Publications:

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Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease.

Brain Communications

Papoutsi, Marina M; Flower, Michael M; Hensman Moss, Davina J DJ; Holmans, Peter P; Estevez-Fraga, Carlos C; Johnson, Eileanoir B EB; Scahill, Rachael I RI; Rees, Geraint G; Langbehn, Douglas D; Tabrizi, Sarah J SJ; ,

Publication Date: 2022

Variant appearance in text: COMT: Val158Val

PubMed Link: 36519153

Variant Present in the following documents:

• fcac279_supplementary_data.pdf

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Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.

Scientific Reports

Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA

Publication Date: 2022-10-14

Variant appearance in text: COMT: V158V

PubMed Link: 36241656

Variant Present in the following documents:

• 41598_2022_20939_MOESM8_ESM.xlsx, sheet 2
• 41598_2022_20939_MOESM6_ESM.xlsx, sheet 2
• 41598_2022_20939_MOESM7_ESM.xlsx, sheet 2
• 41598_2022_20939_MOESM9_ESM.xlsx, sheet 2

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Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD).

Genes

Magwai, Thabo T; Xulu, Khethelo Richman KR

Publication Date: 2022-02-04

Variant appearance in text: COMT: Val158Val

PubMed Link: 35205345

Variant Present in the following documents:

• Main text
• genes-13-00300.pdf

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Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study.

Frontiers In Neuroscience

Spiros, Athan A; Geerts, Hugo H

Publication Date: 2021

Variant appearance in text: COMT: Val158Val

PubMed Link: 34658776

Variant Present in the following documents:

• Main text
• fnins-15-738903.pdf

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Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Comprehensive Physiology

Suarez-Roca, Heberto H; Mamoun, Negmeldeen N; Sigurdson, Martin I MI; Maixner, William W

Publication Date: 2021-02-12

Variant appearance in text: COMT: Val158Val

PubMed Link: 33577130

Variant Present in the following documents:

• Main text

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Coronavirus syndrome: COVID-19 psychotrauma.

European Journal Of Translational Myology

Soloveva, Nadezhda V NV; Makarova, Ekaterina V EV; Kichuk, Irina V IV

Publication Date: 2020-12-31

Variant appearance in text: COMT: Val158Val

PubMed Link: 33520144

Variant Present in the following documents:

• Main text
• ejtm-30-4-9302.pdf

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Is impaired dopaminergic function associated with mobility capacity in older adults?

Geroscience

Moskowitz, Simon S; Russ, David W DW; Clark, Leatha A LA; Wages, Nathan P NP; Grooms, Dustin R DR; Woods, Adam J AJ; Suhr, Julie J; Simon, Janet E JE; O'Shea, Andrew A; Criss, Cody R CR; Fadda, Paolo P; Clark, Brian C BC

Publication Date: 2021-06

Variant appearance in text: COMT: Val158Val

PubMed Link: 33236263

Variant Present in the following documents:

• Main text

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Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia.

Translational Psychiatry

Tao, Ran R; Li, Chao C; Jaffe, Andrew E AE; Shin, Joo Heon JH; Deep-Soboslay, Amy A; Yamin, Rae'e R; Weinberger, Daniel R DR; Hyde, Thomas M TM; Kleinman, Joel E JE

Publication Date: 2020-05-19

Variant appearance in text: COMT: Val158Val

PubMed Link: 32433545

Variant Present in the following documents:

• 41398_2020_Article_832.pdf

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Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders.

Indian Journal Of Psychiatry

Cengiz, Mujgan M; Cezayirli, Esma E; Bayoglu, Burcu B; Asliyuksek, Hizir H; Kocabasoglu, Nese N

Publication Date: 2019

Variant appearance in text: COMT: Val158Val

PubMed Link: 31142902

Variant Present in the following documents:

• Main text

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Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease.

Journal Of Cardiovascular Development And Disease

Mir, Rashid R; Bhat, Musadiq M; Javid, Jamsheed J; Jha, Chandan C; Saxena, Alpana A; Banu, Shaheen S

Publication Date: 2018-07-13

Variant appearance in text: COMT: Val158Val

PubMed Link: 30011860

Variant Present in the following documents:

• Main text
• jcdd-05-00038.pdf

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New insights into the genetics of fibromyalgia.

The Korean Journal Of Internal Medicine

Park, Dong-Jin DJ; Lee, Shin-Seok SS

Publication Date: 2017-11

Variant appearance in text: COMT: Val158Val

PubMed Link: 29056037

Variant Present in the following documents:

• Main text
• kjim-2016-207.pdf

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Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients.

Medical Science Monitor Basic Research

Dhein, Stefan S; Dohmen, Pascal M PM; Sauer, Matthias M; Tews, Julia J; Weickmann, Johannes J; Funkat, Anne-Kathrin AK; Misfeld, Martin M; Borger, Michael A MA; Mohr, Friedrich W FW

Publication Date: 2017-05-19

Variant appearance in text: COMT: Val158Val

PubMed Link: 28522796

Variant Present in the following documents:

• Main text
• medscimonitbasicres-23-223.pdf

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A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development.

Journal Of Experimental Pharmacology

Spiros, Athan A; Geerts, Hugo H

Publication Date: 2012

Variant appearance in text: COMT: Val158Val

PubMed Link: 27186116

Variant Present in the following documents:

• Main text
• jep-4-053.pdf

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The cumulative effect of genetic polymorphisms on depression and brain structural integrity.

Human Brain Mapping

Kostic, Milutin M; Canu, Elisa E; Agosta, Federica F; Munjiza, Ana A; Novakovic, Ivana I; Dobricic, Valerija V; Maria Ferraro, Pilar P; Miler Jerkovic, Vera V; Pekmezovic, Tatjana T; Lecic Tosevski, Dusica D; Filippi, Massimo M

Publication Date: 2016-06

Variant appearance in text: COMT: Val158Val

PubMed Link: 26956059

Variant Present in the following documents:

• Main text

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Exploring Genetic Susceptibility to Fibromyalgia.

Chonnam Medical Journal

Park, Dong-Jin DJ; Kang, Ji-Hyoun JH; Yim, Yi-Rang YR; Kim, Ji-Eun JE; Lee, Jeong-Won JW; Lee, Kyung-Eun KE; Wen, Lihui L; Kim, Tae-Jong TJ; Park, Yong-Wook YW; Lee, Shin-Seok SS

Publication Date: 2015-08

Variant appearance in text: COMT: Val158Val

PubMed Link: 26306300

Variant Present in the following documents:

• Main text

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Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.

Plos One

Dong, Zheng Z; Zhao, Dongbao D; Yang, Chengde C; Zhou, Jingru J; Qian, Qiaoxia Q; Ma, Yanyun Y; He, Hongjun H; Ji, Hengdong H; Yang, Yajun Y; Wang, Xiaofeng X; Xu, Xia X; Pang, Yafei Y; Zou, Hejian H; Jin, Li L; Wang, Jiucun J

Publication Date: 2015

Variant appearance in text: COMT: Val158Val

PubMed Link: 26147675

Variant Present in the following documents:

• Main text
• pone.0131302.pdf

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COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study.

Neuropsychiatric Disease And Treatment

Hayashi, Kenji K; Yoshimura, Reiji R; Kakeda, Shingo S; Kishi, Taro T; Abe, Osamu O; Umene-Nakano, Wakako W; Katsuki, Asuka A; Hori, Hikaru H; Ikenouchi-Sugita, Atsuko A; Watanabe, Keita K; Ide, Satoru S; Ueda, Issei I; Moriya, Junji J; Iwata, Nakao N; Korogi, Yukunori Y; Kubicki, Marek M; Nakamura, Jun J

Publication Date: 2014

Variant appearance in text: COMT: Val158Val

PubMed Link: 25061303

Variant Present in the following documents:

• Main text
• ndt-10-1183.pdf

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Pharmacogenetics of Parkinson's disease - through mechanisms of drug actions.

Current Genomics

Droździk, Marek M; Białecka, Monika M; Kurzawski, Mateusz M

Publication Date: 2013-12

Variant appearance in text: COMT: Val158Val

PubMed Link: 24532988

Variant Present in the following documents:

• Main text
• CG-14-568.pdf

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Count on dopamine: influences of COMT polymorphisms on numerical cognition.

Frontiers In Psychology

Júlio-Costa, Annelise A; Antunes, Andressa M AM; Lopes-Silva, Júlia B JB; Moreira, Bárbara C BC; Vianna, Gabrielle S GS; Wood, Guilherme G; Carvalho, Maria R S MR; Haase, Vitor G VG

Publication Date: 2013

Variant appearance in text: COMT: val158val

PubMed Link: 23966969

Variant Present in the following documents:

• Main text

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Chronic pain after lower abdominal surgery: do catechol-O-methyl transferase/opioid receptor μ-1 polymorphisms contribute?

Molecular Pain

Kolesnikov, Yuri Y; Gabovits, Boris B; Levin, Ariel A; Veske, Andres A; Qin, Li L; Dai, Feng F; Belfer, Inna I

Publication Date: 2013-04-08

Variant appearance in text: COMT: Val158Val

PubMed Link: 23566343

Variant Present in the following documents:

• Main text
• 1744-8069-9-19.pdf

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Dopamine, corticostriatal connectivity, and intertemporal choice.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Kayser, Andrew S AS; Allen, Daicia C DC; Navarro-Cebrian, Ana A; Mitchell, Jennifer M JM; Fields, Howard L HL

Publication Date: 2012-07-04

Variant appearance in text: COMT: Val158Val

PubMed Link: 22764248

Variant Present in the following documents:

• Main text

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The genetic basis of delay discounting and its genetic relationship to alcohol dependence.

Behavioural Processes

Mitchell, Suzanne H SH

Publication Date: 2011-05

Variant appearance in text: COMT: Val158Val

PubMed Link: 21354276

Variant Present in the following documents:

• Main text

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Tolerance and withdrawal from prolonged opioid use in critically ill children.

Pediatrics

Anand, Kanwaljeet J S KJ; Willson, Douglas F DF; Berger, John J; Harrison, Rick R; Meert, Kathleen L KL; Zimmerman, Jerry J; Carcillo, Joseph J; Newth, Christopher J L CJ; Prodhan, Parthak P; Dean, J Michael JM; Nicholson, Carol C; ,

Publication Date: 2010-05

Variant appearance in text: COMT: V158V

PubMed Link: 20403936

Variant Present in the following documents:

• Main text

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Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics

Delorme, Richard R; Betancur, Catalina C; Chaste, Pauline P; Kernéis, Solen S; Stopin, Astrid A; Mouren, Marie-Christine MC; Collet, Corinne C; Bourgeron, Thomas T; Leboyer, Marion M; Launay, Jean-Marie JM

Publication Date: 2010-03-05

Variant appearance in text: COMT: V158V

PubMed Link: 19676096

Variant Present in the following documents:

• Main text

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Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.

Plos One

Voutilainen, Sari S; Tuomainen, Tomi-Pekka TP; Korhonen, Maarit M; Mursu, Jaakko J; Virtanen, Jyrki K JK; Happonen, Pertti P; Alfthan, Georg G; Erlund, Iris I; North, Kari E KE; Mosher, M J MJ; Kauhanen, Jussi J; Tiihonen, Jari J; Kaplan, George A GA; Salonen, Jukka T JT

Publication Date: 2007-01-31

Variant appearance in text: COMT: Val158Val

PubMed Link: 17264883

Variant Present in the following documents:

• Main text
• pone.0000181.pdf

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