Publications:

---

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

Bmc Molecular And Cell Biology

AS Cone, SN Hurwitz, GS Lee, X Yuan, Y Zhou, Y Li, DG Meckes

Publication Date: 2020-07-30

Variant appearance in text: APP: V717F

PMID: 32731849

View BVdb publication page

---

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Acta Neuropathologica Communications

S Kumar, CA Lemere, J Walter

Publication Date: 2020-07-29

Variant appearance in text: APP: V717F

PMID: 32727580

View BVdb publication page

---

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease.

Oxidative Medicine And Cellular Longevity

YF Xian, C Qu, Y Liu, SP Ip, QJ Yuan, W Yang, ZX Lin

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32714487

View BVdb publication page

---

Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19.

F1000Research

H Potter, TD Boyd, P Clarke, VS Pelak, KL Tyler

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32704352

View BVdb publication page

---

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

Cell Reports

G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo

Publication Date: 2020-06-30

Variant appearance in text: APP: Val717Phe

PMID: 32610140

View BVdb publication page

---

The Role of P2X7 Receptor in Alzheimer's Disease.

Frontiers In Molecular Neuroscience

L Francistiová, C Bianchi, C Di Lauro, Á Sebastián-Serrano, L de Diego-García, J Kobolák, A Dinnyés, M Díaz-Hernández

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32581707

View BVdb publication page

---

Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer's Disease.

Frontiers In Molecular Neuroscience

Z Song, Y Xu, W Deng, L Zhang, H Zhu, P Yu, Y Qu, W Zhao, Y Han, C Qin

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32547364

View BVdb publication page

---

Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.

Frontiers In Neuroscience

GS Stephens, CH Fu, CP St Romain, Y Zheng, JJ Botterill, HE Scharfman, Y Liu, J Chin

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32536852

View BVdb publication page

---

Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules

R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba

Publication Date: 2020-06-06

Variant appearance in text: APP: V717F

PMID: 32517180

View BVdb publication page

---

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

International Journal Of Molecular Sciences

L Gatti, F Tinelli, E Scelzo, F Arioli, G Di Fede, L Obici, L Pantoni, G Giaccone, P Caroppo, EA Parati, A Bersano

Publication Date: 2020-05-13

Variant appearance in text: APP: V717F

PMID: 32414028

View BVdb publication page

---

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease.

Cells

R Franco, R Rivas-Santisteban, M Casanovas, A Lillo, CA Saura, G Navarro

Publication Date: 2020-04-26

Variant appearance in text: APP: V717F

PMID: 32357548

View BVdb publication page

---

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases.

Journal Of Biomedical Science

YY Wu, HC Kuo

Publication Date: 2020-04-07

Variant appearance in text: APP: V717F

PMID: 32264890

View BVdb publication page

---

The rare and the common: scale and the genetic imaginary in Alzheimer's disease drug development.

New Genetics And Society

R Milne

Publication Date: 2020

Variant appearance in text: APP: V717F

PMID: 32256202

View BVdb publication page

---

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature Communications

SS Kwak, KJ Washicosky, E Brand, D von Maydell, J Aronson, S Kim, DE Capen, M Cetinbas, R Sadreyev, S Ning, E Bylykbashi, W Xia, SL Wagner, SH Choi, RE Tanzi, DY Kim

Publication Date: 2020-03-13

Variant appearance in text: APP: V717F

PMID: 32170138

View BVdb publication page

---

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease.

Acta Neuropathologica Communications

GM Lloyd, JA Trejo-Lopez, Y Xia, KN McFarland, SJ Lincoln, N Ertekin-Taner, BI Giasson, AT Yachnis, S Prokop

Publication Date: 2020-03-12

Variant appearance in text: APP: V717F

PMID: 32164763

View BVdb publication page

---

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.

Molecules (Basel, Switzerland)

L Bellusci, M Runfola, V Carnicelli, S Sestito, F Fulceri, F Santucci, P Lenzi, F Fornai, S Rapposelli, N Origlia, R Zucchi, G Chiellini

Publication Date: 2020-02-26

Variant appearance in text: APP: V717F

PMID: 32110992

View BVdb publication page

---

Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer's Disease.

Scientific Reports

KH Wong, Y Xie, X Huang, K Kadota, XS Yao, Y Yu, X Chen, A Lu, Z Yang

Publication Date: 2020-02-27

Variant appearance in text: APP: V717F

PMID: 32107408

View BVdb publication page

---

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.

Antioxidants & Redox Signaling

Y Peng, P Gao, L Shi, L Chen, J Liu, J Long

Publication Date: 2020-02-12

Variant appearance in text: APP: V717F

PMID: 32050773

View BVdb publication page

---

Transcriptional Signatures of Tau and Amyloid Neuropathology.

Cell Reports

I Castanho, TK Murray, E Hannon, A Jeffries, E Walker, E Laing, H Baulf, J Harvey, L Bradshaw, A Randall, K Moore, P O'Neill, K Lunnon, DA Collier, Z Ahmed, MJ O'Neill, J Mill

Publication Date: 2020-02-11

Variant appearance in text: APP: V717F

PMID: 32049030

View BVdb publication page

---

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Cell Death & Disease

CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen

Publication Date: 2020-02-06

Variant appearance in text: APP: V717F

PMID: 32029735

View BVdb publication page

---

Fungicide Residues Exposure and Aggregation in a Mouse Model of Alzheimer's Disease.

Environmental Health Perspectives

PA Lafon, Y Wang, M Arango-Lievano, J Torrent, L Salvador-Prince, M Mansuy, N Mestre-Francès, L Givalois, J Liu, JV Mercader, F Jeanneteau, C Desrumaux, V Perrier

Publication Date: 2020-01

Variant appearance in text: APP: V717F

PMID: 31939705

View BVdb publication page

---

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.

Journal Of Neuroinflammation

M Balasubramaniam, PA Parcon, C Bose, L Liu, RA Jones, MR Farlow, RE Mrak, SW Barger, WST Griffin

Publication Date: 2019-12-27

Variant appearance in text: APP: v717f

PMID: 31882005

View BVdb publication page

---

Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.

Cold Spring Harbor Molecular Case Studies

JN Cochran, EC McKinley, M Cochran, MD Amaral, BA Moyers, BN Lasseigne, DE Gray, JMJ Lawlor, JW Prokop, EG Geier, JM Holt, ML Thompson, JS Newberry, JS Yokoyama, EA Worthey, DS Geldmacher, MN Love, GM Cooper, RM Myers, ED Roberson

Publication Date: 2019-12

Variant appearance in text: APP: 2149G>T; Val717Phe; rs63750264

PMID: 31836585

View BVdb publication page

---

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model.

Nature Communications

G Etter, S van der Veldt, F Manseau, I Zarrinkoub, E Trillaud-Doppia, S Williams

Publication Date: 2019-11-22

Variant appearance in text: APP: V717F

PMID: 31757962

View BVdb publication page

---

Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease.

Scientific Reports

K Yuyama, K Takahashi, S Usuki, D Mikami, H Sun, H Hanamatsu, J Furukawa, K Mukai, Y Igarashi

Publication Date: 2019-11-14

Variant appearance in text: APP: V717F

PMID: 31727994

View BVdb publication page

---

Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways.

Neurobiology Of Disease

Z Wei, X Meng, R El Fatimy, B Sun, D Mai, J Zhang, R Arora, A Zeng, P Xu, S Qu, AM Krichevsky, DJ Selkoe, S Li

Publication Date: 2019-10-24

Variant appearance in text: APP: V717F

PMID: 31669733

View BVdb publication page

---

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

M Lei, JD Teo, H Song, HP McEwen, J Yup Lee, TA Couttas, T Duncan, R Chesworth, J Bertz, M Przybyla, J Van Eersel, B Heng, GJ Guillemin, LM Ittner, T Fath, B Garner, A Ittner, T Karl, AS Don

Publication Date: 2019-11-27

Variant appearance in text: APP: V717F

PMID: 31641049

View BVdb publication page

---

Imbalance in the response of pre- and post-synaptic components to amyloidopathy.

Scientific Reports

TL Stephen, F Tamagnini, J Piegsa, K Sung, J Harvey, A Oliver-Evans, TK Murray, Z Ahmed, ML Hutton, A Randall, MJ O'Neill, JS Jackson

Publication Date: 2019-10-16

Variant appearance in text: APP: V717F

PMID: 31619689

View BVdb publication page

---

Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology

A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31583592

View BVdb publication page

---

Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model.

Frontiers In Pharmacology

AR Bilia, P Nardiello, V Piazzini, M Leri, MC Bergonzi, M Bucciantini, F Casamenti

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31507412

View BVdb publication page

---

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad

R Parodi-Rullán, JY Sone, S Fossati

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31306129

View BVdb publication page

---

The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer's Disease.

Nutrients

FJ Sánchez-Muniz, A Macho-González, A Garcimartín, JA Santos-López, J Benedí, S Bastida, MJ González-Muñoz

Publication Date: 2019-07-10

Variant appearance in text: APP: V717F

PMID: 31295866

View BVdb publication page

---

Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Cell Reports

CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang, MS Pyfer, U Tosi, BF Corbett, J Cai, J Lee, J Park, L Iacovitti, HE Scharfman, G Enikolopov, J Chin

Publication Date: 2019-06-25

Variant appearance in text: APP: V717F

PMID: 31242408

View BVdb publication page

---

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Eneuro

RSE Carney

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31147386

View BVdb publication page

---

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.

Frontiers In Molecular Neuroscience

E Vasili, A Dominguez-Meijide, TF Outeiro

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31105524

View BVdb publication page

---

Rapamycin and Alzheimer disease: a double-edged sword?

Autophagy

JM Carosi, TJ Sargeant

Publication Date: 2019-08

Variant appearance in text: APP: V717F

PMID: 31066320

View BVdb publication page

---

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.

Frontiers In Cellular Neuroscience

C Martínez-Frailes, C Di Lauro, C Bianchi, L de Diego-García, Á Sebastián-Serrano, L Boscá, M Díaz-Hernández

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 31031598

View BVdb publication page

---

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.

Aging And Disease

C Bi, S Bi, B Li

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PMID: 31011484

View BVdb publication page

---

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules (Basel, Switzerland)

R Ştefănescu, GD Stanciu, A Luca, IC Caba, BI Tamba, CT Mihai

Publication Date: 2019-03-24

Variant appearance in text: APP: V717F

PMID: 30909659

View BVdb publication page

---

The vexing complexity of the amyloidogenic pathway.

Protein Science : A Publication Of The Protein Society

MA Castro, A Hadziselimovic, CR Sanders

Publication Date: 2019-07

Variant appearance in text: APP: V717F

PMID: 30897251

View BVdb publication page

---

Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease.

Frontiers In Pharmacology

AC Cuello, H Hall, S Do Carmo

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 30886583

View BVdb publication page

---

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Frontiers In Neuroscience

JO Ojo, M Algamal, P Leary, L Abdullah, B Mouzon, JE Evans, M Mullan, F Crawford

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 30837829

View BVdb publication page

---

Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

British Journal Of Pharmacology

LM Ittner, M Klugmann, YD Ke

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PMID: 30817847

View BVdb publication page

---

Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus.

Frontiers In Pharmacology

Y Ano, M Yoshikawa, Y Takaichi, M Michikawa, K Uchida, H Nakayama, A Takashima

Publication Date: 2019

Variant appearance in text: APP: V717F

PMID: 30804789

View BVdb publication page

---

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease.

Acta Neuropathologica Communications

S Sri, CM Pegasiou, CA Cave, K Hough, N Wood, D Gomez-Nicola, K Deinhardt, D Bannerman, VH Perry, M Vargas-Caballero

Publication Date: 2019-02-22

Variant appearance in text: APP: V717F

PMID: 30795807

View BVdb publication page

---

Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease.

Aging Cell

S Jiang, C Shao, F Tang, W Wang, X Zhu

Publication Date: 2019-06

Variant appearance in text: APP: V717F

PMID: 30767411

View BVdb publication page

---

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.

Alzheimer'S Research & Therapy

L Magno, CB Lessard, M Martins, V Lang, P Cruz, Y Asi, M Katan, J Bilsland, T Lashley, P Chakrabarty, TE Golde, PJ Whiting

Publication Date: 2019-02-02

Variant appearance in text: APP: V717F

PMID: 30711010

View BVdb publication page

---

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link.

International Journal Of Molecular Sciences

E Bok, M Jo, S Lee, BR Lee, J Kim, HJ Kim

Publication Date: 2019-01-22

Variant appearance in text: APP: V717F

PMID: 30678217

View BVdb publication page

---

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease.

Molecular Neurodegeneration

S Chakroborty, ES Hill, DT Christian, R Helfrich, S Riley, C Schneider, N Kapecki, S Mustaly-Kalimi, FA Seiler, DA Peterson, AR West, BM Vertel, WN Frost, GE Stutzmann

Publication Date: 2019-01-22

Variant appearance in text: APP: V717F

PMID: 30670054

View BVdb publication page

---

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.

The Journal Of Clinical Investigation

BC Beckelman, W Yang, NP Kasica, HR Zimmermann, X Zhou, CD Keene, AG Ryazanov, T Ma

Publication Date: 2019-02-01

Variant appearance in text: APP: V717F

PMID: 30667373

View BVdb publication page

---

A short perspective on the long road to effective treatments for Alzheimer's disease.

British Journal Of Pharmacology

DS Reynolds

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PMID: 30657599

View BVdb publication page

---

Don't forget astrocytes when targeting Alzheimer's disease.

British Journal Of Pharmacology

JS Sadick, SA Liddelow

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PMID: 30636042

View BVdb publication page

---

Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice.

Eneuro

L Broestl, K Worden, AJ Moreno, EJ Davis, D Wang, B Garay, T Singh, L Verret, JJ Palop, DB Dubal

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 30627643

View BVdb publication page

---

It's all about tau.

Progress In Neurobiology

C Tapia-Rojas, F Cabezas-Opazo, CA Deaton, EH Vergara, GVW Johnson, RA Quintanilla

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PMID: 30605723

View BVdb publication page

---

Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.

Neurobiology Of Aging

CE Evans, RS Thomas, TJ Freeman, M Hvoslef-Eide, MA Good, EJ Kidd

Publication Date: 2019-03

Variant appearance in text: APP: V717F

PMID: 30572184

View BVdb publication page

---

Genetic analysis of neurodegenerative diseases in a pathology cohort.

Neurobiology Of Aging

C Blauwendraat, O Pletnikova, JT Geiger, NA Murphy, Y Abramzon, G Rudow, A Mamais, MS Sabir, B Crain, S Ahmed, LS Rosenthal, CC Bakker, F Faghri, R Chia, J Ding, TM Dawson, A Pantelyat, MS Albert, MA Nalls, SM Resnick, L Ferrucci, MR Cookson, AE Hillis, JC Troncoso, SW Scholz

Publication Date: 2019-04

Variant appearance in text: APP: V717F

PMID: 30528841

View BVdb publication page

---

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

Brain Pathology (Zurich, Switzerland)

P De Rossi, RJ Andrew, TF Musial, V Buggia-Prevot, G Xu, M Ponnusamy, H Ly, SV Krause, RC Rice, V de l'Estoile, T Valin, S Salem, F Despa, DR Borchelt, VP Bindokas, DA Nicholson, G Thinakaran

Publication Date: 2019-07

Variant appearance in text: APP: V717F

PMID: 30506549

View BVdb publication page

---

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA).

Alzheimer'S Research & Therapy

L Pradier, V Blanchard-Brégeon, A Bohme, T Debeir, J Menager, P Benoit, P Barneoud, V Taupin, P Bertrand, P Dugay, B Cameron, Y Shi, S Naimi, M Duchesne, M Gagnaire, T Weeden, T Travaline, D Reczek, L Khiroug, M Slaoui, P Brunel, H Fukuyama, J Ravetch, T Canton, C Cohen

Publication Date: 2018-11-28

Variant appearance in text: APP: V717F

PMID: 30486882

View BVdb publication page

---

Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice.

Frontiers In Aging Neuroscience

F Ugolini, D Lana, P Nardiello, D Nosi, D Pantano, F Casamenti, MG Giovannini

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 30483118

View BVdb publication page

---

Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

J Pacheco-Quinto, D Clausen, R Pérez-González, H Peng, A Meszaros, CB Eckman, E Levy, EA Eckman

Publication Date: 2019-03

Variant appearance in text: APP: V717F

PMID: 30481490

View BVdb publication page

---

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease.

British Journal Of Pharmacology

MIG Lopez Sanchez, P van Wijngaarden, IA Trounce

Publication Date: 2019-09

Variant appearance in text: APP: V717F

PMID: 30471088

View BVdb publication page

---

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Acta Neuropathologica Communications

S Li, M Jin, L Liu, Y Dang, BL Ostaszewski, DJ Selkoe

Publication Date: 2018-11-08

Variant appearance in text: APP: V717F

PMID: 30409172

View BVdb publication page

---

Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism.

Aging

J Yin, S Li, M Nielsen, T Carcione, WS Liang, J Shi

Publication Date: 2018-10-23

Variant appearance in text: APP: V717F

PMID: 30362958

View BVdb publication page

---

Role of purinergic receptors in the Alzheimer's disease.

Purinergic Signalling

M Cieślak, A Wojtczak

Publication Date: 2018-12

Variant appearance in text: APP: V717F

PMID: 30362042

View BVdb publication page

---

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis.

Bmc Neuroscience

O Shabir, J Berwick, SE Francis

Publication Date: 2018-10-17

Variant appearance in text: APP: V717F

PMID: 30333009

View BVdb publication page

---

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer's Disease.

Frontiers In Neuroscience

IC Wood

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 30283297

View BVdb publication page

---

Blood-Brain Barrier: From Physiology to Disease and Back.

Physiological Reviews

MD Sweeney, Z Zhao, A Montagne, AR Nelson, BV Zlokovic

Publication Date: 2019-01-01

Variant appearance in text: APP: V717F

PMID: 30280653

View BVdb publication page

---

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.

Acta Neuropathologica

B Falcon, W Zhang, M Schweighauser, AG Murzin, R Vidal, HJ Garringer, B Ghetti, SHW Scheres, M Goedert

Publication Date: 2018-11

Variant appearance in text: APP: V717F

PMID: 30276465

View BVdb publication page

---

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice.

Frontiers In Molecular Neuroscience

R Franco, D Aguinaga, I Reyes, EI Canela, J Lillo, A Tarutani, M Hasegawa, A Del Ser-Badia, JA Del Rio, MR Kreutz, CA Saura, G Navarro

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 30233307

View BVdb publication page

---

High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer's Disease Pathogenesis.

Metabolites

R González-Domínguez, A Sayago, Á Fernández-Recamales

Publication Date: 2018-09-18

Variant appearance in text: APP: V717F

PMID: 30231538

View BVdb publication page

---

Fragile X and APP: a Decade in Review, a Vision for the Future.

Molecular Neurobiology

CJ Westmark

Publication Date: 2019-06

Variant appearance in text: APP: V717F

PMID: 30225775

View BVdb publication page

---

Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology.

Journal Of Neuroinflammation

SM Rothman, KQ Tanis, P Gandhi, V Malkov, J Marcus, M Pearson, R Stevens, J Gilliland, C Ware, V Mahadomrongkul, E O'Loughlin, G Zeballos, R Smith, BJ Howell, J Klappenbach, M Kennedy, C Mirescu

Publication Date: 2018-09-06

Variant appearance in text: APP: V717F

PMID: 30189875

View BVdb publication page

---

TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Y Gwon, TI Kam, SH Kim, S Song, H Park, B Lim, H Lee, W Lee, DG Jo, YK Jung

Publication Date: 2018-10-17

Variant appearance in text: APP: V717F

PMID: 30185465

View BVdb publication page

---

Preventing synaptic deficits in Alzheimer's disease by inhibiting tumor necrosis factor alpha signaling.

Ibro Reports

C Cavanagh, TP Wong

Publication Date: 2018-06

Variant appearance in text: APP: V717F

PMID: 30135948

View BVdb publication page

---

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.

Nature Reviews. Drug Discovery

B Boland, WH Yu, O Corti, B Mollereau, A Henriques, E Bezard, GM Pastores, DC Rubinsztein, RA Nixon, MR Duchen, GR Mallucci, G Kroemer, B Levine, EL Eskelinen, F Mochel, M Spedding, C Louis, OR Martin, MJ Millan

Publication Date: 2018-09

Variant appearance in text: APP: V717F

PMID: 30116051

View BVdb publication page

---

The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions.

Frontiers In Cellular Neuroscience

E Sidorova-Darmos, R Sommer, JH Eubanks

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 30090057

View BVdb publication page

---

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease.

Neurobiology Of Aging

G Rutigliano, M Stazi, O Arancio, DM Watterson, N Origlia

Publication Date: 2018-10

Variant appearance in text: APP: V717F

PMID: 30007168

View BVdb publication page

---

Metabolic aspects of neuronal degeneration: From a NAD+ point of view.

Neuroscience Research

Y Sasaki

Publication Date: 2019-02

Variant appearance in text: APP: V717F

PMID: 30006197

View BVdb publication page

---

Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.

Neurobiology Of Learning And Memory

TF Musial, E Molina-Campos, LA Bean, N Ybarra, R Borenstein, ML Russo, EW Buss, D Justus, KM Neuman, GD Ayala, SA Mullen, Y Voskobiynyk, CT Tulisiak, JA Fels, NJ Corbett, G Carballo, CD Kennedy, J Popovic, J Ramos-Franco, M Fill, MR Pergande, JA Borgia, GT Corbett, K Pahan, Y Han, DM Chetkovich, RJ Vassar, RW Byrne, M Matthew Oh, TR Stoub, S Remy, JF Disterhoft, DA Nicholson

Publication Date: 2018-10

Variant appearance in text: APP: V717F

PMID: 29906573

View BVdb publication page

---

Alzheimer's Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition.

Frontiers In Cellular Neuroscience

S Mondragón-Rodríguez, N Gu, F Manseau, S Williams

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29867356

View BVdb publication page

---

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

The Journal Of Biological Chemistry

LK Fong, MM Yang, R Dos Santos Chaves, SM Reyna, VF Langness, G Woodruff, EA Roberts, JE Young, LSB Goldstein

Publication Date: 2018-07-20

Variant appearance in text: APP: V717F

PMID: 29858247

View BVdb publication page

---

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.

Journal Of Alzheimer'S Disease : Jad

EN Cline, MA Bicca, KL Viola, WL Klein

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29843241

View BVdb publication page

---

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.

Eneuro

R Brown, AD Lam, A Gonzalez-Sulser, A Ying, M Jones, RC Chou, M Tzioras, CY Jordan, I Jedrasiak-Cape, AL Hemonnot, M Abou Jaoude, AJ Cole, SS Cash, T Saito, T Saido, RR Ribchester, K Hashemi, I Oren

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29780880

View BVdb publication page

---

Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.

Neurobiology Of Aging

R Adalbert, S Milde, C Durrant, K Ando, V Stygelbout, Z Yilmaz, S Gould, JP Brion, MP Coleman

Publication Date: 2018-08

Variant appearance in text: APP: V717F

PMID: 29729423

View BVdb publication page

---

Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids.

Scientific Reports

KJ Cao, KM Elbel, JL Cifelli, J Cirera, CJ Sigurdson, F Paesani, EA Theodorakis, J Yang

Publication Date: 2018-05-03

Variant appearance in text: APP: V717F

PMID: 29725045

View BVdb publication page

---

Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro.

Journal Of Alzheimer'S Disease : Jad

J Zumkehr, CJ Rodriguez-Ortiz, R Medeiros, M Kitazawa

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29710703

View BVdb publication page

---

Can Animal Models Inform on the Relationship between Depression and Alzheimer Disease?

Canadian Journal Of Psychiatry. Revue Canadienne De Psychiatrie

JNK Nyarko, MO Quartey, GB Baker, DD Mousseau

Publication Date: 2019-01

Variant appearance in text: APP: V717F

PMID: 29685068

View BVdb publication page

---

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice.

Scientific Reports

D Shah, A Latif-Hernandez, B De Strooper, T Saito, T Saido, M Verhoye, R D'Hooge, A Van der Linden

Publication Date: 2018-04-19

Variant appearance in text: APP: V717F

PMID: 29674739

View BVdb publication page

---

Complex role of chemokine mediators in animal models of Alzheimer's Disease.

Biomedical Journal

E Martin, C Delarasse

Publication Date: 2018-02

Variant appearance in text: APP: V717F

PMID: 29673550

View BVdb publication page

---

Identification of missing variants by combining multiple analytic pipelines.

Bmc Bioinformatics

Y Ren, JS Reddy, C Pottier, V Sarangi, S Tian, JP Sinnwell, SK McDonnell, JM Biernacka, MM Carrasquillo, OA Ross, N Ertekin-Taner, R Rademakers, M Hudson, LS Mainzer, YW Asmann

Publication Date: 2018-04-16

Variant appearance in text: APP: V717F

PMID: 29661148

View BVdb publication page

---

Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects.

Oxidative Medicine And Cellular Longevity

J Wojsiat, KM Zoltowska, K Laskowska-Kaszub, U Wojda

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29636850

View BVdb publication page

---

Recent Advances: Decoding Alzheimer's Disease With Stem Cells.

Frontiers In Aging Neuroscience

Y Fang, T Gao, B Zhang, J Pu

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29623038

View BVdb publication page

---

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression.

Acta Neuropathologica Communications

A Ruiz-Riquelme, HHC Lau, E Stuart, AN Goczi, Z Wang, G Schmitt-Ulms, JC Watts

Publication Date: 2018-04-03

Variant appearance in text: APP: V717F

PMID: 29615128

View BVdb publication page

---

Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory.

Frontiers In Neuroscience

M Yoshikawa, Y Soeda, M Michikawa, OFX Almeida, A Takashima

Publication Date: 2018

Variant appearance in text: APP: V717F

PMID: 29545742

View BVdb publication page

---

Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer's disease mouse model.

Oncotarget

YH Tai, YY Lin, KC Wang, CL Chang, RY Chen, CC Wu, IH Cheng

Publication Date: 2018-02-13

Variant appearance in text: APP: V717F

PMID: 29535835

View BVdb publication page

---

Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000346798.3	c.2149G>T	p.Val717Phe	missense_variant	17/18	-
ENST00000348990.5	c.1924G>T	p.Val642Phe	missense_variant	15/16	-
ENST00000354192.3	c.1756G>T	p.Val586Phe	missense_variant	14/15	-
ENST00000357903.3	c.2092G>T	p.Val698Phe	missense_variant	16/17	-
ENST00000358918.3	c.2095G>T	p.Val699Phe	missense_variant	16/17	-
ENST00000359726.3	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
ENST00000439274.2	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
ENST00000440126.3	c.2077G>T	p.Val693Phe	missense_variant	16/17	-
ENST00000448388.2	c.1819G>T	p.Val607Phe	missense_variant	15/16	-
ENST00000464867.1	n.496G>T	-	non_coding_transcript_exon_variant	2/3	-
NM_000484.4	c.2149G>T	p.Val717Phe	missense_variant	17/18	-
NM_001136016.3	c.2077G>T	p.Val693Phe	missense_variant	16/17	-
NM_001136129.3	c.1756G>T	p.Val586Phe	missense_variant	14/15	-
NM_001136130.3	c.1981G>T	p.Val661Phe	missense_variant	16/17	-
NM_001136131.2	c.1819G>T	p.Val607Phe	missense_variant	15/16	-
NM_001204301.2	c.2095G>T	p.Val699Phe	missense_variant	16/17	-
NM_001204302.2	c.2038G>T	p.Val680Phe	missense_variant	15/16	-
NM_001204303.2	c.1870G>T	p.Val624Phe	missense_variant	14/15	-
NM_201413.3	c.2092G>T	p.Val698Phe	missense_variant	16/17	-
NM_201414.3	c.1924G>T	p.Val642Phe	missense_variant	15/16	-