Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.
Nature Genetics
Körber, Verena V; Stainczyk, Sabine A SA; Kurilov, Roma R; Henrich, Kai-Oliver KO; Hero, Barbara B; Brors, Benedikt B; Westermann, Frank F; Höfer, Thomas T
Genomic ALK alterations in primary and relapsed neuroblastoma.
British Journal Of Cancer
Rosswog, Carolina C; Fassunke, Jana J; Ernst, Angela A; Schömig-Markiefka, Birgid B; Merkelbach-Bruse, Sabine S; Bartenhagen, Christoph C; Cartolano, Maria M; Ackermann, Sandra S; Theissen, Jessica J; Blattner-Johnson, Mirjam M; Jones, Barbara B; Schramm, Kathrin K; Altmüller, Janine J; Nürnberg, Peter P; Ortmann, Monika M; Berthold, Frank F; Peifer, Martin M; Büttner, Reinhard R; Westermann, Frank F; Schulte, Johannes H JH; Simon, Thorsten T; Hero, Barbara B; Fischer, Matthias M
Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma.
Frontiers In Oncology
Keller, Kaylee M KM; Eleveld, Thomas F TF; Schild, Linda L; van den Handel, Kim K; van den Boogaard, Marlinde M; Amo-Addae, Vicky V; Eising, Selma S; Ober, Kimberley K; Koopmans, Bianca B; Looijenga, Leendert L; Tytgat, Godelieve A M GAM; Ylstra, Bauke B; Molenaar, Jan J JJ; Dolman, M Emmy M MEM; van Hooff, Sander R SR
Loss of ALK hotspot mutations in relapsed neuroblastoma.
Genes, Chromosomes & Cancer
Allinson, Lisa M LM; Potts, Aaron A; Goodman, Angharad A; Bown, Nick N; Bashton, Matthew M; Thompson, Dean D; Basta, Nermine O NO; Gabriel, Alem S AS; McCorkindale, Michael M; Ng, Antony A; McNally, Richard J Q RJQ; Tweddle, Deborah A DA
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.
Jco Precision Oncology
Treis, Diana D; Umapathy, Ganesh G; Fransson, Susanne S; Guan, Jikui J; Mendoza-García, Patricia P; Siaw, Joachim T JT; Wessman, Sandra S; Gordon Murkes, Lena L; Stenman, Jakob J E JJE; Djos, Anna A; Elfman, Lotta H M LHM; Johnsen, John Inge JI; Hallberg, Bengt B; Palmer, Ruth H RH; Martinsson, Tommy T; Kogner, Per P
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.
Jco Precision Oncology
Treis, Diana D; Umapathy, Ganesh G; Fransson, Susanne S; Guan, Jikui J; Mendoza-García, Patricia P; Siaw, Joachim T JT; Wessman, Sandra S; Gordon Murkes, Lena L; Stenman, Jakob J E JJE; Djos, Anna A; Elfman, Lotta H M LHM; Johnsen, John Inge JI; Hallberg, Bengt B; Palmer, Ruth H RH; Martinsson, Tommy T; Kogner, Per P
Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future.
Cancers
Guan, Jikui J; Hallberg, Bengt B; Palmer, Ruth H RH
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Will the clinical development of 4th-generation "double mutant active" ALK TKIs (TPX-0131 and NVL-655) change the future treatment paradigm of ALK+ NSCLC?
Translational Oncology
Ou, Sai-Hong Ignatius SI; Nagasaka, Misako M; Brazel, Danielle D; Hou, Yujie Y; Zhu, Viola W VW
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Bellini, Angela A; Pötschger, Ulrike U; Bernard, Virginie V; Lapouble, Eve E; Baulande, Sylvain S; Ambros, Peter F PF; Auger, Nathalie N; Beiske, Klaus K; Bernkopf, Marie M; Betts, David R DR; Bhalshankar, Jaydutt J; Bown, Nick N; de Preter, Katleen K; Clément, Nathalie N; Combaret, Valérie V; Font de Mora, Jaime J; George, Sally L SL; Jiménez, Irene I; Jeison, Marta M; Marques, Barbara B; Martinsson, Tommy T; Mazzocco, Katia K; Morini, Martina M; Mühlethaler-Mottet, Annick A; Noguera, Rosa R; Pierron, Gaelle G; Rossing, Maria M; Taschner-Mandl, Sabine S; Van Roy, Nadine N; Vicha, Ales A; Chesler, Louis L; Balwierz, Walentyna W; Castel, Victoria V; Elliott, Martin M; Kogner, Per P; Laureys, Geneviève G; Luksch, Roberto R; Malis, Josef J; Popovic-Beck, Maja M; Ash, Shifra S; Delattre, Olivier O; Valteau-Couanet, Dominique D; Tweddle, Deborah A DA; Ladenstein, Ruth R; Schleiermacher, Gudrun G
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Nature Communications
Hartlieb, Sabine A SA; Sieverling, Lina L; Nadler-Holly, Michal M; Ziehm, Matthias M; Toprak, Umut H UH; Herrmann, Carl C; Ishaque, Naveed N; Okonechnikov, Konstantin K; Gartlgruber, Moritz M; Park, Young-Gyu YG; Wecht, Elisa Maria EM; Savelyeva, Larissa L; Henrich, Kai-Oliver KO; Rosswog, Carolina C; Fischer, Matthias M; Hero, Barbara B; Jones, David T W DTW; Pfaff, Elke E; Witt, Olaf O; Pfister, Stefan M SM; Volckmann, Richard R; Koster, Jan J; Kiesel, Katharina K; Rippe, Karsten K; Taschner-Mandl, Sabine S; Ambros, Peter P; Brors, Benedikt B; Selbach, Matthias M; Feuerbach, Lars L; Westermann, Frank F
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
The Embo Journal
Borenäs, Marcus M; Umapathy, Ganesh G; Lai, Wei-Yun WY; Lind, Dan E DE; Witek, Barbara B; Guan, Jikui J; Mendoza-Garcia, Patricia P; Masudi, Tafheem T; Claeys, Arne A; Chuang, Tzu-Po TP; El Wakil, Abeer A; Arefin, Badrul B; Fransson, Susanne S; Koster, Jan J; Johansson, Mathias M; Gaarder, Jennie J; Van den Eynden, Jimmy J; Hallberg, Bengt B; Palmer, Ruth H RH
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations.
Nature Communications
Brady, Samuel W SW; Liu, Yanling Y; Ma, Xiaotu X; Gout, Alexander M AM; Hagiwara, Kohei K; Zhou, Xin X; Wang, Jian J; Macias, Michael M; Chen, Xiaolong X; Easton, John J; Mulder, Heather L HL; Rusch, Michael M; Wang, Lu L; Nakitandwe, Joy J; Lei, Shaohua S; Davis, Eric M EM; Naranjo, Arlene A; Cheng, Cheng C; Maris, John M JM; Downing, James R JR; Cheung, Nai-Kong V NV; Hogarty, Michael D MD; Dyer, Michael A MA; Zhang, Jinghui J
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing.
Oncotarget
Streubel, Anna A; Stenzinger, Albrecht A; Stephan-Falkenau, Susann S; Kollmeier, Jens J; Misch, Daniel D; Blum, Torsten Gerriet TG; Bauer, Torsten T; Landt, Olfert O; Am Ende, Alexander A; Schirmacher, Peter P; Mairinger, Thomas T; Endris, Volker V
Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma.
Oncology Letters
Kimura, Shunsuke S; Hasegawa, Daisuke D; Yoshimoto, Yuri Y; Seki, Masafumi M; Daida, Atsuro A; Sekiguchi, Masahiro M; Hirabayashi, Shinsuke S; Hosoya, Yosuke Y; Kobayashi, Masao M; Miyano, Satoru S; Ogawa, Seishi S; Takita, Junko J; Manabe, Atsushi A
Low Frequency ALK Hotspots Mutations In Neuroblastoma Tumours Detected By Ultra-deep Sequencing: Implications For ALK Inhibitor Treatment.
Scientific Reports
Javanmardi, Niloufar N; Fransson, Susanne S; Djos, Anna A; Sjöberg, Rose-Marie RM; Nilsson, Staffan S; Truvé, Katarina K; Kogner, Per P; Martinsson, Tommy T
Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib.
Cold Spring Harbor Molecular Case Studies
Guan, Jikui J; Fransson, Susanne S; Siaw, Joachim Tetteh JT; Treis, Diana D; Van den Eynden, Jimmy J; Chand, Damini D; Umapathy, Ganesh G; Ruuth, Kristina K; Svenberg, Petter P; Wessman, Sandra S; Shamikh, Alia A; Jacobsson, Hans H; Gordon, Lena L; Stenman, Jakob J; Svensson, Pär-Johan PJ; Hansson, Magnus M; Larsson, Erik E; Martinsson, Tommy T; Palmer, Ruth H RH; Kogner, Per P; Hallberg, Bengt B
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Holla, Vijaykumar R VR; Elamin, Yasir Y YY; Bailey, Ann Marie AM; Johnson, Amber M AM; Litzenburger, Beate C BC; Khotskaya, Yekaterina B YB; Sanchez, Nora S NS; Zeng, Jia J; Shufean, Md Abu MA; Shaw, Kenna R KR; Mendelsohn, John J; Mills, Gordon B GB; Meric-Bernstam, Funda F; Simon, George R GR
Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome.
Plos Genetics
Padovan-Merhar, Olivia M OM; Raman, Pichai P; Ostrovnaya, Irina I; Kalletla, Karthik K; Rubnitz, Kaitlyn R KR; Sanford, Eric M EM; Ali, Siraj M SM; Miller, Vincent A VA; Mossé, Yael P YP; Granger, Meaghan P MP; Weiss, Brian B; Maris, John M JM; Modak, Shakeel S
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.
Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.
Oncotarget
Amin, Amit Dipak AD; Li, Lingxiao L; Rajan, Soumya S SS; Gokhale, Vijay V; Groysman, Matthew J MJ; Pongtornpipat, Praechompoo P; Tapia, Edgar O EO; Wang, Mengdie M; Schatz, Jonathan H JH
New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK.
Oncotarget
Di Paolo, Daniela D; Yang, D D; Pastorino, Fabio F; Emionite, Laura L; Cilli, Michele M; Daga, Antonio A; Destafanis, Elisa E; Di Fiore, Annarita A; Piaggio, Francesca F; Brignole, Chiara C; Xu, Xiaobao X; Liang, Chris C; Gibbons, James J; Ponzoni, Mirco M; Perri, Patrizia P
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.
The Febs Journal
Sattu, Kamaraj K; Hochgräfe, Falko F; Wu, Jianmin J; Umapathy, Ganesh G; Schönherr, Christina C; Ruuth, Kristina K; Chand, Damini D; Witek, Barbara B; Fuchs, James J; Li, Pui-Kai PK; Hugosson, Fredrik F; Daly, Roger J RJ; Palmer, Ruth H RH; Hallberg, Bengt B
Pugh, Trevor J TJ; Morozova, Olena O; Attiyeh, Edward F EF; Asgharzadeh, Shahab S; Wei, Jun S JS; Auclair, Daniel D; Carter, Scott L SL; Cibulskis, Kristian K; Hanna, Megan M; Kiezun, Adam A; Kim, Jaegil J; Lawrence, Michael S MS; Lichenstein, Lee L; McKenna, Aaron A; Pedamallu, Chandra Sekhar CS; Ramos, Alex H AH; Shefler, Erica E; Sivachenko, Andrey A; Sougnez, Carrie C; Stewart, Chip C; Ally, Adrian A; Birol, Inanc I; Chiu, Readman R; Corbett, Richard D RD; Hirst, Martin M; Jackman, Shaun D SD; Kamoh, Baljit B; Khodabakshi, Alireza Hadj AH; Krzywinski, Martin M; Lo, Allan A; Moore, Richard A RA; Mungall, Karen L KL; Qian, Jenny J; Tam, Angela A; Thiessen, Nina N; Zhao, Yongjun Y; Cole, Kristina A KA; Diamond, Maura M; Diskin, Sharon J SJ; Mosse, Yael P YP; Wood, Andrew C AC; Ji, Lingyun L; Sposto, Richard R; Badgett, Thomas T; London, Wendy B WB; Moyer, Yvonne Y; Gastier-Foster, Julie M JM; Smith, Malcolm A MA; Guidry Auvil, Jaime M JM; Gerhard, Daniela S DS; Hogarty, Michael D MD; Jones, Steven J M SJ; Lander, Eric S ES; Gabriel, Stacey B SB; Getz, Gad G; Seeger, Robert C RC; Khan, Javed J; Marra, Marco A MA; Meyerson, Matthew M; Maris, John M JM
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.
Disease Models & Mechanisms
Chand, Damini D; Yamazaki, Yasuo Y; Ruuth, Kristina K; Schönherr, Christina C; Martinsson, Tommy T; Kogner, Per P; Attiyeh, Edward F EF; Maris, John J; Morozova, Olena O; Marra, Marco A MA; Ohira, Miki M; Nakagawara, Akira A; Sandström, Per-Erik PE; Palmer, Ruth H RH; Hallberg, Bengt B