ALK c.3602G>A ;(p.G1201E)

Variant ID: 2-29443615-C-T

NM_004304.4(ALK):c.3602G>A;(p.G1201E)

This variant was identified in 24 publications

View GRCh38 version.




Publications:


Anaplastic lymphoma kinase-special immunity and immunotherapy.

Frontiers In Immunology
Guo, Ye Y; Guo, Hanfei H; Zhang, Yongfei Y; Cui, Jiuwei J
Publication Date: 2022

Variant appearance in text: ALK: G1201E
PubMed Link: 35958559
Variant Present in the following documents:
  • Main text
  • fimmu-13-908894.pdf
View BVdb publication page



Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18

Variant appearance in text: ALK: 3602G>A; Gly1201Glu
PubMed Link: 34797250
Variant Present in the following documents:
  • ct9-12-e00431-s006.xlsx, sheet 1
  • ct9-12-e00431-s005.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ALK: G1201E
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: ALK: G1201E
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review.

Cancers
Al-Jundi, Mohammad M; Thakur, Shilpa S; Gubbi, Sriram S; Klubo-Gwiezdzinska, Joanna J
Publication Date: 2020-07-29

Variant appearance in text: ALK: G1201E
PubMed Link: 32751138
Variant Present in the following documents:
  • Main text
  • cancers-12-02104.pdf
View BVdb publication page



Oncogenic ALK drives tumorigenesis in cutaneous squamous cell carcinoma.

Life Science Alliance
Gualandi, Marco M; Iorio, Maria M; Engeler, Olivia O; Serra-Roma, André A; Gasparre, Giuseppe G; Schulte, Johannes H JH; Hohl, Daniel D; Shakhova, Olga O
Publication Date: 2020-06

Variant appearance in text: ALK: G1201E
PubMed Link: 32312912
Variant Present in the following documents:
  • Main text
  • LSA-2019-00601.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: ALK: G1201E
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells.

Scientific Reports
Cervantes-Madrid, Diana D; Szydzik, Joanna J; Lind, Dan Emil DE; Borenäs, Marcus M; Bemark, Mats M; Cui, Jean J; Palmer, Ruth Helen RH; Hallberg, Bengt B
Publication Date: 2019-12-18

Variant appearance in text: ALK: G1201E
PubMed Link: 31852910
Variant Present in the following documents:
  • 41598_2019_Article_55060.pdf
View BVdb publication page



Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice.

Genes
Tirrò, Elena E; Martorana, Federica F; Romano, Chiara C; Vitale, Silvia Rita SR; Motta, Gianmarco G; Di Gregorio, Sandra S; Massimino, Michele M; Pennisi, Maria Stella MS; Stella, Stefania S; Puma, Adriana A; Gianì, Fiorenza F; Russo, Marco M; Manzella, Livia L; Vigneri, Paolo P
Publication Date: 2019-09-13

Variant appearance in text: ALK: G1201E
PubMed Link: 31540307
Variant Present in the following documents:
  • Main text
  • genes-10-00709.pdf
View BVdb publication page



The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis.

Cancers
Ducray, Stephen P SP; Natarajan, Karthikraj K; Garland, Gavin D GD; Turner, Suzanne D SD; Egger, Gerda G
Publication Date: 2019-07-30

Variant appearance in text: ALK: G1201E
PubMed Link: 31366041
Variant Present in the following documents:
  • Main text
  • cancers-11-01074.pdf
View BVdb publication page



Targeting anaplastic lymphoma kinase in neuroblastoma.

Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Umapathy, Ganesh G; Mendoza-Garcia, Patricia P; Hallberg, Bengt B; Palmer, Ruth H RH
Publication Date: 2019-05

Variant appearance in text: ALK: G1201E
PubMed Link: 30803032
Variant Present in the following documents:
  • Main text
  • APM-127-288.pdf
View BVdb publication page



Unique mutation patterns in anaplastic thyroid cancer identified by comprehensive genomic profiling.

Head & Neck
Khan, Saad A SA; Ci, Bo B; Xie, Yang Y; Gerber, David E DE; Beg, Muhammad S MS; Sherman, Steven I SI; Cabanillas, Maria E ME; Busaidy, Naifa L NL; Burtness, Barbara A BA; Heilmann, Andreas M AM; Bailey, Mark M; Ross, Jeffrey S JS; Sher, David J DJ; Ali, Siraj M SM
Publication Date: 2019-06

Variant appearance in text: ALK: G1201E
PubMed Link: 30758123
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.

Scientific Reports
Li, Jianzong J; Huang, Yue Y; Wu, Miaomiao M; Wu, Chuanfang C; Li, Xin X; Bao, Jinku J
Publication Date: 2018-07-13

Variant appearance in text: ALK: G1201E
PubMed Link: 30006516
Variant Present in the following documents:
  • 41598_2018_28752_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



ALK-rearrangement in non-small-cell lung cancer (NSCLC).

Thoracic Cancer
Du, Xue X; Shao, Yun Y; Qin, Hai-Feng HF; Tai, Yan-Hong YH; Gao, Hong-Jun HJ
Publication Date: 2018-04

Variant appearance in text: ALK: G1201E
PubMed Link: 29488330
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.

Nature Communications
Lauss, Martin M; Donia, Marco M; Harbst, Katja K; Andersen, Rikke R; Mitra, Shamik S; Rosengren, Frida F; Salim, Maryem M; Vallon-Christersson, Johan J; Törngren, Therese T; Kvist, Anders A; Ringnér, Markus M; Svane, Inge Marie IM; Jönsson, Göran G
Publication Date: 2017-11-23

Variant appearance in text: ALK: 3602G>A; G1201E
PubMed Link: 29170503
Variant Present in the following documents:
  • 41467_2017_1460_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation.

Cancers
Guan, Jikui J; Yamazaki, Yasuo Y; Chand, Damini D; van Dijk, Jesper R JR; Ruuth, Kristina K; Palmer, Ruth H RH; Hallberg, Bengt B
Publication Date: 2017-10-30

Variant appearance in text: ALK: G1201E
PubMed Link: 29084134
Variant Present in the following documents:
  • cancers-09-00149.pdf
View BVdb publication page



Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer.

Cancers
Hout, David R DR; Schweitzer, Brock L BL; Lawrence, Kasey K; Morris, Stephan W SW; Tucker, Tracy T; Mazzola, Rosetta R; Skelton, Rachel R; McMahon, Frank F; Handshoe, John J; Lesperance, Mary M; Karsan, Aly A; Saltman, David L DL
Publication Date: 2017-08-01

Variant appearance in text: ALK: G1201E
PubMed Link: 28763012
Variant Present in the following documents:
  • cancers-09-00099.pdf
View BVdb publication page



ALK: a tyrosine kinase target for cancer therapy.

Cold Spring Harbor Molecular Case Studies
Holla, Vijaykumar R VR; Elamin, Yasir Y YY; Bailey, Ann Marie AM; Johnson, Amber M AM; Litzenburger, Beate C BC; Khotskaya, Yekaterina B YB; Sanchez, Nora S NS; Zeng, Jia J; Shufean, Md Abu MA; Shaw, Kenna R KR; Mendelsohn, John J; Mills, Gordon B GB; Meric-Bernstam, Funda F; Simon, George R GR
Publication Date: 2017-01

Variant appearance in text: ALK: G1201E
PubMed Link: 28050598
Variant Present in the following documents:
  • Main text
View BVdb publication page



Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.

Oncotarget
Guan, Jikui J; Wolfstetter, Georg G; Siaw, Joachim J; Chand, Damini D; Hugosson, Fredrik F; Palmer, Ruth H RH; Hallberg, Bengt B
Publication Date: 2017-02-14

Variant appearance in text: ALK: G1201E
PubMed Link: 28030793
Variant Present in the following documents:
  • Main text
  • oncotarget-08-11566.pdf
View BVdb publication page



Personalized therapy in patients with anaplastic thyroid cancer: targeting genetic and epigenetic alterations.

The Journal Of Clinical Endocrinology And Metabolism
Smith, Neal N; Nucera, Carmelo C
Publication Date: 2015-01

Variant appearance in text: ALK: G1201E
PubMed Link: 25347569
Variant Present in the following documents:
  • Main text
View BVdb publication page



ALK-rearrangements and testing methods in non-small cell lung cancer: a review.

Genes & Cancer
Shackelford, Rodney E RE; Vora, Moiz M; Mayhall, Kim K; Cotelingam, James J
Publication Date: 2014-04

Variant appearance in text: ALK: G1201E
PubMed Link: 24955213
Variant Present in the following documents:
  • Main text
  • ganc-05-001.pdf
View BVdb publication page



Recent progress of genome study for anaplastic thyroid cancer.

Genomics & Informatics
Lee, Jieun J; Hwang, Jung-Ah JA; Lee, Eun Kyung EK
Publication Date: 2013-06

Variant appearance in text: ALK: G1201E
PubMed Link: 23843772
Variant Present in the following documents:
  • Main text
  • gni-11-68.pdf
View BVdb publication page



Diagnostic and prognostic markers in differentiated thyroid cancer.

Current Genomics
Gómez Sáez, José M JM
Publication Date: 2011-12

Variant appearance in text: ALK: G1201E
PubMed Link: 22654559
Variant Present in the following documents:
  • Main text
  • CG-12-597.pdf
View BVdb publication page



Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene.

Cancer Research
Murugan, Avaniyapuram Kannan AK; Xing, Mingzhao M
Publication Date: 2011-07-01

Variant appearance in text: ALK: G1201E
PubMed Link: 21596819
Variant Present in the following documents:
  • Main text
View BVdb publication page