ALK c.3766C>T ;(p.L1256F)

Variant ID: 2-29432722-G-A

NM_004304.4(ALK):c.3766C>T;(p.L1256F)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


EML4-ALK biology and drug resistance in Non-Small Cell Lung Cancer: a new phase of discoveries.

Molecular Oncology
Elshatlawy, Mariam M; Sampson, Josephina J; Clarke, Katy K; Bayliss, Richard R
Publication Date: 2023-05-07

Variant appearance in text: ALK: L1256F
PubMed Link: 37149843
Variant Present in the following documents:
  • Main text
  • MOL2-17-950.pdf
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Molecular targeted therapy for anticancer treatment.

Experimental & Molecular Medicine
Min, Hye-Young HY; Lee, Ho-Young HY
Publication Date: 2022-10

Variant appearance in text: ALK: L1256F
PubMed Link: 36224343
Variant Present in the following documents:
  • Main text
  • 12276_2022_Article_864.pdf
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Crizotinib-Resistant ROS1 G2101A Mutation Associated With Sensitivity to Lorlatinib in ROS1-Rearranged NSCLC: Case Report.

Jto Clinical And Research Reports
Begum, Parvin P; Cui, Wanyuan W; Popat, Sanjay S
Publication Date: 2022-09

Variant appearance in text: ALK: L1256F
PubMed Link: 35966191
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Targeting ALK Rearrangements in NSCLC: Current State of the Art.

Frontiers In Oncology
Peng, Ling L; Zhu, Liping L; Sun, Yilan Y; Stebbing, Justin J; Selvaggi, Giovanni G; Zhang, Yongchang Y; Yu, Zhentao Z
Publication Date: 2022

Variant appearance in text: ALK: L1256F
PubMed Link: 35463328
Variant Present in the following documents:
  • Main text
  • fonc-12-863461.pdf
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Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma.

Frontiers In Oncology
Wang, Yuan Y; He, Jing J; Xu, Manyu M; Xue, Qingfeng Q; Zhu, Cindy C; Liu, Juan J; Zhang, Yaping Y; Shi, Wenyu W
Publication Date: 2022

Variant appearance in text: ALK: L1256F
PubMed Link: 35211406
Variant Present in the following documents:
  • Main text
View BVdb publication page



Utility of the Ba/F3 cell system for exploring on-target mechanisms of resistance to targeted therapies for lung cancer.

Cancer Science
Koga, Takamasa T; Suda, Kenichi K; Mitsudomi, Tetsuya T
Publication Date: 2022-03

Variant appearance in text: ALK: L1256F
PubMed Link: 34997674
Variant Present in the following documents:
  • CAS-113-815.pdf
  • CAS-113-815-s001.pdf
View BVdb publication page



Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers
Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD
Publication Date: 2021-11-29

Variant appearance in text: ALK: L1256F
PubMed Link: 34885113
Variant Present in the following documents:
  • Main text
  • cancers-13-06003.pdf
View BVdb publication page



Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers
Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD
Publication Date: 2021-11-29

Variant appearance in text: ALK: L1256F
PubMed Link: 34885113
Variant Present in the following documents:
  • Main text
  • cancers-13-06003.pdf
View BVdb publication page



Two novel strategies to overcome the resistance to ALK tyrosine kinase inhibitor drugs: Macrocyclic inhibitors and proteolysis-targeting chimeras.

Medcomm
Song, Xiaoling X; Zhong, Hui H; Qu, Xiaojuan X; Yang, Linsong L; Jiang, Biao B
Publication Date: 2021-09

Variant appearance in text: ALK: L1256F
PubMed Link: 34766150
Variant Present in the following documents:
  • Main text
  • MCO2-2-341.pdf
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A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review.

Jto Clinical And Research Reports
Zhu, Viola W VW; Nagasaka, Misako M; Madison, Russell R; Schrock, Alexa B AB; Cui, Jean J; Ou, Sai-Hong Ignatius SI
Publication Date: 2021-01

Variant appearance in text: ALK: L1256F
PubMed Link: 34589977
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Will the clinical development of 4th-generation "double mutant active" ALK TKIs (TPX-0131 and NVL-655) change the future treatment paradigm of ALK+ NSCLC?

Translational Oncology
Ou, Sai-Hong Ignatius SI; Nagasaka, Misako M; Brazel, Danielle D; Hou, Yujie Y; Zhu, Viola W VW
Publication Date: 2021-11

Variant appearance in text: ALK: L1256F
PubMed Link: 34365220
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Lin, Jessica J JJ; Choudhury, Noura J NJ; Yoda, Satoshi S; Zhu, Viola W VW; Johnson, Ted W TW; Sakhtemani, Ramin R; Dagogo-Jack, Ibiayi I; Digumarthy, Subba R SR; Lee, Charlotte C; Do, Andrew A; Peterson, Jennifer J; Prutisto-Chang, Kylie K; Malik, Wafa W; Hubbeling, Harper G HG; Langenbucher, Adam A; Schoenfeld, Adam J AJ; Falcon, Christina J CJ; Temel, Jennifer S JS; Sequist, Lecia V LV; Yeap, Beow Y BY; Lennerz, Jochen K JK; Shaw, Alice T AT; Lawrence, Michael S MS; Ou, Sai-Hong Ignatius SI; Hata, Aaron N AN; Drilon, Alexander A; Gainor, Justin F JF
Publication Date: 2021-05-15

Variant appearance in text: ALK: L1256F
PubMed Link: 33685866
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer.

Nature Communications
Mizuta, Hayato H; Okada, Koutaroh K; Araki, Mitsugu M; Adachi, Jun J; Takemoto, Ai A; Kutkowska, Justyna J; Maruyama, Kohei K; Yanagitani, Noriko N; Oh-Hara, Tomoko T; Watanabe, Kana K; Tamai, Keiichi K; Friboulet, Luc L; Katayama, Kazuhiro K; Ma, Biao B; Sasakura, Yoko Y; Sagae, Yukari Y; Kukimoto-Niino, Mutsuko M; Shirouzu, Mikako M; Takagi, Satoshi S; Simizu, Siro S; Nishio, Makoto M; Okuno, Yasushi Y; Fujita, Naoya N; Katayama, Ryohei R
Publication Date: 2021-02-24

Variant appearance in text: ALK: L1256F
PubMed Link: 33627640
Variant Present in the following documents:
  • Main text
  • 41467_2021_21396_MOESM2_ESM.pdf
  • 41467_2021_21396_MOESM1_ESM.pdf
  • 41467_2021_Article_21396.pdf
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ROS1-dependent cancers - biology, diagnostics and therapeutics.

Nature Reviews. Clinical Oncology
Drilon, Alexander A; Jenkins, Chelsea C; Iyer, Sudarshan S; Schoenfeld, Adam A; Keddy, Clare C; Davare, Monika A MA
Publication Date: 2021-01

Variant appearance in text: ALK: L1256F
PubMed Link: 32760015
Variant Present in the following documents:
  • Main text
View BVdb publication page



Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer.

Thoracic Cancer
Takahashi, Ken K; Seto, Yosuke Y; Okada, Koutaroh K; Uematsu, Shinya S; Uchibori, Ken K; Tsukahara, Mika M; Oh-Hara, Tomoko T; Fujita, Naoya N; Yanagitani, Noriko N; Nishio, Makoto M; Okubo, Kenichi K; Katayama, Ryohei R
Publication Date: 2020-03

Variant appearance in text: ALK: L1256F
PubMed Link: 31943796
Variant Present in the following documents:
  • Main text
  • TCA-11-581.pdf
View BVdb publication page



Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.

Ebiomedicine
Okada, Koutaroh K; Araki, Mitsugu M; Sakashita, Takuya T; Ma, Biao B; Kanada, Ryo R; Yanagitani, Noriko N; Horiike, Atsushi A; Koike, Sumie S; Oh-Hara, Tomoko T; Watanabe, Kana K; Tamai, Keiichi K; Maemondo, Makoto M; Nishio, Makoto M; Ishikawa, Takeshi T; Okuno, Yasushi Y; Fujita, Naoya N; Katayama, Ryohei R
Publication Date: 2019-03

Variant appearance in text: ALK: L1256F
PubMed Link: 30662002
Variant Present in the following documents:
  • Main text
  • mmc1.pdf
  • main.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: ALK: L1256F
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page