Variant ID: 21-27269939-C-A

NM_000484.3(APP):c.2010G>T;(p.Lys670Asn)

This variant was identified in 904 publications




Publications:


Brain-Derived Neurotrophic Factor (BDNF) Preserves the Functional Integrity of Neural Networks in the β-Amyloidopathy Model in vitro.

Frontiers In Cell And Developmental Biology
EV Mitroshina, RS Yarkov, TA Mishchenko, VG Krut', MS Gavrish, EA Epifanova, AA Babaev, MV Vedunova
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32733889
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Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

Bmc Molecular And Cell Biology
AS Cone, SN Hurwitz, GS Lee, X Yuan, Y Zhou, Y Li, DG Meckes
Publication Date: 2020-07-30

Variant appearance in text: APP: K670N
PMID: 32731849
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Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Acta Neuropathologica Communications
S Kumar, CA Lemere, J Walter
Publication Date: 2020-07-29

Variant appearance in text: APP: K670N
PMID: 32727580
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Passive immunotherapies targeting Aβ and tau in Alzheimer's disease.

Neurobiology Of Disease
SS Plotkin, NR Cashman
Publication Date: 2020-07-16

Variant appearance in text: APP: K670N
PMID: 32682954
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Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer's Disease.

International Journal Of Molecular Sciences
T Kuboyama, X Yang, C Tohda
Publication Date: 2020-06-30

Variant appearance in text: APP: K670N
PMID: 32630004
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Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.

Frontiers In Neuroscience
T Loeffler, I Schilcher, S Flunkert, B Hutter-Paier
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32595447
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Application of Genetically Engineered Pigs in Biomedical Research.

Genes
M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland
Publication Date: 2020-06-19

Variant appearance in text: APP: K670N
PMID: 32575461
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Role of antioxidants and a nutrient rich diet in Alzheimer's disease.

Open Biology
G Veurink, G Perry, SK Singh
Publication Date: 2020-06

Variant appearance in text: APP: K670N
PMID: 32543351
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Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.

Frontiers In Neuroscience
GS Stephens, CH Fu, CP St Romain, Y Zheng, JJ Botterill, HE Scharfman, Y Liu, J Chin
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32536852
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In vitro Models of Neurodegenerative Diseases.

Frontiers In Cell And Developmental Biology
A Slanzi, G Iannoto, B Rossi, E Zenaro, G Constantin
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32528949
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Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules
R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba
Publication Date: 2020-06-06

Variant appearance in text: APP: K670N
PMID: 32517180
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Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice.

Alzheimer'S Research & Therapy
Y Zhao, R Qian, J Zhang, F Liu, K Iqbal, CL Dai, CX Gong
Publication Date: 2020-06-08

Variant appearance in text: APP: K670N
PMID: 32513253
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Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?

Frontiers In Neuroscience
M Dibattista, S Pifferi, A Menini, J Reisert
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32508565
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A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ42 and tau-induced pathophysiological effects on long-term potentiation.

Alzheimer'S & Dementia (New York, N. Y.)
J Caneus, N Akanda, JW Rumsey, X Guo, M Jackson, CJ Long, F Sommerhage, S Georgieva, NM Kanaan, D Morgan, JJ Hickman
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32490141
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Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.

International Journal Of Molecular Sciences
YH Park, SJ Shin, HS Kim, SB Hong, S Kim, Y Nam, JJ Kim, K Lim, JS Kim, JI Kim, SG Jeon, M Moon
Publication Date: 2020-05-29

Variant appearance in text: APP: K670N
PMID: 32486013
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Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.

International Journal Of Molecular Sciences
S Kim, Y Nam, C Kim, H Lee, S Hong, HS Kim, SJ Shin, YH Park, HN Mai, SM Oh, KS Kim, DH Yoo, WK Chung, H Chung, M Moon
Publication Date: 2020-05-23

Variant appearance in text: APP: K670N
PMID: 32456197
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SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.

Cells
SY Park, JY Kang, T Lee, D Nam, CJ Jeon, JB Kim
Publication Date: 2020-05-21

Variant appearance in text: APP: K670N
PMID: 32455709
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Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.

Neurochemistry International
T Wahle, A Sofranko, S Dekkers, MR Miller, HJ Heusinkveld, C Albrecht, FR Cassee, RPF Schins
Publication Date: 2020-05-15

Variant appearance in text: APP: K670N
PMID: 32422323
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Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

International Journal Of Molecular Sciences
L Gatti, F Tinelli, E Scelzo, F Arioli, G Di Fede, L Obici, L Pantoni, G Giaccone, P Caroppo, EA Parati, A Bersano
Publication Date: 2020-05-13

Variant appearance in text: APP: K670N
PMID: 32414028
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Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

The Journal Of Clinical Investigation
PJ Meakin, BM Coull, Z Tuharska, C McCaffery, I Akoumianakis, C Antoniades, J Brown, KJ Griffin, F Platt, CH Ozber, NY Yuldasheva, N Makava, A Skromna, AR Prescott, AD McNeilly, MK Siddiqui, CNA Palmer, F Khan, ML Ashford
Publication Date: 2020-05-14

Variant appearance in text: APP: K670N
PMID: 32407295
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Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer's Disease.

Scientific Reports
O Shabir, P Sharp, MA Rebollar, L Boorman, C Howarth, SB Wharton, SE Francis, J Berwick
Publication Date: 2020-05-05

Variant appearance in text: APP: K670N
PMID: 32371859
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Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease.

Cells
R Franco, R Rivas-Santisteban, M Casanovas, A Lillo, CA Saura, G Navarro
Publication Date: 2020-04-26

Variant appearance in text: APP: K670N
PMID: 32357548
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New Insights into the Molecular Bases of Familial Alzheimer's Disease.

Journal Of Personalized Medicine
V D'Argenio, D Sarnataro
Publication Date: 2020-04-19

Variant appearance in text: APP: K670N
PMID: 32325882
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Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer's Disease.

Frontiers In Cellular Neuroscience
X Wang, J Wu, S Ma, Y Xie, H Liu, M Yao, Y Zhang, GL Yang, B Yang, R Guo, F Guan
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32292331
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Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
KY Kim, YH Suh, KA Chang
Publication Date: 2020-04-10

Variant appearance in text: APP: K670N
PMID: 32290355
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Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1.

International Journal Of Molecular Sciences
DL Popescu, WE Van Nostrand, JK Robinson
Publication Date: 2020-03-28

Variant appearance in text: APP: K670N
PMID: 32231123
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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature Communications
SS Kwak, KJ Washicosky, E Brand, D von Maydell, J Aronson, S Kim, DE Capen, M Cetinbas, R Sadreyev, S Ning, E Bylykbashi, W Xia, SL Wagner, SH Choi, RE Tanzi, DY Kim
Publication Date: 2020-03-13

Variant appearance in text: APP: K670N
PMID: 32170138
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The Interaction of EphA4 With PDGFRβ Regulates Proliferation and Neuronal Differentiation of Neural Progenitor Cells in vitro and Promotes Neurogenesis in vivo.

Frontiers In Aging Neuroscience
Q Chen, H Song, C Liu, J Xu, C Wei, W Wang, F Han
Publication Date: 2020

Variant appearance in text: APP: K670N
PMID: 32116646
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Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.

Molecules (Basel, Switzerland)
L Bellusci, M Runfola, V Carnicelli, S Sestito, F Fulceri, F Santucci, P Lenzi, F Fornai, S Rapposelli, N Origlia, R Zucchi, G Chiellini
Publication Date: 2020-02-26

Variant appearance in text: APP: K670N
PMID: 32110992
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APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance.

International Journal Of Molecular Sciences
T Tomiyama, H Shimada
Publication Date: 2020-02-19

Variant appearance in text: APP: K670N
PMID: 32093100
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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.

Cells
GH Buniatian, R Weiskirchen, TS Weiss, U Schwinghammer, M Fritz, T Seferyan, B Proksch, M Glaser, A Lourhmati, M Buadze, E Borkham-Kamphorst, F Gaunitz, CH Gleiter, T Lang, E Schaeffeler, R Tremmel, H Cynis, WH Frey, R Gebhardt, SL Friedman, W Mikulits, M Schwab, L Danielyan
Publication Date: 2020-02-17

Variant appearance in text: APP: K670N
PMID: 32089540
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Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice.

Journal Of Neuroinflammation
N Lax, N Fainstein, Y Nishri, A Ben-Zvi, T Ben-Hur
Publication Date: 2020-02-14

Variant appearance in text: APP: K670N
PMID: 32059733
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Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

International Journal Of Molecular Sciences
A Angel, R Volkman, TG Royal, D Offen
Publication Date: 2020-02-09

Variant appearance in text: APP: K670N
PMID: 32050445
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Transcriptional Signatures of Tau and Amyloid Neuropathology.

Cell Reports
I Castanho, TK Murray, E Hannon, A Jeffries, E Walker, E Laing, H Baulf, J Harvey, L Bradshaw, A Randall, K Moore, P O'Neill, K Lunnon, DA Collier, Z Ahmed, MJ O'Neill, J Mill
Publication Date: 2020-02-11

Variant appearance in text: APP: K670N
PMID: 32049030
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Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Cell Death & Disease
CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen
Publication Date: 2020-02-06

Variant appearance in text: APP: K670N
PMID: 32029735
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Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease.

International Journal Of Molecular Sciences
K Ono, M Tsuji
Publication Date: 2020-01-31

Variant appearance in text: APP: K670N
PMID: 32023927
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Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model.

International Journal Of Molecular Sciences
LS Robison, N Francis, DL Popescu, ME Anderson, J Hatfield, F Xu, BJ Anderson, WE Van Nostrand, JK Robinson
Publication Date: 2020-01-28

Variant appearance in text: APP: K670N
PMID: 32012921
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Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.

Iranian Journal Of Basic Medical Sciences
M Iranshahy, B Javadi
Publication Date: 2019-10

Variant appearance in text: APP: K670N
PMID: 31998450
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Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology.

International Journal Of Molecular Sciences
SB Oh, JA Kim, S Park, JY Lee
Publication Date: 2020-01-25

Variant appearance in text: APP: K670N
PMID: 31991844
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Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Aβ42:Aβ40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
WJ Meilandt, H Ngu, A Gogineni, G Lalehzadeh, SH Lee, K Srinivasan, J Imperio, T Wu, M Weber, AJ Kruse, KL Stark, P Chan, M Kwong, Z Modrusan, BA Friedman, J Elstrott, O Foreman, A Easton, M Sheng, DV Hansen
Publication Date: 2020-01-24

Variant appearance in text: APP: K670N
PMID: 31980586
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Fungicide Residues Exposure and Aggregation in a Mouse Model of Alzheimer's Disease.

Environmental Health Perspectives
PA Lafon, Y Wang, M Arango-Lievano, J Torrent, L Salvador-Prince, M Mansuy, N Mestre-Francès, L Givalois, J Liu, JV Mercader, F Jeanneteau, C Desrumaux, V Perrier
Publication Date: 2020-01

Variant appearance in text: APP: K670N
PMID: 31939705
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β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.

Journal Of Alzheimer'S Disease : Jad
Y Ano, R Ohya, Y Takaichi, T Washinuma, K Uchida, A Takashima, H Nakayama
Publication Date: 2020-01-06

Variant appearance in text: APP: K670N
PMID: 31929163
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Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Receptor Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Journal Of Alzheimer'S Disease : Jad
T Khatib, DR Chisholm, A Whiting, B Platt, P McCaffery
Publication Date: 2019-12-23

Variant appearance in text: APP: K670N
PMID: 31884477
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Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer's Disease.

Frontiers In Pharmacology
A Peng, Y Gao, X Zhuang, Y Lin, W He, Y Wang, W Chen, T Chen, X Huang, R Yang, Y Huang, S Xi, X Zhang
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31827437
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MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.

Elife
FH Beraldo, D Palmer, S Memar, DI Wasserman, WV Lee, S Liang, SD Creighton, B Kolisnyk, MF Cowan, J Mels, TS Masood, C Fodor, MA Al-Onaizi, R Bartha, T Gee, LM Saksida, TJ Bussey, SS Strother, VF Prado, BD Winters, MAM Prado
Publication Date: 2019-12-11

Variant appearance in text: APP: K670N
PMID: 31825307
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C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer's disease.

Plos One
E Panayiotou, E Fella, S Andreou, R Papacharalambous, P Gerasimou, P Costeas, S Angeli, I Kousiappa, S Papacostas, T Kyriakides
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31809505
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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ.

Alzheimer'S Research & Therapy
WJ Meilandt, JA Maloney, J Imperio, G Lalehzadeh, T Earr, S Crowell, TW Bainbridge, Y Lu, JA Ernst, RN Fuji, JK Atwal
Publication Date: 2019-12-01

Variant appearance in text: APP: K670N
PMID: 31787113
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Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model.

Nature Communications
G Etter, S van der Veldt, F Manseau, I Zarrinkoub, E Trillaud-Doppia, S Williams
Publication Date: 2019-11-22

Variant appearance in text: APP: K670N
PMID: 31757962
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Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.

Experimental & Molecular Medicine
DK Kim, D Han, J Park, H Choi, JC Park, MY Cha, J Woo, MS Byun, DY Lee, Y Kim, I Mook-Jung
Publication Date: 2019-11-15

Variant appearance in text: APP: K670N
PMID: 31727875
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Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.

Frontiers In Pharmacology
I Dal Prà, U Armato, A Chiarini
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31719824
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Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
M Lei, JD Teo, H Song, HP McEwen, J Yup Lee, TA Couttas, T Duncan, R Chesworth, J Bertz, M Przybyla, J Van Eersel, B Heng, GJ Guillemin, LM Ittner, T Fath, B Garner, A Ittner, T Karl, AS Don
Publication Date: 2019-11-27

Variant appearance in text: APP: K670N
PMID: 31641049
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History and progress of hypotheses and clinical trials for Alzheimer's disease.

Signal Transduction And Targeted Therapy
PP Liu, Y Xie, XY Meng, JS Kang
Publication Date: 2019

Variant appearance in text: APP: Lys670Asn
PMID: 31637009
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Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology
A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31583592
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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Nature Neuroscience
AU Joshi, PS Minhas, SA Liddelow, B Haileselassie, KI Andreasson, GW Dorn, D Mochly-Rosen
Publication Date: 2019-10

Variant appearance in text: APP: K670N
PMID: 31551592
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Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model.

Scientific Reports
R Ciccone, C Franco, I Piccialli, F Boscia, A Casamassa, V de Rosa, P Cepparulo, M Cataldi, L Annunziato, A Pannaccione
Publication Date: 2019-09-19

Variant appearance in text: APP: K670N
PMID: 31537873
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Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model.

Frontiers In Pharmacology
AR Bilia, P Nardiello, V Piazzini, M Leri, MC Bergonzi, M Bucciantini, F Casamenti
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31507412
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Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP.

Aging Cell
MD Tambini, W Yao, L D'Adamio
Publication Date: 2019-12

Variant appearance in text: APP: K670N
PMID: 31496118
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Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.

Brain Pathology (Zurich, Switzerland)
E Sanchez-Mejias, C Nuñez-Diaz, R Sanchez-Varo, A Gomez-Arboledas, JA Garcia-Leon, JJ Fernandez-Valenzuela, M Mejias-Ortega, L Trujillo-Estrada, D Baglietto-Vargas, I Moreno-Gonzalez, JC Davila, J Vitorica, A Gutierrez
Publication Date: 2019-09-06

Variant appearance in text: APP: K670N
PMID: 31491047
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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.

Nature Communications
P Jadiya, DW Kolmetzky, D Tomar, A Di Meco, AA Lombardi, JP Lambert, TS Luongo, MH Ludtmann, D Praticò, JW Elrod
Publication Date: 2019-08-29

Variant appearance in text: APP: K670N
PMID: 31467276
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Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Cell
J Suh, DM Romano, L Nitschke, SP Herrick, BA DiMarzio, V Dzhala, JS Bae, MK Oram, Y Zheng, B Hooli, K Mullin, VA Gennarino, W Wasco, JD Schmahmann, MW Albers, HY Zoghbi, RE Tanzi
Publication Date: 2019-08-22

Variant appearance in text: APP: K670N
PMID: 31442405
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Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
S Kim, Y Nam, YO Jeong, HH Park, SK Lee, SJ Shin, H Jung, BH Kim, SB Hong, YH Park, J Kim, J Yu, DH Yoo, SH Park, SG Jeon, M Moon
Publication Date: 2019-08-16

Variant appearance in text: APP: K670N
PMID: 31426329
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Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration.

Frontiers In Neurology
H Le Stunff, J Véret, N Kassis, J Denom, K Meneyrol, JL Paul, C Cruciani-Guglielmacci, C Magnan, N Janel
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31417486
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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo.

Plos One
KM McAvoy, H Rajamohamed Sait, G Marsh, M Peterson, TL Reynolds, J Gagnon, S Geisler, P Leach, C Roberts, E Cahir-McFarland, RM Ransohoff, A Crotti
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31408457
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Modeling Alzheimer's disease with iPSC-derived brain cells.

Molecular Psychiatry
J Penney, WT Ralvenius, LH Tsai
Publication Date: 2020-01

Variant appearance in text: APP: K670N
PMID: 31391546
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Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease.

Scientific Reports
I Carreras, N Aytan, JK Choi, CM Tognoni, NW Kowall, BG Jenkins, A Dedeoglu
Publication Date: 2019-07-29

Variant appearance in text: APP: K670N
PMID: 31358793
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5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
Z Manji, A Rojas, W Wang, R Dingledine, NH Varvel, T Ganesh
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31322556
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Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.

Journal Of Neuroinflammation
E Medrano-Jiménez, I Jiménez-Ferrer Carrillo, M Pedraza-Escalona, CE Ramírez-Serrano, L Álvarez-Arellano, J Cortés-Mendoza, M Herrera-Ruiz, E Jiménez-Ferrer, A Zamilpa, J Tortoriello, G Pedraza-Alva, L Pérez-Martínez
Publication Date: 2019-07-10

Variant appearance in text: APP: K670N
PMID: 31291963
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Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology.

International Journal Of Molecular Sciences
Y Ano, Y Yoshino, K Uchida, H Nakayama
Publication Date: 2019-06-29

Variant appearance in text: APP: K670N
PMID: 31261895
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Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia.

International Journal Of Molecular Sciences
J Perła-Kaján, H Jakubowski
Publication Date: 2019-06-27

Variant appearance in text: APP: K670N
PMID: 31252610
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Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.

Frontiers In Aging Neuroscience
M Lachen-Montes, A González-Morales, M Palomino, K Ausin, M Gómez-Ochoa, MV Zelaya, I Ferrer, A Pérez-Mediavilla, J Fernández-Irigoyen, E Santamaría
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31244650
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Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Cell Reports
CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang, MS Pyfer, U Tosi, BF Corbett, J Cai, J Lee, J Park, L Iacovitti, HE Scharfman, G Enikolopov, J Chin
Publication Date: 2019-06-25

Variant appearance in text: APP: K670N
PMID: 31242408
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Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
SJ Shin, SG Jeon, JI Kim, YO Jeong, S Kim, YH Park, SK Lee, HH Park, SB Hong, S Oh, JY Hwang, HS Kim, H Park, Y Nam, YY Lee, JJ Kim, SH Park, JS Kim, M Moon
Publication Date: 2019-06-21

Variant appearance in text: APP: K670N
PMID: 31234321
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Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Eneuro
RSE Carney
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31147386
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Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline.

Aging
Y Ano, Y Yoshino, T Kutsukake, R Ohya, T Fukuda, K Uchida, A Takashima, H Nakayama
Publication Date: 2019-05-23

Variant appearance in text: APP: K670N
PMID: 31121563
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Comparing the effect of the novel ionic cocrystal of lithium salicylate proline (LISPRO) with lithium carbonate and lithium salicylate on memory and behavior in female APPswe/PS1dE9 Alzheimer's mice.

Journal Of Neuroscience Research
A Habib, RD Shytle, D Sawmiller, S Koilraj, SA Munna, D Rongo, H Hou, CV Borlongan, G Currier, J Tan
Publication Date: 2019-09

Variant appearance in text: APP: K670N
PMID: 31102295
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Aβ oligomers trigger and accelerate Aβ seeding.

Brain Pathology (Zurich, Switzerland)
N Katzmarski, S Ziegler-Waldkirch, N Scheffler, C Witt, C Abou-Ajram, B Nuscher, M Prinz, C Haass, M Meyer-Luehmann
Publication Date: 2020-01

Variant appearance in text: APP: K670N
PMID: 31099449
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Rapamycin and Alzheimer disease: a double-edged sword?

Autophagy
JM Carosi, TJ Sargeant
Publication Date: 2019-08

Variant appearance in text: APP: K670N
PMID: 31066320
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Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene.

Journal Of Applied Bioinformatics & Computational Biology
Y Zhou, L Chen, X Zhou, Y Pei, S Wei, A Mehmood, YK Xiang, D Wang
Publication Date: 2018

Variant appearance in text: APP: K670N
PMID: 31058201
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18F-FDG-PET in Mouse Models of Alzheimer's Disease.

Frontiers In Medicine
C Bouter, Y Bouter
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31058151
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APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Cell Reports
C Deyts, M Clutter, N Pierce, P Chakrabarty, TB Ladd, A Goddi, AM Rosario, P Cruz, K Vetrivel, SL Wagner, G Thinakaran, TE Golde, AT Parent
Publication Date: 2019-04-30

Variant appearance in text: APP: K670N
PMID: 31042463
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Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.

Frontiers In Cellular Neuroscience
C Martínez-Frailes, C Di Lauro, C Bianchi, L de Diego-García, Á Sebastián-Serrano, L Boscá, M Díaz-Hernández
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 31031598
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Inflammasomes in neuroinflammatory and neurodegenerative diseases.

Embo Molecular Medicine
S Voet, S Srinivasan, M Lamkanfi, G van Loo
Publication Date: 2019-06

Variant appearance in text: APP: K670N
PMID: 31015277
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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Molecular Neurobiology
B Van Gool, SE Storck, SM Reekmans, B Lechat, PLSM Gordts, L Pradier, CU Pietrzik, AJM Roebroek
Publication Date: 2019-10

Variant appearance in text: APP: K670N
PMID: 31004319
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Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response.

Plos One
JE Kim, JJ Park, MR Lee, JY Choi, BR Song, JW Park, MJ Kang, HJ Son, JT Hong, DY Hwang
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 30978260
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Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules (Basel, Switzerland)
R Ştefănescu, GD Stanciu, A Luca, IC Caba, BI Tamba, CT Mihai
Publication Date: 2019-03-24

Variant appearance in text: APP: K670N
PMID: 30909659
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Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice.

American Journal Of Neurodegenerative Disease
YM Kuo, EI Nwankwo, RL Nussbaum, J Rogers, ML Maccecchini
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 30906671
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The vexing complexity of the amyloidogenic pathway.

Protein Science : A Publication Of The Protein Society
MA Castro, A Hadziselimovic, CR Sanders
Publication Date: 2019-07

Variant appearance in text: APP: K670N
PMID: 30897251
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Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease.

Frontiers In Pharmacology
AC Cuello, H Hall, S Do Carmo
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 30886583
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The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration.

Cells
Y Yan, J Bejoy, M Marzano, Y Li
Publication Date: 2019-03-14

Variant appearance in text: APP: K670N
PMID: 30875781
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Decreased Lung Tumor Development in SwAPP Mice through the Downregulation of CHI3L1 and STAT 3 Activity via the Upregulation of miRNA342-3p.

Molecular Therapy. Nucleic Acids
DH Lee, KC Kim, CJ Hwang, KR Park, YS Jung, SY Kim, JY Kim, JK Song, MJ Song, MK Choi, DY Hwang, SB Han, JT Hong
Publication Date: 2019-06-07

Variant appearance in text: APP: K670N
PMID: 30849743
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Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Frontiers In Neuroscience
JO Ojo, M Algamal, P Leary, L Abdullah, B Mouzon, JE Evans, M Mullan, F Crawford
Publication Date: 2019

Variant appearance in text: APP: K670N
PMID: 30837829
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000346798.3 c.2010G>T p.Lys670Asn missense_variant 16/18 -
ENST00000348990.5 c.1785G>T p.Lys595Asn missense_variant 14/16 -
ENST00000354192.3 c.1617G>T p.Lys539Asn missense_variant 13/15 -
ENST00000357903.3 c.1953G>T p.Lys651Asn missense_variant 15/17 -
ENST00000358918.3 c.1956G>T p.Lys652Asn missense_variant 15/17 -
ENST00000359726.3 c.1842G>T p.Lys614Asn missense_variant 15/17 -
ENST00000439274.2 c.1842G>T p.Lys614Asn missense_variant 15/17 -
ENST00000440126.3 c.1938G>T p.Lys646Asn missense_variant 15/17 -
ENST00000448388.2 c.1680G>T p.Lys560Asn missense_variant 14/16 -
ENST00000456209.2 c.717G>T p.Lys239Asn missense_variant 6/7 -
ENST00000464867.1 n.357G>T - non_coding_transcript_exon_variant 1/3 -
NM_000484.4 c.2010G>T p.Lys670Asn missense_variant 16/18 -
NM_001136016.3 c.1938G>T p.Lys646Asn missense_variant 15/17 -
NM_001136129.3 c.1617G>T p.Lys539Asn missense_variant 13/15 -
NM_001136130.3 c.1842G>T p.Lys614Asn missense_variant 15/17 -
NM_001136131.2 c.1680G>T p.Lys560Asn missense_variant 14/16 -
NM_001204301.2 c.1956G>T p.Lys652Asn missense_variant 15/17 -
NM_001204302.2 c.1899G>T p.Lys633Asn missense_variant 14/16 -
NM_001204303.2 c.1731G>T p.Lys577Asn missense_variant 13/15 -
NM_201413.3 c.1953G>T p.Lys651Asn missense_variant 15/17 -
NM_201414.3 c.1785G>T p.Lys595Asn missense_variant 14/16 -