Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia.
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising "MINT" sequencing strategy and therapeutic "DNA-TG" monitoring.
Frontiers In Pharmacology
Guo, Hong-Li HL; Zhao, Yue-Tao YT; Wang, Wei-Jun WJ; Dong, Na N; Hu, Ya-Hui YH; Zhang, Yuan-Yuan YY; Chen, Feng F; Zhou, Li L; Li, Tao T
Pharmacogenetics implementation in the clinics: information and guidelines for germline variants.
Cancer Drug Resistance (Alhambra, Calif.)
Olivera, Gladys G; Sendra, Luis L; Herrero, María José MJ; Berlanga, Pablo P; Gargallo, Pablo P; Yáñez, Yania Y; Urtasun, Andrea A; de Mora, Jaime Font JF; Castel, Victoria V; Cañete, Adela A; Aliño, Salvador F SF
Comprehensive Custom NGS Panel Validation for the Improvement of the Stratification of B-Acute Lymphoblastic Leukemia Patients.
Journal Of Personalized Medicine
Montaño, Adrián A; Hernández-Sánchez, Jesús J; Forero-Castro, Maribel M; Matorra-Miguel, María M; Lumbreras, Eva E; Miguel, Cristina C; Santos, Sandra S; Ramírez-Maldonado, Valentina V; Fuster, José Luís JL; de Las Heras, Natalia N; García-de Coca, Alfonso A; Sierra, Magdalena M; Dávila, Julio J; de la Fuente, Ignacio I; Olivier, Carmen C; Olazabal, Juan J; Martínez, Joaquín J; Vega-García, Nerea N; González, Teresa T; Hernández-Rivas, Jesús María JM; Benito, Rocío R
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell Death & Disease
Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D
Publication Date: 2019-02-27
Variant appearance in text: ITPA: 124+21A>C; rs7270101
Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens.
Plos One
Vasanthakumar, Aparna A; Davis, Justin W JW; Abunimeh, Manal M; Söderholm, Jonas J; Zha, Jiuhong J; Dumas, Emily O EO; Cohen, Daniel E DE; Waring, Jeffrey F JF; Lagging, Martin M
Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV.
Plos One
Peltenburg, N Chantal NC; Bierau, Jörgen J; Bakker, Jaap A JA; Schippers, Jolanda A JA; Lowe, Selwyn H SH; Paulussen, Aimée D C ADC; van den Bosch, Bianca J C BJC; Leers, Mathie P G MPG; Hansen, Bettina E BE; Verbon, Annelies A
Publication Date: 2018
Variant appearance in text: ITPA: 124+21A>C; rs7270101
APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.
Cancer Research And Treatment
Kim, Hyery H; Seo, Heewon H; Park, Yoomi Y; Min, Byung-Joo BJ; Seo, Myung-Eui ME; Park, Kyung Duk KD; Shin, Hee Young HY; Kim, Ju Han JH; Kang, Hyoung Jin HJ
Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.
IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study.
Springerplus
Mangia, Alessandra A; De Ledinghen, Victor V; Bailly, François F; Brahm, Javier J; Keiss, Jazeps J; Valantinas, Jonas J; Rasmann, Nele N; Messinger, Diethelm D; Tatsch, Fernando F; Bakalos, Georgios G; Foster, Graham R GR; ,
PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.
Scientific Reports
Smid, Alenka A; Karas-Kuzelicki, Natasa N; Jazbec, Janez J; Mlinaric-Rascan, Irena I
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.
Molecular Diagnosis & Therapy
Skrzypczak-Zielinska, Marzena M; Borun, Pawel P; Bartkowiak-Kaczmarek, Anna A; Zakerska-Banaszak, Oliwia O; Walczak, Michal M; Dobrowolska, Agnieszka A; Kurzawski, Mateusz M; Waszak, Malgorzata M; Lipinski, Daniel D; Plawski, Andrzej A; Slomski, Ryszard R
The ITPA and C20orf194 Polymorphisms and Hematological Changes During Treatment With Pegylated-Interferon Plus Ribavirin in Patients With Chronic Hepatitis C.
Hepatitis Monthly
Pouryasin, Mohammad M; Keshvari, Maryam M; Sharafi, Heidar H; Alavian, Seyed Moayed SM; Behnava, Bita B; Alavian, Seyed Ehsan SE; Pouryasin, Ali A
Recent advances in management of the HIV/HCV coinfected patient.
Future Virology
Bednasz, Cindy J CJ; Sawyer, Joshua R JR; Martinez, Anthony A; Rose, Patrick G PG; Sithole, Samantha S SS; Hamilton, Holly R HR; Kaufman, Farzia S FS; Venuto, Charles S CS; Ma, Qing Q; Talal, Andrew A; Morse, Gene D GD
Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.
Plos One
About, Frédégonde F; Oudot-Mellakh, Tiphaine T; Niay, Jonathan J; Rabiéga, Pascaline P; Pedergnana, Vincent V; Duffy, Darragh D; Sultanik, Philippe P; Cagnot, Carole C; Carrat, Fabrice F; Marcellin, Patrick P; Zoulim, Fabien F; Larrey, Dominique D; Hézode, Christophe C; Fontaine, Hélène H; Bronowicki, Jean-Pierre JP; Pol, Stanislas S; Albert, Matthew L ML; Theodorou, Ioannis I; Cobat, Aurélie A; Abel, Laurent L; ,