Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
The Journal Of Clinical Investigation
Zhong, Zhihui Z; Ilieva, Hristelina H; Hallagan, Lee L; Bell, Robert R; Singh, Itender I; Paquette, Nicole N; Thiyagarajan, Meenakshisundaram M; Deane, Rashid R; Fernandez, Jose A JA; Lane, Steven S; Zlokovic, Anna B AB; Liu, Todd T; Griffin, John H JH; Chow, Nienwen N; Castellino, Francis J FJ; Stojanovic, Konstantin K; Cleveland, Don W DW; Zlokovic, Berislav V BV