ALK c.3452C>G ;(p.T1151R)

Variant ID: 2-29445273-G-C

NM_004304.4(ALK):c.3452C>G;(p.T1151R)

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Landscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling.

Npj Precision Oncology
Wang, Tiantian T; Wei, Li L; Lu, Qiang Q; Shao, Yanmei Y; You, Shuqing S; Yin, Jiani C JC; Wang, Sha S; Shao, Yang Y; Chen, Zhanhong Z; Wang, Zhe Z
Publication Date: 2022-11-11

Variant appearance in text: ALK: T1151R
PubMed Link: 36369474
Variant Present in the following documents:
  • 41698_2022_Article_325.pdf
View BVdb publication page



AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery
Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,
Publication Date: 2022-09-02

Variant appearance in text: ALK: T1151R
PubMed Link: 35819403
Variant Present in the following documents:
  • cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1
View BVdb publication page



Longitudinal monitoring by next-generation sequencing of plasma cell-free DNA in ALK rearranged NSCLC patients treated with ALK tyrosine kinase inhibitors.

Cancer Medicine
Kwon, Minsuk M; Ku, Bo Mi BM; Olsen, Steve S; Park, Sehhoon S; Lefterova, Martina M; Odegaard, Justin J; Jung, Hyun-Ae HA; Sun, Jong-Mu JM; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Park, Keunchil K; Ahn, Myung-Ju MJ
Publication Date: 2022-08

Variant appearance in text: ALK: T1151R
PubMed Link: 35437925
Variant Present in the following documents:
  • Main text
  • CAM4-11-2944-s001.pdf
  • CAM4-11-2944.pdf
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The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.

The Journal Of Pathology. Clinical Research
Tessier-Cloutier, Basile B; Grewal, Jasleen K JK; Jones, Martin R MR; Pleasance, Erin E; Shen, Yaoqing Y; Cai, Ellen E; Dunham, Chris C; Hoang, Lynn L; Horst, Basil B; Huntsman, David G DG; Ionescu, Diana D; Karnezis, Anthony N AN; Lee, Anna F AF; Lee, Cheng Han CH; Lee, Tae Hoon TH; Twa, David Dw DD; Mungall, Andrew J AJ; Mungall, Karen K; Naso, Julia R JR; Ng, Tony T; Schaeffer, David F DF; Sheffield, Brandon S BS; Skinnider, Brian B; Smith, Tyler T; Williamson, Laura L; Zhong, Ellia E; Regier, Dean A DA; Laskin, Janessa J; Marra, Marco A MA; Gilks, C Blake CB; Jones, Steven Jm SJ; Yip, Stephen S
Publication Date: 2022-07

Variant appearance in text: ALK: T1151R
PubMed Link: 35257510
Variant Present in the following documents:
  • CJP2-8-395-s002.xlsx, sheet 1
View BVdb publication page



Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open
Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K
Publication Date: 2022-02-02

Variant appearance in text: ALK: T1151R
PubMed Link: 35123209
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open
Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K
Publication Date: 2022-02

Variant appearance in text: ALK: T1151R
PubMed Link: 35123209
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology
Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F
Publication Date: 2021

Variant appearance in text: ALK: T1151R
PubMed Link: 34660278
Variant Present in the following documents:
  • Main text
  • fonc-11-713530.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ALK: T1151R
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.

Thoracic Cancer
Mitsumura, Takahiro T; Kumaki, Yuichi Y; Takahashi, Kenta K; Matsudera, Shotaro S; Sakakibara, Rie R; Honda, Takayuki T; Ishizuka, Masahiro M; Iijima, Yuki Y; Shirai, Tsuyoshi T; Okamoto, Tsukasa T; Tateishi, Tomoya T; Sakashita, Hiroyuki H; Miyake, Satoshi S; Ikeda, Sadakatsu S; Miyazaki, Yasunari Y
Publication Date: 2021-09

Variant appearance in text: ALK: T1151R
PubMed Link: 34378333
Variant Present in the following documents:
  • Main text
  • TCA-12-2508.pdf
View BVdb publication page



Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.

Thoracic Cancer
Mitsumura, Takahiro T; Kumaki, Yuichi Y; Takahashi, Kenta K; Matsudera, Shotaro S; Sakakibara, Rie R; Honda, Takayuki T; Ishizuka, Masahiro M; Iijima, Yuki Y; Shirai, Tsuyoshi T; Okamoto, Tsukasa T; Tateishi, Tomoya T; Sakashita, Hiroyuki H; Miyake, Satoshi S; Ikeda, Sadakatsu S; Miyazaki, Yasunari Y
Publication Date: 2021-09

Variant appearance in text: ALK: T1151R
PubMed Link: 34378333
Variant Present in the following documents:
  • Main text
  • TCA-12-2508.pdf
View BVdb publication page



Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences
Fois, Sara S SS; Paliogiannis, Panagiotis P; Zinellu, Angelo A; Fois, Alessandro G AG; Cossu, Antonio A; Palmieri, Giuseppe G
Publication Date: 2021-01-09

Variant appearance in text: ALK: T1151R
PubMed Link: 33435440
Variant Present in the following documents:
  • Main text
  • ijms-22-00612.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: ALK: 3452C>G; T1151R
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: ALK: T1151R
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s004.xlsx, sheet 1
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs113994091
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: ALK: T1151R
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK Inhibitors.

Frontiers In Oncology
Poddubskaya, Elena E; Bondarenko, Alexey A; Boroda, Alexander A; Zotova, Evgenia E; Glusker, Alex A; Sletina, Svetlana S; Makovskaia, Luidmila L; Kopylov, Philipp P; Sekacheva, Marina M; Moisseev, Alexey A; Baranova, Madina M
Publication Date: 2019

Variant appearance in text: ALK: T1151R
PubMed Link: 31681574
Variant Present in the following documents:
  • fonc-09-01026.pdf
View BVdb publication page



Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.

Scientific Reports
Li, Jianzong J; Huang, Yue Y; Wu, Miaomiao M; Wu, Chuanfang C; Li, Xin X; Bao, Jinku J
Publication Date: 2018-07-13

Variant appearance in text: ALK: T1151R
PubMed Link: 30006516
Variant Present in the following documents:
  • 41598_2018_28752_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Genetic susceptibility to neuroblastoma: current knowledge and future directions.

Cell And Tissue Research
Ritenour, Laura E LE; Randall, Michael P MP; Bosse, Kristopher R KR; Diskin, Sharon J SJ
Publication Date: 2018-05

Variant appearance in text: ALK: T1151R
PubMed Link: 29589100
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variation in human drug-related genes.

Genome Medicine
Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS
Publication Date: 2017-12-22

Variant appearance in text: rs113994091
PubMed Link: 29273096
Variant Present in the following documents:
  • 13073_2017_502_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Retinoblastoma and Neuroblastoma Predisposition and Surveillance.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Kamihara, Junne J; Bourdeaut, Franck F; Foulkes, William D WD; Molenaar, Jan J JJ; Mossé, Yaël P YP; Nakagawara, Akira A; Parareda, Andreu A; Scollon, Sarah R SR; Schneider, Kami Wolfe KW; Skalet, Alison H AH; States, Lisa J LJ; Walsh, Michael F MF; Diller, Lisa R LR; Brodeur, Garrett M GM
Publication Date: 2017-07-01

Variant appearance in text: ALK: T1151R
PubMed Link: 28674118
Variant Present in the following documents:
  • Main text
View BVdb publication page



TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Oncotarget
Amin, Amit Dipak AD; Li, Lingxiao L; Rajan, Soumya S SS; Gokhale, Vijay V; Groysman, Matthew J MJ; Pongtornpipat, Praechompoo P; Tapia, Edgar O EO; Wang, Mengdie M; Schatz, Jonathan H JH
Publication Date: 2016-04-26

Variant appearance in text: ALK: T1151R
PubMed Link: 27009859
Variant Present in the following documents:
  • Main text
View BVdb publication page



ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome.

European Journal Of Human Genetics : Ejhg
Bourdeaut, Franck F; Ferrand, Sandrine S; Brugières, Laurence L; Hilbert, Marjorie M; Ribeiro, Agnès A; Lacroix, Ludovic L; Bénard, Jean J; Combaret, Valérie V; Michon, Jean J; Valteau-Couanet, Dominique D; Isidor, Bertrand B; Rialland, Xavier X; Poirée, Maryline M; Defachelles, Anne-Sophie AS; Peuchmaur, Michel M; Schleiermacher, Gudrun G; Pierron, Gaëlle G; Gauthier-Villars, Marion M; Janoueix-Lerosey, Isabelle I; Delattre, Olivier O; ,
Publication Date: 2012-03

Variant appearance in text: ALK: 3452C>G; T1151R
PubMed Link: 22071890
Variant Present in the following documents:
  • Main text
View BVdb publication page