Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.
Scientific Reports
Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA
PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity.
Journal Of Lipid Research
Kim, Daniel Seung DS; Burt, Amber A AA; Ranchalis, Jane E JE; Vuletic, Simona S; Vaisar, Tomas T; Li, Wan-Fen WF; Rosenthal, Elisabeth A EA; Dong, Weijiang W; Eintracht, Jason F JF; Motulsky, Arno G AG; Brunzell, John D JD; Albers, John J JJ; Furlong, Clement E CE; Jarvik, Gail P GP
Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip.
Frontiers In Genetics
Parihar, Ankita A; Wood, G Craig GC; Chu, Xin X; Jin, Qunjan Q; Argyropoulos, George G; Still, Christopher D CD; Shuldiner, Alan R AR; Mitchell, Braxton D BD; Gerhard, Glenn S GS
Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.
Circulation. Cardiovascular Genetics
Kocarnik, Jonathan M JM; Pendergrass, Sarah A SA; Carty, Cara L CL; Pankow, James S JS; Schumacher, Fredrick R FR; Cheng, Iona I; Durda, Peter P; Ambite, José Luis JL; Deelman, Ewa E; Cook, Nancy R NR; Liu, Simin S; Wactawski-Wende, Jean J; Hutter, Carolyn C; Brown-Gentry, Kristin K; Wilson, Sarah S; Best, Lyle G LG; Pankratz, Nathan N; Hong, Ching-Ping CP; Cole, Shelley A SA; Voruganti, V Saroja VS; Bůžkova, Petra P; Jorgensen, Neal W NW; Jenny, Nancy S NS; Wilkens, Lynne R LR; Haiman, Christopher A CA; Kolonel, Laurence N LN; Lacroix, Andrea A; North, Kari K; Jackson, Rebecca R; Le Marchand, Loic L; Hindorff, Lucia A LA; Crawford, Dana C DC; Gross, Myron M; Peters, Ulrike U
Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III).
Bmc Medical Genetics
Goodloe, Robert R; Brown-Gentry, Kristin K; Gillani, Niloufar B NB; Jin, Hailing H; Mayo, Ping P; Allen, Melissa M; McClellan, Bob B; Boston, Jonathan J; Sutcliffe, Cara C; Schnetz-Boutaud, Nathalie N; Dilks, Holli H HH; Crawford, Dana C DC
Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.
Bmc Genetics
Taylor, Kira C KC; Carty, Cara L CL; Dumitrescu, Logan L; Bůžková, Petra P; Cole, Shelley A SA; Hindorff, Lucia L; Schumacher, Fred R FR; Wilkens, Lynne R LR; Shohet, Ralph V RV; Quibrera, P Miguel PM; Johnson, Karen C KC; Henderson, Brian E BE; Haessler, Jeff J; Franceschini, Nora N; Eaton, Charles B CB; Duggan, David J DJ; Cochran, Barbara B; Cheng, Iona I; Carlson, Chris S CS; Brown-Gentry, Kristin K; Anderson, Garnet G; Ambite, Jose Luis JL; Haiman, Christopher C; Le Marchand, Loïc L; Kooperberg, Charles C; Crawford, Dana C DC; Buyske, Steven S; North, Kari E KE; Fornage, Myriam M; ,
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.
Nucleic Acids Research
Feldmann, Radmila R; Fischer, Cornelius C; Kodelja, Vitam V; Behrens, Sarah S; Haas, Stefan S; Vingron, Martin M; Timmermann, Bernd B; Geikowski, Anne A; Sauer, Sascha S
Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.
Cardiovascular Diabetology
Povel, Cécile M CM; Boer, Jolanda M A JM; Onland-Moret, N Charlotte NC; Dollé, Martijn E T ME; Feskens, Edith J M EJ; van der Schouw, Yvonne T YT
Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Plos Genetics
Pollin, Toni I TI; Isakova, Tamara T; Jablonski, Kathleen A KA; de Bakker, Paul I W PI; Taylor, Andrew A; McAteer, Jarred J; Pan, Qing Q; Horton, Edward S ES; Delahanty, Linda M LM; Altshuler, David D; Shuldiner, Alan R AR; Goldberg, Ronald B RB; Florez, Jose C JC; Franks, Paul W PW; ,
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
Plos Genetics
Dumitrescu, Logan L; Carty, Cara L CL; Taylor, Kira K; Schumacher, Fredrick R FR; Hindorff, Lucia A LA; Ambite, José L JL; Anderson, Garnet G; Best, Lyle G LG; Brown-Gentry, Kristin K; Bůžková, Petra P; Carlson, Christopher S CS; Cochran, Barbara B; Cole, Shelley A SA; Devereux, Richard B RB; Duggan, Dave D; Eaton, Charles B CB; Fornage, Myriam M; Franceschini, Nora N; Haessler, Jeff J; Howard, Barbara V BV; Johnson, Karen C KC; Laston, Sandra S; Kolonel, Laurence N LN; Lee, Elisa T ET; MacCluer, Jean W JW; Manolio, Teri A TA; Pendergrass, Sarah A SA; Quibrera, Miguel M; Shohet, Ralph V RV; Wilkens, Lynne R LR; Haiman, Christopher A CA; Le Marchand, Loïc L; Buyske, Steven S; Kooperberg, Charles C; North, Kari E KE; Crawford, Dana C DC
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
Plos Genetics
Lettre, Guillaume G; Palmer, Cameron D CD; Young, Taylor T; Ejebe, Kenechi G KG; Allayee, Hooman H; Benjamin, Emelia J EJ; Bennett, Franklyn F; Bowden, Donald W DW; Chakravarti, Aravinda A; Dreisbach, Al A; Farlow, Deborah N DN; Folsom, Aaron R AR; Fornage, Myriam M; Forrester, Terrence T; Fox, Ervin E; Haiman, Christopher A CA; Hartiala, Jaana J; Harris, Tamara B TB; Hazen, Stanley L SL; Heckbert, Susan R SR; Henderson, Brian E BE; Hirschhorn, Joel N JN; Keating, Brendan J BJ; Kritchevsky, Stephen B SB; Larkin, Emma E; Li, Mingyao M; Rudock, Megan E ME; McKenzie, Colin A CA; Meigs, James B JB; Meng, Yang A YA; Mosley, Tom H TH; Newman, Anne B AB; Newton-Cheh, Christopher H CH; Paltoo, Dina N DN; Papanicolaou, George J GJ; Patterson, Nick N; Post, Wendy S WS; Psaty, Bruce M BM; Qasim, Atif N AN; Qu, Liming L; Rader, Daniel J DJ; Redline, Susan S; Reilly, Muredach P MP; Reiner, Alexander P AP; Rich, Stephen S SS; Rotter, Jerome I JI; Liu, Yongmei Y; Shrader, Peter P; Siscovick, David S DS; Tang, W H Wilson WH; Taylor, Herman A HA; Tracy, Russell P RP; Vasan, Ramachandran S RS; Waters, Kevin M KM; Wilks, Rainford R; Wilson, James G JG; Fabsitz, Richard R RR; Gabriel, Stacey B SB; Kathiresan, Sekar S; Boerwinkle, Eric E
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
Diabetes
De Silva, N Maneka G NM; Freathy, Rachel M RM; Palmer, Tom M TM; Donnelly, Louise A LA; Luan, Jian'an J; Gaunt, Tom T; Langenberg, Claudia C; Weedon, Michael N MN; Shields, Beverley B; Knight, Beatrice A BA; Ward, Kirsten J KJ; Sandhu, Manjinder S MS; Harbord, Roger M RM; McCarthy, Mark I MI; Smith, George Davey GD; Ebrahim, Shah S; Hattersley, Andrew T AT; Wareham, Nicholas N; Lawlor, Debbie A DA; Morris, Andrew D AD; Palmer, Colin N A CN; Frayling, Timothy M TM
Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.
Human Genetics
Gupta, R R; Ejebe, K K; Butler, J J; Lettre, G G; Lyon, H H; Guiducci, C C; Wilks, R R; Bennett, F F; Forrester, T T; Tayo, B B; Musunuru, K K; Hirschhorn, J J; Kathiresan, S S; Cooper, R S RS; McKenzie, C A CA
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.
Nature Genetics
Johansen, Christopher T CT; Wang, Jian J; Lanktree, Matthew B MB; Cao, Henian H; McIntyre, Adam D AD; Ban, Matthew R MR; Martins, Rebecca A RA; Kennedy, Brooke A BA; Hassell, Reina G RG; Visser, Maartje E ME; Schwartz, Stephen M SM; Voight, Benjamin F BF; Elosua, Roberto R; Salomaa, Veikko V; O'Donnell, Christopher J CJ; Dallinga-Thie, Geesje M GM; Anand, Sonia S SS; Yusuf, Salim S; Huff, Murray W MW; Kathiresan, Sekar S; Hegele, Robert A RA
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
Proceedings Of The National Academy Of Sciences Of The United States Of America
Neale, Benjamin M BM; Fagerness, Jesen J; Reynolds, Robyn R; Sobrin, Lucia L; Parker, Margaret M; Raychaudhuri, Soumya S; Tan, Perciliz L PL; Oh, Edwin C EC; Merriam, Joanna E JE; Souied, Eric E; Bernstein, Paul S PS; Li, Binxing B; Frederick, Jeanne M JM; Zhang, Kang K; Brantley, Milam A MA; Lee, Aaron Y AY; Zack, Donald J DJ; Campochiaro, Betsy B; Campochiaro, Peter P; Ripke, Stephan S; Smith, R Theodore RT; Barile, Gaetano R GR; Katsanis, Nicholas N; Allikmets, Rando R; Daly, Mark J MJ; Seddon, Johanna M JM
Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
Circulation. Cardiovascular Genetics
Weissglas-Volkov, Daphna D; Aguilar-Salinas, Carlos A CA; Sinsheimer, Janet S JS; Riba, Laura L; Huertas-Vazquez, Adriana A; Ordoñez-Sánchez, Maria L ML; Rodriguez-Guillen, Rosario R; Cantor, Rita M RM; Tusie-Luna, Teresa T; Pajukanta, Päivi P
Genetic and nongenetic sources of variation in phospholipid transfer protein activity.
Journal Of Lipid Research
Jarvik, Gail P GP; Rajagopalan, Ramakrishnan R; Rosenthal, Elisabeth A EA; Wolfbauer, Gertrud G; McKinstry, Laura L; Vaze, Aditya A; Brunzell, John J; Motulsky, Arno G AG; Nickerson, Deborah A DA; Heagerty, Patrick J PJ; Wijsman, Ellen M EM; Albers, John J JJ
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Lipids In Health And Disease
Ronald, James J; Rajagopalan, Ramakrishnan R; Ranchalis, Jane E JE; Marshall, Julieann K JK; Hatsukami, Thomas S TS; Heagerty, Patrick J PJ; Jarvik, Gail P GP
Common variants at 30 loci contribute to polygenic dyslipidemia.
Nature Genetics
Kathiresan, Sekar S; Willer, Cristen J CJ; Peloso, Gina M GM; Demissie, Serkalem S; Musunuru, Kiran K; Schadt, Eric E EE; Kaplan, Lee L; Bennett, Derrick D; Li, Yun Y; Tanaka, Toshiko T; Voight, Benjamin F BF; Bonnycastle, Lori L LL; Jackson, Anne U AU; Crawford, Gabriel G; Surti, Aarti A; Guiducci, Candace C; Burtt, Noel P NP; Parish, Sarah S; Clarke, Robert R; Zelenika, Diana D; Kubalanza, Kari A KA; Morken, Mario A MA; Scott, Laura J LJ; Stringham, Heather M HM; Galan, Pilar P; Swift, Amy J AJ; Kuusisto, Johanna J; Bergman, Richard N RN; Sundvall, Jouko J; Laakso, Markku M; Ferrucci, Luigi L; Scheet, Paul P; Sanna, Serena S; Uda, Manuela M; Yang, Qiong Q; Lunetta, Kathryn L KL; Dupuis, Josée J; de Bakker, Paul I W PI; O'Donnell, Christopher J CJ; Chambers, John C JC; Kooner, Jaspal S JS; Hercberg, Serge S; Meneton, Pierre P; Lakatta, Edward G EG; Scuteri, Angelo A; Schlessinger, David D; Tuomilehto, Jaakko J; Collins, Francis S FS; Groop, Leif L; Altshuler, David D; Collins, Rory R; Lathrop, G Mark GM; Melander, Olle O; Salomaa, Veikko V; Peltonen, Leena L; Orho-Melander, Marju M; Ordovas, Jose M JM; Boehnke, Michael M; Abecasis, Gonçalo R GR; Mohlke, Karen L KL; Cupples, L Adrienne LA