Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.
Bioorganic & Medicinal Chemistry
Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Spiridonov, Evgeny A EA; Belov, Dmitry S DS; Altieri, Andrea A; Kurkin, Alexander V AV; Debnath, Asim K AK
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.
Journal Of Medicinal Chemistry
Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Belov, Dmitry S DS; Markov, Pavel O PO; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2.
Antimicrobial Agents And Chemotherapy
Buckheit, R W RW; Watson, K K; Fliakas-Boltz, V V; Russell, J J; Loftus, T L TL; Osterling, M C MC; Turpin, J A JA; Pallansch, L A LA; White, E L EL; Lee, J W JW; Lee, S H SH; Oh, J W JW; Kwon, H S HS; Chung, S G SG; Cho, E H EH
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Antimicrobial Agents And Chemotherapy
Furman, P A PA; Jeffrey, J J; Kiefer, L L LL; Feng, J Y JY; Anderson, K S KS; Borroto-Esoda, K K; Hill, E E; Copeland, W C WC; Chu, C K CK; Sommadossi, J P JP; Liberman, I I; Schinazi, R F RF; Painter, G R GR