Publications:

---

Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments.

Theranostics

C Poon, C Pellow, K Hynynen

Publication Date: 2021

Variant appearance in text: APP: V717F

PubMed Link: 33408773

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau.

Frontiers In Neurology

R Brandt, NI Trushina, L Bakota

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 33193056

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.

Acta Neuropathologica Communications

PMJ Quinn, PI Moreira, AF Ambrósio, CH Alves

Publication Date: 2020-11-09

Variant appearance in text: APP: V717F

PubMed Link: 33168089

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Neuron Loss in Alzheimer's Disease: Translation in Transgenic Mouse Models.

International Journal Of Molecular Sciences

O Wirths, S Zampar

Publication Date: 2020-10-30

Variant appearance in text: APP: V717F

PubMed Link: 33143374

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease.

Frontiers In Aging Neuroscience

F Zhu, C Li, F Chu, X Tian, J Zhu

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 33132894

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Epigenetic basis of Alzheimer disease.

World Journal Of Biological Chemistry

AC Tecalco-Cruz, JO Ramírez-Jarquín, ME Alvarez-Sánchez, J Zepeda-Cervantes

Publication Date: 2020-09-27

Variant appearance in text: APP: V717F

PubMed Link: 33024518

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Early-Occurring Dendritic Spines Alterations in Mouse Models of Alzheimer's Disease Inform on Primary Causes of Neurodegeneration.

Frontiers In Synaptic Neuroscience

M Ammassari-Teule

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 33013348

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.

Plos One

C Tackenberg, L Kulic, RM Nitsch

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32966331

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration.

International Journal Of Molecular Sciences

M Al-Onaizi, A Al-Khalifah, D Qasem, A ElAli

Publication Date: 2020-09-19

Variant appearance in text: APP: V717F

PubMed Link: 32961703

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.

Molecular Neurodegeneration

ECB Johnson, K Ho, GQ Yu, M Das, PE Sanchez, B Djukic, I Lopez, X Yu, M Gill, W Zhang, JT Paz, JJ Palop, L Mucke

Publication Date: 2020-09-14

Variant appearance in text: APP: V717F

PubMed Link: 32921309

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer's Disease Mice, Independent of Amyloid-β Pathology.

Journal Of Alzheimer'S Disease Reports

K Oberman, L Gouweleeuw, P Hoogerhout, ULM Eisel, E van Riet, RG Schoemaker

Publication Date: 2020-07-23

Variant appearance in text: APP: V717F

PubMed Link: 32904788

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies.

Acta Neuropathologica Communications

VI Wiersma, JJM Hoozemans, W Scheper

Publication Date: 2020-09-03

Variant appearance in text: APP: V717F

PubMed Link: 32883341

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders.

Disease Models & Mechanisms

J Gamache, Y Yun, O Chiba-Falek

Publication Date: 2020-08-27

Variant appearance in text: APP: V717F

PubMed Link: 32859588

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The P2X7 Receptor: Central Hub of Brain Diseases.

Frontiers In Molecular Neuroscience

R Andrejew, Á Oliveira-Giacomelli, DE Ribeiro, T Glaser, VF Arnaud-Sampaio, C Lameu, H Ulrich

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32848594

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus.

Plos Biology

GA Rodriguez, GM Barrett, KE Duff, SA Hussaini

Publication Date: 2020-08

Variant appearance in text: APP: V717F

PubMed Link: 32822389

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

Bmc Molecular And Cell Biology

AS Cone, SN Hurwitz, GS Lee, X Yuan, Y Zhou, Y Li, DG Meckes

Publication Date: 2020-07-30

Variant appearance in text: APP: V717F

PubMed Link: 32731849

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Acta Neuropathologica Communications

S Kumar, CA Lemere, J Walter

Publication Date: 2020-07-29

Variant appearance in text: APP: V717F

PubMed Link: 32727580

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease.

Oxidative Medicine And Cellular Longevity

YF Xian, C Qu, Y Liu, SP Ip, QJ Yuan, W Yang, ZX Lin

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32714487

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19.

F1000Research

H Potter, TD Boyd, P Clarke, VS Pelak, KL Tyler

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32704352

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

Cell Reports

G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo

Publication Date: 2020-06-30

Variant appearance in text: APP: Val717Phe

PubMed Link: 32610140

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The Role of P2X7 Receptor in Alzheimer's Disease.

Frontiers In Molecular Neuroscience

L Francistiová, C Bianchi, C Di Lauro, Á Sebastián-Serrano, L de Diego-García, J Kobolák, A Dinnyés, M Díaz-Hernández

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32581707

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain.

Journal Of Neuroscience Research

S Ferreira, KA Pitman, S Wang, BS Summers, N Bye, KM Young, CL Cullen

Publication Date: 2020-10

Variant appearance in text: APP: V717F

PubMed Link: 32557778

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer's Disease.

Frontiers In Molecular Neuroscience

Z Song, Y Xu, W Deng, L Zhang, H Zhu, P Yu, Y Qu, W Zhao, Y Han, C Qin

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32547364

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Tau is not necessary for amyloid-β-induced synaptic and memory impairments.

The Journal Of Clinical Investigation

D Puzzo, EK Argyrousi, A Staniszewski, H Zhang, E Calcagno, E Zuccarello, E Acquarone, M Fa', DD Li Puma, C Grassi, L D'Adamio, NM Kanaan, PE Fraser, O Arancio

Publication Date: 2020-09-01

Variant appearance in text: APP: V717F

PubMed Link: 32544084

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.

Frontiers In Neuroscience

GS Stephens, CH Fu, CP St Romain, Y Zheng, JJ Botterill, HE Scharfman, Y Liu, J Chin

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32536852

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules

R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba

Publication Date: 2020-06-06

Variant appearance in text: APP: V717F

PubMed Link: 32517180

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

International Journal Of Molecular Sciences

L Gatti, F Tinelli, E Scelzo, F Arioli, G Di Fede, L Obici, L Pantoni, G Giaccone, P Caroppo, EA Parati, A Bersano

Publication Date: 2020-05-13

Variant appearance in text: APP: V717F

PubMed Link: 32414028

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease.

Cells

R Franco, R Rivas-Santisteban, M Casanovas, A Lillo, CA Saura, G Navarro

Publication Date: 2020-04-26

Variant appearance in text: APP: V717F

PubMed Link: 32357548

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases.

Journal Of Biomedical Science

YY Wu, HC Kuo

Publication Date: 2020-04-07

Variant appearance in text: APP: V717F

PubMed Link: 32264890

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The rare and the common: scale and the genetic imaginary in Alzheimer's disease drug development.

New Genetics And Society

R Milne

Publication Date: 2020

Variant appearance in text: APP: V717F

PubMed Link: 32256202

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature Communications

SS Kwak, KJ Washicosky, E Brand, D von Maydell, J Aronson, S Kim, DE Capen, M Cetinbas, R Sadreyev, S Ning, E Bylykbashi, W Xia, SL Wagner, SH Choi, RE Tanzi, DY Kim

Publication Date: 2020-03-13

Variant appearance in text: APP: V717F

PubMed Link: 32170138

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease.

Acta Neuropathologica Communications

GM Lloyd, JA Trejo-Lopez, Y Xia, KN McFarland, SJ Lincoln, N Ertekin-Taner, BI Giasson, AT Yachnis, S Prokop

Publication Date: 2020-03-12

Variant appearance in text: APP: V717F

PubMed Link: 32164763

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.

Molecules (Basel, Switzerland)

L Bellusci, M Runfola, V Carnicelli, S Sestito, F Fulceri, F Santucci, P Lenzi, F Fornai, S Rapposelli, N Origlia, R Zucchi, G Chiellini

Publication Date: 2020-02-26

Variant appearance in text: APP: V717F

PubMed Link: 32110992

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer's Disease.

Scientific Reports

KH Wong, Y Xie, X Huang, K Kadota, XS Yao, Y Yu, X Chen, A Lu, Z Yang

Publication Date: 2020-02-27

Variant appearance in text: APP: V717F

PubMed Link: 32107408

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.

Antioxidants & Redox Signaling

Y Peng, P Gao, L Shi, L Chen, J Liu, J Long

Publication Date: 2020-06-01

Variant appearance in text: APP: V717F

PubMed Link: 32050773

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Transcriptional Signatures of Tau and Amyloid Neuropathology.

Cell Reports

I Castanho, TK Murray, E Hannon, A Jeffries, E Walker, E Laing, H Baulf, J Harvey, L Bradshaw, A Randall, K Moore, P O'Neill, K Lunnon, DA Collier, Z Ahmed, MJ O'Neill, J Mill

Publication Date: 2020-02-11

Variant appearance in text: APP: V717F

PubMed Link: 32049030

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Cell Death & Disease

CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen

Publication Date: 2020-02-06

Variant appearance in text: APP: V717F

PubMed Link: 32029735

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Fungicide Residues Exposure and Aggregation in a Mouse Model of Alzheimer's Disease.

Environmental Health Perspectives

PA Lafon, Y Wang, M Arango-Lievano, J Torrent, L Salvador-Prince, M Mansuy, N Mestre-Francès, L Givalois, J Liu, JV Mercader, F Jeanneteau, C Desrumaux, V Perrier

Publication Date: 2020-01

Variant appearance in text: APP: V717F

PubMed Link: 31939705

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.

Journal Of Neuroinflammation

M Balasubramaniam, PA Parcon, C Bose, L Liu, RA Jones, MR Farlow, RE Mrak, SW Barger, WST Griffin

Publication Date: 2019-12-27

Variant appearance in text: APP: v717f

PubMed Link: 31882005

Variant Present in the following documents:

• 12974_2019_Article_1669.pdf
• aaaaaMain text

View BVdb publication page

---

Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.

Cold Spring Harbor Molecular Case Studies

JN Cochran, EC McKinley, M Cochran, MD Amaral, BA Moyers, BN Lasseigne, DE Gray, JMJ Lawlor, JW Prokop, EG Geier, JM Holt, ML Thompson, JS Newberry, JS Yokoyama, EA Worthey, DS Geldmacher, MN Love, GM Cooper, RM Myers, ED Roberson

Publication Date: 2019-12

Variant appearance in text: APP: 2149G>T; V717L

PubMed Link: 31836585

Variant Present in the following documents:

• Main text
• MCS003491Coc.pdf
• supp_mcs.a003491_Supplemental_Material.pdf
• supp_mcs.a003491_Supplemental_Table_1.xlsx

View BVdb publication page

---

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model.

Nature Communications

G Etter, S van der Veldt, F Manseau, I Zarrinkoub, E Trillaud-Doppia, S Williams

Publication Date: 2019-11-22

Variant appearance in text: APP: V717F

PubMed Link: 31757962

Variant Present in the following documents:

• 41467_2019_Article_13260.pdf
• aaaaaMain text

View BVdb publication page

---

Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease.

Scientific Reports

K Yuyama, K Takahashi, S Usuki, D Mikami, H Sun, H Hanamatsu, J Furukawa, K Mukai, Y Igarashi

Publication Date: 2019-11-14

Variant appearance in text: APP: V717F

PubMed Link: 31727994

Variant Present in the following documents:

• 41598_2019_Article_53394.pdf
• aaaaaMain text

View BVdb publication page

---

Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways.

Neurobiology Of Disease

Z Wei, X Meng, R El Fatimy, B Sun, D Mai, J Zhang, R Arora, A Zeng, P Xu, S Qu, AM Krichevsky, DJ Selkoe, S Li

Publication Date: 2020-02

Variant appearance in text: APP: V717F

PubMed Link: 31669733

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

M Lei, JD Teo, H Song, HP McEwen, J Yup Lee, TA Couttas, T Duncan, R Chesworth, J Bertz, M Przybyla, J Van Eersel, B Heng, GJ Guillemin, LM Ittner, T Fath, B Garner, A Ittner, T Karl, AS Don

Publication Date: 2019-11-27

Variant appearance in text: APP: V717F

PubMed Link: 31641049

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Imbalance in the response of pre- and post-synaptic components to amyloidopathy.

Scientific Reports

TL Stephen, F Tamagnini, J Piegsa, K Sung, J Harvey, A Oliver-Evans, TK Murray, Z Ahmed, ML Hutton, A Randall, MJ O'Neill, JS Jackson

Publication Date: 2019-10-16

Variant appearance in text: APP: V717F

PubMed Link: 31619689

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology

A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31583592

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases.

Frontiers In Aging Neuroscience

M D'Anca, C Fenoglio, M Serpente, B Arosio, M Cesari, EA Scarpini, D Galimberti

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31555123

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

Journal Of Cell Science

PV Martino Adami, Z Nichtová, DB Weaver, A Bartok, T Wisniewski, DR Jones, S Do Carmo, EM Castaño, AC Cuello, G Hajnóczky, L Morelli

Publication Date: 2019-10-22

Variant appearance in text: APP: V717F

PubMed Link: 31515277

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model.

Frontiers In Pharmacology

AR Bilia, P Nardiello, V Piazzini, M Leri, MC Bergonzi, M Bucciantini, F Casamenti

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31507412

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease.

Frontiers In Pharmacology

D Mango, A Saidi, GY Cisale, M Feligioni, M Corbo, R Nisticò

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31379566

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad

R Parodi-Rullán, JY Sone, S Fossati

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31306129

Variant Present in the following documents:

• Main text
• nihms-1059124.pdf

View BVdb publication page

---

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.

Nature Communications

JS Park, J Lee, ES Jung, MH Kim, IB Kim, H Son, S Kim, S Kim, YM Park, I Mook-Jung, SJ Yu, JH Lee

Publication Date: 2019-07-12

Variant appearance in text: APP: V717F

PubMed Link: 31300647

Variant Present in the following documents:

• 41467_2019_11000_MOESM14_ESM.xlsx

View BVdb publication page

---

The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer's Disease.

Nutrients

FJ Sánchez-Muniz, A Macho-González, A Garcimartín, JA Santos-López, J Benedí, S Bastida, MJ González-Muñoz

Publication Date: 2019-07-10

Variant appearance in text: APP: V717F

PubMed Link: 31295866

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Animal Models of Psychosis in Alzheimer Disease.

The American Journal Of Geriatric Psychiatry : Official Journal Of The American Association For Geriatric Psychiatry

JM Krivinko, J Koppel, A Savonenko, RA Sweet

Publication Date: 2020-01

Variant appearance in text: APP: V717F

PubMed Link: 31278012

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Cell Reports

CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang, MS Pyfer, U Tosi, BF Corbett, J Cai, J Lee, J Park, L Iacovitti, HE Scharfman, G Enikolopov, J Chin

Publication Date: 2019-06-25

Variant appearance in text: APP: V717F

PubMed Link: 31242408

Variant Present in the following documents:

• Main text
• nihms-1532883.pdf
• NIHMS1532883-supplement-2.pdf

View BVdb publication page

---

Modeling Alzheimer's disease with human iPS cells: advancements, lessons, and applications.

Neurobiology Of Disease

S Essayan-Perez, B Zhou, AM Nabet, M Wernig, YA Huang

Publication Date: 2019-10

Variant appearance in text: APP: V717F

PubMed Link: 31202913

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Eneuro

RSE Carney

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31147386

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.

Frontiers In Molecular Neuroscience

E Vasili, A Dominguez-Meijide, TF Outeiro

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31105524

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Rapamycin and Alzheimer disease: a double-edged sword?

Autophagy

JM Carosi, TJ Sargeant

Publication Date: 2019-08

Variant appearance in text: APP: V717F

PubMed Link: 31066320

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.

Frontiers In Cellular Neuroscience

C Martínez-Frailes, C Di Lauro, C Bianchi, L de Diego-García, Á Sebastián-Serrano, L Boscá, M Díaz-Hernández

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 31031598

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.

Aging And Disease

C Bi, S Bi, B Li

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PubMed Link: 31011484

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules (Basel, Switzerland)

R Ştefănescu, GD Stanciu, A Luca, IC Caba, BI Tamba, CT Mihai

Publication Date: 2019-03-24

Variant appearance in text: APP: V717F

PubMed Link: 30909659

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The vexing complexity of the amyloidogenic pathway.

Protein Science : A Publication Of The Protein Society

MA Castro, A Hadziselimovic, CR Sanders

Publication Date: 2019-07

Variant appearance in text: APP: V717F

PubMed Link: 30897251

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease.

Frontiers In Pharmacology

AC Cuello, H Hall, S Do Carmo

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 30886583

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Frontiers In Neuroscience

JO Ojo, M Algamal, P Leary, L Abdullah, B Mouzon, JE Evans, M Mullan, F Crawford

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 30837829

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

British Journal Of Pharmacology

LM Ittner, M Klugmann, YD Ke

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PubMed Link: 30817847

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus.

Frontiers In Pharmacology

Y Ano, M Yoshikawa, Y Takaichi, M Michikawa, K Uchida, H Nakayama, A Takashima

Publication Date: 2019

Variant appearance in text: APP: V717F

PubMed Link: 30804789

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease.

Acta Neuropathologica Communications

S Sri, CM Pegasiou, CA Cave, K Hough, N Wood, D Gomez-Nicola, K Deinhardt, D Bannerman, VH Perry, M Vargas-Caballero

Publication Date: 2019-02-22

Variant appearance in text: APP: V717F

PubMed Link: 30795807

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease.

Aging Cell

S Jiang, C Shao, F Tang, W Wang, X Zhu

Publication Date: 2019-06

Variant appearance in text: APP: V717F

PubMed Link: 30767411

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.

Alzheimer'S Research & Therapy

L Magno, CB Lessard, M Martins, V Lang, P Cruz, Y Asi, M Katan, J Bilsland, T Lashley, P Chakrabarty, TE Golde, PJ Whiting

Publication Date: 2019-02-02

Variant appearance in text: APP: V717F

PubMed Link: 30711010

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link.

International Journal Of Molecular Sciences

E Bok, M Jo, S Lee, BR Lee, J Kim, HJ Kim

Publication Date: 2019-01-22

Variant appearance in text: APP: V717F

PubMed Link: 30678217

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease.

Molecular Neurodegeneration

S Chakroborty, ES Hill, DT Christian, R Helfrich, S Riley, C Schneider, N Kapecki, S Mustaly-Kalimi, FA Seiler, DA Peterson, AR West, BM Vertel, WN Frost, GE Stutzmann

Publication Date: 2019-01-22

Variant appearance in text: APP: V717F

PubMed Link: 30670054

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.

The Journal Of Clinical Investigation

BC Beckelman, W Yang, NP Kasica, HR Zimmermann, X Zhou, CD Keene, AG Ryazanov, T Ma

Publication Date: 2019-02-01

Variant appearance in text: APP: V717F

PubMed Link: 30667373

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A short perspective on the long road to effective treatments for Alzheimer's disease.

British Journal Of Pharmacology

DS Reynolds

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PubMed Link: 30657599

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Don't forget astrocytes when targeting Alzheimer's disease.

British Journal Of Pharmacology

JS Sadick, SA Liddelow

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PubMed Link: 30636042

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice.

Eneuro

L Broestl, K Worden, AJ Moreno, EJ Davis, D Wang, B Garay, T Singh, L Verret, JJ Palop, DB Dubal

Publication Date: 2018

Variant appearance in text: APP: V717F

PubMed Link: 30627643

Variant Present in the following documents:

• Main text

View BVdb publication page

---

It's all about tau.

Progress In Neurobiology

C Tapia-Rojas, F Cabezas-Opazo, CA Deaton, EH Vergara, GVW Johnson, RA Quintanilla

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PubMed Link: 30605723

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.

Neurobiology Of Aging

CE Evans, RS Thomas, TJ Freeman, M Hvoslef-Eide, MA Good, EJ Kidd

Publication Date: 2019-03

Variant appearance in text: APP: V717F

PubMed Link: 30572184

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genetic analysis of neurodegenerative diseases in a pathology cohort.

Neurobiology Of Aging

C Blauwendraat, O Pletnikova, JT Geiger, NA Murphy, Y Abramzon, G Rudow, A Mamais, MS Sabir, B Crain, S Ahmed, LS Rosenthal, CC Bakker, F Faghri, R Chia, J Ding, TM Dawson, A Pantelyat, MS Albert, MA Nalls, SM Resnick, L Ferrucci, MR Cookson, AE Hillis, JC Troncoso, SW Scholz

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PubMed Link: 30528841

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

Brain Pathology (Zurich, Switzerland)

P De Rossi, RJ Andrew, TF Musial, V Buggia-Prevot, G Xu, M Ponnusamy, H Ly, SV Krause, RC Rice, V de l'Estoile, T Valin, S Salem, F Despa, DR Borchelt, VP Bindokas, DA Nicholson, G Thinakaran

Publication Date: 2019-07

Variant appearance in text: APP: V717F

PubMed Link: 30506549

Variant Present in the following documents:

• Main text

View BVdb publication page

---

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA).

Alzheimer'S Research & Therapy

L Pradier, V Blanchard-Brégeon, A Bohme, T Debeir, J Menager, P Benoit, P Barneoud, V Taupin, P Bertrand, P Dugay, B Cameron, Y Shi, S Naimi, M Duchesne, M Gagnaire, T Weeden, T Travaline, D Reczek, L Khiroug, M Slaoui, P Brunel, H Fukuyama, J Ravetch, T Canton, C Cohen

Publication Date: 2018-11-28

Variant appearance in text: APP: V717F

PubMed Link: 30486882

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice.

Frontiers In Aging Neuroscience

F Ugolini, D Lana, P Nardiello, D Nosi, D Pantano, F Casamenti, MG Giovannini

Publication Date: 2018

Variant appearance in text: APP: V717F

PubMed Link: 30483118

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

J Pacheco-Quinto, D Clausen, R Pérez-González, H Peng, A Meszaros, CB Eckman, E Levy, EA Eckman

Publication Date: 2019-03

Variant appearance in text: APP: V717F

PubMed Link: 30481490

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease.

British Journal Of Pharmacology

MIG Lopez Sanchez, P van Wijngaarden, IA Trounce

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PubMed Link: 30471088

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Acta Neuropathologica Communications

S Li, M Jin, L Liu, Y Dang, BL Ostaszewski, DJ Selkoe

Publication Date: 2018-11-08

Variant appearance in text: APP: V717F

PubMed Link: 30409172

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery.

Nitric Oxide : Biology And Chemistry

MA Hollas, M Ben Aissa, SH Lee, JM Gordon-Blake, GRJ Thatcher

Publication Date: 2019-01-01

Variant appearance in text: APP: V717F

PubMed Link: 30394348

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism.

Aging

J Yin, S Li, M Nielsen, T Carcione, WS Liang, J Shi

Publication Date: 2018-10-23

Variant appearance in text: APP: V717F

PubMed Link: 30362958

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Role of purinergic receptors in the Alzheimer's disease.

Purinergic Signalling

M Cieślak, A Wojtczak

Publication Date: 2018-12

Variant appearance in text: APP: V717F

PubMed Link: 30362042

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis.

Bmc Neuroscience

O Shabir, J Berwick, SE Francis

Publication Date: 2018-10-17

Variant appearance in text: APP: V717F

PubMed Link: 30333009

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer's Disease.

Frontiers In Neuroscience

IC Wood

Publication Date: 2018

Variant appearance in text: APP: V717F

PubMed Link: 30283297

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Blood-Brain Barrier: From Physiology to Disease and Back.

Physiological Reviews

MD Sweeney, Z Zhao, A Montagne, AR Nelson, BV Zlokovic

Publication Date: 2019-01-01

Variant appearance in text: APP: V717F

PubMed Link: 30280653

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000346798.3	c.2149G>T	p.Val717Phe	missense_variant	17/18	-
ENST00000348990.5	c.1924G>T	p.Val642Phe	missense_variant	15/16	-
ENST00000354192.3	c.1756G>T	p.Val586Phe	missense_variant	14/15	-
ENST00000357903.3	c.2092G>T	p.Val698Phe	missense_variant	16/17	-
ENST00000358918.3	c.2095G>T	p.Val699Phe	missense_variant	16/17	-
ENST00000359726.3	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
ENST00000439274.2	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
ENST00000440126.3	c.2077G>T	p.Val693Phe	missense_variant	16/17	-
ENST00000448388.2	c.1819G>T	p.Val607Phe	missense_variant	15/16	-
ENST00000464867.1	n.496G>T	-	non_coding_transcript_exon_variant	2/3	-
NM_000484.4	c.2149G>T	p.Val717Phe	missense_variant	17/18	-
NM_001136016.3	c.2077G>T	p.Val693Phe	missense_variant	16/17	-
NM_001136129.3	c.1756G>T	p.Val586Phe	missense_variant	14/15	-
NM_001136130.3	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
NM_001136131.2	c.1819G>T	p.Val607Phe	missense_variant	15/16	-
NM_001204301.2	c.2095G>T	p.Val699Phe	missense_variant	16/17	-
NM_001204302.2	c.2038G>T	p.Val680Phe	missense_variant	15/16	-
NM_001204303.2	c.1870G>T	p.Val624Phe	missense_variant	14/15	-
NM_201413.3	c.2092G>T	p.Val698Phe	missense_variant	16/17	-
NM_201414.3	c.1924G>T	p.Val642Phe	missense_variant	15/16	-