Variant ID: 20-33764554-A-G

NM_006404.4(PROCR):c.655A>G;(p.Ser219Gly)

This variant was identified in 89 publications




Publications:


Gene Variants Associated With Venous Thrombosis: A Replication Study in a Brazilian Multicentre Study.

Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis
AVC Romano, A Barnabé, TB Gadelha, JCC Guerra, R Secolin, FLA Orsi, GCS Campanate, N Wolosker, JM Annichino-Bizzacchi
Publication Date: 2020

Variant appearance in text: rs867186
PubMed Link: 33119405
Variant Present in the following documents:
  • Main text
View BVdb publication page



Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C.

International Journal Of Molecular Sciences
L Martos, J Oto, Á Fernández-Pardo, E Plana, MJ Solmoirago, F Cana, D Hervás, S Bonanad, F Ferrando, F España, S Navarro, P Medina
Publication Date: 2020-08-06

Variant appearance in text: rs867186
PubMed Link: 32781781
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.

Scientific Reports
AS Shadrina, TI Shashkova, AA Torgasheva, SZ Sharapov, L Klarić, ED Pakhomov, DG Alexeev, JF Wilson, YA Tsepilov, PK Joshi, YS Aulchenko
Publication Date: 2020-06-26

Variant appearance in text: rs867186
PubMed Link: 32591598
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome.

Journal Of Clinical & Translational Endocrinology
TM Hussein, D Abd Elmoaty Elneily, F Mohamed Abdelfattah Elsayed, LM El-Attar
Publication Date: 2020-06

Variant appearance in text: EPCR: Ser219Gly
PubMed Link: 32577403
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria.

Frontiers In Genetics
JC Cespedes, J Hibbert, S Krishna, F Yan, PK Bharti, JK Stiles, M Liu
Publication Date: 2020

Variant appearance in text: rs867186
PubMed Link: 32153634
Variant Present in the following documents:
  • Main text
View BVdb publication page



Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.

European Heart Journal
J Borén, MJ Chapman, RM Krauss, CJ Packard, JF Bentzon, CJ Binder, MJ Daemen, LL Demer, RA Hegele, SJ Nicholls, BG Nordestgaard, GF Watts, E Bruckert, S Fazio, BA Ference, I Graham, JD Horton, U Landmesser, U Laufs, L Masana, G Pasterkamp, FJ Raal, KK Ray, H Schunkert, MR Taskinen, B van de Sluis, O Wiklund, L Tokgozoglu, AL Catapano, HN Ginsberg
Publication Date: 2020-06-21

Variant appearance in text: rs867186
PubMed Link: 32052833
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.

Blood
S Lindström, L Wang, EN Smith, W Gordon, A van Hylckama Vlieg, M de Andrade, JA Brody, JW Pattee, J Haessler, BM Brumpton, DI Chasman, P Suchon, MH Chen, C Turman, M Germain, KL Wiggins, J MacDonald, SK Braekkan, SM Armasu, N Pankratz, RD Jackson, JB Nielsen, F Giulianini, MK Puurunen, M Ibrahim, SR Heckbert, SM Damrauer, P Natarajan, D Klarin, , PS de Vries, M Sabater-Lleal, JE Huffman, , TK Bammler, KA Frazer, BM McCauley, K Taylor, JS Pankow, AP Reiner, ME Gabrielsen, JF Deleuze, CJ O'Donnell, J Kim, B McKnight, P Kraft, JB Hansen, FR Rosendaal, JA Heit, BM Psaty, W Tang, C Kooperberg, K Hveem, PM Ridker, PE Morange, AD Johnson, C Kabrhel, DA Trégouët, NL Smith
Publication Date: 2019-11-07

Variant appearance in text: rs867186
PubMed Link: 31420334
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease.

Oxidative Medicine And Cellular Longevity
S Steven, K Frenis, M Oelze, S Kalinovic, M Kuntic, MT Bayo Jimenez, K Vujacic-Mirski, J Helmstädter, S Kröller-Schön, T Münzel, A Daiber
Publication Date: 2019

Variant appearance in text: rs867186
PubMed Link: 31341533
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.

Genome Biology
S Lalonde, VA Codina-Fauteux, SM de Bellefon, F Leblanc, M Beaudoin, MM Simon, R Dali, T Kwan, KS Lo, T Pastinen, G Lettre
Publication Date: 2019-07-08

Variant appearance in text: rs867186
PubMed Link: 31287004
Variant Present in the following documents:
  • 13059_2019_1749_MOESM11_ESM.xlsx
View BVdb publication page



Common Risk Factors Add to Inherited Thrombophilia to Predict Venous Thromboembolism Risk in Families.

Th Open : Companion Journal To Thrombosis And Haemostasis
P Suchon, N Resseguier, M Ibrahim, A Robin, G Venton, MC Barthet, D Brunet, N Saut, MC Alessi, DA Trégouët, PE Morange
Publication Date: 2019-01

Variant appearance in text: rs867186
PubMed Link: 31249979
Variant Present in the following documents:
  • Main text
View BVdb publication page



Host genetic variants in sepsis risk: a field synopsis and meta-analysis.

Critical Care (London, England)
H Lu, D Wen, X Wang, L Gan, J Du, J Sun, L Zeng, J Jiang, A Zhang
Publication Date: 2019-01-25

Variant appearance in text: EPCR: Ser219Gly; rs867186
PubMed Link: 30683156
Variant Present in the following documents:
  • 13054_2019_2313_MOESM2_ESM.xls
  • 13054_2019_2313_MOESM3_ESM.docx
View BVdb publication page



A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

Blood
PS de Vries, M Sabater-Lleal, JE Huffman, J Marten, C Song, N Pankratz, TM Bartz, HG de Haan, GE Delgado, JD Eicher, A Martinez-Perez, CK Ward-Caviness, JA Brody, MH Chen, MPM de Maat, M Frånberg, D Gill, ME Kleber, F Rivadeneira, JM Soria, W Tang, GH Tofler, AG Uitterlinden, A van Hylckama Vlieg, S Seshadri, E Boerwinkle, NM Davies, AK Giese, MK Ikram, SJ Kittner, B McKnight, BM Psaty, AP Reiner, M Sargurupremraj, KD Taylor, , , M Fornage, A Hamsten, W März, FR Rosendaal, JC Souto, A Dehghan, AD Johnson, AC Morrison, CJ O'Donnell, NL Smith
Publication Date: 2019-02-28

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 30642921
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

Plos One
JW Cole, H Xu, K Ryan, T Jaworek, N Dueker, P McArdle, B Gaynor, YC Cheng, J O'Connell, S Bevan, R Malik, NU Ahmed, P Amouyel, S Anjum, JC Bis, D Crosslin, J Danesh, ST Engelter, M Fornage, P Frossard, C Gieger, AK Giese, C Grond-Ginsbach, WK Ho, E Holliday, J Hopewell, M Hussain, W Iqbal, S Jabeen, J Jannes, A Kamal, Y Kamatani, S Kanse, M Kloss, M Lathrop, D Leys, A Lindgren, WT Longstreth, K Mahmood, C Meisinger, TM Metso, T Mosley, M Müller-Nurasyid, B Norrving, E Parati, A Peters, A Pezzini, I Quereshi, A Rasheed, A Rauf, T Salam, J Shen, A Słowik, T Stanne, K Strauch, T Tatlisumak, VN Thijs, S Tiedt, M Traylor, M Waldenberger, M Walters, W Zhao, G Boncoraglio, S Debette, C Jern, C Levi, H Markus, J Meschia, A Rolfs, P Rothwell, D Saleheen, S Seshadri, P Sharma, C Sudlow, B Worrall, , , OC Stine, SJ Kittner, BD Mitchell
Publication Date: 2018

Variant appearance in text: rs867186
PubMed Link: 30383853
Variant Present in the following documents:
  • Main text
  • pone.0206554.s001.docx
View BVdb publication page



Druggability of Coronary Artery Disease Risk Loci.

Circulation. Genomic And Precision Medicine
V Tragante, D Hemerich, M Alshabeeb, I Brænne, H Lempiäinen, RS Patel, HM den Ruijter, MR Barnes, JH Moore, H Schunkert, J Erdmann, FW Asselbergs
Publication Date: 2018-08

Variant appearance in text: rs867186
PubMed Link: 30354342
Variant Present in the following documents:
  • NIHMS976601-supplement-001977_-_Supplemental_Material.pdf
View BVdb publication page



An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU.

Critical Care (London, England)
A Chapelet, Y Foucher, N Gérard, C Rousseau, O Zambon, C Bretonnière, JP Mira, B Charreau, C Guitton
Publication Date: 2018-10-05

Variant appearance in text: rs867186
PubMed Link: 30290852
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.

Scientific Reports
M Munz, GM Richter, BG Loos, S Jepsen, K Divaris, S Offenbacher, A Teumer, B Holtfreter, T Kocher, C Bruckmann, Y Jockel-Schneider, C Graetz, L Munoz, A Bhandari, S Tennstedt, I Staufenbiel, N van der Velde, AG Uitterlinden, LCPGM de Groot, J Wellmann, K Berger, B Krone, P Hoffmann, M Laudes, W Lieb, A Franke, H Dommisch, J Erdmann, AS Schaefer
Publication Date: 2018-09-12

Variant appearance in text: rs867186
PubMed Link: 30209331
Variant Present in the following documents:
  • 41598_2018_31980_MOESM2_ESM.xlsx
View BVdb publication page



Co-regulatory networks of human serum proteins link genetics to disease.

Science (New York, N.Y.)
V Emilsson, M Ilkov, JR Lamb, N Finkel, EF Gudmundsson, R Pitts, H Hoover, V Gudmundsdottir, SR Horman, T Aspelund, L Shu, V Trifonov, S Sigurdsson, A Manolescu, J Zhu, Ö Olafsson, J Jakobsdottir, SA Lesley, J To, J Zhang, TB Harris, LJ Launer, B Zhang, G Eiriksdottir, X Yang, AP Orth, LL Jennings, V Gudnason
Publication Date: 2018-08-24

Variant appearance in text: rs867186
PubMed Link: 30072576
Variant Present in the following documents:
  • NIHMS988330-supplement-Supplementary_Materials.pdf
View BVdb publication page



Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.

Frontiers In Cardiovascular Medicine
B Vilne, H Schunkert
Publication Date: 2018

Variant appearance in text: rs867186
PubMed Link: 30065929
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.

Cardiovascular Diabetology
R Charmet, S Duffy, S Keshavarzi, B Gyorgy, M Marre, P Rossing, AJ McKnight, AP Maxwell, TVS Ahluwalia, AD Paterson, DA Trégouët, S Hadjadj
Publication Date: 2018-04-25

Variant appearance in text: rs867186
PubMed Link: 29695241
Variant Present in the following documents:
  • 12933_2018_705_MOESM6_ESM.xlsx
  • aaaaaMain text
View BVdb publication page



Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension.

International Journal Of Endocrinology
AB Azam, EAB Azizan
Publication Date: 2018

Variant appearance in text: rs867186
PubMed Link: 29666641
Variant Present in the following documents:
  • Main text
View BVdb publication page



The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients.

Infectious Diseases And Therapy
AG Vassiliou, A Kotanidou, Z Mastora, C Tascini, G Cardinali, SE Orfanos
Publication Date: 2018-03

Variant appearance in text: rs867186
PubMed Link: 29549653
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide analysis yields new loci associating with aortic valve stenosis.

Nature Communications
A Helgadottir, G Thorleifsson, S Gretarsdottir, OA Stefansson, V Tragante, RB Thorolfsdottir, I Jonsdottir, T Bjornsson, V Steinthorsdottir, N Verweij, JB Nielsen, W Zhou, L Folkersen, A Martinsson, M Heydarpour, S Prakash, G Oskarsson, T Gudbjartsson, A Geirsson, I Olafsson, EL Sigurdsson, P Almgren, O Melander, A Franco-Cereceda, A Hamsten, L Fritsche, M Lin, B Yang, W Hornsby, D Guo, CM Brummett, G Abecasis, M Mathis, D Milewicz, SC Body, P Eriksson, CJ Willer, K Hveem, C Newton-Cheh, JG Smith, R Danielsen, G Thorgeirsson, U Thorsteinsdottir, DF Gudbjartsson, H Holm, K Stefansson
Publication Date: 2018-03-07

Variant appearance in text: rs867186
PubMed Link: 29511194
Variant Present in the following documents:
  • 41467_2018_3252_MOESM7_ESM.xlsx
  • 41467_2018_3252_MOESM8_ESM.xlsx
View BVdb publication page



Atherosclerosis Is an Inflammatory Disease which Lacks a Common Anti-inflammatory Therapy: How Human Genetics Can Help to This Issue. A Narrative Review.

Frontiers In Pharmacology
C Fava, M Montagnana
Publication Date: 2018

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 29467655
Variant Present in the following documents:
  • Main text
View BVdb publication page



Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis.

Journal Of Proteomics And Genomics Research
C Mao, TD Howard, D Sullivan, Z Fu, G Yu, SJ Parker, R Will, RS Vander Heide, Y Wang, J Hixson, J Van Eyk, DM Herrington
Publication Date: 2017

Variant appearance in text: rs867186
PubMed Link: 29367937
Variant Present in the following documents:
  • NIHMS868301-supplement-supplemental_table_s1.xlsx
View BVdb publication page



Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss.

Journal Of Assisted Reproduction And Genetics
LA Arias-Sosa, ID Acosta, E Lucena-Quevedo, H Moreno-Ortiz, C Esteban-Pérez, M Forero-Castro
Publication Date: 2018-03

Variant appearance in text: rs867186
PubMed Link: 29313278
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphism of the ABO gene associate with thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria.

Oncotarget
Z Long, Y Du, H Li, B Han
Publication Date: 2017-11-03

Variant appearance in text: rs867186
PubMed Link: 29190926
Variant Present in the following documents:
  • Main text
  • oncotarget-08-92411-s001.pdf
View BVdb publication page



Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.

Journal Of Thrombosis And Haemostasis : Jth
NC Olson, LM Raffield, LA Lange, EM Lange, WT Longstreth, G Chauhan, S Debette, S Seshadri, AP Reiner, RP Tracy
Publication Date: 2018-01

Variant appearance in text: EPCR: Ser219Gly; rs867186
PubMed Link: 29112333
Variant Present in the following documents:
  • Main text
View BVdb publication page



Risk prediction of developing venous thrombosis in combined oral contraceptive users.

Plos One
A McDaid, E Logette, V Buchillier, M Muriset, P Suchon, TD Pache, G Tanackovic, Z Kutalik, J Michaud
Publication Date: 2017

Variant appearance in text: rs867186
PubMed Link: 28750087
Variant Present in the following documents:
  • pone.0182041.s001.docx
View BVdb publication page



Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Hypertension (Dallas, Tex. : 1979)
LV Wain, A Vaez, R Jansen, R Joehanes, PJ van der Most, AM Erzurumluoglu, PF O'Reilly, CP Cabrera, HR Warren, LM Rose, GC Verwoert, JJ Hottenga, RJ Strawbridge, T Esko, DE Arking, SJ Hwang, X Guo, Z Kutalik, S Trompet, N Shrine, A Teumer, JS Ried, JC Bis, AV Smith, N Amin, IM Nolte, LP Lyytikäinen, A Mahajan, NJ Wareham, E Hofer, PK Joshi, K Kristiansson, M Traglia, AS Havulinna, A Goel, MA Nalls, S Sõber, D Vuckovic, J Luan, F Del Greco M, KL Ayers, J Marrugat, D Ruggiero, LM Lopez, T Niiranen, S Enroth, AU Jackson, CP Nelson, JE Huffman, W Zhang, J Marten, I Gandin, SE Harris, T Zemunik, Y Lu, E Evangelou, N Shah, MH de Borst, M Mangino, BP Prins, A Campbell, R Li-Gao, G Chauhan, C Oldmeadow, G Abecasis, M Abedi, CM Barbieri, MR Barnes, C Batini, J Beilby, T Blake, M Boehnke, EP Bottinger, PS Braund, M Brown, M Brumat, H Campbell, JC Chambers, M Cocca, F Collins, J Connell, HJ Cordell, JJ Damman, G Davies, EJ de Geus, R de Mutsert, J Deelen, Y Demirkale, ASF Doney, M Dörr, M Farrall, T Ferreira, M Frånberg, H Gao, V Giedraitis, C Gieger, F Giulianini, AJ Gow, A Hamsten, TB Harris, A Hofman, EG Holliday, J Hui, MR Jarvelin, Å Johansson, AD Johnson, P Jousilahti, A Jula, M Kähönen, S Kathiresan, KT Khaw, I Kolcic, S Koskinen, C Langenberg, M Larson, LJ Launer, B Lehne, DCM Liewald, L Lin, L Lind, F Mach, C Mamasoula, C Menni, B Mifsud, Y Milaneschi, A Morgan, AD Morris, AC Morrison, PJ Munson, P Nandakumar, QT Nguyen, T Nutile, AJ Oldehinkel, BA Oostra, E Org, S Padmanabhan, A Palotie, G Paré, A Pattie, BWJH Penninx, N Poulter, PP Pramstaller, OT Raitakari, M Ren, K Rice, PM Ridker, H Riese, S Ripatti, A Robino, JI Rotter, I Rudan, Y Saba, A Saint Pierre, CF Sala, AP Sarin, R Schmidt, R Scott, MA Seelen, DC Shields, D Siscovick, R Sorice, A Stanton, DJ Stott, J Sundström, M Swertz, KD Taylor, S Thom, I Tzoulaki, C Tzourio, AG Uitterlinden, U Völker, P Vollenweider, S Wild, G Willemsen, AF Wright, J Yao, S Thériault, D Conen, J Attia, P Sever, S Debette, DO Mook-Kanamori, E Zeggini, TD Spector, P van der Harst, CNA Palmer, AC Vergnaud, RJF Loos, O Polasek, JM Starr, G Girotto, C Hayward, JS Kooner, CM Lindgren, V Vitart, NJ Samani, J Tuomilehto, U Gyllensten, P Knekt, IJ Deary, M Ciullo, R Elosua, BD Keavney, AA Hicks, RA Scott, P Gasparini, M Laan, Y Liu, H Watkins, CA Hartman, V Salomaa, D Toniolo, M Perola, JF Wilson, H Schmidt, JH Zhao, T Lehtimäki, CM van Duijn, V Gudnason, BM Psaty, A Peters, R Rettig, A James, JW Jukema, DP Strachan, W Palmas, A Metspalu, E Ingelsson, DI Boomsma, OH Franco, M Bochud, C Newton-Cheh, PB Munroe, P Elliott, DI Chasman, A Chakravarti, J Knight, AP Morris, D Levy, MD Tobin, H Snieder, MJ Caulfield, GB Ehret
Publication Date: 2017-07-24

Variant appearance in text: rs867186
PubMed Link: 28739976
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin.

Plos One
S Maknitikul, N Luplertlop, GER Grau, S Ampawong
Publication Date: 2017

Variant appearance in text: rs867186
PubMed Link: 28732053
Variant Present in the following documents:
  • Main text
View BVdb publication page



EPCR Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects.

Frontiers In Physiology
YY Li, JJ Wu, XX Yang, HY Geng, G Gong, HJ Kim
Publication Date: 2017

Variant appearance in text: EPCR: Ser219Gly; rs867186
PubMed Link: 28603500
Variant Present in the following documents:
  • Main text
View BVdb publication page



Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nature Genetics
JMM Howson, W Zhao, DR Barnes, WK Ho, R Young, DS Paul, LL Waite, DF Freitag, EB Fauman, EL Salfati, BB Sun, JD Eicher, AD Johnson, WHH Sheu, SF Nielsen, WY Lin, P Surendran, A Malarstig, JB Wilk, A Tybjærg-Hansen, KL Rasmussen, PR Kamstrup, P Deloukas, J Erdmann, S Kathiresan, NJ Samani, H Schunkert, H Watkins, , R Do, DJ Rader, JA Johnson, SL Hazen, AA Quyyumi, JA Spertus, CJ Pepine, N Franceschini, A Justice, AP Reiner, S Buyske, LA Hindorff, CL Carty, KE North, C Kooperberg, E Boerwinkle, K Young, M Graff, U Peters, D Absher, CA Hsiung, WJ Lee, KD Taylor, YH Chen, IT Lee, X Guo, RH Chung, YJ Hung, JI Rotter, JJ Juang, T Quertermous, TD Wang, A Rasheed, P Frossard, DS Alam, AAS Majumder, E Di Angelantonio, R Chowdhury, , YI Chen, BG Nordestgaard, TL Assimes, J Danesh, AS Butterworth, D Saleheen
Publication Date: 2017-07

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 28530674
Variant Present in the following documents:
  • Main text
  • NIHMS73649-supplement-Supplementary_Information.pdf
  • NIHMS73649-supplement-Supplementary_Tables.xlsx
View BVdb publication page



Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.

Human Genetics
S Lindström, M Germain, M Crous-Bou, EN Smith, PE Morange, A van Hylckama Vlieg, HG de Haan, D Chasman, P Ridker, J Brody, M de Andrade, JA Heit, W Tang, I DeVivo, F Grodstein, NL Smith, D Tregouet, C Kabrhel,
Publication Date: 2017-07

Variant appearance in text: rs867186
PubMed Link: 28528403
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population.

The Journal Of International Medical Research
Y Liang, X Huang, Y Jiang, Y Qin, D Peng, Y Huang, J Li, SR Sooranna, L Pinhu
Publication Date: 2017-04

Variant appearance in text: rs867186
PubMed Link: 28415941
Variant Present in the following documents:
  • Main text
View BVdb publication page



Connecting genetic risk to disease end points through the human blood plasma proteome.

Nature Communications
K Suhre, M Arnold, AM Bhagwat, RJ Cotton, R Engelke, J Raffler, H Sarwath, G Thareja, A Wahl, RK DeLisle, L Gold, M Pezer, G Lauc, MA El-Din Selim, DO Mook-Kanamori, EK Al-Dous, YA Mohamoud, J Malek, K Strauch, H Grallert, A Peters, G Kastenmüller, C Gieger, J Graumann
Publication Date: 2017-02-27

Variant appearance in text: rs867186
PubMed Link: 28240269
Variant Present in the following documents:
  • Main text
  • ncomms14357-s1.pdf
  • ncomms14357-s2.xlsx
View BVdb publication page



Identification of unique venous thromboembolism-susceptibility variants in African-Americans.

Thrombosis And Haemostasis
JA Heit, SM Armasu, BM McCauley, IJ Kullo, H Sicotte, J Pathak, CG Chute, O Gottesman, EP Bottinger, JC Denny, DM Roden, R Li, MD Ritchie, M de Andrade
Publication Date: 2017-04-03

Variant appearance in text: rs867186
PubMed Link: 28203683
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).

Arteriosclerosis, Thrombosis, And Vascular Biology
JS Pankow, W Tang, N Pankratz, W Guan, LC Weng, M Cushman, E Boerwinkle, AR Folsom
Publication Date: 2017-03

Variant appearance in text: rs867186
PubMed Link: 28082259
Variant Present in the following documents:
  • Main text
View BVdb publication page



Bipartite Community Structure of eQTLs.

Plos Computational Biology
J Platig, PJ Castaldi, D DeMeo, J Quackenbush
Publication Date: 2016-09

Variant appearance in text: rs867186
PubMed Link: 27618581
Variant Present in the following documents:
  • pcbi.1005033.s013.xlsx
View BVdb publication page



Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Nature Genetics
P Surendran, F Drenos, R Young, H Warren, JP Cook, AK Manning, N Grarup, X Sim, DR Barnes, K Witkowska, JR Staley, V Tragante, T Tukiainen, H Yaghootkar, N Masca, DF Freitag, T Ferreira, O Giannakopoulou, A Tinker, M Harakalova, E Mihailov, C Liu, AT Kraja, S Fallgaard Nielsen, A Rasheed, M Samuel, W Zhao, LL Bonnycastle, AU Jackson, N Narisu, AJ Swift, L Southam, J Marten, JR Huyghe, A Stančáková, C Fava, T Ohlsson, A Matchan, KE Stirrups, J Bork-Jensen, AP Gjesing, J Kontto, M Perola, S Shaw-Hawkins, AS Havulinna, H Zhang, LA Donnelly, CJ Groves, NW Rayner, MJ Neville, NR Robertson, AM Yiorkas, KH Herzig, E Kajantie, W Zhang, SM Willems, L Lannfelt, G Malerba, N Soranzo, E Trabetti, N Verweij, E Evangelou, A Moayyeri, AC Vergnaud, CP Nelson, A Poveda, TV Varga, M Caslake, AJ de Craen, S Trompet, J Luan, RA Scott, SE Harris, DC Liewald, R Marioni, C Menni, AE Farmaki, G Hallmans, F Renström, JE Huffman, M Hassinen, S Burgess, RS Vasan, JF Felix, , M Uria-Nickelsen, A Malarstig, DF Reily, M Hoek, T Vogt, H Lin, W Lieb, , M Traylor, HF Markus, , HM Highland, AE Justice, E Marouli, , J Lindström, M Uusitupa, P Komulainen, TA Lakka, R Rauramaa, O Polasek, I Rudan, O Rolandsson, PW Franks, G Dedoussis, TD Spector, , P Jousilahti, S Männistö, IJ Deary, JM Starr, C Langenberg, NJ Wareham, MJ Brown, AF Dominiczak, JM Connell, JW Jukema, N Sattar, I Ford, CJ Packard, T Esko, R Mägi, A Metspalu, RA de Boer, P van der Meer, P van der Harst, , G Gambaro, E Ingelsson, L Lind, PI de Bakker, ME Numans, I Brandslund, C Christensen, ER Petersen, E Korpi-Hyövälti, H Oksa, JC Chambers, JS Kooner, AI Blakemore, S Franks, MR Jarvelin, LL Husemoen, A Linneberg, T Skaaby, B Thuesen, F Karpe, J Tuomilehto, AS Doney, AD Morris, CN Palmer, OL Holmen, K Hveem, CJ Willer, T Tuomi, L Groop, A Käräjämäki, A Palotie, S Ripatti, V Salomaa, DS Alam, AA Shafi Majumder, E Di Angelantonio, R Chowdhury, MI McCarthy, N Poulter, AV Stanton, P Sever, P Amouyel, D Arveiler, S Blankenberg, J Ferrières, F Kee, K Kuulasmaa, M Müller-Nurasyid, G Veronesi, J Virtamo, P Deloukas, , P Elliott, , E Zeggini, S Kathiresan, O Melander, J Kuusisto, M Laakso, S Padmanabhan, D Porteous, C Hayward, G Scotland, FS Collins, KL Mohlke, T Hansen, O Pedersen, M Boehnke, HM Stringham, , P Frossard, C Newton-Cheh, , MD Tobin, BG Nordestgaard, , , , , MJ Caulfield, A Mahajan, AP Morris, M Tomaszewski, NJ Samani, D Saleheen, FW Asselbergs, CM Lindgren, J Danesh, LV Wain, AS Butterworth, JM Howson, PB Munroe
Publication Date: 2016-10

Variant appearance in text: rs867186
PubMed Link: 27618447
Variant Present in the following documents:
  • Main text
  • NIHMS69533-supplement-Supplementary_Tables.xlsx
View BVdb publication page



Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.

Nature Communications
CL Miller, M Pjanic, T Wang, T Nguyen, A Cohain, JD Lee, L Perisic, U Hedin, RK Kundu, D Majmudar, JB Kim, O Wang, C Betsholtz, A Ruusalepp, O Franzén, TL Assimes, SB Montgomery, EE Schadt, JLM Björkegren, T Quertermous
Publication Date: 2016-07-08

Variant appearance in text: rs867186
PubMed Link: 27386823
Variant Present in the following documents:
  • Main text
  • ncomms12092-s5.xlsx
  • ncomms12092-s6.xlsx
View BVdb publication page



The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.

Scientific Reports
E Shabani, RO Opoka, P Bangirana, GS Park, GM Vercellotti, W Guan, JS Hodges, T Lavstsen, CC John
Publication Date: 2016-06-03

Variant appearance in text: rs867186
PubMed Link: 27255786
Variant Present in the following documents:
  • Main text
  • srep27084-s1.pdf
View BVdb publication page



Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.

Critical Care (London, England)
A Sapru, KD Liu, J Wiemels, H Hansen, L Pawlikowska, A Poon, E Jorgenson, JS Witte, CS Calfee, LB Ware, MA Matthay,
Publication Date: 2016-05-23

Variant appearance in text: rs867186
PubMed Link: 27215212
Variant Present in the following documents:
  • 13054_2016_1330_MOESM1_ESM.doc
View BVdb publication page



Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Nature Communications
J Kettunen, A Demirkan, P Würtz, HH Draisma, T Haller, R Rawal, A Vaarhorst, AJ Kangas, LP Lyytikäinen, M Pirinen, R Pool, AP Sarin, P Soininen, T Tukiainen, Q Wang, M Tiainen, T Tynkkynen, N Amin, T Zeller, M Beekman, J Deelen, KW van Dijk, T Esko, JJ Hottenga, EM van Leeuwen, T Lehtimäki, E Mihailov, RJ Rose, AJ de Craen, C Gieger, M Kähönen, M Perola, S Blankenberg, MJ Savolainen, A Verhoeven, J Viikari, G Willemsen, DI Boomsma, CM van Duijn, J Eriksson, A Jula, MR Järvelin, J Kaprio, A Metspalu, O Raitakari, V Salomaa, PE Slagboom, M Waldenberger, S Ripatti, M Ala-Korpela
Publication Date: 2016-03-23

Variant appearance in text: rs867186
PubMed Link: 27005778
Variant Present in the following documents:
  • ncomms11122-s1.pdf
View BVdb publication page



Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.

Circulation Research
M LeBlanc, V Zuber, BK Andreassen, A Witoelar, L Zeng, F Bettella, Y Wang, LK McEvoy, WK Thompson, AJ Schork, S Reppe, E Barrett-Connor, S Ligthart, A Dehghan, KM Gautvik, CP Nelson, H Schunkert, NJ Samani, , PM Ridker, DI Chasman, P Aukrust, S Djurovic, A Frigessi, RS Desikan, AM Dale, OA Andreassen
Publication Date: 2016-01-08

Variant appearance in text: rs867186
PubMed Link: 26487741
Variant Present in the following documents:
  • Main text
View BVdb publication page



CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.

Genome Biology
L Wang, SH Oehlers, ST Espenschied, JF Rawls, DM Tobin, DC Ko
Publication Date: 2015-09-15

Variant appearance in text: rs867186
PubMed Link: 26374098
Variant Present in the following documents:
  • 13059_2015_722_MOESM1_ESM.docx
View BVdb publication page



Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

Arteriosclerosis, Thrombosis, And Vascular Biology
I Brænne, M Civelek, B Vilne, A Di Narzo, AD Johnson, Y Zhao, B Reiz, V Codoni, TR Webb, H Foroughi Asl, SE Hamby, L Zeng, DA Trégouët, K Hao, EJ Topol, EE Schadt, X Yang, NJ Samani, JL Björkegren, J Erdmann, H Schunkert, AJ Lusis,
Publication Date: 2015-10

Variant appearance in text: PROCR: S219G; rs867186
PubMed Link: 26293461
Variant Present in the following documents:
  • Main text
  • NIHMS714198-supplement-4.xlsx
  • NIHMS714198-supplement-5.xlsx
  • NIHMS714198-supplement-7.xlsx
  • NIHMS714198-supplement-8.xlsx
View BVdb publication page



Dissecting the genetic determinants of hemostasis and thrombosis.

Current Opinion In Hematology
KC Desch
Publication Date: 2015-09

Variant appearance in text: rs867186
PubMed Link: 26248003
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tobacco smoking is associated with methylation of genes related to coronary artery disease.

Clinical Epigenetics
RV Steenaard, S Ligthart, L Stolk, MJ Peters, JB van Meurs, AG Uitterlinden, A Hofman, OH Franco, A Dehghan
Publication Date: 2015

Variant appearance in text: rs867186
PubMed Link: 26015811
Variant Present in the following documents:
  • 13148_2015_88_MOESM1_ESM.xlsx
View BVdb publication page



Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology.

Plos One
F Drenos, E Grossi, M Buscema, SE Humphries
Publication Date: 2015

Variant appearance in text: rs867186
PubMed Link: 25951190
Variant Present in the following documents:
  • Main text
  • pone.0125876.s006.xlsx
  • pone.0125876.s007.xlsx
  • pone.0125876.s008.xlsx
View BVdb publication page



Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

American Journal Of Human Genetics
M Germain, DI Chasman, H de Haan, W Tang, S Lindström, LC Weng, M de Andrade, MC de Visser, KL Wiggins, P Suchon, N Saut, DM Smadja, G Le Gal, A van Hylckama Vlieg, A Di Narzo, K Hao, CP Nelson, A Rocanin-Arjo, L Folkersen, R Monajemi, LM Rose, JA Brody, E Slagboom, D Aïssi, F Gagnon, JF Deleuze, P Deloukas, C Tzourio, JF Dartigues, C Berr, KD Taylor, M Civelek, P Eriksson, , BM Psaty, J Houwing-Duitermaat, AH Goodall, F Cambien, P Kraft, P Amouyel, NJ Samani, S Basu, PM Ridker, FR Rosendaal, C Kabrhel, AR Folsom, J Heit, PH Reitsma, DA Trégouët, NL Smith, PE Morange
Publication Date: 2015-04-02

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 25772935
Variant Present in the following documents:
  • mmc1.pdf
  • mmc3.pdf
View BVdb publication page



Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children.

Plos One
K Schuldt, C Ehmen, J Evans, J May, D Ansong, J Sievertsen, B Muntau, G Ruge, T Agbenyega, RD Horstmann
Publication Date: 2014

Variant appearance in text: rs867186
PubMed Link: 25541704
Variant Present in the following documents:
  • Main text
  • pone.0115770.s002.doc
View BVdb publication page



Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study.

Bmc Cancer
M Tinholt, MK Viken, AE Dahm, HK Vollan, KK Sahlberg, O Garred, AL Børresen-Dale, AF Jacobsen, V Kristensen, I Bukholm, R Kåresen, E Schlichting, G Skretting, BA Lie, PM Sandset, N Iversen
Publication Date: 2014-11-19

Variant appearance in text: rs867186
PubMed Link: 25407022
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study.

Genetic Epidemiology
MS Munir, LC Weng, W Tang, S Basu, JS Pankow, N Matijevic, M Cushman, E Boerwinkle, AR Folsom
Publication Date: 2014-12

Variant appearance in text: PROCR: S219G; rs867186
PubMed Link: 25376901
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.

Blood
LV Mohan Rao, CT Esmon, UR Pendurthi
Publication Date: 2014-09-04

Variant appearance in text: rs867186
PubMed Link: 25049281
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cis and trans effects of human genomic variants on gene expression.

Plos Genetics
J Bryois, A Buil, DM Evans, JP Kemp, SB Montgomery, DF Conrad, KM Ho, S Ring, M Hurles, P Deloukas, G Davey Smith, ET Dermitzakis
Publication Date: 2014-07

Variant appearance in text: rs867186
PubMed Link: 25010687
Variant Present in the following documents:
  • pgen.1004461.s012.xlsx
View BVdb publication page



Single nucleotide variants in the protein C pathway and mortality in dialysis patients.

Plos One
G Ocak, C Drechsler, CY Vossen, HL Vos, FR Rosendaal, PH Reitsma, MM Hoffmann, W März, WH Ouwehand, RT Krediet, EW Boeschoten, FW Dekker, C Wanner, M Verduijn
Publication Date: 2014

Variant appearance in text: rs867186
PubMed Link: 24816905
Variant Present in the following documents:
  • Main text
View BVdb publication page



A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.

Nature Genetics
S Kohsaka, N Shukla, N Ameur, T Ito, CK Ng, L Wang, D Lim, A Marchetti, A Viale, M Pirun, ND Socci, LX Qin, R Sciot, J Bridge, S Singer, P Meyers, LH Wexler, FG Barr, S Dogan, JA Fletcher, JS Reis-Filho, M Ladanyi
Publication Date: 2014-06

Variant appearance in text: rs867186
PubMed Link: 24793135
Variant Present in the following documents:
  • NIHMS635209-supplement-Table_3.xlsx
View BVdb publication page



The Effects of Endothelial Protein C Receptor Gene Polymorphisms on the Plasma sEPCR Level in Venous Thrombosis Patients.

Turkish Journal Of Haematology : Official Journal Of Turkish Society Of Haematology
A Karabıyık, E Yılmaz, Y Eğin, N Akar
Publication Date: 2012-03

Variant appearance in text: EPCR: ser219gly; rs867186
PubMed Link: 24744624
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.

Malaria Journal
I Naka, J Patarapotikul, H Hananantachai, H Imai, J Ohashi
Publication Date: 2014-03-17

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 24635948
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endothelial protein C receptor and pediatric arterial stroke.

Turkish Journal Of Haematology : Official Journal Of Turkish Society Of Haematology
N Akar, A Karabıyık, G Deda
Publication Date: 2013-03

Variant appearance in text: EPCR: ser219gly; rs867186
PubMed Link: 24385751
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.

Plos One
JD Mosley, SL Van Driest, EK Larkin, PE Weeke, JS Witte, QS Wells, JH Karnes, Y Guo, L Bastarache, LM Olson, CA McCarty, JA Pacheco, GP Jarvik, DS Carrell, EB Larson, DR Crosslin, IJ Kullo, G Tromp, H Kuivaniemi, DJ Carey, MD Ritchie, JC Denny, DM Roden
Publication Date: 2013

Variant appearance in text: rs867186
PubMed Link: 24349080
Variant Present in the following documents:
  • pone.0081503.s006.xlsx
View BVdb publication page



Biobanking across the phenome - at the center of chronic disease research.

Bmc Public Health
M Imboden, NM Probst-Hensch
Publication Date: 2013-11-25

Variant appearance in text: rs867186
PubMed Link: 24274136
Variant Present in the following documents:
  • 1471-2458-13-1094-S2.xlsx
View BVdb publication page



Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.

Thrombosis And Haemostasis
TR Gaunt, D Zabaneh, S Shah, A Guyatt, C Ladroue, M Kumari, F Drenos, T Shah, PJ Talmud, JP Casas, G Lowe, A Rumley, DA Lawlor, M Kivimaki, J Whittaker, AD Hingorani, SE Humphries, IN Day
Publication Date: 2013-11

Variant appearance in text: rs867186
PubMed Link: 24178511
Variant Present in the following documents:
  • NIHMS58613-supplement-Supplementary_Data.doc
View BVdb publication page



Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.

Intensive Care Medicine
AG Vassiliou, NA Maniatis, A Kotanidou, M Kallergi, FS Karystinaki, E Letsiou, C Glynos, P Kopterides, D Vassiliadi, N Nikitas, I Dimopoulou, A Armaganidis, SE Orfanos
Publication Date: 2013-10

Variant appearance in text: EPCR: Ser219Gly; rs867186
PubMed Link: 23881209
Variant Present in the following documents:
  • Main text
View BVdb publication page



GStream: improving SNP and CNV coverage on genome-wide association studies.

Plos One
A Alonso, S Marsal, R Tortosa, O Canela-Xandri, A Julià
Publication Date: 2013

Variant appearance in text: rs867186
PubMed Link: 23844243
Variant Present in the following documents:
  • pone.0068822.s013.xlsx
View BVdb publication page



Genetic variants associated with protein C levels.

Journal Of Thrombosis And Haemostasis : Jth
CY Vossen, BP Koeleman, SJ Hasstedt, IJ Nijman, IJ Renkens, PW Callas, FR Rosendaal, EG Bovill
Publication Date: 2013-04

Variant appearance in text: rs867186
PubMed Link: 23387557
Variant Present in the following documents:
  • Main text
View BVdb publication page



Large-scale association analysis identifies new risk loci for coronary artery disease.

Nature Genetics
, P Deloukas, S Kanoni, C Willenborg, M Farrall, TL Assimes, JR Thompson, E Ingelsson, D Saleheen, J Erdmann, BA Goldstein, K Stirrups, IR König, JB Cazier, A Johansson, AS Hall, JY Lee, CJ Willer, JC Chambers, T Esko, L Folkersen, A Goel, E Grundberg, AS Havulinna, WK Ho, JC Hopewell, N Eriksson, ME Kleber, K Kristiansson, P Lundmark, LP Lyytikäinen, S Rafelt, D Shungin, RJ Strawbridge, G Thorleifsson, E Tikkanen, N Van Zuydam, BF Voight, LL Waite, W Zhang, A Ziegler, D Absher, D Altshuler, AJ Balmforth, I Barroso, PS Braund, C Burgdorf, S Claudi-Boehm, D Cox, M Dimitriou, R Do, , , AS Doney, N El Mokhtari, P Eriksson, K Fischer, P Fontanillas, A Franco-Cereceda, B Gigante, L Groop, S Gustafsson, J Hager, G Hallmans, BG Han, SE Hunt, HM Kang, T Illig, T Kessler, JW Knowles, G Kolovou, J Kuusisto, C Langenberg, C Langford, K Leander, ML Lokki, A Lundmark, MI McCarthy, C Meisinger, O Melander, E Mihailov, S Maouche, AD Morris, M Müller-Nurasyid, , K Nikus, JF Peden, NW Rayner, A Rasheed, S Rosinger, D Rubin, MP Rumpf, A Schäfer, M Sivananthan, C Song, AF Stewart, ST Tan, G Thorgeirsson, CE van der Schoot, PJ Wagner, , GA Wells, PS Wild, TP Yang, P Amouyel, D Arveiler, H Basart, M Boehnke, E Boerwinkle, P Brambilla, F Cambien, AL Cupples, U de Faire, A Dehghan, P Diemert, SE Epstein, A Evans, MM Ferrario, J Ferrières, D Gauguier, AS Go, AH Goodall, V Gudnason, SL Hazen, H Holm, C Iribarren, Y Jang, M Kähönen, F Kee, HS Kim, N Klopp, W Koenig, W Kratzer, K Kuulasmaa, M Laakso, R Laaksonen, JY Lee, L Lind, WH Ouwehand, S Parish, JE Park, NL Pedersen, A Peters, T Quertermous, DJ Rader, V Salomaa, E Schadt, SH Shah, J Sinisalo, K Stark, K Stefansson, DA Trégouët, J Virtamo, L Wallentin, N Wareham, ME Zimmermann, MS Nieminen, C Hengstenberg, MS Sandhu, T Pastinen, AC Syvänen, GK Hovingh, G Dedoussis, PW Franks, T Lehtimäki, A Metspalu, PA Zalloua, A Siegbahn, S Schreiber, S Ripatti, SS Blankenberg, M Perola, R Clarke, BO Boehm, C O'Donnell, MP Reilly, W März, R Collins, S Kathiresan, A Hamsten, JS Kooner, U Thorsteinsdottir, J Danesh, CN Palmer, R Roberts, H Watkins, H Schunkert, NJ Samani
Publication Date: 2013-01

Variant appearance in text: rs867186
PubMed Link: 23202125
Variant Present in the following documents:
  • NIHMS468575-supplement-Supplementary_data.pdf
  • NIHMS468575-supplement-Supplementary_table_09.pdf
View BVdb publication page



Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study.

Bmc Medical Genetics
C Kallel, W Cohen, N Saut, S Blankenberg, R Schnabel, HJ Rupprecht, C Bickel, T Munzel, DA Tregouet, PE Morange
Publication Date: 2012-11-08

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 23136988
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mapping cis- and trans-regulatory effects across multiple tissues in twins.

Nature Genetics
E Grundberg, KS Small, ÅK Hedman, AC Nica, A Buil, S Keildson, JT Bell, TP Yang, E Meduri, A Barrett, J Nisbett, M Sekowska, A Wilk, SY Shin, D Glass, M Travers, JL Min, S Ring, K Ho, G Thorleifsson, A Kong, U Thorsteindottir, C Ainali, AS Dimas, N Hassanali, C Ingle, D Knowles, M Krestyaninova, CE Lowe, P Di Meglio, SB Montgomery, L Parts, S Potter, G Surdulescu, L Tsaprouni, S Tsoka, V Bataille, R Durbin, FO Nestle, S O'Rahilly, N Soranzo, CM Lindgren, KT Zondervan, KR Ahmadi, EE Schadt, K Stefansson, GD Smith, MI McCarthy, P Deloukas, ET Dermitzakis, TD Spector,
Publication Date: 2012-10

Variant appearance in text: rs867186
PubMed Link: 22941192
Variant Present in the following documents:
  • NIHMS50099-supplement-1.pdf
View BVdb publication page



Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

American Journal Of Human Genetics
W Tang, C Schwienbacher, LM Lopez, Y Ben-Shlomo, T Oudot-Mellakh, AD Johnson, NJ Samani, S Basu, M Gögele, G Davies, GD Lowe, DA Tregouet, A Tan, JS Pankow, A Tenesa, D Levy, CB Volpato, A Rumley, AJ Gow, C Minelli, JW Yarnell, DJ Porteous, JM Starr, J Gallacher, E Boerwinkle, PM Visscher, PP Pramstaller, M Cushman, V Emilsson, AS Plump, N Matijevic, PE Morange, IJ Deary, AA Hicks, AR Folsom
Publication Date: 2012-07-13

Variant appearance in text: rs867186
PubMed Link: 22703881
Variant Present in the following documents:
  • Main text
  • mmc1.pdf
  • mmc2.xlsx
View BVdb publication page



Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

Neurobiology Of Disease
DG Hernandez, MA Nalls, M Moore, S Chong, A Dillman, D Trabzuni, JR Gibbs, M Ryten, S Arepalli, ME Weale, AB Zonderman, J Troncoso, R O'Brien, R Walker, C Smith, S Bandinelli, BJ Traynor, J Hardy, AB Singleton, MR Cookson
Publication Date: 2012-07

Variant appearance in text: rs867186
PubMed Link: 22433082
Variant Present in the following documents:
  • mmc1.xls
View BVdb publication page



The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

Blood
J Dennis, CY Johnson, AS Adediran, M de Andrade, JA Heit, PE Morange, DA Trégouët, F Gagnon
Publication Date: 2012-03-08

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 22251481
Variant Present in the following documents:
  • Main text
View BVdb publication page



A genome-wide association study of the Protein C anticoagulant pathway.

Plos One
G Athanasiadis, A Buil, JC Souto, M Borrell, S López, A Martinez-Perez, M Lathrop, J Fontcuberta, L Almasy, JM Soria
Publication Date: 2011

Variant appearance in text: EPCR: S219G; rs867186
PubMed Link: 22216198
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetics of venous thrombosis: insights from a new genome wide association study.

Plos One
M Germain, N Saut, N Greliche, C Dina, JC Lambert, C Perret, W Cohen, T Oudot-Mellakh, G Antoni, MC Alessi, D Zelenika, F Cambien, L Tiret, M Bertrand, AM Dupuy, L Letenneur, M Lathrop, J Emmerich, P Amouyel, DA Trégouët, PE Morange
Publication Date: 2011

Variant appearance in text: PROCR: Ser219Gly; rs867186
PubMed Link: 21980494
Variant Present in the following documents:
  • Main text
  • pone.0025581.s001.doc
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000216968.4 c.655A>G p.Ser219Gly missense_variant 4/4 -
ENST00000540582.1 c.-16-29816T>C - intron_variant - 5/13
NM_001355008.2 c.-101-10880T>C - intron_variant - 4/14
NM_006404.5 c.655A>G p.Ser219Gly missense_variant 4/4 -