The Allosteric Antagonist of the Sigma-2 Receptors-Elayta (CT1812) as a Therapeutic Candidate for Mild to Moderate Alzheimer's Disease: A Scoping Systematic Review.
Life (Basel, Switzerland)
Rasheed, Anum A; Zaheer, Ahmad Bin AB; Munawwar, Aqsa A; Sarfraz, Zouina Z; Sarfraz, Azza A; Robles-Velasco, Karla K; Cherrez-Ojeda, Ivan I
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer's disease brain extracts.
Alzheimer'S Research & Therapy
Sandberg, Anders A; Berenjeno-Correa, Ernesto E; Rodriguez, Rosa Crespo RC; Axenhus, Michael M; Weiss, Sophia Schedin SS; Batenburg, Kevin K; Hoozemans, Jeroen J M JJM; Tjernberg, Lars O LO; Scheper, Wiep W
Rare Amyloid Precursor Protein Point Mutations Recapitulate Worldwide Migration and Admixture in Healthy Individuals: Implications for the Study of Neurodegeneration.
International Journal Of Molecular Sciences
Abondio, Paolo P; Bruno, Francesco F; Bruni, Amalia Cecilia AC; Luiselli, Donata D
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles.
International Journal Of Molecular Sciences
Mesangeau, Christophe C; Carato, Pascal P; Renault, Nicolas N; Coevoet, Mathilde M; Larchanché, Paul-Emmanuel PE; Barczyk, Amélie A; Buée, Luc L; Sergeant, Nicolas N; Melnyk, Patricia P
A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease.
Molecular Psychiatry
Catania, Marcella M; Colombo, Laura L; Sorrentino, Stefano S; Cagnotto, Alfredo A; Lucchetti, Jacopo J; Barbagallo, Maria Chiara MC; Vannetiello, Ilaria I; Vecchi, Elena Rita ER; Favagrossa, Monica M; Costanza, Massimo M; Giaccone, Giorgio G; Salmona, Mario M; Tagliavini, Fabrizio F; Di Fede, Giuseppe G
Exploring the Involvement of the Amyloid Precursor Protein A673T Mutation against Amyloid Pathology and Alzheimer's Disease in Relation to Therapeutic Editing Tools.
Pharmaceutics
Stanciu, Gabriela Dumitrita GD; Ababei, Daniela Carmen DC; Rusu, Razvan Nicolae RN; Bild, Veronica V; Tamba, Bogdan-Ionel BI
Publication Date: 2022-06-15
Variant appearance in text: APP: A673T; rs63750847
PTPRD and DCC Are Novel BACE1 Substrates Differentially Expressed in Alzheimer's Disease: A Data Mining and Bioinformatics Study.
International Journal Of Molecular Sciences
Taylor, Hannah A HA; Simmons, Katie J KJ; Clavane, Eva M EM; Trevelyan, Christopher J CJ; Brown, Jane M JM; Przemyłska, Lena L; Watt, Nicole T NT; Matthews, Laura C LC; Meakin, Paul J PJ
CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation.
Molecular Therapy. Nucleic Acids
Konstantinidis, Evangelos E; Molisak, Agnieszka A; Perrin, Florian F; Streubel-Gallasch, Linn L; Fayad, Sarah S; Kim, Daniel Y DY; Petri, Karl K; Aryee, Martin J MJ; Aguilar, Ximena X; György, Bence B; Giedraitis, Vilmantas V; Joung, J Keith JK; Pattanayak, Vikram V; Essand, Magnus M; Erlandsson, Anna A; Berezovska, Oksana O; Ingelsson, Martin M
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Cellular And Molecular Life Sciences : Cmls
Marengo, Liana L; Armbrust, Fred F; Schoenherr, Caroline C; Storck, Steffen E SE; Schmitt, Ulrich U; Zampar, Silvia S; Wirths, Oliver O; Altmeppen, Hermann H; Glatzel, Markus M; Kaether, Christoph C; Weggen, Sascha S; Becker-Pauly, Christoph C; Pietrzik, Claus U CU
MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kim, Jinhu J; Kim, Seungjoon S; Kim, Hyeonho H; Hwang, In-Wook IW; Bae, Sungwon S; Karki, Sudeep S; Kim, Dongwook D; Ogelman, Roberto R; Bang, Geul G; Kim, Jin Young JY; Kajander, Tommi T; Um, Ji Won JW; Oh, Won Chan WC; Ko, Jaewon J
MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kim, Jinhu J; Kim, Seungjoon S; Kim, Hyeonho H; Hwang, In-Wook IW; Bae, Sungwon S; Karki, Sudeep S; Kim, Dongwook D; Ogelman, Roberto R; Bang, Geul G; Kim, Jin Young JY; Kajander, Tommi T; Um, Ji Won JW; Oh, Won Chan WC; Ko, Jaewon J
Amyloid Precursor Protein A713T Mutation in Calabrian Patients with Alzheimer's Disease: A Population Genomics Approach to Estimate Inheritance from a Common Ancestor.
Biomedicines
Abondio, Paolo P; Sarno, Stefania S; Giuliani, Cristina C; Laganà, Valentina V; Maletta, Raffaele R; Bernardi, Livia L; Bruno, Francesco F; Colao, Rosanna R; Puccio, Gianfranco G; Frangipane, Francesca F; Borroni, Barbara B; Van Broeckhoven, Christine C; Luiselli, Donata D; Bruni, Amalia A
Amyloid Precursor Protein A713T Mutation in Calabrian Patients with Alzheimer's Disease: A Population Genomics Approach to Estimate Inheritance from a Common Ancestor.
Biomedicines
Abondio, Paolo P; Sarno, Stefania S; Giuliani, Cristina C; Laganà, Valentina V; Maletta, Raffaele R; Bernardi, Livia L; Bruno, Francesco F; Colao, Rosanna R; Puccio, Gianfranco G; Frangipane, Francesca F; Borroni, Barbara B; Van Broeckhoven, Christine C; Luiselli, Donata D; Bruni, Amalia A
Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.
Translational Psychiatry
Chen, Hung-Hsin HH; Petty, Lauren E LE; Sha, Jin J; Zhao, Yi Y; Kuzma, Amanda A; Valladares, Otto O; , ; Bush, William W; Naj, Adam C AC; Gamazon, Eric R ER; Below, Jennifer E JE
Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.
Translational Psychiatry
Chen, Hung-Hsin HH; Petty, Lauren E LE; Sha, Jin J; Zhao, Yi Y; Kuzma, Amanda A; Valladares, Otto O; , ; Bush, William W; Naj, Adam C AC; Gamazon, Eric R ER; Below, Jennifer E JE
Engineered pegRNAs improve prime editing efficiency.
Nature Biotechnology
Nelson, James W JW; Randolph, Peyton B PB; Shen, Simon P SP; Everette, Kelcee A KA; Chen, Peter J PJ; Anzalone, Andrew V AV; An, Meirui M; Newby, Gregory A GA; Chen, Jonathan C JC; Hsu, Alvin A; Liu, David R DR
Publication Date: 2022-03
Variant appearance in text: APP: Ala673Thr; rs63750847
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.
Science Translational Medicine
Liu, Chia-Chen CC; Murray, Melissa E ME; Li, Xia X; Zhao, Na N; Wang, Na N; Heckman, Michael G MG; Shue, Francis F; Martens, Yuka Y; Li, Yonghe Y; Raulin, Ana-Caroline AC; Rosenberg, Cassandra L CL; Doss, Sydney V SV; Zhao, Jing J; Wren, Melissa C MC; Jia, Lin L; Ren, Yingxue Y; Ikezu, Tadafumi C TC; Lu, Wenyan W; Fu, Yuan Y; Caulfield, Thomas T; Trottier, Zachary A ZA; Knight, Joshua J; Chen, Yixing Y; Linares, Cynthia C; Wang, Xue X; Kurti, Aishe A; Asmann, Yan W YW; Wszolek, Zbigniew K ZK; Smith, Glenn E GE; Vemuri, Prashanthi P; Kantarci, Kejal K; Knopman, David S DS; Lowe, Val J VJ; Jack, Clifford R CR; Parisi, Joseph E JE; Ferman, Tanis J TJ; Boeve, Bradley F BF; Graff-Radford, Neill R NR; Petersen, Ronald C RC; Younkin, Steven G SG; Fryer, John D JD; Wang, Hu H; Han, Xianlin X; Frieden, Carl C; Dickson, Dennis W DW; Ross, Owen A OA; Bu, Guojun G
Hampel, Harald H; Hardy, John J; Blennow, Kaj K; Chen, Christopher C; Perry, George G; Kim, Seung Hyun SH; Villemagne, Victor L VL; Aisen, Paul P; Vendruscolo, Michele M; Iwatsubo, Takeshi T; Masters, Colin L CL; Cho, Min M; Lannfelt, Lars L; Cummings, Jeffrey L JL; Vergallo, Andrea A
Publication Date: 2021-08-30
Variant appearance in text: APP: A673T; rs63750847
Hampel, Harald H; Hardy, John J; Blennow, Kaj K; Chen, Christopher C; Perry, George G; Kim, Seung Hyun SH; Villemagne, Victor L VL; Aisen, Paul P; Vendruscolo, Michele M; Iwatsubo, Takeshi T; Masters, Colin L CL; Cho, Min M; Lannfelt, Lars L; Cummings, Jeffrey L JL; Vergallo, Andrea A
Publication Date: 2021-10
Variant appearance in text: APP: A673T; rs63750847
Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer's Disease.
International Journal Of Molecular Sciences
Jalali, David D; Guevarra, Justine Anne JA; Martinez, Luz L; Hung, Lily L; Vonhoff, Fernando J FJ