Publications:

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Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer.

International Journal Of Molecular Sciences

Wulf, Anna M AM; Moreno, Marcela M MM; Paka, Chloé C; Rampasekova, Alexandra A; Liu, Karen J KJ

Publication Date: 2021-10-29

Variant appearance in text: ALK: M1166R

PubMed Link: 34769149

Variant Present in the following documents:

• Main text
• ijms-22-11718.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ALK: M1166R

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed ALK F1174L-mutated neuroblastoma.

Cold Spring Harbor Molecular Case Studies

Liu, Tingting T; Merguerian, Matthew D MD; Rowe, Steven P SP; Pratilas, Christine A CA; Chen, Allen R AR; Ladle, Brian H BH

Publication Date: 2021-08

Variant appearance in text: ALK: M1166R

PubMed Link: 34210658

Variant Present in the following documents:

• Main text
• MCS006064Liu.pdf

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Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2021-03-09

Variant appearance in text: ALK: M1166R

PubMed Link: 33674381

Variant Present in the following documents:

• Main text
• pnas.202019132.pdf

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: ALK: M1166R

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

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Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics

Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z

Publication Date: 2021-05-20

Variant appearance in text: ALK: M1166R

PubMed Link: 32510566

Variant Present in the following documents:

• Main text

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: ALK: M1166R

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular And Molecular Life Sciences : Cmls

Jordan, E Joseph EJ; Patil, Keshav K; Suresh, Krishna K; Park, Jin H JH; Mosse, Yael P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2019-07

Variant appearance in text: ALK: M1166R

PubMed Link: 30982079

Variant Present in the following documents:

• Main text

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Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces.

International Journal Of Molecular Sciences

Huang, Hao H

Publication Date: 2018-11-02

Variant appearance in text: ALK: M1166R

PubMed Link: 30400214

Variant Present in the following documents:

• Main text
• ijms-19-03448.pdf

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Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.

Acs Medicinal Chemistry Letters

Johnson, Ted W TW; Bolanos, Ben B; Brooun, Alexei A; Gallego, Rebecca A RA; Gehlhaar, Dan D; Jalaie, Mehran M; McTigue, Michele M; Timofeevski, Sergei S

Publication Date: 2018-09-13

Variant appearance in text: ALK: M1166R

PubMed Link: 30258533

Variant Present in the following documents:

• Main text

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Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.

Scientific Reports

Li, Jianzong J; Huang, Yue Y; Wu, Miaomiao M; Wu, Chuanfang C; Li, Xin X; Bao, Jinku J

Publication Date: 2018-07-13

Variant appearance in text: ALK: M1166R

PubMed Link: 30006516

Variant Present in the following documents:

• 41598_2018_28752_MOESM3_ESM.xlsx, sheet 1

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ALK: a tyrosine kinase target for cancer therapy.

Cold Spring Harbor Molecular Case Studies

Holla, Vijaykumar R VR; Elamin, Yasir Y YY; Bailey, Ann Marie AM; Johnson, Amber M AM; Litzenburger, Beate C BC; Khotskaya, Yekaterina B YB; Sanchez, Nora S NS; Zeng, Jia J; Shufean, Md Abu MA; Shaw, Kenna R KR; Mendelsohn, John J; Mills, Gordon B GB; Meric-Bernstam, Funda F; Simon, George R GR

Publication Date: 2017-01

Variant appearance in text: ALK: M1166R

PubMed Link: 28050598

Variant Present in the following documents:

• Main text
• HollaMCS001115.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: ALK: M1166R

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s4.xls, sheet 1

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The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN.

Disease Models & Mechanisms

Guan, J J; Tucker, E R ER; Wan, H H; Chand, D D; Danielson, L S LS; Ruuth, K K; El Wakil, A A; Witek, B B; Jamin, Y Y; Umapathy, G G; Robinson, S P SP; Johnson, T W TW; Smeal, T T; Martinsson, T T; Chesler, L L; Palmer, R H RH; Hallberg, B B

Publication Date: 2016-09-01

Variant appearance in text: ALK: M1166R

PubMed Link: 27483357

Variant Present in the following documents:

• Main text

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Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Mossé, Yael P YP

Publication Date: 2016-02-01

Variant appearance in text: ALK: M1166R

PubMed Link: 26503946

Variant Present in the following documents:

• Main text

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Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Kopetz, Scott S; Desai, Jayesh J; Chan, Emily E; Hecht, Joel Randolph JR; O'Dwyer, Peter J PJ; Maru, Dipen D; Morris, Van V; Janku, Filip F; Dasari, Arvind A; Chung, Woonbook W; Issa, Jean-Pierre J JP; Gibbs, Peter P; James, Brian B; Powis, Garth G; Nolop, Keith B KB; Bhattacharya, Suman S; Saltz, Leonard L

Publication Date: 2015-12-01

Variant appearance in text: ALK: M1166R

PubMed Link: 26460303

Variant Present in the following documents:

• supp_33.34.4032_DS_2015.632497.pdf

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: ALK: M1166R

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 3

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ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.

Cancer Cell

Bresler, Scott C SC; Weiser, Daniel A DA; Huwe, Peter J PJ; Park, Jin H JH; Krytska, Kateryna K; Ryles, Hannah H; Laudenslager, Marci M; Rappaport, Eric F EF; Wood, Andrew C AC; McGrady, Patrick W PW; Hogarty, Michael D MD; London, Wendy B WB; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP

Publication Date: 2014-11-10

Variant appearance in text: ALK: M1166R

PubMed Link: 25517749

Variant Present in the following documents:

• Main text

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Integrating in silico prediction methods, molecular docking, and molecular dynamics simulation to predict the impact of ALK missense mutations in structural perspective.

Biomed Research International

Doss, C George Priya CG; Chakraborty, Chiranjib C; Chen, Luonan L; Zhu, Hailong H

Publication Date: 2014

Variant appearance in text: ALK: M1166R

PubMed Link: 25054154

Variant Present in the following documents:

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Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

Disease Models & Mechanisms

Chand, Damini D; Yamazaki, Yasuo Y; Ruuth, Kristina K; Schönherr, Christina C; Martinsson, Tommy T; Kogner, Per P; Attiyeh, Edward F EF; Maris, John J; Morozova, Olena O; Marra, Marco A MA; Ohira, Miki M; Nakagawara, Akira A; Sandström, Per-Erik PE; Palmer, Ruth H RH; Hallberg, Bengt B

Publication Date: 2013-03

Variant appearance in text: ALK: M1166R

PubMed Link: 23104988

Variant Present in the following documents:

• Main text

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Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.

Cancer Biology & Therapy

Dickstein, Rian J RJ; Nitti, Giovanni G; Dinney, Colin P CP; Davies, Barry R BR; Kamat, Ashish M AM; McConkey, David J DJ

Publication Date: 2012-11

Variant appearance in text: ALK: M1166R

PubMed Link: 22895070

Variant Present in the following documents:

• Main text

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Emerging importance of ALK in neuroblastoma.

Seminars In Cancer Biology

Azarova, Anna M AM; Gautam, Gargi G; George, Rani E RE

Publication Date: 2011-10

Variant appearance in text: ALK: M1166R

PubMed Link: 21945349

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: ALK: M1166R

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Anaplastic lymphoma kinase: signalling in development and disease.

The Biochemical Journal

Palmer, Ruth H RH; Vernersson, Emma E; Grabbe, Caroline C; Hallberg, Bengt B

Publication Date: 2009-05-27

Variant appearance in text: ALK: M1166R

PubMed Link: 19459784

Variant Present in the following documents:

• Main text
• bj4200345.pdf

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Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Expert Review Of Anticancer Therapy

Webb, Thomas R TR; Slavish, Jake J; George, Rani E RE; Look, A Thomas AT; Xue, Liquan L; Jiang, Qin Q; Cui, Xiaoli X; Rentrop, Walter B WB; Morris, Stephan W SW

Publication Date: 2009-03

Variant appearance in text: ALK: M1166R

PubMed Link: 19275511

Variant Present in the following documents:

• Main text

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Identification of ALK as a major familial neuroblastoma predisposition gene.

Nature

Mossé, Yaël P YP; Laudenslager, Marci M; Longo, Luca L; Cole, Kristina A KA; Wood, Andrew A; Attiyeh, Edward F EF; Laquaglia, Michael J MJ; Sennett, Rachel R; Lynch, Jill E JE; Perri, Patrizia P; Laureys, Geneviève G; Speleman, Frank F; Kim, Cecilia C; Hou, Cuiping C; Hakonarson, Hakon H; Torkamani, Ali A; Schork, Nicholas J NJ; Brodeur, Garrett M GM; Tonini, Gian P GP; Rappaport, Eric E; Devoto, Marcella M; Maris, John M JM

Publication Date: 2008-10-16

Variant appearance in text: ALK: 3497T>G; M1166R

PubMed Link: 18724359

Variant Present in the following documents:

• Main text

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