Variant ID: 21-27264096-C-T

NM_000484.3(APP):c.2149G>A;(p.Val717Ile)

This variant was identified in 603 publications




Publications:


Brain-Derived Neurotrophic Factor (BDNF) Preserves the Functional Integrity of Neural Networks in the β-Amyloidopathy Model in vitro.

Frontiers In Cell And Developmental Biology
EV Mitroshina, RS Yarkov, TA Mishchenko, VG Krut', MS Gavrish, EA Epifanova, AA Babaev, MV Vedunova
Publication Date: 2020

Variant appearance in text: APP: V717I
PMID: 32733889
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Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Acta Neuropathologica Communications
S Kumar, CA Lemere, J Walter
Publication Date: 2020-07-29

Variant appearance in text: APP: V717I
PMID: 32727580
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Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease.

Molecular Neurodegeneration
H Wang, KK Dey, PC Chen, Y Li, M Niu, JH Cho, X Wang, B Bai, Y Jiao, SR Chepyala, V Haroutunian, B Zhang, TG Beach, J Peng
Publication Date: 2020-07-25

Variant appearance in text: APP: V717I
PMID: 32711556
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Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer's Disease.

International Journal Of Molecular Sciences
T Kuboyama, X Yang, C Tohda
Publication Date: 2020-06-30

Variant appearance in text: APP: V717I
PMID: 32630004
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Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.

Frontiers In Neuroscience
T Loeffler, I Schilcher, S Flunkert, B Hutter-Paier
Publication Date: 2020

Variant appearance in text: APP: V717I
PMID: 32595447
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Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.

Stem Cell Reports
Y Pomeshchik, O Klementieva, J Gil, I Martinsson, MG Hansen, T de Vries, A Sancho-Balsells, K Russ, E Savchenko, A Collin, AR Vaz, S Bagnoli, B Nacmias, C Rampon, S Sorbi, D Brites, G Marko-Varga, Z Kokaia, M Rezeli, GK Gouras, L Roybon
Publication Date: 2020-06-14

Variant appearance in text: APP: V717I
PMID: 32589876
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Application of Genetically Engineered Pigs in Biomedical Research.

Genes
M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland
Publication Date: 2020-06-19

Variant appearance in text: APP: V717I
PMID: 32575461
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In vitro Models of Neurodegenerative Diseases.

Frontiers In Cell And Developmental Biology
A Slanzi, G Iannoto, B Rossi, E Zenaro, G Constantin
Publication Date: 2020

Variant appearance in text: APP: V717I
PMID: 32528949
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Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules
R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba
Publication Date: 2020-06-06

Variant appearance in text: APP: V717I
PMID: 32517180
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Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice.

Alzheimer'S Research & Therapy
Y Zhao, R Qian, J Zhang, F Liu, K Iqbal, CL Dai, CX Gong
Publication Date: 2020-06-08

Variant appearance in text: APP: V717I
PMID: 32513253
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Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.

International Journal Of Molecular Sciences
YH Park, SJ Shin, HS Kim, SB Hong, S Kim, Y Nam, JJ Kim, K Lim, JS Kim, JI Kim, SG Jeon, M Moon
Publication Date: 2020-05-29

Variant appearance in text: APP: V717I
PMID: 32486013
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Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.

International Journal Of Molecular Sciences
S Kim, Y Nam, C Kim, H Lee, S Hong, HS Kim, SJ Shin, YH Park, HN Mai, SM Oh, KS Kim, DH Yoo, WK Chung, H Chung, M Moon
Publication Date: 2020-05-23

Variant appearance in text: APP: V717I
PMID: 32456197
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SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.

Cells
SY Park, JY Kang, T Lee, D Nam, CJ Jeon, JB Kim
Publication Date: 2020-05-21

Variant appearance in text: APP: V717I
PMID: 32455709
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Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.

Neurochemistry International
T Wahle, A Sofranko, S Dekkers, MR Miller, HJ Heusinkveld, C Albrecht, FR Cassee, RPF Schins
Publication Date: 2020-05-15

Variant appearance in text: APP: V717I
PMID: 32422323
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Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

International Journal Of Molecular Sciences
L Gatti, F Tinelli, E Scelzo, F Arioli, G Di Fede, L Obici, L Pantoni, G Giaccone, P Caroppo, EA Parati, A Bersano
Publication Date: 2020-05-13

Variant appearance in text: APP: V717I
PMID: 32414028
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Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer's Disease.

Molecular Neurobiology
H Jęśko, PL Wencel, S Wójtowicz, J Strosznajder, WJ Lukiw, RP Strosznajder
Publication Date: 2020-04-30

Variant appearance in text: APP: V717I
PMID: 32356173
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New Insights into the Molecular Bases of Familial Alzheimer's Disease.

Journal Of Personalized Medicine
V D'Argenio, D Sarnataro
Publication Date: 2020-04-19

Variant appearance in text: APP: V717I
PMID: 32325882
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Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons.

Scientific Reports
C Sackmann, M Hallbeck
Publication Date: 2020-04-16

Variant appearance in text: APP: V717I
PMID: 32300132
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Are ketogenic diets promising for Alzheimer's disease? A translational review.

Alzheimer'S Research & Therapy
M Lilamand, B Porte, E Cognat, J Hugon, F Mouton-Liger, C Paquet
Publication Date: 2020-04-14

Variant appearance in text: APP: V717I
PMID: 32290868
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The rare and the common: scale and the genetic imaginary in Alzheimer's disease drug development.

New Genetics And Society
R Milne
Publication Date: 2020

Variant appearance in text: APP: V717I
PMID: 32256202
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The Genetics of Alzheimer's Disease in the Chinese Population.

International Journal Of Molecular Sciences
CL Gan, T Zhang, TH Lee
Publication Date: 2020-03-30

Variant appearance in text: APP: V717I
PMID: 32235595
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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature Communications
SS Kwak, KJ Washicosky, E Brand, D von Maydell, J Aronson, S Kim, DE Capen, M Cetinbas, R Sadreyev, S Ning, E Bylykbashi, W Xia, SL Wagner, SH Choi, RE Tanzi, DY Kim
Publication Date: 2020-03-13

Variant appearance in text: APP: V717I
PMID: 32170138
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Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease.

Acta Neuropathologica Communications
GM Lloyd, JA Trejo-Lopez, Y Xia, KN McFarland, SJ Lincoln, N Ertekin-Taner, BI Giasson, AT Yachnis, S Prokop
Publication Date: 2020-03-12

Variant appearance in text: APP: Val717Ile
PMID: 32164763
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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.

Cells
GH Buniatian, R Weiskirchen, TS Weiss, U Schwinghammer, M Fritz, T Seferyan, B Proksch, M Glaser, A Lourhmati, M Buadze, E Borkham-Kamphorst, F Gaunitz, CH Gleiter, T Lang, E Schaeffeler, R Tremmel, H Cynis, WH Frey, R Gebhardt, SL Friedman, W Mikulits, M Schwab, L Danielyan
Publication Date: 2020-02-17

Variant appearance in text: APP: V717I
PMID: 32089540
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Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice.

Journal Of Neuroinflammation
N Lax, N Fainstein, Y Nishri, A Ben-Zvi, T Ben-Hur
Publication Date: 2020-02-14

Variant appearance in text: APP: V717I
PMID: 32059733
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Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.

Antioxidants & Redox Signaling
Y Peng, P Gao, L Shi, L Chen, J Liu, J Long
Publication Date: 2020-02-12

Variant appearance in text: APP: V717I
PMID: 32050773
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Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

International Journal Of Molecular Sciences
A Angel, R Volkman, TG Royal, D Offen
Publication Date: 2020-02-09

Variant appearance in text: APP: V717I
PMID: 32050445
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Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Cell Death & Disease
CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen
Publication Date: 2020-02-06

Variant appearance in text: APP: V717I
PMID: 32029735
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Effects of neural stem cell transplantation in Alzheimer's disease models.

Journal Of Biomedical Science
Y Hayashi, HT Lin, CC Lee, KJ Tsai
Publication Date: 2020-01-27

Variant appearance in text: APP: V717I
PMID: 31987051
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YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.

Nature Communications
H Tanaka, H Homma, K Fujita, K Kondo, S Yamada, X Jin, M Waragai, G Ohtomo, A Iwata, K Tagawa, N Atsuta, M Katsuno, N Tomita, K Furukawa, Y Saito, T Saito, A Ichise, S Shibata, H Arai, T Saido, M Sudol, SI Muramatsu, H Okano, EJ Mufson, G Sobue, S Murayama, H Okazawa
Publication Date: 2020-01-24

Variant appearance in text: APP: V717I
PMID: 31980612
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Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease.

Alzheimer'S Research & Therapy
M Quan, T Zhao, Y Tang, P Luo, W Wang, Q Qin, T Li, Q Wang, J Fang, J Jia
Publication Date: 2020-01-14

Variant appearance in text: APP: V717I
PMID: 31937364
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β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.

Journal Of Alzheimer'S Disease : Jad
Y Ano, R Ohya, Y Takaichi, T Washinuma, K Uchida, A Takashima, H Nakayama
Publication Date: 2020-01-06

Variant appearance in text: APP: V717I
PMID: 31929163
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VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice.

Molecular Neurodegeneration
F El Gaamouch, M Audrain, WJ Lin, N Beckmann, C Jiang, S Hariharan, PS Heeger, EE Schadt, S Gandy, ME Ehrlich, SR Salton
Publication Date: 2020-01-10

Variant appearance in text: APP: V717I
PMID: 31924226
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Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Receptor Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Journal Of Alzheimer'S Disease : Jad
T Khatib, DR Chisholm, A Whiting, B Platt, P McCaffery
Publication Date: 2019-12-23

Variant appearance in text: APP: V717I
PMID: 31884477
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Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer's Disease.

Frontiers In Aging Neuroscience
C Samaey, A Schreurs, S Stroobants, D Balschun
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31866856
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A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.

Aging Cell
JX Song, S Malampati, Y Zeng, SSK Durairajan, CB Yang, BC Tong, A Iyaswamy, WB Shang, SG Sreenivasmurthy, Z Zhu, KH Cheung, JH Lu, C Tang, N Xu, M Li
Publication Date: 2019-12-19

Variant appearance in text: APP: V717I
PMID: 31858697
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Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model.

Journal Of Neuroinflammation
M Cai, JH Lee, EJ Yang
Publication Date: 2019-12-13

Variant appearance in text: APP: V717I
PMID: 31836020
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From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes.

Bioinformation
M Aathi, S Piramanayagam
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31831959
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Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer's Disease.

Frontiers In Pharmacology
A Peng, Y Gao, X Zhuang, Y Lin, W He, Y Wang, W Chen, T Chen, X Huang, R Yang, Y Huang, S Xi, X Zhang
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31827437
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Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways.

Nature Reviews. Neurology
SM Greenberg, BJ Bacskai, M Hernandez-Guillamon, J Pruzin, R Sperling, SJ van Veluw
Publication Date: 2019-12-11

Variant appearance in text: APP: Val717Ile
PMID: 31827267
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MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.

Elife
FH Beraldo, D Palmer, S Memar, DI Wasserman, WV Lee, S Liang, SD Creighton, B Kolisnyk, MF Cowan, J Mels, TS Masood, C Fodor, MA Al-Onaizi, R Bartha, T Gee, LM Saksida, TJ Bussey, SS Strother, VF Prado, BD Winters, MAM Prado
Publication Date: 2019-12-11

Variant appearance in text: APP: V717I
PMID: 31825307
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C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer's disease.

Plos One
E Panayiotou, E Fella, S Andreou, R Papacharalambous, P Gerasimou, P Costeas, S Angeli, I Kousiappa, S Papacostas, T Kyriakides
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31809505
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Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.

Experimental & Molecular Medicine
DK Kim, D Han, J Park, H Choi, JC Park, MY Cha, J Woo, MS Byun, DY Lee, Y Kim, I Mook-Jung
Publication Date: 2019-11-15

Variant appearance in text: APP: V717I
PMID: 31727875
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Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology
A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31583592
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APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease.

International Journal Of Molecular Sciences
VV Giau, E Bagyinszky, YC Youn, SSA An, S Kim
Publication Date: 2019-09-25

Variant appearance in text: APP: Val717Ile
PMID: 31557888
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Risk Factors for Alzheimer's Disease: Focus on Stress.

Frontiers In Pharmacology
A Caruso, F Nicoletti, A Gaetano, S Scaccianoce
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31551781
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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Nature Neuroscience
AU Joshi, PS Minhas, SA Liddelow, B Haileselassie, KI Andreasson, GW Dorn, D Mochly-Rosen
Publication Date: 2019-10

Variant appearance in text: APP: V717I
PMID: 31551592
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Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.

Brain Pathology (Zurich, Switzerland)
E Sanchez-Mejias, C Nuñez-Diaz, R Sanchez-Varo, A Gomez-Arboledas, JA Garcia-Leon, JJ Fernandez-Valenzuela, M Mejias-Ortega, L Trujillo-Estrada, D Baglietto-Vargas, I Moreno-Gonzalez, JC Davila, J Vitorica, A Gutierrez
Publication Date: 2019-09-06

Variant appearance in text: APP: V717I
PMID: 31491047
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Transthyretin expression in the postischemic brain.

Plos One
D Talhada, I Gonçalves, C Reis Santos, K Ruscher
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31479465
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Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
S Kim, Y Nam, YO Jeong, HH Park, SK Lee, SJ Shin, H Jung, BH Kim, SB Hong, YH Park, J Kim, J Yu, DH Yoo, SH Park, SG Jeon, M Moon
Publication Date: 2019-08-16

Variant appearance in text: APP: V717I
PMID: 31426329
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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo.

Plos One
KM McAvoy, H Rajamohamed Sait, G Marsh, M Peterson, TL Reynolds, J Gagnon, S Geisler, P Leach, C Roberts, E Cahir-McFarland, RM Ransohoff, A Crotti
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31408457
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Ketogenic Diet in Alzheimer's Disease.

International Journal Of Molecular Sciences
M Rusek, R Pluta, M Ułamek-Kozioł, SJ Czuczwar
Publication Date: 2019-08-09

Variant appearance in text: APP: V717I
PMID: 31405021
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Modeling Alzheimer's disease with iPSC-derived brain cells.

Molecular Psychiatry
J Penney, WT Ralvenius, LH Tsai
Publication Date: 2020-01

Variant appearance in text: APP: V717I
PMID: 31391546
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Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer's disease.

Scientific Reports
M Wang, VS Ramasamy, M Samidurai, J Jo
Publication Date: 2019-07-29

Variant appearance in text: APP: V717I
PMID: 31358853
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Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease.

Scientific Reports
I Carreras, N Aytan, JK Choi, CM Tognoni, NW Kowall, BG Jenkins, A Dedeoglu
Publication Date: 2019-07-29

Variant appearance in text: APP: V717I
PMID: 31358793
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5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
Z Manji, A Rojas, W Wang, R Dingledine, NH Varvel, T Ganesh
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 31322556
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Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.

Journal Of Neuroinflammation
E Medrano-Jiménez, I Jiménez-Ferrer Carrillo, M Pedraza-Escalona, CE Ramírez-Serrano, L Álvarez-Arellano, J Cortés-Mendoza, M Herrera-Ruiz, E Jiménez-Ferrer, A Zamilpa, J Tortoriello, G Pedraza-Alva, L Pérez-Martínez
Publication Date: 2019-07-10

Variant appearance in text: APP: V717I
PMID: 31291963
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Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology.

International Journal Of Molecular Sciences
Y Ano, Y Yoshino, K Uchida, H Nakayama
Publication Date: 2019-06-29

Variant appearance in text: APP: V717I
PMID: 31261895
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Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.

The Journal Of Biological Chemistry
SW Tam, R Feng, WK Lau, AC Law, PK Yeung, SK Chung
Publication Date: 2019-08-16

Variant appearance in text: APP: V717I
PMID: 31248984
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Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
SJ Shin, SG Jeon, JI Kim, YO Jeong, S Kim, YH Park, SK Lee, HH Park, SB Hong, S Oh, JY Hwang, HS Kim, H Park, Y Nam, YY Lee, JJ Kim, SH Park, JS Kim, M Moon
Publication Date: 2019-06-21

Variant appearance in text: APP: V717I
PMID: 31234321
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Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline.

Aging
Y Ano, Y Yoshino, T Kutsukake, R Ohya, T Fukuda, K Uchida, A Takashima, H Nakayama
Publication Date: 2019-05-23

Variant appearance in text: APP: V717I
PMID: 31121563
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Aβ oligomers trigger and accelerate Aβ seeding.

Brain Pathology (Zurich, Switzerland)
N Katzmarski, S Ziegler-Waldkirch, N Scheffler, C Witt, C Abou-Ajram, B Nuscher, M Prinz, C Haass, M Meyer-Luehmann
Publication Date: 2020-01

Variant appearance in text: APP: V717I
PMID: 31099449
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Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?

Journal Of Clinical Medicine
K Govindpani, LG McNamara, NR Smith, C Vinnakota, HJ Waldvogel, RL Faull, A Kwakowsky
Publication Date: 2019-05-10

Variant appearance in text: APP: V717I
PMID: 31083442
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Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene.

Journal Of Applied Bioinformatics & Computational Biology
Y Zhou, L Chen, X Zhou, Y Pei, S Wei, A Mehmood, YK Xiang, D Wang
Publication Date: 2018

Variant appearance in text: APP: V717I
PMID: 31058201
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Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.

Science Translational Medicine
A Aoyagi, C Condello, J Stöhr, W Yue, BM Rivera, JC Lee, AL Woerman, G Halliday, S van Duinen, M Ingelsson, L Lannfelt, C Graff, TD Bird, CD Keene, WW Seeley, WF DeGrado, SB Prusiner
Publication Date: 2019-05-01

Variant appearance in text: APP: V717I
PMID: 31043574
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APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Cell Reports
C Deyts, M Clutter, N Pierce, P Chakrabarty, TB Ladd, A Goddi, AM Rosario, P Cruz, K Vetrivel, SL Wagner, G Thinakaran, TE Golde, AT Parent
Publication Date: 2019-04-30

Variant appearance in text: APP: V717I
PMID: 31042463
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Inflammasomes in neuroinflammatory and neurodegenerative diseases.

Embo Molecular Medicine
S Voet, S Srinivasan, M Lamkanfi, G van Loo
Publication Date: 2019-06

Variant appearance in text: APP: V717I
PMID: 31015277
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Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.

Aging And Disease
C Bi, S Bi, B Li
Publication Date: 2019-04

Variant appearance in text: APP: V717I
PMID: 31011484
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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Molecular Neurobiology
B Van Gool, SE Storck, SM Reekmans, B Lechat, PLSM Gordts, L Pradier, CU Pietrzik, AJM Roebroek
Publication Date: 2019-10

Variant appearance in text: APP: V717I
PMID: 31004319
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Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease.

Open Biology
YY Wu, FL Chiu, CS Yeh, HC Kuo
Publication Date: 2019-01-31

Variant appearance in text: APP: V717I
PMID: 30958120
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Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice.

International Journal Of Molecular Sciences
QV Duong, ML Kintzing, WE Kintzing, IM Abdallah, AD Brannen, A Kaddoumi
Publication Date: 2019-03-25

Variant appearance in text: APP: V717I
PMID: 30934587
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Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules (Basel, Switzerland)
R Ştefănescu, GD Stanciu, A Luca, IC Caba, BI Tamba, CT Mihai
Publication Date: 2019-03-24

Variant appearance in text: APP: V717I
PMID: 30909659
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The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration.

Cells
Y Yan, J Bejoy, M Marzano, Y Li
Publication Date: 2019-03-14

Variant appearance in text: APP: V717I
PMID: 30875781
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Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

The Journal Of Biological Chemistry
HH Jarosz-Griffiths, NJ Corbett, HA Rowland, K Fisher, AC Jones, J Baron, GJ Howell, SA Cowley, S Chintawar, MZ Cader, KAB Kellett, NM Hooper
Publication Date: 2019-04-26

Variant appearance in text: APP: V717I
PMID: 30872401
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Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance.

Science Advances
RY Pan, J Ma, XX Kong, XF Wang, SS Li, XL Qi, YH Yan, J Cheng, Q Liu, W Jin, CH Tan, Z Yuan
Publication Date: 2019-02

Variant appearance in text: APP: V717I
PMID: 30820451
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Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

British Journal Of Pharmacology
LM Ittner, M Klugmann, YD Ke
Publication Date: 2019-09

Variant appearance in text: APP: V717I
PMID: 30817847
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Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus.

Frontiers In Pharmacology
Y Ano, M Yoshikawa, Y Takaichi, M Michikawa, K Uchida, H Nakayama, A Takashima
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 30804789
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Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease.

Neural Regeneration Research
B Martinez, PV Peplow
Publication Date: 2019-07

Variant appearance in text: APP: V717I
PMID: 30804241
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The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease.

Frontiers In Pharmacology
H Park, S Kang, E Nam, YH Suh, KA Chang
Publication Date: 2019

Variant appearance in text: APP: V717I
PMID: 30733674
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The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.

Scientific Reports
AD Snow, GM Castillo, BP Nguyen, PY Choi, JA Cummings, J Cam, Q Hu, T Lake, W Pan, AJ Kastin, DA Kirschner, SG Wood, E Rockenstein, E Masliah, S Lorimer, RE Tanzi, L Larsen
Publication Date: 2019-02-06

Variant appearance in text: APP: V717I
PMID: 30728442
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Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.

Scientific Reports
A Androuin, YS Abada, M Ly, M Santin, A Petiet, S Epelbaum, A Bertrand, B Delatour
Publication Date: 2019-02-04

Variant appearance in text: APP: V717I
PMID: 30718666
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Multi-faceted therapeutic strategy for treatment of Alzheimer's disease by concurrent administration of etodolac and α-tocopherol.

Neurobiology Of Disease
KH Elfakhri, IM Abdallah, AD Brannen, A Kaddoumi
Publication Date: 2019-05

Variant appearance in text: APP: V717I
PMID: 30710675
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REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.

Cell Reports
K Meyer, HM Feldman, T Lu, D Drake, ET Lim, KH Ling, NA Bishop, Y Pan, J Seo, YT Lin, SC Su, GM Church, LH Tsai, BA Yankner
Publication Date: 2019-01-29

Variant appearance in text: APP: V717I
PMID: 30699343
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PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model.

Nature Communications
N Rosenzweig, R Dvir-Szternfeld, A Tsitsou-Kampeli, H Keren-Shaul, H Ben-Yehuda, P Weill-Raynal, L Cahalon, A Kertser, K Baruch, I Amit, A Weiner, M Schwartz
Publication Date: 2019-01-28

Variant appearance in text: APP: V717I
PMID: 30692527
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Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease.

Frontiers In Molecular Neuroscience
XY Chen, YF Du, L Chen
Publication Date: 2018

Variant appearance in text: APP: V717I
PMID: 30687008
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Dementia with Lewy bodies: an update and outlook.

Molecular Neurodegeneration
TF Outeiro, DJ Koss, D Erskine, L Walker, M Kurzawa-Akanbi, D Burn, P Donaghy, C Morris, JP Taylor, A Thomas, J Attems, I McKeith
Publication Date: 2019-01-21

Variant appearance in text: APP: V717I; rs63750264
PMID: 30665447
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A short perspective on the long road to effective treatments for Alzheimer's disease.

British Journal Of Pharmacology
DS Reynolds
Publication Date: 2019-09

Variant appearance in text: APP: V717I
PMID: 30657599
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3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice.

The Journal Of Experimental Medicine
D Lazic, AP Sagare, AM Nikolakopoulou, JH Griffin, R Vassar, BV Zlokovic
Publication Date: 2019-02-04

Variant appearance in text: APP: V717I
PMID: 30647119
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Don't forget astrocytes when targeting Alzheimer's disease.

British Journal Of Pharmacology
JS Sadick, SA Liddelow
Publication Date: 2019-09

Variant appearance in text: APP: V717I
PMID: 30636042
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Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.

Scientific Reports
SD Creighton, AL Mendell, D Palmer, BE Kalisch, NJ MacLusky, VF Prado, MAM Prado, BD Winters
Publication Date: 2019-01-11

Variant appearance in text: APP: V717I
PMID: 30635592
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CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage.

Nature Communications
J Sun, J Carlson-Stevermer, U Das, M Shen, M Delenclos, AM Snead, SY Koo, L Wang, D Qiao, J Loi, AJ Petersen, M Stockton, A Bhattacharyya, MV Jones, X Zhao, PJ McLean, AA Sproul, K Saha, S Roy
Publication Date: 2019-01-03

Variant appearance in text: APP: V717I
PMID: 30604771
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Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine.

Neuron
SM Neuner, SE Heuer, MJ Huentelman, KMS O'Connell, CC Kaczorowski
Publication Date: 2019-02-06

Variant appearance in text: APP: V717I
PMID: 30595332
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Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.

Cell Reports
COY Hung, FJ Livesey
Publication Date: 2018-12-26

Variant appearance in text: APP: V717I
PMID: 30590039
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000346798.3 c.2149G>A p.Val717Ile missense_variant 17/18 -
ENST00000348990.5 c.1924G>A p.Val642Ile missense_variant 15/16 -
ENST00000354192.3 c.1756G>A p.Val586Ile missense_variant 14/15 -
ENST00000357903.3 c.2092G>A p.Val698Ile missense_variant 16/17 -
ENST00000358918.3 c.2095G>A p.Val699Ile missense_variant 16/17 -
ENST00000359726.3 c.1981G>A p.Val661Ile missense_variant 16/17 -
ENST00000439274.2 c.1981G>A p.Val661Ile missense_variant 16/17 -
ENST00000440126.3 c.2077G>A p.Val693Ile missense_variant 16/17 -
ENST00000448388.2 c.1819G>A p.Val607Ile missense_variant 15/16 -
ENST00000464867.1 n.496G>A - non_coding_transcript_exon_variant 2/3 -
NM_000484.4 c.2149G>A p.Val717Ile missense_variant 17/18 -
NM_001136016.3 c.2077G>A p.Val693Ile missense_variant 16/17 -
NM_001136129.3 c.1756G>A p.Val586Ile missense_variant 14/15 -
NM_001136130.3 c.1981G>A p.Val661Ile missense_variant 16/17 -
NM_001136131.2 c.1819G>A p.Val607Ile missense_variant 15/16 -
NM_001204301.2 c.2095G>A p.Val699Ile missense_variant 16/17 -
NM_001204302.2 c.2038G>A p.Val680Ile missense_variant 15/16 -
NM_001204303.2 c.1870G>A p.Val624Ile missense_variant 14/15 -
NM_201413.3 c.2092G>A p.Val698Ile missense_variant 16/17 -
NM_201414.3 c.1924G>A p.Val642Ile missense_variant 15/16 -