Publications:

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A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal.

Science Advances

Chen, Chengjuan C; Yin, Yuan Y; Shi, Gaona G; Zhou, Yu Y; Shao, Shuai S; Wei, Yazi Y; Wu, Lei L; Zhang, Dayong D; Sun, Lan L; Zhang, Tiantai T

Publication Date: 2022-08-19

Variant appearance in text: ALK: V559D

PubMed Link: 35984890

Variant Present in the following documents:

• sciadv.abo4363_sm.pdf

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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.

Cell Reports

Schiapparelli, Paula P; Pirman, Natasha L NL; Mohler, Kyle K; Miranda-Herrera, Pierre A PA; Zarco, Natanael N; Kilic, Onur O; Miller, Chad C; Shah, Sagar R SR; Rogulina, Svetlana S; Hungerford, William W; Abriola, Laura L; Hoyer, Denton D; Turk, Benjamin E BE; Guerrero-Cázares, Hugo H; Isaacs, Farren J FJ; Quiñones-Hinojosa, Alfredo A; Levchenko, Andre A; Rinehart, Jesse J

Publication Date: 2021-07-20

Variant appearance in text: ALK: V559D

PubMed Link: 34289367

Variant Present in the following documents:

• NIHMS1726840-supplement-2.xlsx, sheet 1

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Evolution of kinase polypharmacology across HSP90 drug discovery.

Cell Chemical Biology

Antolin, Albert A AA; Clarke, Paul A PA; Collins, Ian I; Workman, Paul P; Al-Lazikani, Bissan B

Publication Date: 2021-10-21

Variant appearance in text: ALK: V559D

PubMed Link: 34077750

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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CSF1R signaling is a regulator of pathogenesis in progressive MS.

Cell Death & Disease

Hagan, Nellwyn N; Kane, John L JL; Grover, Deepak D; Woodworth, Lisa L; Madore, Charlotte C; Saleh, Jacqueline J; Sancho, Jose J; Liu, Jinyu J; Li, Yi Y; Proto, Jonathan J; Zelic, Matija M; Mahan, Amy A; Kothe, Michael M; Scholte, Andrew A AA; Fitzgerald, Maria M; Gisevius, Barbara B; Haghikia, Aiden A; Butovsky, Oleg O; Ofengeim, Dimitry D

Publication Date: 2020-10-23

Variant appearance in text: ALK: V559D

PubMed Link: 33097690

Variant Present in the following documents:

• 41419_2020_Article_3084.pdf

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Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor.

Angewandte Chemie (International Ed. In English)

Foley, Daniel J DJ; Zinken, Sarah S; Corkery, Dale D; Laraia, Luca L; Pahl, Axel A; Wu, Yao-Wen YW; Waldmann, Herbert H

Publication Date: 2020-07-20

Variant appearance in text: ALK: V559D

PubMed Link: 32108411

Variant Present in the following documents:

• ANIE-59-12470-s001.pdf

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Molecules (Basel, Switzerland)

Asquith, Christopher R M CRM; Bennett, James M JM; Su, Lianyong L; Laitinen, Tuomo T; Elkins, Jonathan M JM; Pickett, Julie E JE; Wells, Carrow I CI; Li, Zengbiao Z; Willson, Timothy M TM; Zuercher, William J WJ

Publication Date: 2019-11-06

Variant appearance in text: ALK: V559D

PubMed Link: 31698822

Variant Present in the following documents:

• molecules-24-04016-s001.pdf

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Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.

Acs Medicinal Chemistry Letters

Dodo, Kosuke K; Kuboki, Erika E; Shimizu, Tadashi T; Imamura, Ryu R; Magarisawa, Megumi M; Takahashi, Masahiro M; Tokuhiro, Takuto T; Yotsumoto, Satoshi S; Asano, Kenichi K; Nakao, Shuhei S; Terayama, Naoki N; Suda, Takashi T; Tanaka, Masato M; Sodeoka, Mikiko M

Publication Date: 2019-09-12

Variant appearance in text: ALK: V559D

PubMed Link: 31531196

Variant Present in the following documents:

• ml9b00142_si_001.pdf

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Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular And Molecular Life Sciences : Cmls

Jordan, E Joseph EJ; Patil, Keshav K; Suresh, Krishna K; Park, Jin H JH; Mosse, Yael P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2019-07

Variant appearance in text: ALK: V559D

PubMed Link: 30982079

Variant Present in the following documents:

• Main text

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B

Publication Date: 2019-02-12

Variant appearance in text: ALK: V559D

PubMed Link: 30683722

Variant Present in the following documents:

• pnas.1812963116.sapp.pdf

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Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy.

Journal Of Hematology & Oncology

Rossari, Federico F; Minutolo, Filippo F; Orciuolo, Enrico E

Publication Date: 2018-06-20

Variant appearance in text: ALK: V559D

PubMed Link: 29925402

Variant Present in the following documents:

• Main text

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Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

Chemical Science

Robke, Lucas L; Futamura, Yushi Y; Konstantinidis, Georgios G; Wilke, Julian J; Aono, Harumi H; Mahmoud, Zhwan Z; Watanabe, Nobumoto N; Wu, Yao-Wen YW; Osada, Hiroyuki H; Laraia, Luca L; Waldmann, Herbert H

Publication Date: 2018-03-21

Variant appearance in text: ALK: V559D

PubMed Link: 29732085

Variant Present in the following documents:

• SC-009-C7SC05040B-s001.pdf

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Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury.

Acs Medicinal Chemistry Letters

Dodo, Kosuke K; Shimizu, Tadashi T; Sasamori, Jun J; Aihara, Kazuyuki K; Terayama, Naoki N; Nakao, Shuhei S; Iuchi, Katsuya K; Takahashi, Masahiro M; Sodeoka, Mikiko M

Publication Date: 2018-03-08

Variant appearance in text: ALK: V559D

PubMed Link: 29541357

Variant Present in the following documents:

• ml7b00454_si_001.pdf

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.

Nature Biotechnology

Yu, Channing C; Mannan, Aristotle M AM; Yvone, Griselda Metta GM; Ross, Kenneth N KN; Zhang, Yan-Ling YL; Marton, Melissa A MA; Taylor, Bradley R BR; Crenshaw, Andrew A; Gould, Joshua Z JZ; Tamayo, Pablo P; Weir, Barbara A BA; Tsherniak, Aviad A; Wong, Bang B; Garraway, Levi A LA; Shamji, Alykhan F AF; Palmer, Michelle A MA; Foley, Michael A MA; Winckler, Wendy W; Schreiber, Stuart L SL; Kung, Andrew L AL; Golub, Todd R TR

Publication Date: 2016-04

Variant appearance in text: ALK: V559D

PubMed Link: 26928769

Variant Present in the following documents:

• NIHMS744739-supplement-2.pdf

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Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases.

Cell Reports

Duong-Ly, Krisna C KC; Devarajan, Karthik K; Liang, Shuguang S; Horiuchi, Kurumi Y KY; Wang, Yuren Y; Ma, Haiching H; Peterson, Jeffrey R JR

Publication Date: 2016-02-02

Variant appearance in text: ALK: V559D

PubMed Link: 26776524

Variant Present in the following documents:

• Main text

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Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

The Journal Of Investigative Dermatology

Siroy, Alan E AE; Boland, Genevieve M GM; Milton, Denái R DR; Roszik, Jason J; Frankian, Silva S; Malke, Jared J; Haydu, Lauren L; Prieto, Victor G VG; Tetzlaff, Michael M; Ivan, Doina D; Wang, Wei-Lien WL; Torres-Cabala, Carlos C; Curry, Jonathan J; Roy-Chowdhuri, Sinchita S; Broaddus, Russell R; Rashid, Asif A; Stewart, John J; Gershenwald, Jeffrey E JE; Amaria, Rodabe N RN; Patel, Sapna P SP; Papadopoulos, Nicholas E NE; Bedikian, Agop A; Hwu, Wen-Jen WJ; Hwu, Patrick P; Diab, Adi A; Woodman, Scott E SE; Aldape, Kenneth D KD; Luthra, Rajyalakshmi R; Patel, Keyur P KP; Shaw, Kenna R KR; Mills, Gordon B GB; Mendelsohn, John J; Meric-Bernstam, Funda F; Kim, Kevin B KB; Routbort, Mark J MJ; Lazar, Alexander J AJ; Davies, Michael A MA

Publication Date: 2015-02

Variant appearance in text: ALK: V559D

PubMed Link: 25148578

Variant Present in the following documents:

• NIHMS622327-supplement-supplement_1.pdf

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Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.

Journal Of Medicinal Chemistry

Bavetsias, Vassilios V; Crumpler, Simon S; Sun, Chongbo C; Avery, Sian S; Atrash, Butrus B; Faisal, Amir A; Moore, Andrew S AS; Kosmopoulou, Magda M; Brown, Nathan N; Sheldrake, Peter W PW; Bush, Katherine K; Henley, Alan A; Box, Gary G; Valenti, Melanie M; de Haven Brandon, Alexis A; Raynaud, Florence I FI; Workman, Paul P; Eccles, Suzanne A SA; Bayliss, Richard R; Linardopoulos, Spiros S; Blagg, Julian J

Publication Date: 2012-10-25

Variant appearance in text: ALK: V559D

PubMed Link: 23043539

Variant Present in the following documents:

• jm300952s_si_001.pdf

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An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit.

Bioorganic & Medicinal Chemistry Letters

Deng, Xianming X; Zhou, Wenjun W; Weisberg, Ellen E; Wang, Jinhua J; Zhang, Jianming J; Sasaki, Takaaki T; Nelson, Erik E; Griffin, James D JD; Jänne, Pasi A PA; Gray, Nathanael S NS

Publication Date: 2012-07-15

Variant appearance in text: ALK: V559D

PubMed Link: 22727638

Variant Present in the following documents:

• Main text

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