Variant ID: 20-43042364-C-T

NM_000457.4(HNF4A):c.416C>T;(p.Thr139Ile)

This variant was identified in 80 publications




Publications:


Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.

Gigascience
BB Chu, KL Keys, CA German, H Zhou, JJ Zhou, EM Sobel, JS Sinsheimer, K Lange
Publication Date: 2020-06-01

Variant appearance in text: rs1800961
PMID: 32491161
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Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors.

Diabetes, Metabolic Syndrome And Obesity : Targets And Therapy
BZ Witka, DJ Oktaviani, M Marcellino, MI Barliana, R Abdulah
Publication Date: 2019

Variant appearance in text: rs1800961
PMID: 31908510
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Data on a genome-wide association study of type 2 diabetes in a Maya population.

Data In Brief
A Totomoch-Serra, MG Domínguez-Cruz, ML Muñoz, MG García-Escalante, J Burgueño, Á Díaz-Badillo, N Valadez-González, DP Escalante
Publication Date: 2020-02

Variant appearance in text: rs1800961
PMID: 31872004
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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Nature Genetics
A Tin, J Marten, VL Halperin Kuhns, Y Li, M Wuttke, H Kirsten, KB Sieber, C Qiu, M Gorski, Z Yu, A Giri, G Sveinbjornsson, M Li, AY Chu, A Hoppmann, LJ O'Connor, B Prins, T Nutile, D Noce, M Akiyama, M Cocca, S Ghasemi, PJ van der Most, K Horn, Y Xu, C Fuchsberger, S Sedaghat, S Afaq, N Amin, J Ärnlöv, SJL Bakker, N Bansal, D Baptista, S Bergmann, ML Biggs, G Biino, E Boerwinkle, EP Bottinger, TS Boutin, M Brumat, R Burkhardt, E Campana, A Campbell, H Campbell, RJ Carroll, E Catamo, JC Chambers, M Ciullo, MP Concas, J Coresh, T Corre, D Cusi, SC Felicita, MH de Borst, A De Grandi, R de Mutsert, APJ de Vries, G Delgado, A Demirkan, O Devuyst, K Dittrich, KU Eckardt, G Ehret, K Endlich, MK Evans, RT Gansevoort, P Gasparini, V Giedraitis, C Gieger, G Girotto, M Gögele, SD Gordon, DF Gudbjartsson, V Gudnason, , T Haller, P Hamet, TB Harris, C Hayward, AA Hicks, E Hofer, H Holm, W Huang, N Hutri-Kähönen, SJ Hwang, MA Ikram, RM Lewis, E Ingelsson, J Jakobsdottir, I Jonsdottir, H Jonsson, PK Joshi, NS Josyula, B Jung, M Kähönen, Y Kamatani, M Kanai, SM Kerr, W Kiess, ME Kleber, W Koenig, JS Kooner, A Körner, P Kovacs, BK Krämer, F Kronenberg, M Kubo, B Kühnel, M La Bianca, LA Lange, B Lehne, T Lehtimäki, , J Liu, M Loeffler, RJF Loos, LP Lyytikäinen, R Magi, A Mahajan, NG Martin, W März, D Mascalzoni, K Matsuda, C Meisinger, T Meitinger, A Metspalu, Y Milaneschi, , CJ O'Donnell, OD Wilson, JM Gaziano, PP Mishra, KL Mohlke, N Mononen, GW Montgomery, DO Mook-Kanamori, M Müller-Nurasyid, GN Nadkarni, MA Nalls, M Nauck, K Nikus, B Ning, IM Nolte, R Noordam, JR O'Connell, I Olafsson, S Padmanabhan, BWJH Penninx, T Perls, A Peters, M Pirastu, N Pirastu, G Pistis, O Polasek, B Ponte, DJ Porteous, T Poulain, MH Preuss, TJ Rabelink, LM Raffield, OT Raitakari, R Rettig, M Rheinberger, KM Rice, F Rizzi, A Robino, I Rudan, A Krajcoviechova, R Cifkova, R Rueedi, D Ruggiero, KA Ryan, Y Saba, E Salvi, H Schmidt, R Schmidt, CM Shaffer, AV Smith, BH Smith, CN Spracklen, K Strauch, M Stumvoll, P Sulem, SM Tajuddin, A Teren, J Thiery, CHL Thio, U Thorsteinsdottir, D Toniolo, A Tönjes, J Tremblay, AG Uitterlinden, S Vaccargiu, P van der Harst, CM van Duijn, N Verweij, U Völker, P Vollenweider, G Waeber, M Waldenberger, JB Whitfield, SH Wild, JF Wilson, Q Yang, W Zhang, AB Zonderman, M Bochud, JG Wilson, SA Pendergrass, K Ho, A Parsa, PP Pramstaller, BM Psaty, CA Böger, H Snieder, AS Butterworth, Y Okada, TL Edwards, K Stefansson, K Susztak, M Scholz, IM Heid, AM Hung, A Teumer, C Pattaro, OM Woodward, V Vitart, A Köttgen
Publication Date: 2019-10

Variant appearance in text: HNF4A: T139I; rs1800961
PMID: 31578528
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Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes.

Human Heredity
Y Yu, L Xia, S Lee, X Zhou, HM Stringham, M Boehnke, B Mukherjee
Publication Date: 2018

Variant appearance in text: rs1800961
PMID: 31132756
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Identifying genetic markers associated with susceptibility to cardiovascular diseases.

Future Science Oa
H Shukla, JL Mason, A Sabyah
Publication Date: 2019-01

Variant appearance in text: rs1800961
PMID: 30652019
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Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.

Nature Communications
E Ferkingstad, A Oddsson, S Gretarsdottir, S Benonisdottir, G Thorleifsson, AM Deaton, S Jonsson, OA Stefansson, GL Norddahl, F Zink, GA Arnadottir, B Gunnarsson, GH Halldorsson, A Helgadottir, BO Jensson, RP Kristjansson, G Sveinbjornsson, DA Sverrisson, G Masson, I Olafsson, GI Eyjolfsson, O Sigurdardottir, H Holm, I Jonsdottir, S Olafsson, T Steingrimsdottir, T Rafnar, ES Bjornsson, U Thorsteinsdottir, DF Gudbjartsson, P Sulem, K Stefansson
Publication Date: 2018-11-30

Variant appearance in text: HNF4A: Thr139Ile; rs1800961
PMID: 30504769
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Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.

International Journal Of Epidemiology
X Wang, JY Dai, D Albanes, V Arndt, SI Berndt, S Bézieau, H Brenner, DD Buchanan, K Butterbach, B Caan, G Casey, PT Campbell, AT Chan, Z Chen, J Chang-Claude, M Cotterchio, DF Easton, GG Giles, E Giovannucci, WM Grady, M Hoffmeister, JL Hopper, L Hsu, MA Jenkins, AD Joshi, JW Lampe, SC Larsson, F Lejbkowicz, L Li, A Lindblom, L Le Marchand, V Martin, RL Milne, V Moreno, PA Newcomb, K Offitt, S Ogino, PDP Pharoah, M Pinchev, JD Potter, HS Rennert, G Rennert, W Saliba, C Schafmayer, RE Schoen, P Schrotz-King, ML Slattery, M Song, C Stegmaier, SJ Weinstein, A Wolk, MO Woods, AH Wu, SB Gruber, U Peters, E White
Publication Date: 2019-06-01

Variant appearance in text: rs1800961
PMID: 30476131
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

American Journal Of Human Genetics
S Ligthart, A Vaez, U Võsa, MG Stathopoulou, PS de Vries, BP Prins, PJ Van der Most, T Tanaka, E Naderi, LM Rose, Y Wu, R Karlsson, M Barbalic, H Lin, R Pool, G Zhu, A Macé, C Sidore, S Trompet, M Mangino, M Sabater-Lleal, JP Kemp, A Abbasi, T Kacprowski, N Verweij, AV Smith, T Huang, C Marzi, MF Feitosa, KK Lohman, ME Kleber, Y Milaneschi, C Mueller, M Huq, E Vlachopoulou, LP Lyytikäinen, C Oldmeadow, J Deelen, M Perola, JH Zhao, B Feenstra, , M Amini, , J Lahti, KE Schraut, M Fornage, B Suktitipat, WM Chen, X Li, T Nutile, G Malerba, J Luan, T Bak, N Schork, F Del Greco M, E Thiering, A Mahajan, RE Marioni, E Mihailov, J Eriksson, AB Ozel, W Zhang, M Nethander, YC Cheng, S Aslibekyan, W Ang, I Gandin, L Yengo, L Portas, C Kooperberg, E Hofer, KB Rajan, C Schurmann, W den Hollander, TS Ahluwalia, J Zhao, HHM Draisma, I Ford, N Timpson, A Teumer, H Huang, S Wahl, Y Liu, J Huang, HW Uh, F Geller, PK Joshi, LR Yanek, E Trabetti, B Lehne, D Vozzi, M Verbanck, G Biino, Y Saba, I Meulenbelt, JR O'Connell, M Laakso, F Giulianini, PKE Magnusson, CM Ballantyne, JJ Hottenga, GW Montgomery, F Rivadineira, R Rueedi, M Steri, KH Herzig, DJ Stott, C Menni, M Frånberg, B St Pourcain, SB Felix, TH Pers, SJL Bakker, P Kraft, A Peters, D Vaidya, G Delgado, JH Smit, V Großmann, J Sinisalo, I Seppälä, SR Williams, EG Holliday, M Moed, C Langenberg, K Räikkönen, J Ding, H Campbell, MM Sale, YI Chen, AL James, D Ruggiero, N Soranzo, CA Hartman, EN Smith, GS Berenson, C Fuchsberger, D Hernandez, CMT Tiesler, V Giedraitis, D Liewald, K Fischer, D Mellström, A Larsson, Y Wang, WR Scott, M Lorentzon, J Beilby, KA Ryan, CE Pennell, D Vuckovic, B Balkau, MP Concas, R Schmidt, CF Mendes de Leon, EP Bottinger, M Kloppenburg, L Paternoster, M Boehnke, AW Musk, G Willemsen, DM Evans, PAF Madden, M Kähönen, Z Kutalik, M Zoledziewska, V Karhunen, SB Kritchevsky, N Sattar, G Lachance, R Clarke, TB Harris, OT Raitakari, JR Attia, D van Heemst, E Kajantie, R Sorice, G Gambaro, RA Scott, AA Hicks, L Ferrucci, M Standl, CM Lindgren, JM Starr, M Karlsson, L Lind, JZ Li, JC Chambers, TA Mori, EJCN de Geus, AC Heath, NG Martin, J Auvinen, BM Buckley, AJM de Craen, M Waldenberger, K Strauch, T Meitinger, RJ Scott, M McEvoy, M Beekman, C Bombieri, PM Ridker, KL Mohlke, NL Pedersen, AC Morrison, DI Boomsma, JB Whitfield, DP Strachan, A Hofman, P Vollenweider, F Cucca, MR Jarvelin, JW Jukema, TD Spector, A Hamsten, T Zeller, AG Uitterlinden, M Nauck, V Gudnason, L Qi, H Grallert, IB Borecki, JI Rotter, W März, PS Wild, ML Lokki, M Boyle, V Salomaa, M Melbye, JG Eriksson, JF Wilson, BWJH Penninx, DM Becker, BB Worrall, G Gibson, RM Krauss, M Ciullo, G Zaza, NJ Wareham, AJ Oldehinkel, LJ Palmer, SS Murray, PP Pramstaller, S Bandinelli, J Heinrich, E Ingelsson, IJ Deary, R Mägi, L Vandenput, P van der Harst, KC Desch, JS Kooner, C Ohlsson, C Hayward, T Lehtimäki, AR Shuldiner, DK Arnett, LJ Beilin, A Robino, P Froguel, M Pirastu, T Jess, W Koenig, RJF Loos, DA Evans, H Schmidt, GD Smith, PE Slagboom, G Eiriksdottir, AP Morris, BM Psaty, RP Tracy, IM Nolte, E Boerwinkle, S Visvikis-Siest, AP Reiner, M Gross, JC Bis, L Franke, OH Franco, EJ Benjamin, DI Chasman, J Dupuis, H Snieder, A Dehghan, BZ Alizadeh
Publication Date: 2018-11-01

Variant appearance in text: rs1800961
PMID: 30388399
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Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.

Plos Medicine
MS Udler, J Kim, M von Grotthuss, S Bonàs-Guarch, JB Cole, J Chiou, , M Boehnke, M Laakso, G Atzmon, B Glaser, JM Mercader, K Gaulton, J Flannick, G Getz, JC Florez
Publication Date: 2018-09

Variant appearance in text: rs1800961
PMID: 30240442
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Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Human Molecular Genetics
JM Kocarnik, M Richard, M Graff, J Haessler, S Bien, C Carlson, CL Carty, AP Reiner, CL Avery, CM Ballantyne, AZ LaCroix, TL Assimes, M Barbalic, N Pankratz, W Tang, R Tao, D Chen, GA Talavera, ML Daviglus, DA Chirinos-Medina, R Pereira, K Nishimura, P Bužková, LG Best, JL Ambite, I Cheng, DC Crawford, LA Hindorff, M Fornage, G Heiss, KE North, CA Haiman, U Peters, L Le Marchand, C Kooperberg
Publication Date: 2018-08-15

Variant appearance in text: rs1800961
PMID: 29878111
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Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients.

Frontiers In Pharmacology
E De Mattia, E Cecchin, M Montico, A Labriet, C Guillemette, E Dreussi, R Roncato, A Bignucolo, A Buonadonna, M D'Andrea, L Coppola, S Lonardi, E Lévesque, D Jonker, F Couture, G Toffoli
Publication Date: 2018

Variant appearance in text: rs1800961
PMID: 29706892
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Nature Genetics
A Mahajan, J Wessel, SM Willems, W Zhao, NR Robertson, AY Chu, W Gan, H Kitajima, D Taliun, NW Rayner, X Guo, Y Lu, M Li, RA Jensen, Y Hu, S Huo, KK Lohman, W Zhang, JP Cook, BP Prins, J Flannick, N Grarup, VV Trubetskoy, J Kravic, YJ Kim, DV Rybin, H Yaghootkar, M Müller-Nurasyid, K Meidtner, R Li-Gao, TV Varga, J Marten, J Li, AV Smith, P An, S Ligthart, S Gustafsson, G Malerba, A Demirkan, JF Tajes, V Steinthorsdottir, M Wuttke, C Lecoeur, M Preuss, LF Bielak, M Graff, HM Highland, AE Justice, DJ Liu, E Marouli, GM Peloso, HR Warren, , , , S Afaq, S Afzal, E Ahlqvist, P Almgren, N Amin, LB Bang, AG Bertoni, C Bombieri, J Bork-Jensen, I Brandslund, JA Brody, NP Burtt, M Canouil, YI Chen, YS Cho, C Christensen, SV Eastwood, KU Eckardt, K Fischer, G Gambaro, V Giedraitis, ML Grove, HG de Haan, S Hackinger, Y Hai, S Han, A Tybjærg-Hansen, MF Hivert, B Isomaa, S Jäger, ME Jørgensen, T Jørgensen, A Käräjämäki, BJ Kim, SS Kim, HA Koistinen, P Kovacs, J Kriebel, F Kronenberg, K Läll, LA Lange, JJ Lee, B Lehne, H Li, KH Lin, A Linneberg, CT Liu, J Liu, M Loh, R Mägi, V Mamakou, R McKean-Cowdin, G Nadkarni, M Neville, SF Nielsen, I Ntalla, PA Peyser, W Rathmann, K Rice, SS Rich, L Rode, O Rolandsson, S Schönherr, E Selvin, KS Small, A Stančáková, P Surendran, KD Taylor, TM Teslovich, B Thorand, G Thorleifsson, A Tin, A Tönjes, A Varbo, DR Witte, AR Wood, P Yajnik, J Yao, L Yengo, R Young, P Amouyel, H Boeing, E Boerwinkle, EP Bottinger, R Chowdhury, FS Collins, G Dedoussis, A Dehghan, P Deloukas, MM Ferrario, J Ferrières, JC Florez, P Frossard, V Gudnason, TB Harris, SR Heckbert, JMM Howson, M Ingelsson, S Kathiresan, F Kee, J Kuusisto, C Langenberg, LJ Launer, CM Lindgren, S Männistö, T Meitinger, O Melander, KL Mohlke, M Moitry, AD Morris, AD Murray, R de Mutsert, M Orho-Melander, KR Owen, M Perola, A Peters, MA Province, A Rasheed, PM Ridker, F Rivadineira, FR Rosendaal, AH Rosengren, V Salomaa, WH Sheu, R Sladek, BH Smith, K Strauch, AG Uitterlinden, R Varma, CJ Willer, M Blüher, AS Butterworth, JC Chambers, DI Chasman, J Danesh, C van Duijn, J Dupuis, OH Franco, PW Franks, P Froguel, H Grallert, L Groop, BG Han, T Hansen, AT Hattersley, C Hayward, E Ingelsson, SLR Kardia, F Karpe, JS Kooner, A Köttgen, K Kuulasmaa, M Laakso, X Lin, L Lind, Y Liu, RJF Loos, J Marchini, A Metspalu, D Mook-Kanamori, BG Nordestgaard, CNA Palmer, JS Pankow, O Pedersen, BM Psaty, R Rauramaa, N Sattar, MB Schulze, N Soranzo, TD Spector, K Stefansson, M Stumvoll, U Thorsteinsdottir, T Tuomi, J Tuomilehto, NJ Wareham, JG Wilson, E Zeggini, RA Scott, I Barroso, TM Frayling, MO Goodarzi, JB Meigs, M Boehnke, D Saleheen, AP Morris, JI Rotter, MI McCarthy
Publication Date: 2018-04

Variant appearance in text: HNF4A: Thr139Ile; rs1800961
PMID: 29632382
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An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.

Genome Medicine
J Zhao, F Cheng, P Jia, N Cox, JC Denny, Z Zhao
Publication Date: 2018-01-29

Variant appearance in text: HNF4A: T139I; rs1800961
PMID: 29378629
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Interactions between Genetics and Sugar-Sweetened Beverage Consumption on Health Outcomes: A Review of Gene-Diet Interaction Studies.

Frontiers In Endocrinology
DE Haslam, NM McKeown, MA Herman, AH Lichtenstein, HS Dashti
Publication Date: 2017

Variant appearance in text: rs1800961
PMID: 29375475
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Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

Jama Psychiatry
FP Hartwig, MC Borges, BL Horta, J Bowden, G Davey Smith
Publication Date: 2017-12-01

Variant appearance in text: rs1800961
PMID: 29094161
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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

Plos Genetics
JP Davis, JR Huyghe, AE Locke, AU Jackson, X Sim, HM Stringham, TM Teslovich, RP Welch, C Fuchsberger, N Narisu, PS Chines, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke
Publication Date: 2017-10

Variant appearance in text: rs1800961
PMID: 29084231
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Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

Lipids In Health And Disease
CS Paththinige, ND Sirisena, V Dissanayake
Publication Date: 2017-06-02

Variant appearance in text: rs1800961
PMID: 28577571
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Diabetes
RA Scott, LJ Scott, R Mägi, L Marullo, KJ Gaulton, M Kaakinen, N Pervjakova, TH Pers, AD Johnson, JD Eicher, AU Jackson, T Ferreira, Y Lee, C Ma, V Steinthorsdottir, G Thorleifsson, L Qi, NR Van Zuydam, A Mahajan, H Chen, P Almgren, BF Voight, H Grallert, M Müller-Nurasyid, JS Ried, NW Rayner, N Robertson, LC Karssen, EM van Leeuwen, SM Willems, C Fuchsberger, P Kwan, TM Teslovich, P Chanda, M Li, Y Lu, C Dina, D Thuillier, L Yengo, L Jiang, T Sparso, HA Kestler, H Chheda, L Eisele, S Gustafsson, M Frånberg, RJ Strawbridge, R Benediktsson, AB Hreidarsson, A Kong, G Sigurðsson, ND Kerrison, J Luan, L Liang, T Meitinger, M Roden, B Thorand, T Esko, E Mihailov, C Fox, CT Liu, D Rybin, B Isomaa, V Lyssenko, T Tuomi, DJ Couper, JS Pankow, N Grarup, CT Have, ME Jørgensen, T Jørgensen, A Linneberg, MC Cornelis, RM van Dam, DJ Hunter, P Kraft, Q Sun, S Edkins, KR Owen, JRB Perry, AR Wood, E Zeggini, J Tajes-Fernandes, GR Abecasis, LL Bonnycastle, PS Chines, HM Stringham, HA Koistinen, L Kinnunen, B Sennblad, TW Mühleisen, MM Nöthen, S Pechlivanis, D Baldassarre, K Gertow, SE Humphries, E Tremoli, N Klopp, J Meyer, G Steinbach, R Wennauer, JG Eriksson, S Mӓnnistö, L Peltonen, E Tikkanen, G Charpentier, E Eury, S Lobbens, B Gigante, K Leander, O McLeod, EP Bottinger, O Gottesman, D Ruderfer, M Blüher, P Kovacs, A Tonjes, NM Maruthur, C Scapoli, R Erbel, KH Jöckel, S Moebus, U de Faire, A Hamsten, M Stumvoll, P Deloukas, PJ Donnelly, TM Frayling, AT Hattersley, S Ripatti, V Salomaa, NL Pedersen, BO Boehm, RN Bergman, FS Collins, KL Mohlke, J Tuomilehto, T Hansen, O Pedersen, I Barroso, L Lannfelt, E Ingelsson, L Lind, CM Lindgren, S Cauchi, P Froguel, RJF Loos, B Balkau, H Boeing, PW Franks, A Barricarte Gurrea, D Palli, YT van der Schouw, D Altshuler, LC Groop, C Langenberg, NJ Wareham, E Sijbrands, CM van Duijn, JC Florez, JB Meigs, E Boerwinkle, C Gieger, K Strauch, A Metspalu, AD Morris, CNA Palmer, FB Hu, U Thorsteinsdottir, K Stefansson, J Dupuis, AP Morris, M Boehnke, MI McCarthy, I Prokopenko,
Publication Date: 2017-11

Variant appearance in text: HNF4A: Thr139Ile; rs1800961
PMID: 28566273
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Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention.

The Journal Of Clinical Endocrinology And Metabolism
LK Billings, KA Jablonski, AS Warner, YC Cheng, JB McAteer, L Tipton, AR Shuldiner, DA Ehrmann, AK Manning, D Dabelea, PW Franks, SE Kahn, TI Pollin, WC Knowler, D Altshuler, JC Florez,
Publication Date: 2017-08-01

Variant appearance in text: HNF4A: Thr139Ile; rs1800961
PMID: 28453780
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Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Human Molecular Genetics
N Zubair, M Graff, J Luis Ambite, WS Bush, G Kichaev, Y Lu, A Manichaikul, WH Sheu, D Absher, TL Assimes, SJ Bielinski, EP Bottinger, P Buzkova, LM Chuang, RH Chung, B Cochran, L Dumitrescu, O Gottesman, JW Haessler, C Haiman, G Heiss, CA Hsiung, YJ Hung, CM Hwu, JJ Juang, L Le Marchand, IT Lee, WJ Lee, LA Lin, D Lin, SY Lin, RH Mackey, LW Martin, B Pasaniuc, U Peters, I Predazzi, T Quertermous, AP Reiner, J Robinson, JI Rotter, KK Ryckman, PJ Schreiner, E Stahl, R Tao, MY Tsai, LL Waite, TD Wang, S Buyske, YD Ida Chen, I Cheng, DC Crawford, RJF Loos, SS Rich, M Fornage, KE North, C Kooperberg, CL Carty
Publication Date: 2016-12-15

Variant appearance in text: rs1800961
PMID: 28426890
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Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study.

Experimental And Therapeutic Medicine
HL Gallardo-Blanco, JZ Villarreal-Perez, RM Cerda-Flores, A Figueroa, CN Sanchez-Dominguez, JM Gutierrez-Valverde, IC Torres-Muñoz, FJ Lavalle-Gonzalez, EC Gallegos-Cabriales, LE Martinez-Garza
Publication Date: 2017-02

Variant appearance in text: rs1800961
PMID: 28352326
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Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

Plos One
PS de Vries, M Sabater-Lleal, DI Chasman, S Trompet, TS Ahluwalia, A Teumer, ME Kleber, MH Chen, JJ Wang, JR Attia, RE Marioni, M Steri, LC Weng, R Pool, V Grossmann, JA Brody, C Venturini, T Tanaka, LM Rose, C Oldmeadow, J Mazur, S Basu, M Frånberg, Q Yang, S Ligthart, JJ Hottenga, A Rumley, A Mulas, AJ de Craen, A Grotevendt, KD Taylor, GE Delgado, A Kifley, LM Lopez, TL Berentzen, M Mangino, S Bandinelli, AC Morrison, A Hamsten, G Tofler, MP de Maat, HH Draisma, GD Lowe, M Zoledziewska, N Sattar, KJ Lackner, U Völker, B McKnight, J Huang, EG Holliday, MA McEvoy, JM Starr, PG Hysi, DG Hernandez, W Guan, F Rivadeneira, WL McArdle, PE Slagboom, T Zeller, BM Psaty, AG Uitterlinden, EJ de Geus, DJ Stott, H Binder, A Hofman, OH Franco, JI Rotter, L Ferrucci, TD Spector, IJ Deary, W März, A Greinacher, PS Wild, F Cucca, DI Boomsma, H Watkins, W Tang, PM Ridker, JW Jukema, RJ Scott, P Mitchell, T Hansen, CJ O'Donnell, NL Smith, DP Strachan, A Dehghan
Publication Date: 2017

Variant appearance in text: rs1800961
PMID: 28107422
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Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.

Scientific Reports
R López-Mejías, F Genre, S Remuzgo-Martínez, C González-Juanatey, M Robustillo-Villarino, J Llorca, A Corrales, E Vicente, JA Miranda-Filloy, C Magro, B Tejera-Segura, MA Ramírez Huaranga, T Pina, R Blanco, JJ Alegre-Sancho, E Raya, V Mijares, B Ubilla, MD Mínguez Sánchez, C Gómez-Vaquero, A Balsa, D Pascual-Salcedo, FJ López-Longo, P Carreira, I González-Álvaro, L Rodríguez-Rodríguez, B Fernández-Gutiérrez, I Ferraz-Amaro, S Castañeda, J Martín, MA González-Gay
Publication Date: 2016-08-18

Variant appearance in text: rs1800961
PMID: 27534721
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The genetic architecture of type 2 diabetes.

Nature
C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, KJ Gaulton, C Ma, P Fontanillas, L Moutsianas, DJ McCarthy, MA Rivas, JRB Perry, X Sim, TW Blackwell, NR Robertson, NW Rayner, P Cingolani, AE Locke, JF Tajes, HM Highland, J Dupuis, PS Chines, CM Lindgren, C Hartl, AU Jackson, H Chen, JR Huyghe, M van de Bunt, RD Pearson, A Kumar, M Müller-Nurasyid, N Grarup, HM Stringham, ER Gamazon, J Lee, Y Chen, RA Scott, JE Below, P Chen, J Huang, MJ Go, ML Stitzel, D Pasko, SCJ Parker, TV Varga, T Green, NL Beer, AG Day-Williams, T Ferreira, T Fingerlin, M Horikoshi, C Hu, I Huh, MK Ikram, BJ Kim, Y Kim, YJ Kim, MS Kwon, J Lee, S Lee, KH Lin, TJ Maxwell, Y Nagai, X Wang, RP Welch, J Yoon, W Zhang, N Barzilai, BF Voight, BG Han, CP Jenkinson, T Kuulasmaa, J Kuusisto, A Manning, MCY Ng, ND Palmer, B Balkau, A Stančáková, HE Abboud, H Boeing, V Giedraitis, D Prabhakaran, O Gottesman, J Scott, J Carey, P Kwan, G Grant, JD Smith, BM Neale, S Purcell, AS Butterworth, JMM Howson, HM Lee, Y Lu, SH Kwak, W Zhao, J Danesh, VKL Lam, KS Park, D Saleheen, WY So, CHT Tam, U Afzal, D Aguilar, R Arya, T Aung, E Chan, C Navarro, CY Cheng, D Palli, A Correa, JE Curran, D Rybin, VS Farook, SP Fowler, BI Freedman, M Griswold, DE Hale, PJ Hicks, CC Khor, S Kumar, B Lehne, D Thuillier, WY Lim, J Liu, YT van der Schouw, M Loh, SK Musani, S Puppala, WR Scott, L Yengo, ST Tan, HA Taylor, F Thameem, G Wilson, TY Wong, PR Njølstad, JC Levy, M Mangino, LL Bonnycastle, T Schwarzmayr, J Fadista, GL Surdulescu, C Herder, CJ Groves, T Wieland, J Bork-Jensen, I Brandslund, C Christensen, HA Koistinen, ASF Doney, L Kinnunen, T Esko, AJ Farmer, L Hakaste, D Hodgkiss, J Kravic, V Lyssenko, M Hollensted, ME Jørgensen, T Jørgensen, C Ladenvall, JM Justesen, A Käräjämäki, J Kriebel, W Rathmann, L Lannfelt, T Lauritzen, N Narisu, A Linneberg, O Melander, L Milani, M Neville, M Orho-Melander, L Qi, Q Qi, M Roden, O Rolandsson, A Swift, AH Rosengren, K Stirrups, AR Wood, E Mihailov, C Blancher, MO Carneiro, J Maguire, R Poplin, K Shakir, T Fennell, M DePristo, MH de Angelis, P Deloukas, AP Gjesing, G Jun, P Nilsson, J Murphy, R Onofrio, B Thorand, T Hansen, C Meisinger, FB Hu, B Isomaa, F Karpe, L Liang, A Peters, C Huth, SP O'Rahilly, CNA Palmer, O Pedersen, R Rauramaa, J Tuomilehto, V Salomaa, RM Watanabe, AC Syvänen, RN Bergman, D Bharadwaj, EP Bottinger, YS Cho, GR Chandak, JCN Chan, KS Chia, MJ Daly, SB Ebrahim, C Langenberg, P Elliott, KA Jablonski, DM Lehman, W Jia, RCW Ma, TI Pollin, M Sandhu, N Tandon, P Froguel, I Barroso, YY Teo, E Zeggini, RJF Loos, KS Small, JS Ried, RA DeFronzo, H Grallert, B Glaser, A Metspalu, NJ Wareham, M Walker, E Banks, C Gieger, E Ingelsson, HK Im, T Illig, PW Franks, G Buck, J Trakalo, D Buck, I Prokopenko, R Mägi, L Lind, Y Farjoun, KR Owen, AL Gloyn, K Strauch, T Tuomi, JS Kooner, JY Lee, T Park, P Donnelly, AD Morris, AT Hattersley, DW Bowden, FS Collins, G Atzmon, JC Chambers, TD Spector, M Laakso, TM Strom, GI Bell, J Blangero, R Duggirala, ES Tai, G McVean, CL Hanis, JG Wilson, M Seielstad, TM Frayling, JB Meigs, NJ Cox, R Sladek, ES Lander, S Gabriel, NP Burtt, KL Mohlke, T Meitinger, L Groop, G Abecasis, JC Florez, LJ Scott, AP Morris, HM Kang, M Boehnke, D Altshuler, MI McCarthy
Publication Date: 2016-08-04

Variant appearance in text: HNF4A: Thr139Ile
PMID: 27398621
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Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

American Journal Of Human Genetics
N Chami, MH Chen, AJ Slater, JD Eicher, E Evangelou, SM Tajuddin, L Love-Gregory, T Kacprowski, UM Schick, A Nomura, A Giri, S Lessard, JA Brody, C Schurmann, N Pankratz, LR Yanek, A Manichaikul, R Pazoki, E Mihailov, WD Hill, LM Raffield, A Burt, TM Bartz, DM Becker, LC Becker, E Boerwinkle, J Bork-Jensen, EP Bottinger, ML O'Donoghue, DR Crosslin, S de Denus, MP Dubé, P Elliott, G Engström, MK Evans, JS Floyd, M Fornage, H Gao, A Greinacher, V Gudnason, T Hansen, TB Harris, C Hayward, J Hernesniemi, HM Highland, JN Hirschhorn, A Hofman, MR Irvin, M Kähönen, E Lange, LJ Launer, T Lehtimäki, J Li, DC Liewald, A Linneberg, Y Liu, Y Lu, LP Lyytikäinen, R Mägi, RA Mathias, O Melander, A Metspalu, N Mononen, MA Nalls, DA Nickerson, K Nikus, CJ O'Donnell, M Orho-Melander, O Pedersen, A Petersmann, L Polfus, BM Psaty, OT Raitakari, E Raitoharju, M Richard, KM Rice, F Rivadeneira, JI Rotter, F Schmidt, AV Smith, JM Starr, KD Taylor, A Teumer, BH Thuesen, ES Torstenson, RP Tracy, I Tzoulaki, NA Zakai, C Vacchi-Suzzi, CM van Duijn, FJ van Rooij, M Cushman, IJ Deary, DR Velez Edwards, AC Vergnaud, L Wallentin, DM Waterworth, HD White, JG Wilson, AB Zonderman, S Kathiresan, N Grarup, T Esko, RJ Loos, LA Lange, N Faraday, NA Abumrad, TL Edwards, SK Ganesh, PL Auer, AD Johnson, AP Reiner, G Lettre
Publication Date: 2016-07-07

Variant appearance in text: rs1800961
PMID: 27346685
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

Plos Medicine
BP Prins, A Abbasi, A Wong, A Vaez, I Nolte, N Franceschini, PE Stuart, J Guterriez Achury, V Mistry, JP Bradfield, AM Valdes, J Bras, A Shatunov, , , , , , , , , , , , , , , C Lu, B Han, S Raychaudhuri, S Bevan, MD Mayes, LC Tsoi, E Evangelou, RP Nair, SF Grant, C Polychronakos, TR Radstake, DA van Heel, ML Dunstan, NW Wood, A Al-Chalabi, A Dehghan, H Hakonarson, HS Markus, JT Elder, J Knight, DE Arking, TD Spector, BP Koeleman, CM van Duijn, J Martin, AP Morris, RK Weersma, C Wijmenga, PB Munroe, JR Perry, JG Pouget, Y Jamshidi, H Snieder, BZ Alizadeh
Publication Date: 2016-06

Variant appearance in text: rs1800961
PMID: 27327646
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Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

Bmc Genomics
S Ligthart, A Vaez, YH Hsu, , , , R Stolk, AG Uitterlinden, A Hofman, BZ Alizadeh, OH Franco, A Dehghan
Publication Date: 2016-06-10

Variant appearance in text: rs1800961
PMID: 27286809
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Analysis of single nucleotide polymorphisms implicate mTOR signalling in the development of new-onset diabetes after transplantation.

Bba Clinical
S Chand, AJ McKnight, S Shabir, W Chan, JA McCaughan, AP Maxwell, L Harper, R Borrows
Publication Date: 2016-06

Variant appearance in text: rs1800961
PMID: 27051588
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Uncovering the molecular pathogenesis of congenital hyperinsulinism by panel gene sequencing in 32 Chinese patients.

Molecular Genetics & Genomic Medicine
ZC Fan, JW Ni, L Yang, LY Hu, SM Ma, M Mei, BJ Sun, HJ Wang, WH Zhou
Publication Date: 2015-11

Variant appearance in text: HNF4A: 416C>T; rs1800961
PMID: 26740944
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Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.

Diabetologia
AK Nair, P Piaggi, NA McLean, M Kaur, S Kobes, WC Knowler, C Bogardus, RL Hanson, LJ Baier
Publication Date: 2016-03

Variant appearance in text: MODY: Thr139Ile; rs1800961
PMID: 26670163
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A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Human Molecular Genetics
PS de Vries, DI Chasman, M Sabater-Lleal, MH Chen, JE Huffman, M Steri, W Tang, A Teumer, RE Marioni, V Grossmann, JJ Hottenga, S Trompet, M Müller-Nurasyid, JH Zhao, JA Brody, ME Kleber, X Guo, JJ Wang, PL Auer, JR Attia, LR Yanek, TS Ahluwalia, J Lahti, C Venturini, T Tanaka, LF Bielak, PK Joshi, A Rocanin-Arjo, I Kolcic, P Navarro, LM Rose, C Oldmeadow, H Riess, J Mazur, S Basu, A Goel, Q Yang, M Ghanbari, G Willemsen, A Rumley, E Fiorillo, AJ de Craen, A Grotevendt, R Scott, KD Taylor, GE Delgado, J Yao, A Kifley, C Kooperberg, R Qayyum, LM Lopez, TL Berentzen, K Räikkönen, M Mangino, S Bandinelli, PA Peyser, S Wild, DA Trégouët, AF Wright, J Marten, T Zemunik, AC Morrison, B Sennblad, G Tofler, MP de Maat, EJ de Geus, GD Lowe, M Zoledziewska, N Sattar, H Binder, U Völker, M Waldenberger, KT Khaw, B Mcknight, J Huang, NS Jenny, EG Holliday, L Qi, MG Mcevoy, DM Becker, JM Starr, AP Sarin, PG Hysi, DG Hernandez, MA Jhun, H Campbell, A Hamsten, F Rivadeneira, WL Mcardle, PE Slagboom, T Zeller, W Koenig, BM Psaty, T Haritunians, J Liu, A Palotie, AG Uitterlinden, DJ Stott, A Hofman, OH Franco, O Polasek, I Rudan, PE Morange, JF Wilson, SL Kardia, L Ferrucci, TD Spector, JG Eriksson, T Hansen, IJ Deary, LC Becker, RJ Scott, P Mitchell, W März, NJ Wareham, A Peters, A Greinacher, PS Wild, JW Jukema, DI Boomsma, C Hayward, F Cucca, R Tracy, H Watkins, AP Reiner, AR Folsom, PM Ridker, CJ O'Donnell, NL Smith, DP Strachan, A Dehghan
Publication Date: 2016-01-15

Variant appearance in text: rs1800961
PMID: 26561523
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Nature Genetics
KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, A Mahajan, A Locke, NW Rayner, N Robertson, RA Scott, I Prokopenko, LJ Scott, T Green, T Sparso, D Thuillier, L Yengo, H Grallert, S Wahl, M Frånberg, RJ Strawbridge, H Kestler, H Chheda, L Eisele, S Gustafsson, V Steinthorsdottir, G Thorleifsson, L Qi, LC Karssen, EM van Leeuwen, SM Willems, M Li, H Chen, C Fuchsberger, P Kwan, C Ma, M Linderman, Y Lu, SK Thomsen, JK Rundle, NL Beer, M van de Bunt, A Chalisey, HM Kang, BF Voight, GR Abecasis, P Almgren, D Baldassarre, B Balkau, R Benediktsson, M Blüher, H Boeing, LL Bonnycastle, EP Bottinger, NP Burtt, J Carey, G Charpentier, PS Chines, MC Cornelis, DJ Couper, AT Crenshaw, RM van Dam, AS Doney, M Dorkhan, S Edkins, JG Eriksson, T Esko, E Eury, J Fadista, J Flannick, P Fontanillas, C Fox, PW Franks, K Gertow, C Gieger, B Gigante, O Gottesman, GB Grant, N Grarup, CJ Groves, M Hassinen, CT Have, C Herder, OL Holmen, AB Hreidarsson, SE Humphries, DJ Hunter, AU Jackson, A Jonsson, ME Jørgensen, T Jørgensen, WH Kao, ND Kerrison, L Kinnunen, N Klopp, A Kong, P Kovacs, P Kraft, J Kravic, C Langford, K Leander, L Liang, P Lichtner, CM Lindgren, E Lindholm, A Linneberg, CT Liu, S Lobbens, J Luan, V Lyssenko, S Männistö, O McLeod, J Meyer, E Mihailov, G Mirza, TW Mühleisen, M Müller-Nurasyid, C Navarro, MM Nöthen, NN Oskolkov, KR Owen, D Palli, S Pechlivanis, L Peltonen, JR Perry, CG Platou, M Roden, D Ruderfer, D Rybin, YT van der Schouw, B Sennblad, G Sigurðsson, A Stančáková, G Steinbach, P Storm, K Strauch, HM Stringham, Q Sun, B Thorand, E Tikkanen, A Tonjes, J Trakalo, E Tremoli, T Tuomi, R Wennauer, S Wiltshire, AR Wood, E Zeggini, I Dunham, E Birney, L Pasquali, J Ferrer, RJ Loos, J Dupuis, JC Florez, E Boerwinkle, JS Pankow, C van Duijn, E Sijbrands, JB Meigs, FB Hu, U Thorsteinsdottir, K Stefansson, TA Lakka, R Rauramaa, M Stumvoll, NL Pedersen, L Lind, SM Keinanen-Kiukaanniemi, E Korpi-Hyövälti, TE Saaristo, J Saltevo, J Kuusisto, M Laakso, A Metspalu, R Erbel, KH Jöcke, S Moebus, S Ripatti, V Salomaa, E Ingelsson, BO Boehm, RN Bergman, FS Collins, KL Mohlke, H Koistinen, J Tuomilehto, K Hveem, I Njølstad, P Deloukas, PJ Donnelly, TM Frayling, AT Hattersley, U de Faire, A Hamsten, T Illig, A Peters, S Cauchi, R Sladek, P Froguel, T Hansen, O Pedersen, AD Morris, CN Palmer, S Kathiresan, O Melander, PM Nilsson, LC Groop, I Barroso, C Langenberg, NJ Wareham, CA O'Callaghan, AL Gloyn, D Altshuler, M Boehnke, TM Teslovich, MI McCarthy, AP Morris,
Publication Date: 2015-12

Variant appearance in text: HNF4A: T139I; rs1800961
PMID: 26551672
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Is Whole Exome Sequencing Clinically Practical in the Management of Pediatric Crohn's Disease?

Gut And Liver
SH Oh, J Baek, KM Kim, EJ Lee, Y Jung, YJ Lee, HS Jin, BD Ye, SK Yang, JK Lee, EJ Seo, HT Lim, I Lee, K Song
Publication Date: 2015-11-23

Variant appearance in text: rs1800961
PMID: 26503572
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New insights from monogenic diabetes for "common" type 2 diabetes.

Frontiers In Genetics
DS Tallapragada, S Bhaskar, GR Chandak
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 26300908
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Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.

Plos One
AM Kulminski, I Culminskaya, KG Arbeev, L Arbeeva, SV Ukraintseva, E Stallard, D Wu, AI Yashin
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 26295473
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Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes.

Plos One
X Kong, Q Zhao, X Xing, B Zhang, X Zhang, J Hong, W Yang
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 26252223
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Vitamin D and C-Reactive Protein: A Mendelian Randomization Study.

Plos One
MC Liefaard, S Ligthart, A Vitezova, A Hofman, AG Uitterlinden, JC Kiefte-de Jong, OH Franco, MC Zillikens, A Dehghan
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 26147588
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Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.

Blood
JE Huffman, PS de Vries, AC Morrison, M Sabater-Lleal, T Kacprowski, PL Auer, JA Brody, DI Chasman, MH Chen, X Guo, LA Lin, RE Marioni, M Müller-Nurasyid, LR Yanek, N Pankratz, ML Grove, MP de Maat, M Cushman, KL Wiggins, L Qi, B Sennblad, SE Harris, O Polasek, H Riess, F Rivadeneira, LM Rose, A Goel, KD Taylor, A Teumer, AG Uitterlinden, D Vaidya, J Yao, W Tang, D Levy, M Waldenberger, DM Becker, AR Folsom, F Giulianini, A Greinacher, A Hofman, CC Huang, C Kooperberg, A Silveira, JM Starr, K Strauch, RJ Strawbridge, AF Wright, B McKnight, OH Franco, N Zakai, RA Mathias, BM Psaty, PM Ridker, GH Tofler, U Völker, H Watkins, M Fornage, A Hamsten, IJ Deary, E Boerwinkle, W Koenig, JI Rotter, C Hayward, A Dehghan, AP Reiner, CJ O'Donnell, NL Smith
Publication Date: 2015-09-10

Variant appearance in text: HNF4A: T139I; rs1800961
PMID: 26105150
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Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.

Plos One
S Ligthart, PS de Vries, AG Uitterlinden, A Hofman, , OH Franco, DI Chasman, A Dehghan
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 25768928
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Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth.

Plos One
V Marcil, D Amre, EG Seidman, F Boudreau, FP Gendron, D Ménard, JF Beaulieu, D Sinnett, M Lambert, E Levy
Publication Date: 2015

Variant appearance in text: rs1800961
PMID: 25671620
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Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.

Circulation
C Yao, BH Chen, R Joehanes, B Otlu, X Zhang, C Liu, T Huan, O Tastan, LA Cupples, JB Meigs, CS Fox, JE Freedman, P Courchesne, CJ O'Donnell, PJ Munson, S Keles, D Levy
Publication Date: 2015-02-10

Variant appearance in text: rs1800961
PMID: 25533967
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Phenotypic heterogeneity in monogenic diabetes: the clinical and diagnostic utility of a gene panel-based next-generation sequencing approach.

Molecular Genetics And Metabolism
G Alkorta-Aranburu, D Carmody, YW Cheng, V Nelakuditi, L Ma, JT Dickens, S Das, SAW Greeley, D Del Gaudio
Publication Date: 2014-12

Variant appearance in text: HNF4A: 416C>T
PMID: 25306193
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IBD candidate genes and intestinal barrier regulation.

Inflammatory Bowel Diseases
DF McCole
Publication Date: 2014-10

Variant appearance in text: rs1800961
PMID: 25215613
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A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave.

Plos One
C Lamina, M Haun, S Coassin, A Kloss-Brandstätter, C Gieger, A Peters, H Grallert, K Strauch, T Meitinger, L Kedenko, B Paulweber, F Kronenberg
Publication Date: 2014

Variant appearance in text: rs1800961
PMID: 25050552
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A Simple Scalable Association Hypothesis Test Combining Gene-wide Evidence From Multiple Polymorphisms.

British Journal Of Medicine And Medical Research
D Vaidya, LR Yanek, RA Mathias, TF Moy, DM Becker, LC Becker
Publication Date: 2014-03

Variant appearance in text: rs1800961
PMID: 24688980
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Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.

Circulation. Cardiovascular Genetics
JM Kocarnik, SA Pendergrass, CL Carty, JS Pankow, FR Schumacher, I Cheng, P Durda, JL Ambite, E Deelman, NR Cook, S Liu, J Wactawski-Wende, C Hutter, K Brown-Gentry, S Wilson, LG Best, N Pankratz, CP Hong, SA Cole, VS Voruganti, P Bůžkova, NW Jorgensen, NS Jenny, LR Wilkens, CA Haiman, LN Kolonel, A Lacroix, K North, R Jackson, L Le Marchand, LA Hindorff, DC Crawford, M Gross, U Peters
Publication Date: 2014-04

Variant appearance in text: rs1800961
PMID: 24622110
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Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants.

The Application Of Clinical Genetics
S Sayols-Baixeras, C Lluís-Ganella, G Lucas, R Elosua
Publication Date: 2014

Variant appearance in text: rs1800961
PMID: 24520200
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Genetics of new-onset diabetes after transplantation.

Journal Of The American Society Of Nephrology : Jasn
JA McCaughan, AJ McKnight, AP Maxwell
Publication Date: 2014-05

Variant appearance in text: rs1800961
PMID: 24309190
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Characterization of statin dose response in electronic medical records.

Clinical Pharmacology And Therapeutics
WQ Wei, Q Feng, L Jiang, MS Waitara, OF Iwuchukwu, DM Roden, M Jiang, H Xu, RM Krauss, JI Rotter, DA Nickerson, RL Davis, RL Berg, PL Peissig, CA McCarty, RA Wilke, JC Denny
Publication Date: 2014-03

Variant appearance in text: rs1800961
PMID: 24096969
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Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study.

Cancer Causes & Control : Ccc
AE Prizment, AR Folsom, J Dreyfus, KE Anderson, K Visvanathan, CE Joshu, EA Platz, JS Pankow
Publication Date: 2013-12

Variant appearance in text: rs1800961
PMID: 24036889
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Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

Plos One
R Dorajoo, R Li, MK Ikram, J Liu, P Froguel, J Lee, X Sim, RT Ong, WT Tay, C Peng, TL Young, AI Blakemore, CY Cheng, T Aung, P Mitchell, JJ Wang, CC Klaver, E Boerwinkle, R Klein, DS Siscovick, RA Jensen, V Gudnason, AV Smith, YY Teo, TY Wong, ES Tai, CK Heng, Y Friedlander
Publication Date: 2013

Variant appearance in text: rs1800961
PMID: 23844046
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A multiethnic replication study of plasma lipoprotein levels-associated SNPs identified in recent GWAS.

Plos One
EK Bryant, AS Dressen, CH Bunker, JE Hokanson, RF Hamman, MI Kamboh, FY Demirci
Publication Date: 2013

Variant appearance in text: rs1800961
PMID: 23717430
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Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.

Bmc Genetics
KC Taylor, CL Carty, L Dumitrescu, P Bůžková, SA Cole, L Hindorff, FR Schumacher, LR Wilkens, RV Shohet, PM Quibrera, KC Johnson, BE Henderson, J Haessler, N Franceschini, CB Eaton, DJ Duggan, B Cochran, I Cheng, CS Carlson, K Brown-Gentry, G Anderson, JL Ambite, C Haiman, L Le Marchand, C Kooperberg, DC Crawford, S Buyske, KE North, M Fornage,
Publication Date: 2013-05-01

Variant appearance in text: rs1800961
PMID: 23634756
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Linear regression in genetic association studies.

Plos One
P Bůžková
Publication Date: 2013

Variant appearance in text: rs1800961
PMID: 23437286
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Examination of Rare Variants in HNF4 α in European Americans with Type 2 Diabetes.

Journal Of Diabetes & Metabolism
JN Hellwege, PJ Hicks, ND Palmer, MC Ng, BI Freedman, DW Bowden
Publication Date: 2011-10-20

Variant appearance in text: rs1800961
PMID: 23227446
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Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

Cardiovascular Diabetology
CM Povel, JM Boer, NC Onland-Moret, ME Dollé, EJ Feskens, YT van der Schouw
Publication Date: 2012-10-29

Variant appearance in text: rs1800961
PMID: 23101478
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Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease.

Genes And Immunity
V Marcil, D Sinnett, E Seidman, F Boudreau, FP Gendron, JF Beaulieu, D Menard, M Lambert, A Bitton, R Sanchez, D Amre, E Levy
Publication Date: 2012-10

Variant appearance in text: rs1800961
PMID: 22914433
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An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations.

Nature Genetics
V Segura, BJ Vilhjálmsson, A Platt, A Korte, Ü Seren, Q Long, M Nordborg
Publication Date: 2012-06-17

Variant appearance in text: rs1800961
PMID: 22706313
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Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study.

Circulation. Cardiovascular Genetics
CL Carty, P Buzková, M Fornage, N Franceschini, S Cole, G Heiss, LA Hindorff, BV Howard, S Mann, LW Martin, Y Zhang, TC Matise, R Prentice, AP Reiner, C Kooperberg
Publication Date: 2012-04-01

Variant appearance in text: rs1800961
PMID: 22403240
View BVdb publication page



Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.

Antimicrobial Agents And Chemotherapy
M Arab-Alameddine, A Fayet-Mello, R Lubomirov, M Neely, J di Iulio, A Owen, M Boffito, M Cavassini, HF Günthard, K Rentsch, T Buclin, M Aouri, A Telenti, LA Decosterd, M Rotger, C Csajka,
Publication Date: 2012-06

Variant appearance in text: rs1800961
PMID: 22371894
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Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Frontiers In Pharmacology
K Klein, S Winter, M Turpeinen, M Schwab, UM Zanger
Publication Date: 2010

Variant appearance in text: HNF4: T139I; rs1800961
PMID: 21918647
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Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk.

Molecular Neurodegeneration
CR Simmons, F Zou, SG Younkin, S Estus
Publication Date: 2011-08-25

Variant appearance in text: rs1800961
PMID: 21867541
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Implications of discoveries from genome-wide association studies in current cardiovascular practice.

World Journal Of Cardiology
P Jeemon, K Pettigrew, C Sainsbury, D Prabhakaran, S Padmanabhan
Publication Date: 2011-07-26

Variant appearance in text: rs1800961
PMID: 21860704
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Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

Plos Genetics
L Dumitrescu, CL Carty, K Taylor, FR Schumacher, LA Hindorff, JL Ambite, G Anderson, LG Best, K Brown-Gentry, P Bůžková, CS Carlson, B Cochran, SA Cole, RB Devereux, D Duggan, CB Eaton, M Fornage, N Franceschini, J Haessler, BV Howard, KC Johnson, S Laston, LN Kolonel, ET Lee, JW MacCluer, TA Manolio, SA Pendergrass, M Quibrera, RV Shohet, LR Wilkens, CA Haiman, L Le Marchand, S Buyske, C Kooperberg, KE North, DC Crawford
Publication Date: 2011-06

Variant appearance in text: rs1800961
PMID: 21738485
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A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.

Human Molecular Genetics
KC Taylor, LA Lange, D Zabaneh, E Lange, BJ Keating, W Tang, NL Smith, JA Delaney, M Kumari, A Hingorani, KE North, M Kivimaki, RP Tracy, CJ O'Donnell, AR Folsom, D Green, SE Humphries, AP Reiner
Publication Date: 2011-09-01

Variant appearance in text: rs1800961
PMID: 21676895
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Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

Circulation
A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, C Lu, N Pellikka, H Wallaschofski, J Kettunen, P Henneman, J Baumert, DP Strachan, C Fuchsberger, V Vitart, JF Wilson, G Paré, S Naitza, ME Rudock, I Surakka, EJ de Geus, BZ Alizadeh, J Guralnik, A Shuldiner, T Tanaka, RY Zee, RB Schnabel, V Nambi, M Kavousi, S Ripatti, M Nauck, NL Smith, AV Smith, J Sundvall, P Scheet, Y Liu, A Ruokonen, LM Rose, MG Larson, RC Hoogeveen, NB Freimer, A Teumer, RP Tracy, LJ Launer, JE Buring, JF Yamamoto, AR Folsom, EJ Sijbrands, J Pankow, P Elliott, JF Keaney, W Sun, AP Sarin, JD Fontes, S Badola, BC Astor, A Hofman, A Pouta, K Werdan, KH Greiser, O Kuss, HE Meyer zu Schwabedissen, J Thiery, Y Jamshidi, IM Nolte, N Soranzo, TD Spector, H Völzke, AN Parker, T Aspelund, D Bates, L Young, K Tsui, DS Siscovick, X Guo, JI Rotter, M Uda, D Schlessinger, I Rudan, AA Hicks, BW Penninx, B Thorand, C Gieger, J Coresh, G Willemsen, TB Harris, AG Uitterlinden, MR Järvelin, K Rice, D Radke, V Salomaa, K Willems van Dijk, E Boerwinkle, RS Vasan, L Ferrucci, QD Gibson, S Bandinelli, H Snieder, DI Boomsma, X Xiao, H Campbell, C Hayward, PP Pramstaller, CM van Duijn, L Peltonen, BM Psaty, V Gudnason, PM Ridker, G Homuth, W Koenig, CM Ballantyne, JC Witteman, EJ Benjamin, M Perola, DI Chasman
Publication Date: 2011-02-22

Variant appearance in text: rs1800961
PMID: 21300955
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Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids.

Atherosclerosis
CG Walker, RJ Loos, AD Olson, GS Frost, BA Griffin, JA Lovegrove, TA Sanders, SA Jebb
Publication Date: 2011-04

Variant appearance in text: rs1800961
PMID: 21292264
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Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

Blood
CL Wassel, LA Lange, BJ Keating, KC Taylor, AD Johnson, C Palmer, LA Ho, NL Smith, EM Lange, Y Li, Q Yang, JA Delaney, W Tang, G Tofler, S Redline, HA Taylor, JG Wilson, RP Tracy, DR Jacobs, AR Folsom, D Green, CJ O'Donnell, AP Reiner
Publication Date: 2011-01-06

Variant appearance in text: rs1800961
PMID: 20978265
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A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.

Diabetologia
B Jafar-Mohammadi, CJ Groves, AP Gjesing, BM Herrera, W Winckler, HM Stringham, AP Morris, T Lauritzen, AS Doney, AD Morris, MN Weedon, AJ Swift, J Kuusisto, M Laakso, D Altshuler, AT Hattersley, FS Collins, M Boehnke, T Hansen, O Pedersen, CN Palmer, TM Frayling, , AL Gloyn, MI McCarthy
Publication Date: 2011-01

Variant appearance in text: rs1800961
PMID: 20878384
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Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

American Journal Of Epidemiology
OA Panagiotou, E Evangelou, JP Ioannidis
Publication Date: 2010-10-15

Variant appearance in text: rs1800961
PMID: 20876667
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Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.

Human Genetics
R Gupta, K Ejebe, J Butler, G Lettre, H Lyon, C Guiducci, R Wilks, F Bennett, T Forrester, B Tayo, K Musunuru, J Hirschhorn, S Kathiresan, RS Cooper, CA McKenzie
Publication Date: 2010-11

Variant appearance in text: rs1800961
PMID: 20839009
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Genetic causes of high and low serum HDL-cholesterol.

Journal Of Lipid Research
D Weissglas-Volkov, P Pajukanta
Publication Date: 2010-08

Variant appearance in text: rs1800961
PMID: 20421590
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The genetics of obesity and the metabolic syndrome.

Endocrine, Metabolic & Immune Disorders Drug Targets
KL Monda, KE North, SC Hunt, DC Rao, MA Province, AT Kraja
Publication Date: 2010-06

Variant appearance in text: rs1800961
PMID: 20406164
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Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

Proceedings Of The National Academy Of Sciences Of The United States Of America
BM Neale, J Fagerness, R Reynolds, L Sobrin, M Parker, S Raychaudhuri, PL Tan, EC Oh, JE Merriam, E Souied, PS Bernstein, B Li, JM Frederick, K Zhang, MA Brantley, AY Lee, DJ Zack, B Campochiaro, P Campochiaro, S Ripke, RT Smith, GR Barile, N Katsanis, R Allikmets, MJ Daly, JM Seddon
Publication Date: 2010-04-20

Variant appearance in text: rs1800961
PMID: 20385826
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Genetics of lipid disorders.

Current Opinion In Cardiology
J Pirruccello, S Kathiresan
Publication Date: 2010-05

Variant appearance in text: rs1800961
PMID: 20224388
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Variance component model to account for sample structure in genome-wide association studies.

Nature Genetics
HM Kang, JH Sul, SK Service, NA Zaitlen, SY Kong, NB Freimer, C Sabatti, E Eskin
Publication Date: 2010-04

Variant appearance in text: rs1800961
PMID: 20208533
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Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

Lipids In Health And Disease
J Ronald, R Rajagopalan, JE Ranchalis, JK Marshall, TS Hatsukami, PJ Heagerty, GP Jarvik
Publication Date: 2009-12-01

Variant appearance in text: rs1800961
PMID: 19951432
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Common variants at 30 loci contribute to polygenic dyslipidemia.

Nature Genetics
S Kathiresan, CJ Willer, GM Peloso, S Demissie, K Musunuru, EE Schadt, L Kaplan, D Bennett, Y Li, T Tanaka, BF Voight, LL Bonnycastle, AU Jackson, G Crawford, A Surti, C Guiducci, NP Burtt, S Parish, R Clarke, D Zelenika, KA Kubalanza, MA Morken, LJ Scott, HM Stringham, P Galan, AJ Swift, J Kuusisto, RN Bergman, J Sundvall, M Laakso, L Ferrucci, P Scheet, S Sanna, M Uda, Q Yang, KL Lunetta, J Dupuis, PI de Bakker, CJ O'Donnell, JC Chambers, JS Kooner, S Hercberg, P Meneton, EG Lakatta, A Scuteri, D Schlessinger, J Tuomilehto, FS Collins, L Groop, D Altshuler, R Collins, GM Lathrop, O Melander, V Salomaa, L Peltonen, M Orho-Melander, JM Ordovas, M Boehnke, GR Abecasis, KL Mohlke, LA Cupples
Publication Date: 2009-01

Variant appearance in text: rs1800961
PMID: 19060906
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Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.

Diabetes
YL Muller, AM Infante, RL Hanson, L Love-Gregory, W Knowler, C Bogardus, LJ Baier
Publication Date: 2005-10

Variant appearance in text: rs1800961
PMID: 16186411
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000316099.4 c.416C>T p.Thr139Ile missense_variant 4/10 -
ENST00000316673.4 c.350C>T p.Thr117Ile missense_variant 4/10 -
ENST00000372920.1 c.*183C>T - 3_prime_UTR_variant,NMD_transcript_variant 5/11 -
ENST00000415691.2 c.416C>T p.Thr139Ile missense_variant 4/10 -
ENST00000443598.2 c.416C>T p.Thr139Ile missense_variant 4/8 -
ENST00000457232.1 c.350C>T p.Thr117Ile missense_variant 4/10 -
ENST00000609795.1 c.350C>T p.Thr117Ile missense_variant 4/8 -
NM_000457.4 c.416C>T p.Thr139Ile missense_variant 4/10 -
NM_001030003.3 c.350C>T p.Thr117Ile missense_variant 4/10 -
NM_001030004.3 c.350C>T p.Thr117Ile missense_variant 4/8 -
NM_001258355.2 c.395C>T p.Thr132Ile missense_variant 5/11 -
NM_001287182.2 c.341C>T p.Thr114Ile missense_variant 5/11 -
NM_001287183.1 c.341C>T p.Thr114Ile missense_variant 5/11 -
NM_001287184.2 c.341C>T p.Thr114Ile missense_variant 5/9 -
NM_175914.4 c.350C>T p.Thr117Ile missense_variant 4/10 -
NM_178849.3 c.416C>T p.Thr139Ile missense_variant 4/10 -
NM_178850.3 c.416C>T p.Thr139Ile missense_variant 4/8 -