A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review.
Jto Clinical And Research Reports
Zhu, Viola W VW; Nagasaka, Misako M; Madison, Russell R; Schrock, Alexa B AB; Cui, Jean J; Ou, Sai-Hong Ignatius SI
Will the clinical development of 4th-generation "double mutant active" ALK TKIs (TPX-0131 and NVL-655) change the future treatment paradigm of ALK+ NSCLC?
Translational Oncology
Ou, Sai-Hong Ignatius SI; Nagasaka, Misako M; Brazel, Danielle D; Hou, Yujie Y; Zhu, Viola W VW
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Lin, Jessica J JJ; Choudhury, Noura J NJ; Yoda, Satoshi S; Zhu, Viola W VW; Johnson, Ted W TW; Sakhtemani, Ramin R; Dagogo-Jack, Ibiayi I; Digumarthy, Subba R SR; Lee, Charlotte C; Do, Andrew A; Peterson, Jennifer J; Prutisto-Chang, Kylie K; Malik, Wafa W; Hubbeling, Harper G HG; Langenbucher, Adam A; Schoenfeld, Adam J AJ; Falcon, Christina J CJ; Temel, Jennifer S JS; Sequist, Lecia V LV; Yeap, Beow Y BY; Lennerz, Jochen K JK; Shaw, Alice T AT; Lawrence, Michael S MS; Ou, Sai-Hong Ignatius SI; Hata, Aaron N AN; Drilon, Alexander A; Gainor, Justin F JF
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS