Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.
Genome Biology
Ge, Xiangyu X; Frank-Bertoncelj, Mojca M; Klein, Kerstin K; McGovern, Amanda A; Kuret, Tadeja T; Houtman, Miranda M; Burja, Blaž B; Micheroli, Raphael R; Shi, Chenfu C; Marks, Miriam M; Filer, Andrew A; Buckley, Christopher D CD; Orozco, Gisela G; Distler, Oliver O; Morris, Andrew P AP; Martin, Paul P; Eyre, Stephen S; Ospelt, Caroline C
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells.
Npj Systems Biology And Applications
Immanuel, Selva Rupa Christinal SRC; Ghanate, Avinash D AD; Parmar, Dharmeshkumar S DS; Yadav, Ritu R; Uthup, Riya R; Panchagnula, Venkateswarlu V; Raghunathan, Anu A
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Nature Communications
Huang, Qin Qin QQ; Tang, Howard H F HHF; Teo, Shu Mei SM; Mok, Danny D; Ritchie, Scott C SC; Nath, Artika P AP; Brozynska, Marta M; Salim, Agus A; Bakshi, Andrew A; Holt, Barbara J BJ; Khor, Chiea Chuen CC; Sly, Peter D PD; Holt, Patrick G PG; Holt, Kathryn E KE; Inouye, Michael M
Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.
International Journal Of Molecular Sciences
Mikhaylenko, Dmitry S DS; Nemtsova, Marina V MV; Bure, Irina V IV; Kuznetsova, Ekaterina B EB; Alekseeva, Ekaterina A EA; Tarasov, Vadim V VV; Lukashev, Alexander N AN; Beloukhova, Marina I MI; Deviatkin, Andrei A AA; Zamyatnin, Andrey A AA
Resolving mechanisms of immune-mediated disease in primary CD4 T cells.
Embo Molecular Medicine
Bourges, Christophe C; Groff, Abigail F AF; Burren, Oliver S OS; Gerhardinger, Chiara C; Mattioli, Kaia K; Hutchinson, Anna A; Hu, Theodore T; Anand, Tanmay T; Epping, Madeline W MW; Wallace, Chris C; Smith, Kenneth Gc KG; Rinn, John L JL; Lee, James C JC
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells.
Frontiers In Immunology
Guderud, Kari K; Sunde, Line H LH; Flåm, Siri T ST; Mæhlen, Marthe T MT; Mjaavatten, Maria D MD; Lillegraven, Siri S; Aga, Anna-Birgitte AB; Evenrød, Ida M IM; Norli, Ellen S ES; Andreassen, Bettina K BK; Franzenburg, Sören S; Franke, Andre A; Haavardsholm, Espen A EA; Rayner, Simon S; Gervin, Kristina K; Lie, Benedicte A BA
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.
Scientific Reports
Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA
Genome-wide association study of medication-use and associated disease in the UK Biobank.
Nature Communications
Wu, Yeda Y; Byrne, Enda M EM; Zheng, Zhili Z; Kemper, Kathryn E KE; Yengo, Loic L; Mallett, Andrew J AJ; Yang, Jian J; Visscher, Peter M PM; Wray, Naomi R NR
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.
Genome Medicine
Márquez, Ana A; Kerick, Martin M; Zhernakova, Alexandra A; Gutierrez-Achury, Javier J; Chen, Wei-Min WM; Onengut-Gumuscu, Suna S; González-Álvaro, Isidoro I; Rodriguez-Rodriguez, Luis L; Rios-Fernández, Raquel R; González-Gay, Miguel A MA; , ; , ; , ; , ; Mayes, Maureen D MD; Raychaudhuri, Soumya S; Rich, Stephen S SS; Wijmenga, Cisca C; Martín, Javier J
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
Human Molecular Genetics
Laufer, Vincent A VA; Tiwari, Hemant K HK; Reynolds, Richard J RJ; Danila, Maria I MI; Wang, Jelai J; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Kottyan, Leah C LC; Harley, John B JB; Mikuls, Ted R TR; Gregersen, Peter K PK; Absher, Devin M DM; Langefeld, Carl D CD; Arnett, Donna K DK; Bridges, S Louis SL
Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.
Genome Research
Newman, Jeremy R B JRB; Conesa, Ana A; Mika, Matthew M; New, Felicia N FN; Onengut-Gumuscu, Suna S; Atkinson, Mark A MA; Rich, Stephen S SS; McIntyre, Lauren M LM; Concannon, Patrick P
Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer.
Oncotarget
Timofeeva, Olga A OA; Palechor-Ceron, Nancy N; Li, Guanglei G; Yuan, Hang H; Krawczyk, Ewa E; Zhong, Xiaogang X; Liu, Geng G; Upadhyay, Geeta G; Dakic, Aleksandra A; Yu, Songtao S; Fang, Shuang S; Choudhury, Sujata S; Zhang, Xueping X; Ju, Andrew A; Lee, Myeong-Seon MS; Dan, Han C HC; Ji, Youngmi Y; Hou, Yong Y; Zheng, Yun-Ling YL; Albanese, Chris C; Rhim, Johng J; Schlegel, Richard R; Dritschilo, Anatoly A; Liu, Xuefeng X
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
Nature Genetics
Ji, Sun-Gou SG; Juran, Brian D BD; Mucha, Sören S; Folseraas, Trine T; Jostins, Luke L; Melum, Espen E; Kumasaka, Natsuhiko N; Atkinson, Elizabeth J EJ; Schlicht, Erik M EM; Liu, Jimmy Z JZ; Shah, Tejas T; Gutierrez-Achury, Javier J; Boberg, Kirsten M KM; Bergquist, Annika A; Vermeire, Severine S; Eksteen, Bertus B; Durie, Peter R PR; Farkkila, Martti M; Müller, Tobias T; Schramm, Christoph C; Sterneck, Martina M; Weismüller, Tobias J TJ; Gotthardt, Daniel N DN; Ellinghaus, David D; Braun, Felix F; Teufel, Andreas A; Laudes, Mattias M; Lieb, Wolfgang W; Jacobs, Gunnar G; Beuers, Ulrich U; Weersma, Rinse K RK; Wijmenga, Cisca C; Marschall, Hanns-Ulrich HU; Milkiewicz, Piotr P; Pares, Albert A; Kontula, Kimmo K; Chazouillères, Olivier O; Invernizzi, Pietro P; Goode, Elizabeth E; Spiess, Kelly K; Moore, Carmel C; Sambrook, Jennifer J; Ouwehand, Willem H WH; Roberts, David J DJ; Danesh, John J; Floreani, Annarosa A; Gulamhusein, Aliya F AF; Eaton, John E JE; Schreiber, Stefan S; Coltescu, Catalina C; Bowlus, Christopher L CL; Luketic, Velimir A VA; Odin, Joseph A JA; Chopra, Kapil B KB; Kowdley, Kris V KV; Chalasani, Naga N; Manns, Michael P MP; Srivastava, Brijesh B; Mells, George G; Sandford, Richard N RN; Alexander, Graeme G; Gaffney, Daniel J DJ; Chapman, Roger W RW; Hirschfield, Gideon M GM; de Andrade, Mariza M; , ; , ; , ; Rushbrook, Simon M SM; Franke, Andre A; Karlsen, Tom H TH; Lazaridis, Konstantinos N KN; Anderson, Carl A CA
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
Nature Genetics
Ellinghaus, David D; Jostins, Luke L; Spain, Sarah L SL; Cortes, Adrian A; Bethune, Jörn J; Han, Buhm B; Park, Yu Rang YR; Raychaudhuri, Soumya S; Pouget, Jennie G JG; Hübenthal, Matthias M; Folseraas, Trine T; Wang, Yunpeng Y; Esko, Tonu T; Metspalu, Andres A; Westra, Harm-Jan HJ; Franke, Lude L; Pers, Tune H TH; Weersma, Rinse K RK; Collij, Valerie V; D'Amato, Mauro M; Halfvarson, Jonas J; Jensen, Anders Boeck AB; Lieb, Wolfgang W; Degenhardt, Franziska F; Forstner, Andreas J AJ; Hofmann, Andrea A; , ; , ; , ; , ; , ; Schreiber, Stefan S; Mrowietz, Ulrich U; Juran, Brian D BD; Lazaridis, Konstantinos N KN; Brunak, Søren S; Dale, Anders M AM; Trembath, Richard C RC; Weidinger, Stephan S; Weichenthal, Michael M; Ellinghaus, Eva E; Elder, James T JT; Barker, Jonathan N W N JN; Andreassen, Ole A OA; McGovern, Dermot P DP; Karlsen, Tom H TH; Barrett, Jeffrey C JC; Parkes, Miles M; Brown, Matthew A MA; Franke, Andre A
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
Annals Of The Rheumatic Diseases
Kim, Kwangwoo K; Bang, So-Young SY; Lee, Hye-Soon HS; Cho, Soo-Kyung SK; Choi, Chan-Bum CB; Sung, Yoon-Kyoung YK; Kim, Tae-Hwan TH; Jun, Jae-Bum JB; Yoo, Dae Hyun DH; Kang, Young Mo YM; Kim, Seong-Kyu SK; Suh, Chang-Hee CH; Shim, Seung-Cheol SC; Lee, Shin-Seok SS; Lee, Jisoo J; Chung, Won Tae WT; Choe, Jung-Yoon JY; Shin, Hyoung Doo HD; Lee, Jong-Young JY; Han, Bok-Ghee BG; Nath, Swapan K SK; Eyre, Steve S; Bowes, John J; Pappas, Dimitrios A DA; Kremer, Joel M JM; Gonzalez-Gay, Miguel A MA; Rodriguez-Rodriguez, Luis L; Ärlestig, Lisbeth L; Okada, Yukinori Y; Diogo, Dorothée D; Liao, Katherine P KP; Karlson, Elizabeth W EW; Raychaudhuri, Soumya S; Rantapää-Dahlqvist, Solbritt S; Martin, Javier J; Klareskog, Lars L; Padyukov, Leonid L; Gregersen, Peter K PK; Worthington, Jane J; Greenberg, Jeffrey D JD; Plenge, Robert M RM; Bae, Sang-Cheol SC
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Nature
Okada, Yukinori Y; Wu, Di D; Trynka, Gosia G; Raj, Towfique T; Terao, Chikashi C; Ikari, Katsunori K; Kochi, Yuta Y; Ohmura, Koichiro K; Suzuki, Akari A; Yoshida, Shinji S; Graham, Robert R RR; Manoharan, Arun A; Ortmann, Ward W; Bhangale, Tushar T; Denny, Joshua C JC; Carroll, Robert J RJ; Eyler, Anne E AE; Greenberg, Jeffrey D JD; Kremer, Joel M JM; Pappas, Dimitrios A DA; Jiang, Lei L; Yin, Jian J; Ye, Lingying L; Su, Ding-Feng DF; Yang, Jian J; Xie, Gang G; Keystone, Ed E; Westra, Harm-Jan HJ; Esko, Tõnu T; Metspalu, Andres A; Zhou, Xuezhong X; Gupta, Namrata N; Mirel, Daniel D; Stahl, Eli A EA; Diogo, Dorothée D; Cui, Jing J; Liao, Katherine K; Guo, Michael H MH; Myouzen, Keiko K; Kawaguchi, Takahisa T; Coenen, Marieke J H MJ; van Riel, Piet L C M PL; van de Laar, Mart A F J MA; Guchelaar, Henk-Jan HJ; Huizinga, Tom W J TW; Dieudé, Philippe P; Mariette, Xavier X; Bridges, S Louis SL; Zhernakova, Alexandra A; Toes, Rene E M RE; Tak, Paul P PP; Miceli-Richard, Corinne C; Bang, So-Young SY; Lee, Hye-Soon HS; Martin, Javier J; Gonzalez-Gay, Miguel A MA; Rodriguez-Rodriguez, Luis L; Rantapää-Dahlqvist, Solbritt S; Arlestig, Lisbeth L; Choi, Hyon K HK; Kamatani, Yoichiro Y; Galan, Pilar P; Lathrop, Mark M; , ; , ; Eyre, Steve S; Bowes, John J; Barton, Anne A; de Vries, Niek N; Moreland, Larry W LW; Criswell, Lindsey A LA; Karlson, Elizabeth W EW; Taniguchi, Atsuo A; Yamada, Ryo R; Kubo, Michiaki M; Liu, Jun S JS; Bae, Sang-Cheol SC; Worthington, Jane J; Padyukov, Leonid L; Klareskog, Lars L; Gregersen, Peter K PK; Raychaudhuri, Soumya S; Stranger, Barbara E BE; De Jager, Philip L PL; Franke, Lude L; Visscher, Peter M PM; Brown, Matthew A MA; Yamanaka, Hisashi H; Mimori, Tsuneyo T; Takahashi, Atsushi A; Xu, Huji H; Behrens, Timothy W TW; Siminovitch, Katherine A KA; Momohara, Shigeki S; Matsuda, Fumihiko F; Yamamoto, Kazuhiko K; Plenge, Robert M RM
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
Nature Genetics
Trynka, Gosia G; Hunt, Karen A KA; Bockett, Nicholas A NA; Romanos, Jihane J; Mistry, Vanisha V; Szperl, Agata A; Bakker, Sjoerd F SF; Bardella, Maria Teresa MT; Bhaw-Rosun, Leena L; Castillejo, Gemma G; de la Concha, Emilio G EG; de Almeida, Rodrigo Coutinho RC; Dias, Kerith-Rae M KR; van Diemen, Cleo C CC; Dubois, Patrick C A PC; Duerr, Richard H RH; Edkins, Sarah S; Franke, Lude L; Fransen, Karin K; Gutierrez, Javier J; Heap, Graham A R GA; Hrdlickova, Barbara B; Hunt, Sarah S; Plaza Izurieta, Leticia L; Izzo, Valentina V; Joosten, Leo A B LA; Langford, Cordelia C; Mazzilli, Maria Cristina MC; Mein, Charles A CA; Midah, Vandana V; Mitrovic, Mitja M; Mora, Barbara B; Morelli, Marinita M; Nutland, Sarah S; Núñez, Concepción C; Onengut-Gumuscu, Suna S; Pearce, Kerra K; Platteel, Mathieu M; Polanco, Isabel I; Potter, Simon S; Ribes-Koninckx, Carmen C; Ricaño-Ponce, Isis I; Rich, Stephen S SS; Rybak, Anna A; Santiago, José Luis JL; Senapati, Sabyasachi S; Sood, Ajit A; Szajewska, Hania H; Troncone, Riccardo R; Varadé, Jezabel J; Wallace, Chris C; Wolters, Victorien M VM; Zhernakova, Alexandra A; , ; , ; , ; Thelma, B K BK; Cukrowska, Bozena B; Urcelay, Elena E; Bilbao, Jose Ramon JR; Mearin, M Luisa ML; Barisani, Donatella D; Barrett, Jeffrey C JC; Plagnol, Vincent V; Deloukas, Panos P; Wijmenga, Cisca C; van Heel, David A DA