ALK c.3532A>C ;(p.N1178H)

Variant ID: 2-29443685-T-G

NM_004304.4(ALK):c.3532A>C;(p.N1178H)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ALK: N1178H
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: ALK: N1178H
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



First-line treatment of advanced ALK-positive non-small-cell lung cancer.

Lung Cancer (Auckland, N.Z.)
Gandhi, Shipra S; Chen, Hongbin H; Zhao, Yujie Y; Dy, Grace K GK
Publication Date: 2015

Variant appearance in text: ALK: N1178H
PubMed Link: 28210152
Variant Present in the following documents:
  • Main text
View BVdb publication page



ALK: a tyrosine kinase target for cancer therapy.

Cold Spring Harbor Molecular Case Studies
Holla, Vijaykumar R VR; Elamin, Yasir Y YY; Bailey, Ann Marie AM; Johnson, Amber M AM; Litzenburger, Beate C BC; Khotskaya, Yekaterina B YB; Sanchez, Nora S NS; Zeng, Jia J; Shufean, Md Abu MA; Shaw, Kenna R KR; Mendelsohn, John J; Mills, Gordon B GB; Meric-Bernstam, Funda F; Simon, George R GR
Publication Date: 2017-01

Variant appearance in text: ALK: N1178H
PubMed Link: 28050598
Variant Present in the following documents:
  • Main text
  • HollaMCS001115.pdf
View BVdb publication page



NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922.

Oncotarget
Mologni, Luca L; Ceccon, Monica M; Pirola, Alessandra A; Chiriano, Gianpaolo G; Piazza, Rocco R; Scapozza, Leonardo L; Gambacorti-Passerini, Carlo C
Publication Date: 2015-03-20

Variant appearance in text: ALK: N1178H
PubMed Link: 25749034
Variant Present in the following documents:
  • Main text
  • oncotarget-06-5720-s001.pdf
  • oncotarget-06-5720.pdf
View BVdb publication page