Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics.
Diabetologia
Patel, Kashyap A KA; Ozbek, Mehmet N MN; Yildiz, Melek M; Guran, Tulay T; Kocyigit, Cemil C; Acar, Sezer S; Siklar, Zeynep Z; Atar, Muge M; Colclough, Kevin K; Houghton, Jayne J; Johnson, Matthew B MB; Ellard, Sian S; Flanagan, Sarah E SE; Cizmecioglu, Filiz F; Berberoglu, Merih M; Demir, Korcan K; Catli, Gonul G; Bas, Serpil S; Akcay, Teoman T; Demirbilek, Huseyin H; Weedon, Michael N MN; Hattersley, Andrew T AT
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Type 1 diabetes: genes associated with disease development.
Central-European Journal Of Immunology
Klak, Marta M; Gomółka, Magdalena M; Kowalska, Patrycja P; Cichoń, Justyna J; Ambrożkiewicz, Filip F; Serwańska-Świętek, Marta M; Berman, Andrzej A; Wszoła, Michał M
De-coding genetic risk variants in type 1 diabetes.
Immunology And Cell Biology
Shapiro, Melanie R MR; Thirawatananond, Puchong P; Peters, Leeana L; Sharp, Robert C RC; Ogundare, Similoluwa S; Posgai, Amanda L AL; Perry, Daniel J DJ; Brusko, Todd M TM
Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.
Plos One
Sinha, Sushmita S; Renavikar, Pranav S PS; Crawford, Michael P MP; Steward-Tharp, Scott M SM; Brate, Ashley A; Tsalikian, Eva E; Tansey, Michael M; Shivapour, Ezzatollah T ET; Cho, Tracey T; Kamholz, John J; Karandikar, Nitin J NJ
Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.
Diabetologia
Claessens, Laura A LA; Wesselius, Joris J; van Lummel, Menno M; Laban, Sandra S; Mulder, Flip F; Mul, Dick D; Nikolic, Tanja T; Aanstoot, Henk-Jan HJ; Koeleman, Bobby P C BPC; Roep, Bart O BO
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years.
Bmj Open
Lynam, Anita A; McDonald, Timothy T; Hill, Anita A; Dennis, John J; Oram, Richard R; Pearson, Ewan E; Weedon, Michael M; Hattersley, Andrew A; Owen, Katharine K; Shields, Beverley B; Jones, Angus A
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.
Pediatric Diabetes
Winkler, Christiane C; Haupt, Florian F; Heigermoser, Martin M; Zapardiel-Gonzalo, Jose J; Ohli, Jasmin J; Faure, Theresa T; Kalideri, Evdokia E; Hommel, Angela A; Delivani, Petrina P; Berner, Reinhard R; Kordonouri, Olga O; Roloff, Frank F; von dem Berge, Thekla T; Lange, Karin K; Oltarzewski, Mariusz M; Glab, Ryszard R; Szypowska, Agnieszka A; Snape, Matthew D MD; Vatish, Manu M; Todd, John A JA; Larsson, Helena E HE; Ramelius, Anita A; Kördel, Jeanette Å JÅ; Casteels, Kristina K; Paulus, Jasmin J; Ziegler, Anette G AG; Bonifacio, Ezio E; ,
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.
Diabetes
Hippich, Markus M; Beyerlein, Andreas A; Hagopian, William A WA; Krischer, Jeffrey P JP; Vehik, Kendra K; Knoop, Jan J; Winker, Christiane C; Toppari, Jorma J; Lernmark, Åke Å; Rewers, Marian J MJ; Steck, Andrea K AK; She, Jin-Xiong JX; Akolkar, Beena B; Robertson, Catherine C CC; Onengut-Gumuscu, Suna S; Rich, Stephen S SS; Bonifacio, Ezio E; Ziegler, Anette-G AG; , ; ,
An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells.
Scientific Reports
Sinha, Sushmita S; Borcherding, Nicholas N; Renavikar, Pranav S PS; Crawford, Michael P MP; Tsalikian, Eva E; Tansey, Michael M; Shivapour, Ezzatollah T ET; Bittner, Frank F; Kamholz, John J; Olalde, Heena H; Gibson, Emilee E; Karandikar, Nitin J NJ
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific Reports
Perry, Daniel J DJ; Wasserfall, Clive H CH; Oram, Richard A RA; Williams, MacKenzie D MD; Posgai, Amanda A; Muir, Andrew B AB; Haller, Michael J MJ; Schatz, Desmond A DA; Wallet, Mark A MA; Mathews, Clayton E CE; Atkinson, Mark A MA; Brusko, Todd M TM
Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.
Cell
Koues, Olivia I OI; Collins, Patrick L PL; Cella, Marina M; Robinette, Michelle L ML; Porter, Sofia I SI; Pyfrom, Sarah C SC; Payton, Jacqueline E JE; Colonna, Marco M; Oltz, Eugene M EM
Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.
Journal Of Diabetes Research
Brorsson, Caroline A CA; Nielsen, Lotte B LB; Andersen, Marie Louise ML; Kaur, Simranjeet S; Bergholdt, Regine R; Hansen, Lars L; Mortensen, Henrik B HB; Pociot, Flemming F; Størling, Joachim J; ,
Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes.
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.
Diabetes
Törn, Carina C; Hadley, David D; Lee, Hye-Seung HS; Hagopian, William W; Lernmark, Åke Å; Simell, Olli O; Rewers, Marian M; Ziegler, Anette A; Schatz, Desmond D; Akolkar, Beena B; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Toppari, Jorma J; Mykkänen, Juha J; Ilonen, Jorma J; Rich, Stephen S SS; She, Jin-Xiong JX; Steck, Andrea K AK; Krischer, Jeffrey J; ,
Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.
Pediatric Diabetes
Steck, Andrea K AK; Dong, Fran F; Wong, Randall R; Fouts, Alexandra A; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Rewers, Marian J MJ
Heritability and genomics of gene expression in peripheral blood.
Nature Genetics
Wright, Fred A FA; Sullivan, Patrick F PF; Brooks, Andrew I AI; Zou, Fei F; Sun, Wei W; Xia, Kai K; Madar, Vered V; Jansen, Rick R; Chung, Wonil W; Zhou, Yi-Hui YH; Abdellaoui, Abdel A; Batista, Sandra S; Butler, Casey C; Chen, Guanhua G; Chen, Ting-Huei TH; D'Ambrosio, David D; Gallins, Paul P; Ha, Min Jin MJ; Hottenga, Jouke Jan JJ; Huang, Shunping S; Kattenberg, Mathijs M; Kochar, Jaspreet J; Middeldorp, Christel M CM; Qu, Ani A; Shabalin, Andrey A; Tischfield, Jay J; Todd, Laura L; Tzeng, Jung-Ying JY; van Grootheest, Gerard G; Vink, Jacqueline M JM; Wang, Qi Q; Wang, Wei W; Wang, Weibo W; Willemsen, Gonneke G; Smit, Johannes H JH; de Geus, Eco J EJ; Yin, Zhaoyu Z; Penninx, Brenda W J H BW; Boomsma, Dorret I DI
Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.
Diabetes
Steck, Andrea K AK; Wong, Randall R; Wagner, Brandie B; Johnson, Kelly K; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Eisenbarth, George S GS; Rewers, Marian J MJ
Confirmation of novel type 1 diabetes risk loci in families.
Diabetologia
Cooper, J D JD; Howson, J M M JM; Smyth, D D; Walker, N M NM; Stevens, H H; Yang, J H M JH; She, J-X JX; Eisenbarth, G S GS; Rewers, M M; Todd, J A JA; Akolkar, B B; Concannon, P P; Erlich, H A HA; Julier, C C; Morahan, G G; Nerup, J J; Nierras, C C; Pociot, F F; Rich, S S SS; ,
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Plos Genetics
Bradfield, Jonathan P JP; Qu, Hui-Qi HQ; Wang, Kai K; Zhang, Haitao H; Sleiman, Patrick M PM; Kim, Cecilia E CE; Mentch, Frank D FD; Qiu, Haijun H; Glessner, Joseph T JT; Thomas, Kelly A KA; Frackelton, Edward C EC; Chiavacci, Rosetta M RM; Imielinski, Marcin M; Monos, Dimitri S DS; Pandey, Rahul R; Bakay, Marina M; Grant, Struan F A SF; Polychronakos, Constantin C; Hakonarson, Hakon H
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.
Diabetes
Morahan, Grant G; Mehta, Munish M; James, Ian I; Chen, Wei-Min WM; Akolkar, Beena B; Erlich, Henry A HA; Hilner, Joan E JE; Julier, Cécile C; Nerup, Jørn J; Nierras, Concepcion C; Pociot, Flemming F; Todd, John A JA; Rich, Stephen S SS; ,
Pociot, Flemming F; Akolkar, Beena B; Concannon, Patrick P; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nierras, Concepcion R CR; Todd, John A JA; Rich, Stephen S SS; Nerup, Jørn J
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature Genetics
Barrett, Jeffrey C JC; Clayton, David G DG; Concannon, Patrick P; Akolkar, Beena B; Cooper, Jason D JD; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nerup, Jørn J; Nierras, Concepcion C; Plagnol, Vincent V; Pociot, Flemming F; Schuilenburg, Helen H; Smyth, Deborah J DJ; Stevens, Helen H; Todd, John A JA; Walker, Neil M NM; Rich, Stephen S SS; ,