Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.
Hgg Advances
Young, Kristin L KL; Fisher, Virginia V; Deng, Xuan X; Brody, Jennifer A JA; Graff, Misa M; Lim, Elise E; Lin, Bridget M BM; Xu, Hanfei H; Amin, Najaf N; An, Ping P; Aslibekyan, Stella S; Fohner, Alison E AE; Hidalgo, Bertha B; Lenzini, Petra P; Kraaij, Robert R; Medina-Gomez, Carolina C; Prokić, Ivana I; Rivadeneira, Fernando F; Sitlani, Colleen C; Tao, Ran R; van Rooij, Jeroen J; Zhang, Di D; Broome, Jai G JG; Buth, Erin J EJ; Heavner, Benjamin D BD; Jain, Deepti D; Smith, Albert V AV; Barnes, Kathleen K; Boorgula, Meher Preethi MP; Chavan, Sameer S; Darbar, Dawood D; De Andrade, Mariza M; Guo, Xiuqing X; Haessler, Jeffrey J; Irvin, Marguerite R MR; Kalyani, Rita R RR; Kardia, Sharon L R SLR; Kooperberg, Charles C; Kim, Wonji W; Mathias, Rasika A RA; McDonald, Merry-Lynn ML; Mitchell, Braxton D BD; Peyser, Patricia A PA; Regan, Elizabeth A EA; Redline, Susan S; Reiner, Alexander P AP; Rich, Stephen S SS; Rotter, Jerome I JI; Smith, Jennifer A JA; Weiss, Scott S; Wiggins, Kerri L KL; Yanek, Lisa R LR; Arnett, Donna D; Heard-Costa, Nancy L NL; Leal, Suzanne S; Lin, Danyu D; McKnight, Barbara B; Province, Michael M; van Duijn, Cornelia M CM; North, Kari E KE; Cupples, L Adrienne LA; Liu, Ching-Ti CT
Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations.
Genes
Primorac, Dragan D; Molnar, Vilim V; Rod, Eduard E; Jeleč, Željko Ž; Čukelj, Fabijan F; Matišić, Vid V; Vrdoljak, Trpimir T; Hudetz, Damir D; Hajsok, Hana H; Borić, Igor I
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk.
Cell
Richard, Daniel D; Liu, Zun Z; Cao, Jiaxue J; Kiapour, Ata M AM; Willen, Jessica J; Yarlagadda, Siddharth S; Jagoda, Evelyn E; Kolachalama, Vijaya B VB; Sieker, Jakob T JT; Chang, Gary H GH; Muthuirulan, Pushpanathan P; Young, Mariel M; Masson, Anand A; Konrad, Johannes J; Hosseinzadeh, Shayan S; Maridas, David E DE; Rosen, Vicki V; Krawetz, Roman R; Roach, Neil N; Capellini, Terence D TD
Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.
Genome Research
Zhang, Tongwu T; Choi, Jiyeon J; Kovacs, Michael A MA; Shi, Jianxin J; Xu, Mai M; , ; , ; Goldstein, Alisa M AM; Trower, Adam J AJ; Bishop, D Timothy DT; Iles, Mark M MM; Duffy, David L DL; MacGregor, Stuart S; Amundadottir, Laufey T LT; Law, Matthew H MH; Loftus, Stacie K SK; Pavan, William J WJ; Brown, Kevin M KM
Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.
Nature Genetics
Hysi, Pirro G PG; Valdes, Ana M AM; Liu, Fan F; Furlotte, Nicholas A NA; Evans, David M DM; Bataille, Veronique V; Visconti, Alessia A; Hemani, Gibran G; McMahon, George G; Ring, Susan M SM; Smith, George Davey GD; Duffy, David L DL; Zhu, Gu G; Gordon, Scott D SD; Medland, Sarah E SE; Lin, Bochao D BD; Willemsen, Gonneke G; Jan Hottenga, Jouke J; Vuckovic, Dragana D; Girotto, Giorgia G; Gandin, Ilaria I; Sala, Cinzia C; Concas, Maria Pina MP; Brumat, Marco M; Gasparini, Paolo P; Toniolo, Daniela D; Cocca, Massimiliano M; Robino, Antonietta A; Yazar, Seyhan S; Hewitt, Alex W AW; Chen, Yan Y; Zeng, Changqing C; Uitterlinden, Andre G AG; Ikram, M Arfan MA; Hamer, Merel A MA; van Duijn, Cornelia M CM; Nijsten, Tamar T; Mackey, David A DA; Falchi, Mario M; Boomsma, Dorret I DI; Martin, Nicholas G NG; , ; Hinds, David A DA; Kayser, Manfred M; Spector, Timothy D TD
New genetic loci link adipose and insulin biology to body fat distribution.
Nature
Shungin, Dmitry D; Winkler, Thomas W TW; Croteau-Chonka, Damien C DC; Ferreira, Teresa T; Locke, Adam E AE; Mägi, Reedik R; Strawbridge, Rona J RJ; Pers, Tune H TH; Fischer, Krista K; Justice, Anne E AE; Workalemahu, Tsegaselassie T; Wu, Joseph M W JMW; Buchkovich, Martin L ML; Heard-Costa, Nancy L NL; Roman, Tamara S TS; Drong, Alexander W AW; Song, Ci C; Gustafsson, Stefan S; Day, Felix R FR; Esko, Tonu T; Fall, Tove T; Kutalik, Zoltán Z; Luan, Jian'an J; Randall, Joshua C JC; Scherag, André A; Vedantam, Sailaja S; Wood, Andrew R AR; Chen, Jin J; Fehrmann, Rudolf R; Karjalainen, Juha J; Kahali, Bratati B; Liu, Ching-Ti CT; Schmidt, Ellen M EM; Absher, Devin D; Amin, Najaf N; Anderson, Denise D; Beekman, Marian M; Bragg-Gresham, Jennifer L JL; Buyske, Steven S; Demirkan, Ayse A; Ehret, Georg B GB; Feitosa, Mary F MF; Goel, Anuj A; Jackson, Anne U AU; Johnson, Toby T; Kleber, Marcus E ME; Kristiansson, Kati K; Mangino, Massimo M; Leach, Irene Mateo IM; Medina-Gomez, Carolina C; Palmer, Cameron D CD; 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Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.
Plos Genetics
Innocenti, Federico F; Cooper, Gregory M GM; Stanaway, Ian B IB; Gamazon, Eric R ER; Smith, Joshua D JD; Mirkov, Snezana S; Ramirez, Jacqueline J; Liu, Wanqing W; Lin, Yvonne S YS; Moloney, Cliona C; Aldred, Shelly Force SF; Trinklein, Nathan D ND; Schuetz, Erin E; Nickerson, Deborah A DA; Thummel, Ken E KE; Rieder, Mark J MJ; Rettie, Allan E AE; Ratain, Mark J MJ; Cox, Nancy J NJ; Brown, Christopher D CD
Genome-wide association study of height and body mass index in Australian twin families.
Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies
Liu, Jimmy Z JZ; Medland, Sarah E SE; Wright, Margaret J MJ; Henders, Anjali K AK; Heath, Andrew C AC; Madden, Pamela A F PA; Duncan, Alexis A; Montgomery, Grant W GW; Martin, Nicholas G NG; McRae, Allan F AF
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
Human Molecular Genetics
Tönjes, Anke A; Koriath, Moritz M; Schleinitz, Dorit D; Dietrich, Kerstin K; Böttcher, Yvonne Y; Rayner, Nigel W NW; Almgren, Peter P; Enigk, Beate B; Richter, Olaf O; Rohm, Silvio S; Fischer-Rosinsky, Antje A; Pfeiffer, Andreas A; Hoffmann, Katrin K; Krohn, Knut K; Aust, Gabriela G; Spranger, Joachim J; Groop, Leif L; Blüher, Matthias M; Kovacs, Peter P; Stumvoll, Michael M
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
Plos Genetics
Lowe, Jennifer K JK; Maller, Julian B JB; Pe'er, Itsik I; Neale, Benjamin M BM; Salit, Jacqueline J; Kenny, Eimear E EE; Shea, Jessica L JL; Burkhardt, Ralph R; Smith, J Gustav JG; Ji, Weizhen W; Noel, Martha M; Foo, Jia Nee JN; Blundell, Maude L ML; Skilling, Vita V; Garcia, Laura L; Sullivan, Marcia L ML; Lee, Heather E HE; Labek, Anna A; Ferdowsian, Hope H; Auerbach, Steven B SB; Lifton, Richard P RP; Newton-Cheh, Christopher C; Breslow, Jan L JL; Stoffel, Markus M; Daly, Mark J MJ; Altshuler, David M DM; Friedman, Jeffrey M JM
Identification of ten loci associated with height highlights new biological pathways in human growth.
Nature Genetics
Lettre, Guillaume G; Jackson, Anne U AU; Gieger, Christian C; Schumacher, Fredrick R FR; Berndt, Sonja I SI; Sanna, Serena S; Eyheramendy, Susana S; Voight, Benjamin F BF; Butler, Johannah L JL; Guiducci, Candace C; Illig, Thomas T; Hackett, Rachel R; Heid, Iris M IM; Jacobs, Kevin B KB; Lyssenko, Valeriya V; Uda, Manuela M; , ; , ; , ; , ; , ; , ; Boehnke, Michael M; Chanock, Stephen J SJ; Groop, Leif C LC; Hu, Frank B FB; Isomaa, Bo B; Kraft, Peter P; Peltonen, Leena L; Salomaa, Veikko V; Schlessinger, David D; Hunter, David J DJ; Hayes, Richard B RB; Abecasis, Gonçalo R GR; Wichmann, H-Erich HE; Mohlke, Karen L KL; Hirschhorn, Joel N JN
Common variants in the GDF5-UQCC region are associated with variation in human height.
Nature Genetics
Sanna, Serena S; Jackson, Anne U AU; Nagaraja, Ramaiah R; Willer, Cristen J CJ; Chen, Wei-Min WM; Bonnycastle, Lori L LL; Shen, Haiqing H; Timpson, Nicholas N; Lettre, Guillaume G; Usala, Gianluca G; Chines, Peter S PS; Stringham, Heather M HM; Scott, Laura J LJ; Dei, Mariano M; Lai, Sandra S; Albai, Giuseppe G; Crisponi, Laura L; Naitza, Silvia S; Doheny, Kimberly F KF; Pugh, Elizabeth W EW; Ben-Shlomo, Yoav Y; Ebrahim, Shah S; Lawlor, Debbie A DA; Bergman, Richard N RN; Watanabe, Richard M RM; Uda, Manuela M; Tuomilehto, Jaakko J; Coresh, Josef J; Hirschhorn, Joel N JN; Shuldiner, Alan R AR; Schlessinger, David D; Collins, Francis S FS; Davey Smith, George G; Boerwinkle, Eric E; Cao, Antonio A; Boehnke, Michael M; Abecasis, Gonçalo R GR; Mohlke, Karen L KL