Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
Nature Medicine
Goldsmith, Kelly C KC; Park, Julie R JR; Kayser, Kimberly K; Malvar, Jemily J; Chi, Yueh-Yun YY; Groshen, Susan G SG; Villablanca, Judith G JG; Krytska, Kateryna K; Lai, Lillian M LM; Acharya, Patricia T PT; Goodarzian, Fariba F; Pawel, Bruce B; Shimada, Hiroyuki H; Ghazarian, Susan S; States, Lisa L; Marshall, Lynley L; Chesler, Louis L; Granger, Meaghan M; Desai, Ami V AV; Mody, Rajen R; Morgenstern, Daniel A DA; Shusterman, Suzanne S; Macy, Margaret E ME; Pinto, Navin N; Schleiermacher, Gudrun G; Vo, Kieuhoa K; Thurm, Holger C HC; Chen, Joseph J; Liyanage, Marlon M; Peltz, Gerson G; Matthay, Katherine K KK; Berko, Esther R ER; Maris, John M JM; Marachelian, Araz A; Mossé, Yael P YP
Genomic ALK alterations in primary and relapsed neuroblastoma.
British Journal Of Cancer
Rosswog, Carolina C; Fassunke, Jana J; Ernst, Angela A; Schömig-Markiefka, Birgid B; Merkelbach-Bruse, Sabine S; Bartenhagen, Christoph C; Cartolano, Maria M; Ackermann, Sandra S; Theissen, Jessica J; Blattner-Johnson, Mirjam M; Jones, Barbara B; Schramm, Kathrin K; Altmüller, Janine J; Nürnberg, Peter P; Ortmann, Monika M; Berthold, Frank F; Peifer, Martin M; Büttner, Reinhard R; Westermann, Frank F; Schulte, Johannes H JH; Simon, Thorsten T; Hero, Barbara B; Fischer, Matthias M
Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.
Nature Communications
Shukla, N N; Levine, M F MF; Gundem, G G; Domenico, D D; Spitzer, B B; Bouvier, N N; Arango-Ossa, J E JE; Glodzik, D D; Medina-Martínez, J S JS; Bhanot, U U; Gutiérrez-Abril, J J; Zhou, Y Y; Fiala, E E; Stockfisch, E E; Li, S S; Rodriguez-Sanchez, M I MI; O'Donohue, T T; Cobbs, C C; Roehrl, M H A MHA; Benhamida, J J; Iglesias Cardenas, F F; Ortiz, M M; Kinnaman, M M; Roberts, S S; Ladanyi, M M; Modak, S S; Farouk-Sait, S S; Slotkin, E E; Karajannis, M A MA; Dela Cruz, F F; Glade Bender, J J; Zehir, A A; Viale, A A; Walsh, M F MF; Kung, A L AL; Papaemmanuil, E E
Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors.
Discover. Oncology
Jahangiri, Leila L; Pucci, Perla P; Ishola, Tala T; Pereira, Joao J; Cavanagh, Megan L ML; Turner, Suzanne D SD
From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.
Journal Of Personalized Medicine
Decaesteker, Bieke B; Durinck, Kaat K; Van Roy, Nadine N; De Wilde, Bram B; Van Neste, Christophe C; Van Haver, Stéphane S; Roberts, Stephen S; De Preter, Katleen K; Vermeirssen, Vanessa V; Speleman, Frank F
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs.
International Journal Of Molecular Sciences
Ciaccio, Roberto R; De Rosa, Piergiuseppe P; Aloisi, Sara S; Viggiano, Marta M; Cimadom, Leonardo L; Zadran, Suleman Khan SK; Perini, Giovanni G; Milazzo, Giorgio G
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs.
International Journal Of Molecular Sciences
Ciaccio, Roberto R; De Rosa, Piergiuseppe P; Aloisi, Sara S; Viggiano, Marta M; Cimadom, Leonardo L; Zadran, Suleman Khan SK; Perini, Giovanni G; Milazzo, Giorgio G
BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy.
Translational Oncology
Chilamakuri, Rameswari R; Rouse, Danielle C DC; Yu, Yang Y; Kabir, Abbas S AS; Muth, Aaron A; Yang, Jianhua J; Lipton, Jeffery M JM; Agarwal, Saurabh S
BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy.
Translational Oncology
Chilamakuri, Rameswari R; Rouse, Danielle C DC; Yu, Yang Y; Kabir, Abbas S AS; Muth, Aaron A; Yang, Jianhua J; Lipton, Jeffery M JM; Agarwal, Saurabh S
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Bellini, Angela A; Pötschger, Ulrike U; Bernard, Virginie V; Lapouble, Eve E; Baulande, Sylvain S; Ambros, Peter F PF; Auger, Nathalie N; Beiske, Klaus K; Bernkopf, Marie M; Betts, David R DR; Bhalshankar, Jaydutt J; Bown, Nick N; de Preter, Katleen K; Clément, Nathalie N; Combaret, Valérie V; Font de Mora, Jaime J; George, Sally L SL; Jiménez, Irene I; Jeison, Marta M; Marques, Barbara B; Martinsson, Tommy T; Mazzocco, Katia K; Morini, Martina M; Mühlethaler-Mottet, Annick A; Noguera, Rosa R; Pierron, Gaelle G; Rossing, Maria M; Taschner-Mandl, Sabine S; Van Roy, Nadine N; Vicha, Ales A; Chesler, Louis L; Balwierz, Walentyna W; Castel, Victoria V; Elliott, Martin M; Kogner, Per P; Laureys, Geneviève G; Luksch, Roberto R; Malis, Josef J; Popovic-Beck, Maja M; Ash, Shifra S; Delattre, Olivier O; Valteau-Couanet, Dominique D; Tweddle, Deborah A DA; Ladenstein, Ruth R; Schleiermacher, Gudrun G
Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor.
Translational Oncology
Quinn, Colin H CH; Beierle, Andee M AM; Williams, Adele P AP; Marayati, Raoud R; Bownes, Laura V LV; Markert, Hooper R HR; Aye, Jamie M JM; Stewart, Jerry E JE; Mroczek-Musulman, Elizabeth E; Crossman, David K DK; Yoon, Karina J KJ; Beierle, Elizabeth A EA
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R
Neuroblastoma Invasion Strategies Are Regulated by the Extracellular Matrix.
Cancers
Gavin, Cian C; Geerts, Nele N; Cavanagh, Brenton B; Haynes, Meagan M; Reynolds, C Patrick CP; Loessner, Daniela D; Ewald, Andrew J AJ; Piskareva, Olga O
Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells.
Scientific Reports
Cervantes-Madrid, Diana D; Szydzik, Joanna J; Lind, Dan Emil DE; Borenäs, Marcus M; Bemark, Mats M; Cui, Jean J; Palmer, Ruth Helen RH; Hallberg, Bengt B
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status.
Nature Communications
Trigg, Ricky M RM; Lee, Liam C LC; Prokoph, Nina N; Jahangiri, Leila L; Reynolds, C Patrick CP; Amos Burke, G A GA; Probst, Nicola A NA; Han, Miaojun M; Matthews, Jamie D JD; Lim, Hong Kai HK; Manners, Eleanor E; Martinez, Sonia S; Pastor, Joaquin J; Blanco-Aparicio, Carmen C; Merkel, Olaf O; de Los Fayos Alonso, Ines Garces IG; Kodajova, Petra P; Tangermann, Simone S; Högler, Sandra S; Luo, Ji J; Kenner, Lukas L; Turner, Suzanne D SD
Standard operating procedure for curation and clinical interpretation of variants in cancer.
Genome Medicine
Danos, Arpad M AM; Krysiak, Kilannin K; Barnell, Erica K EK; Coffman, Adam C AC; McMichael, Joshua F JF; Kiwala, Susanna S; Spies, Nicholas C NC; Sheta, Lana M LM; Pema, Shahil P SP; Kujan, Lynzey L; Clark, Kaitlin A KA; Wollam, Amber Z AZ; Rao, Shruti S; Ritter, Deborah I DI; Sonkin, Dmitriy D; Raca, Gordana G; Lin, Wan-Hsin WH; Grisdale, Cameron J CJ; Kim, Raymond H RH; Wagner, Alex H AH; Madhavan, Subha S; Griffith, Malachi M; Griffith, Obi L OL