Variant ID: 21-27269938-T-A

NM_000484.3(APP):c.2011A>T;(p.Met671Leu)

This variant was identified in 510 publications




Publications:


Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease.

Frontiers In Physiology
L Li, XK Tong, M Hosseini Kahnouei, D Vallerand, E Hamel, H Girouard
Publication Date: 2021

Variant appearance in text: APP: M671L
PubMed Link: 34475828
Variant Present in the following documents:
  • Main text
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Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
D Reimers, M Vallejo-Muñoz, MJ Casarejos, A Jimenez-Escrig, R Gonzalo-Gobernado, E Bazan
Publication Date: 2021-08-13

Variant appearance in text: APP: M671L
PubMed Link: 34445402
Variant Present in the following documents:
  • Main text
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Effects of Mild Excitotoxic Stimulus on Mitochondria Ca2+ Handling in Hippocampal Cultures of a Mouse Model of Alzheimer's Disease.

Cells
G Rigotto, L Zentilin, T Pozzan, E Basso
Publication Date: 2021-08-10

Variant appearance in text: APP: M671L
PubMed Link: 34440815
Variant Present in the following documents:
  • Main text
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Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.

Frontiers In Aging Neuroscience
AL Oblak, PB Lin, KP Kotredes, RS Pandey, D Garceau, HM Williams, A Uyar, R O'Rourke, S O'Rourke, C Ingraham, D Bednarczyk, M Belanger, ZA Cope, GJ Little, SG Williams, C Ash, A Bleckert, T Ragan, BA Logsdon, LM Mangravite, SJ Sukoff Rizzo, PR Territo, GW Carter, GR Howell, M Sasner, BT Lamb
Publication Date: 2021

Variant appearance in text: APP: M671L
PubMed Link: 34366832
Variant Present in the following documents:
  • Main text
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Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages.

Frontiers In Neuroscience
M Zhang, L Zhong, X Han, G Xiong, D Xu, S Zhang, H Cheng, K Chiu, Y Xu
Publication Date: 2021

Variant appearance in text: APP: M671L
PubMed Link: 34366774
Variant Present in the following documents:
  • Main text
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Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease.

Frontiers In Aging Neuroscience
JL Martinez, MD Zammit, NR West, BT Christian, A Bhattacharyya
Publication Date: 2021

Variant appearance in text: APP: Met671Leu
PubMed Link: 34322015
Variant Present in the following documents:
  • Main text
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Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling.

Acta Neuropathologica Communications
P Jadiya, JF Garbincius, JW Elrod
Publication Date: 2021-07-07

Variant appearance in text: APP: M671L
PubMed Link: 34233766
Variant Present in the following documents:
  • Main text
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Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer's Disease.

International Journal Of Molecular Sciences
D Jalali, JA Guevarra, L Martinez, L Hung, FJ Vonhoff
Publication Date: 2021-06-29

Variant appearance in text: APP: M671L
PubMed Link: 34209883
Variant Present in the following documents:
  • Main text
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Curcugreen Treatment Prevented Splenomegaly and Other Peripheral Organ Abnormalities in 3xTg and 5xFAD Mouse Models of Alzheimer's Disease.

Antioxidants (Basel, Switzerland)
J Manna, GL Dunbar, P Maiti
Publication Date: 2021-06-02

Variant appearance in text: APP: M671L
PubMed Link: 34199639
Variant Present in the following documents:
  • Main text
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Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology.

Brain : A Journal Of Neurology
M Ries, H Watts, BC Mota, MY Lopez, CK Donat, N Baxan, JA Pickering, TW Chau, A Semmler, B Gurung, R Aleksynas, L Abelleira-Hervas, SJ Iqbal, C Romero-Molina, G Hernandez-Mir, A d'Amati, C Reutelingsperger, MH Goldfinger, SM Gentleman, FV Leuven, E Solito, M Sastre
Publication Date: 2021-06-20

Variant appearance in text: APP: M671L
PubMed Link: 34148071
Variant Present in the following documents:
  • Main text
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Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease.

Acta Neuropathologica Communications
Y Lin, J Jin, R Lv, Y Luo, W Dai, W Li, Y Tang, Y Wang, X Ye, WJ Lin
Publication Date: 2021-06-02

Variant appearance in text: APP: M671L
PubMed Link: 34078467
Variant Present in the following documents:
  • Main text
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Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.

International Journal Of Molecular Sciences
T Nakai, K Yamada, H Mizoguchi
Publication Date: 2021-05-24

Variant appearance in text: APP: M671L
PubMed Link: 34074018
Variant Present in the following documents:
  • Main text
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Physical Exercise-Induced Myokines in Neurodegenerative Diseases.

International Journal Of Molecular Sciences
B Lee, M Shin, Y Park, SY Won, KS Cho
Publication Date: 2021-05-28

Variant appearance in text: APP: M671L
PubMed Link: 34071457
Variant Present in the following documents:
  • Main text
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A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse.

International Journal Of Molecular Sciences
AJ López-Gambero, C Rosell-Valle, D Medina-Vera, JA Navarro, A Vargas, P Rivera, C Sanjuan, F Rodríguez de Fonseca, J Suárez
Publication Date: 2021-05-20

Variant appearance in text: APP: M671L
PubMed Link: 34065168
Variant Present in the following documents:
  • Main text
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Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model.

Molecules (Basel, Switzerland)
Q Yuan, X Liu, Y Zhang, YF Xian, J Zou, X Zhang, P Huang, YQ Song, ZX Lin
Publication Date: 2021-05-04

Variant appearance in text: APP: M671L
PubMed Link: 34064330
Variant Present in the following documents:
  • Main text
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Alzheimer's disease-associated β-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.

The Journal Of Biological Chemistry
O Bocharova, NP Pandit, K Molesworth, A Fisher, O Mychko, N Makarava, IV Baskakov
Publication Date: 2021-05-27

Variant appearance in text: APP: M671L
PubMed Link: 34052228
Variant Present in the following documents:
  • Main text
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Gut microbial involvement in Alzheimer's disease pathogenesis.

Aging
Y Zhang, R Geng, Q Tu
Publication Date: 2021-05-10

Variant appearance in text: APP: M671L
PubMed Link: 33971619
Variant Present in the following documents:
  • Main text
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Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease.

Aging Cell
F Du, Q Yu, S Yan, Z Zhang, JR Vangavaragu, D Chen, SF Yan, SS Yan
Publication Date: 2021-05-05

Variant appearance in text: APP: M671L
PubMed Link: 33951271
Variant Present in the following documents:
  • Main text
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Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease.

Frontiers In Aging Neuroscience
A Wiȩckowska-Gacek, A Mietelska-Porowska, D Chutorański, M Wydrych, J Długosz, U Wojda
Publication Date: 2021

Variant appearance in text: APP: M671L
PubMed Link: 33867971
Variant Present in the following documents:
  • Main text
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Therapeutic B-cell depletion reverses progression of Alzheimer's disease.

Nature Communications
K Kim, X Wang, E Ragonnaud, M Bodogai, T Illouz, M DeLuca, RA McDevitt, F Gusev, E Okun, E Rogaev, A Biragyn
Publication Date: 2021-04-12

Variant appearance in text: APP: M671L
PubMed Link: 33846335
Variant Present in the following documents:
  • Main text
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Ginkgo biloba extract improves cognitive function and increases neurogenesis by reducing Aβ pathology in 5×FAD mice.

American Journal Of Translational Research
W Ge, C Ren, L Xing, L Guan, C Zhang, X Sun, G Wang, H Niu, S Qun
Publication Date: 2021

Variant appearance in text: APP: M671L
PubMed Link: 33841671
Variant Present in the following documents:
  • Main text
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Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.

Neurobiology Of Aging
F Kara, ME Belloy, R Voncken, Z Sarwari, Y Garima, C Anckaerts, A Langbeen, V Leysen, D Shah, J Jacobs, J Hamaide, P Bols, J Van Audekerke, J Daans, C Guglielmetti, K Kantarci, V Prevot, S Roßner, P Ponsaerts, A Van der Linden, M Verhoye
Publication Date: 2021-02-22

Variant appearance in text: APP: M671L
PubMed Link: 33765427
Variant Present in the following documents:
  • Main text
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Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer's disease.

Scientific Reports
E Rosales Jubal, M Schwalm, M Dos Santos Guilherme, F Schuck, S Reinhardt, A Tose, Z Barger, MK Roesler, N Ruffini, A Wierczeiko, MJ Schmeisser, U Schmitt, K Endres, A Stroh
Publication Date: 2021-03-23

Variant appearance in text: APP: M671L
PubMed Link: 33758244
Variant Present in the following documents:
  • Main text
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Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer's disease.

Journal Of Neuroinflammation
N Davis, BC Mota, L Stead, EOC Palmer, L Lombardero, R Rodríguez-Puertas, V de Paola, SJ Barnes, M Sastre
Publication Date: 2021-03-17

Variant appearance in text: APP: M671L
PubMed Link: 33731156
Variant Present in the following documents:
  • Main text
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Impaired cognitive flexibility induced by chronic cerebral hypoperfusion in 5XFAD transgenic mouse model of mixed dementia.

The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences
MS Kim, J Bang, BY Kim, WK Jeon
Publication Date: 2021-03-12

Variant appearance in text: APP: M671L
PubMed Link: 33709149
Variant Present in the following documents:
  • Main text
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Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

The Journal Of Biological Chemistry
F Checler, E Afram, R Pardossi-Piquard, I Lauritzen
Publication Date: 2021-03-01

Variant appearance in text: APP: M671L
PubMed Link: 33662398
Variant Present in the following documents:
  • Main text
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INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.

Neurobiology Of Disease
AP Tsai, PB Lin, C Dong, M Moutinho, BT Casali, Y Liu, BT Lamb, GE Landreth, AL Oblak, K Nho
Publication Date: 2021-02-22

Variant appearance in text: APP: M671L
PubMed Link: 33631273
Variant Present in the following documents:
  • Main text
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Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies.

Nutrients
P Londzin, M Zamora, B Kąkol, A Taborek, J Folwarczna
Publication Date: 2021-02-06

Variant appearance in text: APP: M671L
PubMed Link: 33562156
Variant Present in the following documents:
  • Main text
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Platycodon grandiflorum Root Protects against Aβ-Induced Cognitive Dysfunction and Pathology in Female Models of Alzheimer's Disease.

Antioxidants (Basel, Switzerland)
Y Nam, SJ Shin, YH Park, MJ Kim, SG Jeon, H Lee, Y Choi, TJ Kim, SM Shin, JJ Kim, DH Yoo, HD Kim, S Kim, M Moon
Publication Date: 2021-02-01

Variant appearance in text: APP: M671L
PubMed Link: 33535469
Variant Present in the following documents:
  • Main text
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Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice.

Journal Of Alzheimer'S Disease : Jad
M Gnanaprakash, A Staniszewski, H Zhang, R Pitstick, MP Kavanaugh, O Arancio, RE Nicholls
Publication Date: 2021-01-14

Variant appearance in text: APP: M671L
PubMed Link: 33459709
Variant Present in the following documents:
  • Main text
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Neuroprotective Effects of Coffee Bioactive Compounds: A Review.

International Journal Of Molecular Sciences
K Socała, A Szopa, A Serefko, E Poleszak, P Wlaź
Publication Date: 2020-12-24

Variant appearance in text: APP: M671L
PubMed Link: 33374338
Variant Present in the following documents:
  • Main text
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Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau.

Frontiers In Neurology
R Brandt, NI Trushina, L Bakota
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 33193056
Variant Present in the following documents:
  • Main text
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Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2.

International Journal Of Molecular Sciences
SH Jeon, N Kim, YJ Ju, MS Gee, D Lee, JK Lee
Publication Date: 2020-11-10

Variant appearance in text: APP: M671L
PubMed Link: 33182586
Variant Present in the following documents:
  • Main text
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Studying the Relationship of Intermittent Fasting and β-Amyloid in Animal Model of Alzheimer's Disease: A Scoping Review.

Nutrients
ML Nasaruddin, SA Syed Abd Halim, MA Kamaruzzaman
Publication Date: 2020-10-21

Variant appearance in text: APP: M671L
PubMed Link: 33096730
Variant Present in the following documents:
  • Main text
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Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.

Plos One
C Tackenberg, L Kulic, RM Nitsch
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32966331
Variant Present in the following documents:
  • Supplemental file
  • Main text
View BVdb publication page



Conductive Hearing Loss Aggravates Memory Decline in Alzheimer Model Mice.

Frontiers In Neuroscience
JS Kim, HJ Lee, S Lee, HS Lee, YJ Jeong, Y Son, JM Kim, YJ Lee, MH Park
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32903751
Variant Present in the following documents:
  • Main text
View BVdb publication page



Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice.

Journal Of Neuroinflammation
D Liu, Y Zhao, Y Qi, Y Gao, D Tu, Y Wang, HM Gao, H Zhou
Publication Date: 2020-08-31

Variant appearance in text: APP: M671L
PubMed Link: 32867800
Variant Present in the following documents:
  • Main text
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Brain region-specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer's disease.

Lipids In Health And Disease
M Dey, FJ Gunn-Moore, B Platt, TK Smith
Publication Date: 2020-08-31

Variant appearance in text: APP: M671L
PubMed Link: 32867761
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders.

Frontiers In Physiology
JJ Lochhead, J Yang, PT Ronaldson, TP Davis
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32848858
Variant Present in the following documents:
  • Main text
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Brain-Derived Neurotrophic Factor (BDNF) Preserves the Functional Integrity of Neural Networks in the β-Amyloidopathy Model in vitro.

Frontiers In Cell And Developmental Biology
EV Mitroshina, RS Yarkov, TA Mishchenko, VG Krut', MS Gavrish, EA Epifanova, AA Babaev, MV Vedunova
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32733889
Variant Present in the following documents:
  • Main text
  • fcell-08-00582.pdf
View BVdb publication page



Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease.

Acta Neuropathologica Communications
C Mezö, N Dokalis, O Mossad, O Staszewski, J Neuber, B Yilmaz, D Schnepf, MG de Agüero, SC Ganal-Vonarburg, AJ Macpherson, M Meyer-Luehmann, P Staeheli, T Blank, M Prinz, D Erny
Publication Date: 2020-07-29

Variant appearance in text: APP: M671L
PubMed Link: 32727612
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells.

International Journal Of Molecular Sciences
E Scremin, M Agostini, A Leparulo, T Pozzan, E Greotti, C Fasolato
Publication Date: 2020-07-25

Variant appearance in text: APP: M671L
PubMed Link: 32722509
Variant Present in the following documents:
  • Supplemental file
  • Main text
View BVdb publication page



Passive immunotherapies targeting Aβ and tau in Alzheimer's disease.

Neurobiology Of Disease
SS Plotkin, NR Cashman
Publication Date: 2020-10

Variant appearance in text: APP: M671L
PubMed Link: 32682954
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice.

Journal Of Alzheimer'S Disease : Jad
Y Shi, L Zhang, X Gao, J Zhang, M Ben Abou, G Liang, Q Meng, A Hepner, MF Eckenhoff, H Wei
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32623395
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.

Frontiers In Neuroscience
GS Stephens, CH Fu, CP St Romain, Y Zheng, JJ Botterill, HE Scharfman, Y Liu, J Chin
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32536852
Variant Present in the following documents:
  • Main text
  • fnins-14-00472.pdf
View BVdb publication page



Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules
R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba
Publication Date: 2020-06-06

Variant appearance in text: APP: M671L
PubMed Link: 32517180
Variant Present in the following documents:
  • Main text
  • biomolecules-10-00870.pdf
View BVdb publication page



Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?

Frontiers In Neuroscience
M Dibattista, S Pifferi, A Menini, J Reisert
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 32508565
Variant Present in the following documents:
  • Main text
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Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer's Disease.

Scientific Reports
O Shabir, P Sharp, MA Rebollar, L Boorman, C Howarth, SB Wharton, SE Francis, J Berwick
Publication Date: 2020-05-05

Variant appearance in text: APP: M671L
PubMed Link: 32371859
Variant Present in the following documents:
  • Supplemental file
  • 41598_2020_Article_64334.pdf
  • Main text
View BVdb publication page



New Insights into the Molecular Bases of Familial Alzheimer's Disease.

Journal Of Personalized Medicine
V D'Argenio, D Sarnataro
Publication Date: 2020-04-19

Variant appearance in text: APP: M671L
PubMed Link: 32325882
Variant Present in the following documents:
  • Main text
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Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice.

Journal Of Neuroinflammation
N Lax, N Fainstein, Y Nishri, A Ben-Zvi, T Ben-Hur
Publication Date: 2020-02-14

Variant appearance in text: APP: M671L
PubMed Link: 32059733
Variant Present in the following documents:
  • 12974_2020_Article_1738.pdf
View BVdb publication page



Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease.

International Journal Of Molecular Sciences
K Ono, M Tsuji
Publication Date: 2020-01-31

Variant appearance in text: APP: M671L
PubMed Link: 32023927
Variant Present in the following documents:
  • ijms-21-00952.pdf
  • Main text
View BVdb publication page



Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.

Iranian Journal Of Basic Medical Sciences
M Iranshahy, B Javadi
Publication Date: 2019-10

Variant appearance in text: APP: M671L
PubMed Link: 31998450
Variant Present in the following documents:
  • IJBMS-22-1102.pdf
View BVdb publication page



Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
WJ Meilandt, H Ngu, A Gogineni, G Lalehzadeh, SH Lee, K Srinivasan, J Imperio, T Wu, M Weber, AJ Kruse, KL Stark, P Chan, M Kwong, Z Modrusan, BA Friedman, J Elstrott, O Foreman, A Easton, M Sheng, DV Hansen
Publication Date: 2020-02-26

Variant appearance in text: APP: M671L
PubMed Link: 31980586
Variant Present in the following documents:
  • zns1956.pdf
View BVdb publication page



β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.

Journal Of Alzheimer'S Disease : Jad
Y Ano, R Ohya, Y Takaichi, T Washinuma, K Uchida, A Takashima, H Nakayama
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 31929163
Variant Present in the following documents:
  • Main text
View BVdb publication page



Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Journal Of Alzheimer'S Disease : Jad
T Khatib, DR Chisholm, A Whiting, B Platt, P McCaffery
Publication Date: 2020

Variant appearance in text: APP: M671L
PubMed Link: 31884477
Variant Present in the following documents:
  • Main text
View BVdb publication page



Donecopride, a Swiss army knife with potential against Alzheimer's disease.

British Journal Of Pharmacology
C Rochais, C Lecoutey, K Hamidouche, P Giannoni, F Gaven, E Cem, S Mignani, K Baranger, T Freret, J Bockaert, S Rivera, M Boulouard, P Dallemagne, S Claeysen
Publication Date: 2020-05

Variant appearance in text: APP: M671L
PubMed Link: 31881553
Variant Present in the following documents:
  • Main text
View BVdb publication page



Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.

Experimental & Molecular Medicine
DK Kim, D Han, J Park, H Choi, JC Park, MY Cha, J Woo, MS Byun, DY Lee, Y Kim, I Mook-Jung
Publication Date: 2019-11-15

Variant appearance in text: APP: M671L
PubMed Link: 31727875
Variant Present in the following documents:
  • 12276_2019_Article_326.pdf
  • Main text
View BVdb publication page



Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.

Frontiers In Pharmacology
I Dal Prà, U Armato, A Chiarini
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31719824
Variant Present in the following documents:
  • Main text
View BVdb publication page



History and progress of hypotheses and clinical trials for Alzheimer's disease.

Signal Transduction And Targeted Therapy
PP Liu, Y Xie, XY Meng, JS Kang
Publication Date: 2019

Variant appearance in text: APP: Met671Leu
PubMed Link: 31637009
Variant Present in the following documents:
  • Main text
View BVdb publication page



Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology
A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31583592
Variant Present in the following documents:
  • nihms-1581159.pdf
  • Main text
View BVdb publication page



Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model.

Scientific Reports
R Ciccone, C Franco, I Piccialli, F Boscia, A Casamassa, V de Rosa, P Cepparulo, M Cataldi, L Annunziato, A Pannaccione
Publication Date: 2019-09-19

Variant appearance in text: APP: M671L
PubMed Link: 31537873
Variant Present in the following documents:
  • 41598_2019_Article_50018.pdf
  • Main text
View BVdb publication page



Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
M Ishii, AJ Hiller, L Pham, MJ McGuire, C Iadecola, G Wang
Publication Date: 2019-10-30

Variant appearance in text: APP: M671L
PubMed Link: 31537707
Variant Present in the following documents:
  • zns8816.pdf
  • Main text
View BVdb publication page



Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

Journal Of Cell Science
PV Martino Adami, Z Nichtová, DB Weaver, A Bartok, T Wisniewski, DR Jones, S Do Carmo, EM Castaño, AC Cuello, G Hajnóczky, L Morelli
Publication Date: 2019-10-22

Variant appearance in text: APP: M671L
PubMed Link: 31515277
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.

Brain Pathology (Zurich, Switzerland)
E Sanchez-Mejias, C Nuñez-Diaz, R Sanchez-Varo, A Gomez-Arboledas, JA Garcia-Leon, JJ Fernandez-Valenzuela, M Mejias-Ortega, L Trujillo-Estrada, D Baglietto-Vargas, I Moreno-Gonzalez, JC Davila, J Vitorica, A Gutierrez
Publication Date: 2020-03

Variant appearance in text: APP: M671L
PubMed Link: 31491047
Variant Present in the following documents:
  • Supplemental file
  • Main text
  • BPA-30-345.pdf
View BVdb publication page



Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.

Nature Communications
P Jadiya, DW Kolmetzky, D Tomar, A Di Meco, AA Lombardi, JP Lambert, TS Luongo, MH Ludtmann, D Praticò, JW Elrod
Publication Date: 2019-08-29

Variant appearance in text: APP: M671L
PubMed Link: 31467276
Variant Present in the following documents:
  • 41467_2019_Article_11813.pdf
  • Main text
  • 41467_2019_11813_MOESM1_ESM.pdf
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Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
S Kim, Y Nam, YO Jeong, HH Park, SK Lee, SJ Shin, H Jung, BH Kim, SB Hong, YH Park, J Kim, J Yu, DH Yoo, SH Park, SG Jeon, M Moon
Publication Date: 2019-08-16

Variant appearance in text: APP: M671L
PubMed Link: 31426329
Variant Present in the following documents:
  • ijms-20-03992.pdf
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Modeling Alzheimer's disease with iPSC-derived brain cells.

Molecular Psychiatry
J Penney, WT Ralvenius, LH Tsai
Publication Date: 2020-01

Variant appearance in text: APP: M671L
PubMed Link: 31391546
Variant Present in the following documents:
  • 41380_2019_Article_468.pdf
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Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease.

Frontiers In Pharmacology
D Mango, A Saidi, GY Cisale, M Feligioni, M Corbo, R Nisticò
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31379566
Variant Present in the following documents:
  • Main text
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5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
Z Manji, A Rojas, W Wang, R Dingledine, NH Varvel, T Ganesh
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31322556
Variant Present in the following documents:
  • Main text
  • nihms-1607954.pdf
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Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.

Journal Of Neuroinflammation
E Medrano-Jiménez, I Jiménez-Ferrer Carrillo, M Pedraza-Escalona, CE Ramírez-Serrano, L Álvarez-Arellano, J Cortés-Mendoza, M Herrera-Ruiz, E Jiménez-Ferrer, A Zamilpa, J Tortoriello, G Pedraza-Alva, L Pérez-Martínez
Publication Date: 2019-07-10

Variant appearance in text: APP: M671L
PubMed Link: 31291963
Variant Present in the following documents:
  • Main text
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model.

Neurotherapeutics : The Journal Of The American Society For Experimental Neurotherapeutics
K Baranger, M van Gijsel-Bonnello, D Stephan, W Carpentier, S Rivera, M Khrestchatisky, B Gharib, M De Reggi, P Benech
Publication Date: 2019-10

Variant appearance in text: APP: M671L
PubMed Link: 31267473
Variant Present in the following documents:
  • Main text
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Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology.

International Journal Of Molecular Sciences
Y Ano, Y Yoshino, K Uchida, H Nakayama
Publication Date: 2019-06-29

Variant appearance in text: APP: M671L
PubMed Link: 31261895
Variant Present in the following documents:
  • Main text
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LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Cell
BL Heckmann, BJW Teubner, B Tummers, E Boada-Romero, L Harris, M Yang, CS Guy, SS Zakharenko, DR Green
Publication Date: 2019-07-25

Variant appearance in text: APP: M671L
PubMed Link: 31257024
Variant Present in the following documents:
  • nihms-1532619.pdf
  • Main text
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Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia.

International Journal Of Molecular Sciences
J Perła-Kaján, H Jakubowski
Publication Date: 2019-06-27

Variant appearance in text: APP: M671L
PubMed Link: 31252610
Variant Present in the following documents:
  • ijms-20-03140.pdf
  • Main text
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Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.

Frontiers In Aging Neuroscience
M Lachen-Montes, A González-Morales, M Palomino, K Ausin, M Gómez-Ochoa, MV Zelaya, I Ferrer, A Pérez-Mediavilla, J Fernández-Irigoyen, E Santamaría
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31244650
Variant Present in the following documents:
  • Main text
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Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Cell Reports
CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang, MS Pyfer, U Tosi, BF Corbett, J Cai, J Lee, J Park, L Iacovitti, HE Scharfman, G Enikolopov, J Chin
Publication Date: 2019-06-25

Variant appearance in text: APP: M671L
PubMed Link: 31242408
Variant Present in the following documents:
  • Main text
  • nihms-1532883.pdf
  • NIHMS1532883-supplement-2.pdf
View BVdb publication page



Analysis of Motor Function in the Tg4-42 Mouse Model of Alzheimer's Disease.

Frontiers In Behavioral Neuroscience
JM Wagner, ME Sichler, EM Schleicher, TN Franke, C Irwin, MJ Löw, N Beindorff, C Bouter, TA Bayer, Y Bouter
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31156407
Variant Present in the following documents:
  • Main text
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Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline.

Aging
Y Ano, Y Yoshino, T Kutsukake, R Ohya, T Fukuda, K Uchida, A Takashima, H Nakayama
Publication Date: 2019-05-23

Variant appearance in text: APP: M671L
PubMed Link: 31121563
Variant Present in the following documents:
  • Main text
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Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
S Kwon, I Moreno-Gonzalez, K Taylor-Presse, G Edwards Iii, N Gamez, O Calderon, B Zhu, FC Velasquez, C Soto, EM Sevick-Muraca
Publication Date: 2019

Variant appearance in text: APP: M671L
PubMed Link: 31104026
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000346798.3 c.2011A>T p.Met671Leu missense_variant 16/18 -
ENST00000348990.5 c.1786A>T p.Met596Leu missense_variant 14/16 -
ENST00000354192.3 c.1618A>T p.Met540Leu missense_variant 13/15 -
ENST00000357903.3 c.1954A>T p.Met652Leu missense_variant 15/17 -
ENST00000358918.3 c.1957A>T p.Met653Leu missense_variant 15/17 -
ENST00000359726.3 c.1843A>T p.Met615Leu missense_variant 15/17 -
ENST00000439274.2 c.1843A>T p.Met615Leu missense_variant 15/17 -
ENST00000440126.3 c.1939A>T p.Met647Leu missense_variant 15/17 -
ENST00000448388.2 c.1681A>T p.Met561Leu missense_variant 14/16 -
ENST00000456209.2 c.718A>T p.Met240Leu missense_variant 6/7 -
ENST00000464867.1 n.358A>T - non_coding_transcript_exon_variant 1/3 -
NM_000484.4 c.2011A>T p.Met671Leu missense_variant 16/18 -
NM_001136016.3 c.1939A>T p.Met647Leu missense_variant 15/17 -
NM_001136129.3 c.1618A>T p.Met540Leu missense_variant 13/15 -
NM_001136130.3 c.1843A>T p.Met615Leu missense_variant 15/17 -
NM_001136131.2 c.1681A>T p.Met561Leu missense_variant 14/16 -
NM_001204301.2 c.1957A>T p.Met653Leu missense_variant 15/17 -
NM_001204302.2 c.1900A>T p.Met634Leu missense_variant 14/16 -
NM_001204303.2 c.1732A>T p.Met578Leu missense_variant 13/15 -
NM_201413.3 c.1954A>T p.Met652Leu missense_variant 15/17 -
NM_201414.3 c.1786A>T p.Met596Leu missense_variant 14/16 -