PRNP c.505_506delinsGG ;(p.Y169G)

Variant ID: 20-4680371-TA-GG

NM_000311.3(PRNP):c.505_506delinsGG;(p.Y169G)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Structurally distinct external solvent-exposed domains drive replication of major human prions.

Plos Pathogens
Siddiqi, Mohammad Khursheed MK; Kim, Chae C; Haldiman, Tracy T; Kacirova, Miroslava M; Wang, Benlian B; Bohon, Jen J; Chance, Mark R MR; Kiselar, Janna J; Safar, Jiri G JG
Publication Date: 2021-06

Variant appearance in text: CJD: Y169G
PubMed Link: 34138981
Variant Present in the following documents:
  • Main text
  • ppat.1009642.pdf
View BVdb publication page



Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier.

Molecular Neurobiology
Harrathi, Chafik C; Fernández-Borges, Natalia N; Eraña, Hasier H; Elezgarai, Saioa R SR; Venegas, Vanessa V; Charco, Jorge M JM; Castilla, Joaquín J
Publication Date: 2019-08

Variant appearance in text: CJD: Y169G
PubMed Link: 30592012
Variant Present in the following documents:
  • Main text
  • 12035_2018_Article_1443.pdf
View BVdb publication page



De Novo Generation of a Unique Cervid Prion Strain Using Protein Misfolding Cyclic Amplification.

Msphere
Meyerett-Reid, Crystal C; Wyckoff, A Christy AC; Spraker, Terry T; Pulford, Bruce B; Bender, Heather H; Zabel, Mark D MD
Publication Date: 2017

Variant appearance in text: CJD: Y169G
PubMed Link: 28144628
Variant Present in the following documents:
  • Main text
  • mSphere.00372-16.pdf
View BVdb publication page



Human prion protein sequence elements impede cross-species chronic wasting disease transmission.

The Journal Of Clinical Investigation
Kurt, Timothy D TD; Jiang, Lin L; Fernández-Borges, Natalia N; Bett, Cyrus C; Liu, Jun J; Yang, Tom T; Spraker, Terry R TR; Castilla, Joaquín J; Eisenberg, David D; Kong, Qingzhong Q; Sigurdson, Christina J CJ
Publication Date: 2015-04

Variant appearance in text: CJD: Y169G
PubMed Link: 25705888
Variant Present in the following documents:
  • Main text
View BVdb publication page



A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.

The Journal Of Biological Chemistry
Kurt, Timothy D TD; Jiang, Lin L; Bett, Cyrus C; Eisenberg, David D; Sigurdson, Christina J CJ
Publication Date: 2014-04-11

Variant appearance in text: PRNP: Y169G
PubMed Link: 24596090
Variant Present in the following documents:
  • Main text
View BVdb publication page