Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis.
Haemoglobin switching modulator SNPs rs5006884 is associated with increased HbA2 in β-thalassaemia carriers.
Archives Of Medical Science : Ams
Cyrus, Cyril C; Vatte, Chittibabu C; Chathoth, Shahanas S; Sayed, Abdul Azeez AA; Borgio, J Francis JF; Alrubaish, Mohammed Abdullah MA; Alfalah, Rawan R; Alsaikhan, Jana J; Al Ali, Amein K AK
Surveillance for sickle cell disease, United Republic of Tanzania.
Bulletin Of The World Health Organization
Ambrose, Emmanuela E EE; Smart, Luke R LR; Charles, Mwesige M; Hernandez, Arielle G AG; Latham, Teresa T; Hokororo, Adolfine A; Beyanga, Medard M; Howard, Thad A TA; Kamugisha, Erasmus E; McElhinney, Kathryn E KE; Tebuka, Erius E; Ware, Russell E RE
A novel mutation in the erythroid transcription factor KLF1 is likely responsible for ameliorating β-thalassemia major.
Human Mutation
Fanis, Pavlos P; Kousiappa, Ioanna I; Phylactides, Marios M; Kyrri, Andreani A; Hadjigavriel, Michael M; Christou, Soteroula S; Sitarou, Maria M; Kleanthous, Marina M
Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients.
Biomed Research International
Cyrus, Cyril C; Vatte, Chittibabu C; Borgio, J Francis JF; Al-Rubaish, Abdullah A; Chathoth, Shahanas S; Nasserullah, Zaki A ZA; Jarrash, Sana Al SA; Sulaiman, Ahmed A; Qutub, Hatem H; Alsaleem, Hassan H; Alzahrani, Alhusain J AJ; Steinberg, Martin H MH; Ali, Amein K Al AK
Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.
Experimental Biology And Medicine (Maywood, N.J.)
Liu, Li L; Pertsemlidis, Alexander A; Ding, Liang-Hao LH; Story, Michael D MD; Steinberg, Martin H MH; Sebastiani, Paola P; Hoppe, Carolyn C; Ballas, Samir K SK; Pace, Betty S BS
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia.
American Journal Of Hematology
Belfer, Inna I; Youngblood, Victoria V; Darbari, Deepika S DS; Wang, Zhengyuan Z; Diaw, Lena L; Freeman, Lita L; Desai, Krupa K; Dizon, Michael M; Allen, Darlene D; Cunnington, Colin C; Channon, Keith M KM; Milton, Jacqueline J; Hartley, Stephen W SW; Nolan, Vikki V; Kato, Gregory J GJ; Steinberg, Martin H MH; Goldman, David D; Taylor, James G JG
Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia.
Blood
Ware, Russell E RE; Despotovic, Jenny M JM; Mortier, Nicole A NA; Flanagan, Jonathan M JM; He, Jin J; Smeltzer, Matthew P MP; Kimble, Amy C AC; Aygun, Banu B; Wu, Song S; Howard, Thad T; Sparreboom, Alex A
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Lettre, Guillaume G; Sankaran, Vijay G VG; Bezerra, Marcos André C MA; Araújo, Aderson S AS; Uda, Manuela M; Sanna, Serena S; Cao, Antonio A; Schlessinger, David D; Costa, Fernando F FF; Hirschhorn, Joel N JN; Orkin, Stuart H SH