, Lieke L LL; Dolman, M Emmy M MEM; Essing, Anke H W AHW; Koopmans, Bianca B; Helleday, Thomas T; Drost, Jarno J; van Boxtel, Ruben R; Versteeg, Rogier R; Koster, Jan J; Molenaar, Jan J JJ
Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells.
Cancer Research
Van de Velde, Lee-Ann LA; Allen, E Kaitlynn EK; Crawford, Jeremy Chase JC; Wilson, Taylor L TL; Guy, Clifford S CS; Russier, Marion M; Zeitler, Leonie L; Bahrami, Armita A; Finkelstein, David D; Pelletier, Stephane S; Schultz-Cherry, Stacey S; Thomas, Paul G PG; Murray, Peter J PJ
Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells.
Cancer Research
Van de Velde, Lee-Ann LA; Allen, E Kaitlynn EK; Crawford, Jeremy Chase JC; Wilson, Taylor L TL; Guy, Clifford S CS; Russier, Marion M; Zeitler, Leonie L; Bahrami, Armita A; Finkelstein, David D; Pelletier, Stephane S; Schultz-Cherry, Stacey S; Thomas, Paul G PG; Murray, Peter J PJ
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
The Embo Journal
Borenäs, Marcus M; Umapathy, Ganesh G; Lai, Wei-Yun WY; Lind, Dan E DE; Witek, Barbara B; Guan, Jikui J; Mendoza-Garcia, Patricia P; Masudi, Tafheem T; Claeys, Arne A; Chuang, Tzu-Po TP; El Wakil, Abeer A; Arefin, Badrul B; Fransson, Susanne S; Koster, Jan J; Johansson, Mathias M; Gaarder, Jennie J; Van den Eynden, Jimmy J; Hallberg, Bengt B; Palmer, Ruth H RH
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells.
Scientific Reports
Cervantes-Madrid, Diana D; Szydzik, Joanna J; Lind, Dan Emil DE; Borenäs, Marcus M; Bemark, Mats M; Cui, Jean J; Palmer, Ruth Helen RH; Hallberg, Bengt B
Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib.
Cold Spring Harbor Molecular Case Studies
Guan, Jikui J; Fransson, Susanne S; Siaw, Joachim Tetteh JT; Treis, Diana D; Van den Eynden, Jimmy J; Chand, Damini D; Umapathy, Ganesh G; Ruuth, Kristina K; Svenberg, Petter P; Wessman, Sandra S; Shamikh, Alia A; Jacobsson, Hans H; Gordon, Lena L; Stenman, Jakob J; Svensson, Pär-Johan PJ; Hansson, Magnus M; Larsson, Erik E; Martinsson, Tommy T; Palmer, Ruth H RH; Kogner, Per P; Hallberg, Bengt B
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN.
Disease Models & Mechanisms
Guan, J J; Tucker, E R ER; Wan, H H; Chand, D D; Danielson, L S LS; Ruuth, K K; El Wakil, A A; Witek, B B; Jamin, Y Y; Umapathy, G G; Robinson, S P SP; Johnson, T W TW; Smeal, T T; Martinsson, T T; Chesler, L L; Palmer, R H RH; Hallberg, B B
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.
Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Chang, Wendy W; Brohl, Andrew S AS; Patidar, Rajesh R; Sindiri, Sivasish S; Shern, Jack F JF; Wei, Jun S JS; Song, Young K YK; Yohe, Marielle E ME; Gryder, Berkley B; Zhang, Shile S; Calzone, Kathleen A KA; Shivaprasad, Nityashree N; Wen, Xinyu X; Badgett, Thomas C TC; Miettinen, Markku M; Hartman, Kip R KR; League-Pascual, James C JC; Trahair, Toby N TN; Widemann, Brigitte C BC; Merchant, Melinda S MS; Kaplan, Rosandra N RN; Lin, Jimmy C JC; Khan, Javed J
ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.
Cancer Cell
Bresler, Scott C SC; Weiser, Daniel A DA; Huwe, Peter J PJ; Park, Jin H JH; Krytska, Kateryna K; Ryles, Hannah H; Laudenslager, Marci M; Rappaport, Eric F EF; Wood, Andrew C AC; McGrady, Patrick W PW; Hogarty, Michael D MD; London, Wendy B WB; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP
Dielectrophoretic capture and genetic analysis of single neuroblastoma tumor cells.
Frontiers In Oncology
Carpenter, Erica L EL; Rader, JulieAnn J; Ruden, Jacob J; Rappaport, Eric F EF; Hunter, Kristen N KN; Hallberg, Paul L PL; Krytska, Kate K; O'Dwyer, Peter J PJ; Mosse, Yael P YP
Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.
The Lancet. Oncology
Mossé, Yael P YP; Lim, Megan S MS; Voss, Stephan D SD; Wilner, Keith K; Ruffner, Katherine K; Laliberte, Julie J; Rolland, Delphine D; Balis, Frank M FM; Maris, John M JM; Weigel, Brenda J BJ; Ingle, Ashish M AM; Ahern, Charlotte C; Adamson, Peter C PC; Blaney, Susan M SM
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.
Expert Review Of Anticancer Therapy
Webb, Thomas R TR; Slavish, Jake J; George, Rani E RE; Look, A Thomas AT; Xue, Liquan L; Jiang, Qin Q; Cui, Xiaoli X; Rentrop, Walter B WB; Morris, Stephan W SW