Publications:

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Brain-Derived Neurotrophic Factor (BDNF) Preserves the Functional Integrity of Neural Networks in the β-Amyloidopathy Model in vitro.

Frontiers In Cell And Developmental Biology

EV Mitroshina, RS Yarkov, TA Mishchenko, VG Krut', MS Gavrish, EA Epifanova, AA Babaev, MV Vedunova

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32733889

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Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

Bmc Molecular And Cell Biology

AS Cone, SN Hurwitz, GS Lee, X Yuan, Y Zhou, Y Li, DG Meckes

Publication Date: 2020-07-30

Variant appearance in text: APP: K670N

PMID: 32731849

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Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.

Acta Neuropathologica Communications

S Kumar, CA Lemere, J Walter

Publication Date: 2020-07-29

Variant appearance in text: APP: K670N

PMID: 32727580

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Passive immunotherapies targeting Aβ and tau in Alzheimer's disease.

Neurobiology Of Disease

SS Plotkin, NR Cashman

Publication Date: 2020-07-16

Variant appearance in text: APP: K670N

PMID: 32682954

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Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer's Disease.

International Journal Of Molecular Sciences

T Kuboyama, X Yang, C Tohda

Publication Date: 2020-06-30

Variant appearance in text: APP: K670N

PMID: 32630004

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Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.

Frontiers In Neuroscience

T Loeffler, I Schilcher, S Flunkert, B Hutter-Paier

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32595447

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Application of Genetically Engineered Pigs in Biomedical Research.

Genes

M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland

Publication Date: 2020-06-19

Variant appearance in text: APP: K670N

PMID: 32575461

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Role of antioxidants and a nutrient rich diet in Alzheimer's disease.

Open Biology

G Veurink, G Perry, SK Singh

Publication Date: 2020-06

Variant appearance in text: APP: K670N

PMID: 32543351

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Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.

Frontiers In Neuroscience

GS Stephens, CH Fu, CP St Romain, Y Zheng, JJ Botterill, HE Scharfman, Y Liu, J Chin

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32536852

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In vitro Models of Neurodegenerative Diseases.

Frontiers In Cell And Developmental Biology

A Slanzi, G Iannoto, B Rossi, E Zenaro, G Constantin

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32528949

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Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Biomolecules

R Stefanescu, GD Stanciu, A Luca, L Paduraru, BI Tamba

Publication Date: 2020-06-06

Variant appearance in text: APP: K670N

PMID: 32517180

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Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice.

Alzheimer'S Research & Therapy

Y Zhao, R Qian, J Zhang, F Liu, K Iqbal, CL Dai, CX Gong

Publication Date: 2020-06-08

Variant appearance in text: APP: K670N

PMID: 32513253

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Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?

Frontiers In Neuroscience

M Dibattista, S Pifferi, A Menini, J Reisert

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32508565

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A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ42 and tau-induced pathophysiological effects on long-term potentiation.

Alzheimer'S & Dementia (New York, N. Y.)

J Caneus, N Akanda, JW Rumsey, X Guo, M Jackson, CJ Long, F Sommerhage, S Georgieva, NM Kanaan, D Morgan, JJ Hickman

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32490141

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Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.

International Journal Of Molecular Sciences

YH Park, SJ Shin, HS Kim, SB Hong, S Kim, Y Nam, JJ Kim, K Lim, JS Kim, JI Kim, SG Jeon, M Moon

Publication Date: 2020-05-29

Variant appearance in text: APP: K670N

PMID: 32486013

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Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.

International Journal Of Molecular Sciences

S Kim, Y Nam, C Kim, H Lee, S Hong, HS Kim, SJ Shin, YH Park, HN Mai, SM Oh, KS Kim, DH Yoo, WK Chung, H Chung, M Moon

Publication Date: 2020-05-23

Variant appearance in text: APP: K670N

PMID: 32456197

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SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.

Cells

SY Park, JY Kang, T Lee, D Nam, CJ Jeon, JB Kim

Publication Date: 2020-05-21

Variant appearance in text: APP: K670N

PMID: 32455709

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Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.

Neurochemistry International

T Wahle, A Sofranko, S Dekkers, MR Miller, HJ Heusinkveld, C Albrecht, FR Cassee, RPF Schins

Publication Date: 2020-05-15

Variant appearance in text: APP: K670N

PMID: 32422323

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Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

International Journal Of Molecular Sciences

L Gatti, F Tinelli, E Scelzo, F Arioli, G Di Fede, L Obici, L Pantoni, G Giaccone, P Caroppo, EA Parati, A Bersano

Publication Date: 2020-05-13

Variant appearance in text: APP: K670N

PMID: 32414028

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Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

The Journal Of Clinical Investigation

PJ Meakin, BM Coull, Z Tuharska, C McCaffery, I Akoumianakis, C Antoniades, J Brown, KJ Griffin, F Platt, CH Ozber, NY Yuldasheva, N Makava, A Skromna, AR Prescott, AD McNeilly, MK Siddiqui, CNA Palmer, F Khan, ML Ashford

Publication Date: 2020-05-14

Variant appearance in text: APP: K670N

PMID: 32407295

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Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer's Disease.

Scientific Reports

O Shabir, P Sharp, MA Rebollar, L Boorman, C Howarth, SB Wharton, SE Francis, J Berwick

Publication Date: 2020-05-05

Variant appearance in text: APP: K670N

PMID: 32371859

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Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease.

Cells

R Franco, R Rivas-Santisteban, M Casanovas, A Lillo, CA Saura, G Navarro

Publication Date: 2020-04-26

Variant appearance in text: APP: K670N

PMID: 32357548

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New Insights into the Molecular Bases of Familial Alzheimer's Disease.

Journal Of Personalized Medicine

V D'Argenio, D Sarnataro

Publication Date: 2020-04-19

Variant appearance in text: APP: K670N

PMID: 32325882

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Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer's Disease.

Frontiers In Cellular Neuroscience

X Wang, J Wu, S Ma, Y Xie, H Liu, M Yao, Y Zhang, GL Yang, B Yang, R Guo, F Guan

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32292331

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Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences

KY Kim, YH Suh, KA Chang

Publication Date: 2020-04-10

Variant appearance in text: APP: K670N

PMID: 32290355

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Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1.

International Journal Of Molecular Sciences

DL Popescu, WE Van Nostrand, JK Robinson

Publication Date: 2020-03-28

Variant appearance in text: APP: K670N

PMID: 32231123

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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature Communications

SS Kwak, KJ Washicosky, E Brand, D von Maydell, J Aronson, S Kim, DE Capen, M Cetinbas, R Sadreyev, S Ning, E Bylykbashi, W Xia, SL Wagner, SH Choi, RE Tanzi, DY Kim

Publication Date: 2020-03-13

Variant appearance in text: APP: K670N

PMID: 32170138

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The Interaction of EphA4 With PDGFRβ Regulates Proliferation and Neuronal Differentiation of Neural Progenitor Cells in vitro and Promotes Neurogenesis in vivo.

Frontiers In Aging Neuroscience

Q Chen, H Song, C Liu, J Xu, C Wei, W Wang, F Han

Publication Date: 2020

Variant appearance in text: APP: K670N

PMID: 32116646

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Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.

Molecules (Basel, Switzerland)

L Bellusci, M Runfola, V Carnicelli, S Sestito, F Fulceri, F Santucci, P Lenzi, F Fornai, S Rapposelli, N Origlia, R Zucchi, G Chiellini

Publication Date: 2020-02-26

Variant appearance in text: APP: K670N

PMID: 32110992

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APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance.

International Journal Of Molecular Sciences

T Tomiyama, H Shimada

Publication Date: 2020-02-19

Variant appearance in text: APP: K670N

PMID: 32093100

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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.

Cells

GH Buniatian, R Weiskirchen, TS Weiss, U Schwinghammer, M Fritz, T Seferyan, B Proksch, M Glaser, A Lourhmati, M Buadze, E Borkham-Kamphorst, F Gaunitz, CH Gleiter, T Lang, E Schaeffeler, R Tremmel, H Cynis, WH Frey, R Gebhardt, SL Friedman, W Mikulits, M Schwab, L Danielyan

Publication Date: 2020-02-17

Variant appearance in text: APP: K670N

PMID: 32089540

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Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice.

Journal Of Neuroinflammation

N Lax, N Fainstein, Y Nishri, A Ben-Zvi, T Ben-Hur

Publication Date: 2020-02-14

Variant appearance in text: APP: K670N

PMID: 32059733

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Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

International Journal Of Molecular Sciences

A Angel, R Volkman, TG Royal, D Offen

Publication Date: 2020-02-09

Variant appearance in text: APP: K670N

PMID: 32050445

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Transcriptional Signatures of Tau and Amyloid Neuropathology.

Cell Reports

I Castanho, TK Murray, E Hannon, A Jeffries, E Walker, E Laing, H Baulf, J Harvey, L Bradshaw, A Randall, K Moore, P O'Neill, K Lunnon, DA Collier, Z Ahmed, MJ O'Neill, J Mill

Publication Date: 2020-02-11

Variant appearance in text: APP: K670N

PMID: 32049030

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Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.

Cell Death & Disease

CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen

Publication Date: 2020-02-06

Variant appearance in text: APP: K670N

PMID: 32029735

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Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease.

International Journal Of Molecular Sciences

K Ono, M Tsuji

Publication Date: 2020-01-31

Variant appearance in text: APP: K670N

PMID: 32023927

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Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model.

International Journal Of Molecular Sciences

LS Robison, N Francis, DL Popescu, ME Anderson, J Hatfield, F Xu, BJ Anderson, WE Van Nostrand, JK Robinson

Publication Date: 2020-01-28

Variant appearance in text: APP: K670N

PMID: 32012921

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Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.

Iranian Journal Of Basic Medical Sciences

M Iranshahy, B Javadi

Publication Date: 2019-10

Variant appearance in text: APP: K670N

PMID: 31998450

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Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology.

International Journal Of Molecular Sciences

SB Oh, JA Kim, S Park, JY Lee

Publication Date: 2020-01-25

Variant appearance in text: APP: K670N

PMID: 31991844

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Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Aβ42:Aβ40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

WJ Meilandt, H Ngu, A Gogineni, G Lalehzadeh, SH Lee, K Srinivasan, J Imperio, T Wu, M Weber, AJ Kruse, KL Stark, P Chan, M Kwong, Z Modrusan, BA Friedman, J Elstrott, O Foreman, A Easton, M Sheng, DV Hansen

Publication Date: 2020-01-24

Variant appearance in text: APP: K670N

PMID: 31980586

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Fungicide Residues Exposure and Aggregation in a Mouse Model of Alzheimer's Disease.

Environmental Health Perspectives

PA Lafon, Y Wang, M Arango-Lievano, J Torrent, L Salvador-Prince, M Mansuy, N Mestre-Francès, L Givalois, J Liu, JV Mercader, F Jeanneteau, C Desrumaux, V Perrier

Publication Date: 2020-01

Variant appearance in text: APP: K670N

PMID: 31939705

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β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.

Journal Of Alzheimer'S Disease : Jad

Y Ano, R Ohya, Y Takaichi, T Washinuma, K Uchida, A Takashima, H Nakayama

Publication Date: 2020-01-06

Variant appearance in text: APP: K670N

PMID: 31929163

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Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Receptor Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Journal Of Alzheimer'S Disease : Jad

T Khatib, DR Chisholm, A Whiting, B Platt, P McCaffery

Publication Date: 2019-12-23

Variant appearance in text: APP: K670N

PMID: 31884477

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Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer's Disease.

Frontiers In Pharmacology

A Peng, Y Gao, X Zhuang, Y Lin, W He, Y Wang, W Chen, T Chen, X Huang, R Yang, Y Huang, S Xi, X Zhang

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31827437

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MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.

Elife

FH Beraldo, D Palmer, S Memar, DI Wasserman, WV Lee, S Liang, SD Creighton, B Kolisnyk, MF Cowan, J Mels, TS Masood, C Fodor, MA Al-Onaizi, R Bartha, T Gee, LM Saksida, TJ Bussey, SS Strother, VF Prado, BD Winters, MAM Prado

Publication Date: 2019-12-11

Variant appearance in text: APP: K670N

PMID: 31825307

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C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer's disease.

Plos One

E Panayiotou, E Fella, S Andreou, R Papacharalambous, P Gerasimou, P Costeas, S Angeli, I Kousiappa, S Papacostas, T Kyriakides

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31809505

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ.

Alzheimer'S Research & Therapy

WJ Meilandt, JA Maloney, J Imperio, G Lalehzadeh, T Earr, S Crowell, TW Bainbridge, Y Lu, JA Ernst, RN Fuji, JK Atwal

Publication Date: 2019-12-01

Variant appearance in text: APP: K670N

PMID: 31787113

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Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model.

Nature Communications

G Etter, S van der Veldt, F Manseau, I Zarrinkoub, E Trillaud-Doppia, S Williams

Publication Date: 2019-11-22

Variant appearance in text: APP: K670N

PMID: 31757962

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Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.

Experimental & Molecular Medicine

DK Kim, D Han, J Park, H Choi, JC Park, MY Cha, J Woo, MS Byun, DY Lee, Y Kim, I Mook-Jung

Publication Date: 2019-11-15

Variant appearance in text: APP: K670N

PMID: 31727875

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Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.

Frontiers In Pharmacology

I Dal Prà, U Armato, A Chiarini

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31719824

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Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

M Lei, JD Teo, H Song, HP McEwen, J Yup Lee, TA Couttas, T Duncan, R Chesworth, J Bertz, M Przybyla, J Van Eersel, B Heng, GJ Guillemin, LM Ittner, T Fath, B Garner, A Ittner, T Karl, AS Don

Publication Date: 2019-11-27

Variant appearance in text: APP: K670N

PMID: 31641049

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History and progress of hypotheses and clinical trials for Alzheimer's disease.

Signal Transduction And Targeted Therapy

PP Liu, Y Xie, XY Meng, JS Kang

Publication Date: 2019

Variant appearance in text: APP: Lys670Asn

PMID: 31637009

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Astroglia in Alzheimer's Disease.

Advances In Experimental Medicine And Biology

A Verkhratsky, V Parpura, JJ Rodriguez-Arellano, R Zorec

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31583592

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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Nature Neuroscience

AU Joshi, PS Minhas, SA Liddelow, B Haileselassie, KI Andreasson, GW Dorn, D Mochly-Rosen

Publication Date: 2019-10

Variant appearance in text: APP: K670N

PMID: 31551592

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Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model.

Scientific Reports

R Ciccone, C Franco, I Piccialli, F Boscia, A Casamassa, V de Rosa, P Cepparulo, M Cataldi, L Annunziato, A Pannaccione

Publication Date: 2019-09-19

Variant appearance in text: APP: K670N

PMID: 31537873

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Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model.

Frontiers In Pharmacology

AR Bilia, P Nardiello, V Piazzini, M Leri, MC Bergonzi, M Bucciantini, F Casamenti

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31507412

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Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP.

Aging Cell

MD Tambini, W Yao, L D'Adamio

Publication Date: 2019-12

Variant appearance in text: APP: K670N

PMID: 31496118

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Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.

Brain Pathology (Zurich, Switzerland)

E Sanchez-Mejias, C Nuñez-Diaz, R Sanchez-Varo, A Gomez-Arboledas, JA Garcia-Leon, JJ Fernandez-Valenzuela, M Mejias-Ortega, L Trujillo-Estrada, D Baglietto-Vargas, I Moreno-Gonzalez, JC Davila, J Vitorica, A Gutierrez

Publication Date: 2019-09-06

Variant appearance in text: APP: K670N

PMID: 31491047

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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.

Nature Communications

P Jadiya, DW Kolmetzky, D Tomar, A Di Meco, AA Lombardi, JP Lambert, TS Luongo, MH Ludtmann, D Praticò, JW Elrod

Publication Date: 2019-08-29

Variant appearance in text: APP: K670N

PMID: 31467276

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Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Cell

J Suh, DM Romano, L Nitschke, SP Herrick, BA DiMarzio, V Dzhala, JS Bae, MK Oram, Y Zheng, B Hooli, K Mullin, VA Gennarino, W Wasco, JD Schmahmann, MW Albers, HY Zoghbi, RE Tanzi

Publication Date: 2019-08-22

Variant appearance in text: APP: K670N

PMID: 31442405

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Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences

S Kim, Y Nam, YO Jeong, HH Park, SK Lee, SJ Shin, H Jung, BH Kim, SB Hong, YH Park, J Kim, J Yu, DH Yoo, SH Park, SG Jeon, M Moon

Publication Date: 2019-08-16

Variant appearance in text: APP: K670N

PMID: 31426329

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Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration.

Frontiers In Neurology

H Le Stunff, J Véret, N Kassis, J Denom, K Meneyrol, JL Paul, C Cruciani-Guglielmacci, C Magnan, N Janel

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31417486

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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo.

Plos One

KM McAvoy, H Rajamohamed Sait, G Marsh, M Peterson, TL Reynolds, J Gagnon, S Geisler, P Leach, C Roberts, E Cahir-McFarland, RM Ransohoff, A Crotti

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31408457

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Modeling Alzheimer's disease with iPSC-derived brain cells.

Molecular Psychiatry

J Penney, WT Ralvenius, LH Tsai

Publication Date: 2020-01

Variant appearance in text: APP: K670N

PMID: 31391546

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Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease.

Scientific Reports

I Carreras, N Aytan, JK Choi, CM Tognoni, NW Kowall, BG Jenkins, A Dedeoglu

Publication Date: 2019-07-29

Variant appearance in text: APP: K670N

PMID: 31358793

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5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad

Z Manji, A Rojas, W Wang, R Dingledine, NH Varvel, T Ganesh

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31322556

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Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.

Journal Of Neuroinflammation

E Medrano-Jiménez, I Jiménez-Ferrer Carrillo, M Pedraza-Escalona, CE Ramírez-Serrano, L Álvarez-Arellano, J Cortés-Mendoza, M Herrera-Ruiz, E Jiménez-Ferrer, A Zamilpa, J Tortoriello, G Pedraza-Alva, L Pérez-Martínez

Publication Date: 2019-07-10

Variant appearance in text: APP: K670N

PMID: 31291963

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Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology.

International Journal Of Molecular Sciences

Y Ano, Y Yoshino, K Uchida, H Nakayama

Publication Date: 2019-06-29

Variant appearance in text: APP: K670N

PMID: 31261895

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Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia.

International Journal Of Molecular Sciences

J Perła-Kaján, H Jakubowski

Publication Date: 2019-06-27

Variant appearance in text: APP: K670N

PMID: 31252610

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Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.

Frontiers In Aging Neuroscience

M Lachen-Montes, A González-Morales, M Palomino, K Ausin, M Gómez-Ochoa, MV Zelaya, I Ferrer, A Pérez-Mediavilla, J Fernández-Irigoyen, E Santamaría

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31244650

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Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Cell Reports

CH Fu, DM Iascone, I Petrof, A Hazra, X Zhang, MS Pyfer, U Tosi, BF Corbett, J Cai, J Lee, J Park, L Iacovitti, HE Scharfman, G Enikolopov, J Chin

Publication Date: 2019-06-25

Variant appearance in text: APP: K670N

PMID: 31242408

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Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer's Disease.

International Journal Of Molecular Sciences

SJ Shin, SG Jeon, JI Kim, YO Jeong, S Kim, YH Park, SK Lee, HH Park, SB Hong, S Oh, JY Hwang, HS Kim, H Park, Y Nam, YY Lee, JJ Kim, SH Park, JS Kim, M Moon

Publication Date: 2019-06-21

Variant appearance in text: APP: K670N

PMID: 31234321

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Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Eneuro

RSE Carney

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31147386

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Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline.

Aging

Y Ano, Y Yoshino, T Kutsukake, R Ohya, T Fukuda, K Uchida, A Takashima, H Nakayama

Publication Date: 2019-05-23

Variant appearance in text: APP: K670N

PMID: 31121563

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Comparing the effect of the novel ionic cocrystal of lithium salicylate proline (LISPRO) with lithium carbonate and lithium salicylate on memory and behavior in female APPswe/PS1dE9 Alzheimer's mice.

Journal Of Neuroscience Research

A Habib, RD Shytle, D Sawmiller, S Koilraj, SA Munna, D Rongo, H Hou, CV Borlongan, G Currier, J Tan

Publication Date: 2019-09

Variant appearance in text: APP: K670N

PMID: 31102295

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Aβ oligomers trigger and accelerate Aβ seeding.

Brain Pathology (Zurich, Switzerland)

N Katzmarski, S Ziegler-Waldkirch, N Scheffler, C Witt, C Abou-Ajram, B Nuscher, M Prinz, C Haass, M Meyer-Luehmann

Publication Date: 2020-01

Variant appearance in text: APP: K670N

PMID: 31099449

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Rapamycin and Alzheimer disease: a double-edged sword?

Autophagy

JM Carosi, TJ Sargeant

Publication Date: 2019-08

Variant appearance in text: APP: K670N

PMID: 31066320

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Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene.

Journal Of Applied Bioinformatics & Computational Biology

Y Zhou, L Chen, X Zhou, Y Pei, S Wei, A Mehmood, YK Xiang, D Wang

Publication Date: 2018

Variant appearance in text: APP: K670N

PMID: 31058201

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18F-FDG-PET in Mouse Models of Alzheimer's Disease.

Frontiers In Medicine

C Bouter, Y Bouter

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31058151

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APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Cell Reports

C Deyts, M Clutter, N Pierce, P Chakrabarty, TB Ladd, A Goddi, AM Rosario, P Cruz, K Vetrivel, SL Wagner, G Thinakaran, TE Golde, AT Parent

Publication Date: 2019-04-30

Variant appearance in text: APP: K670N

PMID: 31042463

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Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.

Frontiers In Cellular Neuroscience

C Martínez-Frailes, C Di Lauro, C Bianchi, L de Diego-García, Á Sebastián-Serrano, L Boscá, M Díaz-Hernández

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 31031598

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Inflammasomes in neuroinflammatory and neurodegenerative diseases.

Embo Molecular Medicine

S Voet, S Srinivasan, M Lamkanfi, G van Loo

Publication Date: 2019-06

Variant appearance in text: APP: K670N

PMID: 31015277

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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Molecular Neurobiology

B Van Gool, SE Storck, SM Reekmans, B Lechat, PLSM Gordts, L Pradier, CU Pietrzik, AJM Roebroek

Publication Date: 2019-10

Variant appearance in text: APP: K670N

PMID: 31004319

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Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response.

Plos One

JE Kim, JJ Park, MR Lee, JY Choi, BR Song, JW Park, MJ Kang, HJ Son, JT Hong, DY Hwang

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 30978260

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Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Molecules (Basel, Switzerland)

R Ştefănescu, GD Stanciu, A Luca, IC Caba, BI Tamba, CT Mihai

Publication Date: 2019-03-24

Variant appearance in text: APP: K670N

PMID: 30909659

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Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice.

American Journal Of Neurodegenerative Disease

YM Kuo, EI Nwankwo, RL Nussbaum, J Rogers, ML Maccecchini

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 30906671

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The vexing complexity of the amyloidogenic pathway.

Protein Science : A Publication Of The Protein Society

MA Castro, A Hadziselimovic, CR Sanders

Publication Date: 2019-07

Variant appearance in text: APP: K670N

PMID: 30897251

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Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease.

Frontiers In Pharmacology

AC Cuello, H Hall, S Do Carmo

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 30886583

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The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration.

Cells

Y Yan, J Bejoy, M Marzano, Y Li

Publication Date: 2019-03-14

Variant appearance in text: APP: K670N

PMID: 30875781

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Decreased Lung Tumor Development in SwAPP Mice through the Downregulation of CHI3L1 and STAT 3 Activity via the Upregulation of miRNA342-3p.

Molecular Therapy. Nucleic Acids

DH Lee, KC Kim, CJ Hwang, KR Park, YS Jung, SY Kim, JY Kim, JK Song, MJ Song, MK Choi, DY Hwang, SB Han, JT Hong

Publication Date: 2019-06-07

Variant appearance in text: APP: K670N

PMID: 30849743

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Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Frontiers In Neuroscience

JO Ojo, M Algamal, P Leary, L Abdullah, B Mouzon, JE Evans, M Mullan, F Crawford

Publication Date: 2019

Variant appearance in text: APP: K670N

PMID: 30837829

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000346798.3	c.2010G>T	p.Lys670Asn	missense_variant	16/18	-
ENST00000348990.5	c.1785G>T	p.Lys595Asn	missense_variant	14/16	-
ENST00000354192.3	c.1617G>T	p.Lys539Asn	missense_variant	13/15	-
ENST00000357903.3	c.1953G>T	p.Lys651Asn	missense_variant	15/17	-
ENST00000358918.3	c.1956G>T	p.Lys652Asn	missense_variant	15/17	-
ENST00000359726.3	c.1842G>T	p.Lys614Asn	missense_variant	15/17	-
ENST00000439274.2	c.1842G>T	p.Lys614Asn	missense_variant	15/17	-
ENST00000440126.3	c.1938G>T	p.Lys646Asn	missense_variant	15/17	-
ENST00000448388.2	c.1680G>T	p.Lys560Asn	missense_variant	14/16	-
ENST00000456209.2	c.717G>T	p.Lys239Asn	missense_variant	6/7	-
ENST00000464867.1	n.357G>T	-	non_coding_transcript_exon_variant	1/3	-
NM_000484.4	c.2010G>T	p.Lys670Asn	missense_variant	16/18	-
NM_001136016.3	c.1938G>T	p.Lys646Asn	missense_variant	15/17	-
NM_001136129.3	c.1617G>T	p.Lys539Asn	missense_variant	13/15	-
NM_001136130.3	c.1842G>T	p.Lys614Asn	missense_variant	15/17	-
NM_001136131.2	c.1680G>T	p.Lys560Asn	missense_variant	14/16	-
NM_001204301.2	c.1956G>T	p.Lys652Asn	missense_variant	15/17	-
NM_001204302.2	c.1899G>T	p.Lys633Asn	missense_variant	14/16	-
NM_001204303.2	c.1731G>T	p.Lys577Asn	missense_variant	13/15	-
NM_201413.3	c.1953G>T	p.Lys651Asn	missense_variant	15/17	-
NM_201414.3	c.1785G>T	p.Lys595Asn	missense_variant	14/16	-