Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity.
Frontiers In Immunology
Zhong, Wujuan W; Kollipara, Avinash A; Liu, Yutong Y; Wang, Yuhan Y; O'Connell, Catherine M CM; Poston, Taylor B TB; Yount, Kacy K; Wiesenfeld, Harold C HC; Hillier, Sharon L SL; Li, Yun Y; Darville, Toni T; Zheng, Xiaojing X
Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.
Nature Communications
Khatri, Bhuwan B; Tessneer, Kandice L KL; Rasmussen, Astrid A; Aghakhanian, Farhang F; Reksten, Tove Ragna TR; Adler, Adam A; Alevizos, Ilias I; Anaya, Juan-Manuel JM; Aqrawi, Lara A LA; Baecklund, Eva E; Brun, Johan G JG; Bucher, Sara Magnusson SM; Eloranta, Maija-Leena ML; Engelke, Fiona F; Forsblad-d'Elia, Helena H; Glenn, Stuart B SB; Hammenfors, Daniel D; Imgenberg-Kreuz, Juliana J; Jensen, Janicke Liaaen JL; Johnsen, Svein Joar Auglænd SJA; Jonsson, Malin V MV; Kvarnström, Marika M; Kelly, Jennifer A JA; Li, He H; Mandl, Thomas T; Martín, Javier J; Nocturne, Gaétane G; Norheim, Katrine Brække KB; Palm, Øyvind Ø; Skarstein, Kathrine K; Stolarczyk, Anna M AM; Taylor, Kimberly E KE; Teruel, Maria M; Theander, Elke E; Venuturupalli, Swamy S; Wallace, Daniel J DJ; Grundahl, Kiely M KM; Hefner, Kimberly S KS; Radfar, Lida L; Lewis, David M DM; Stone, Donald U DU; Kaufman, C Erick CE; Brennan, Michael T MT; Guthridge, Joel M JM; James, Judith A JA; Scofield, R Hal RH; Gaffney, Patrick M PM; Criswell, Lindsey A LA; Jonsson, Roland R; Eriksson, Per P; Bowman, Simon J SJ; Omdal, Roald R; Rönnblom, Lars L; Warner, Blake B; Rischmueller, Maureen M; Witte, Torsten T; Farris, A Darise AD; Mariette, Xavier X; Alarcon-Riquelme, Marta E ME; , ; Shiboski, Caroline H CH; , ; Wahren-Herlenius, Marie M; Ng, Wan-Fai WF; , ; Sivils, Kathy L KL; Adrianto, Indra I; Nordmark, Gunnel G; Lessard, Christopher J CJ
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.
Genome Biology
Ge, Xiangyu X; Frank-Bertoncelj, Mojca M; Klein, Kerstin K; McGovern, Amanda A; Kuret, Tadeja T; Houtman, Miranda M; Burja, Blaž B; Micheroli, Raphael R; Shi, Chenfu C; Marks, Miriam M; Filer, Andrew A; Buckley, Christopher D CD; Orozco, Gisela G; Distler, Oliver O; Morris, Andrew P AP; Martin, Paul P; Eyre, Stephen S; Ospelt, Caroline C
Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.
Biology
Akhtar, Mehran M; Ali, Yasir Y; Islam, Zia-Ul ZU; Arshad, Maria M; Rauf, Mamoona M; Ali, Muhammad M; Maodaa, Saleh N SN; Al-Farraj, Saleh A SA; El-Serehy, Hamed A HA; Jalil, Fazal F
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations.
Scientific Reports
Castro-Santos, P P; Verdugo, R A RA; Alonso-Arias, R R; Gutiérrez, M A MA; Suazo, J J; Aguillón, J C JC; Olloquequi, J J; Pinochet, C C; Lucia, A A; Quiñones, L A LA; Díaz-Peña, R R
Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing.
Clinical Epigenetics
Shao, Xiaojian X; Hudson, Marie M; Colmegna, Ines I; Greenwood, Celia M T CMT; Fritzler, Marvin J MJ; Awadalla, Philip P; Pastinen, Tomi T; Bernatsky, Sasha S
Genome-wide association study of medication-use and associated disease in the UK Biobank.
Nature Communications
Wu, Yeda Y; Byrne, Enda M EM; Zheng, Zhili Z; Kemper, Kathryn E KE; Yengo, Loic L; Mallett, Andrew J AJ; Yang, Jian J; Visscher, Peter M PM; Wray, Naomi R NR
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
Human Molecular Genetics
Laufer, Vincent A VA; Tiwari, Hemant K HK; Reynolds, Richard J RJ; Danila, Maria I MI; Wang, Jelai J; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Kottyan, Leah C LC; Harley, John B JB; Mikuls, Ted R TR; Gregersen, Peter K PK; Absher, Devin M DM; Langefeld, Carl D CD; Arnett, Donna K DK; Bridges, S Louis SL
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms.
Nature Communications
Pierce, Brandon L BL; Tong, Lin L; Argos, Maria M; Demanelis, Kathryn K; Jasmine, Farzana F; Rakibuz-Zaman, Muhammad M; Sarwar, Golam G; Islam, Md Tariqul MT; Shahriar, Hasan H; Islam, Tariqul T; Rahman, Mahfuzar M; Yunus, Md M; Kibriya, Muhammad G MG; Chen, Lin S LS; Ahsan, Habibul H
CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.
Arthritis & Rheumatology (Hoboken, N.J.)
Thalayasingam, Nishanthi N; Nair, Nisha N; Skelton, Andrew J AJ; Massey, Jonathan J; Anderson, Amy E AE; Clark, Alexander D AD; Diboll, Julie J; Lendrem, Dennis W DW; Reynard, Louise N LN; Cordell, Heather J HJ; Eyre, Stephen S; Isaacs, John D JD; Barton, Anne A; Pratt, Arthur G AG
Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression.
Human Genetics
Cavalli, Marco M; Pan, Gang G; Nord, Helena H; Wallerman, Ola O; Wallén Arzt, Emelie E; Berggren, Olof O; Elvers, Ingegerd I; Eloranta, Maija-Leena ML; Rönnblom, Lars L; Lindblad Toh, Kerstin K; Wadelius, Claes C
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.
Nature Genetics
Sun, Celi C; Molineros, Julio E JE; Looger, Loren L LL; Zhou, Xu-Jie XJ; Kim, Kwangwoo K; Okada, Yukinori Y; Ma, Jianyang J; Qi, Yuan-Yuan YY; Kim-Howard, Xana X; Motghare, Prasenjeet P; Bhattarai, Krishna K; Adler, Adam A; Bang, So-Young SY; Lee, Hye-Soon HS; Kim, Tae-Hwan TH; Kang, Young Mo YM; Suh, Chang-Hee CH; Chung, Won Tae WT; Park, Yong-Beom YB; Choe, Jung-Yoon JY; Shim, Seung Cheol SC; Kochi, Yuta Y; Suzuki, Akari A; Kubo, Michiaki M; Sumida, Takayuki T; Yamamoto, Kazuhiko K; Lee, Shin-Seok SS; Kim, Young Jin YJ; Han, Bok-Ghee BG; Dozmorov, Mikhail M; Kaufman, Kenneth M KM; Wren, Jonathan D JD; Harley, John B JB; Shen, Nan N; Chua, Kek Heng KH; Zhang, Hong H; Bae, Sang-Cheol SC; Nath, Swapan K SK
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
Annals Of The Rheumatic Diseases
Kim, Kwangwoo K; Bang, So-Young SY; Lee, Hye-Soon HS; Cho, Soo-Kyung SK; Choi, Chan-Bum CB; Sung, Yoon-Kyoung YK; Kim, Tae-Hwan TH; Jun, Jae-Bum JB; Yoo, Dae Hyun DH; Kang, Young Mo YM; Kim, Seong-Kyu SK; Suh, Chang-Hee CH; Shim, Seung-Cheol SC; Lee, Shin-Seok SS; Lee, Jisoo J; Chung, Won Tae WT; Choe, Jung-Yoon JY; Shin, Hyoung Doo HD; Lee, Jong-Young JY; Han, Bok-Ghee BG; Nath, Swapan K SK; Eyre, Steve S; Bowes, John J; Pappas, Dimitrios A DA; Kremer, Joel M JM; Gonzalez-Gay, Miguel A MA; Rodriguez-Rodriguez, Luis L; Ärlestig, Lisbeth L; Okada, Yukinori Y; Diogo, Dorothée D; Liao, Katherine P KP; Karlson, Elizabeth W EW; Raychaudhuri, Soumya S; Rantapää-Dahlqvist, Solbritt S; Martin, Javier J; Klareskog, Lars L; Padyukov, Leonid L; Gregersen, Peter K PK; Worthington, Jane J; Greenberg, Jeffrey D JD; Plenge, Robert M RM; Bae, Sang-Cheol SC
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Nature
Okada, Yukinori Y; Wu, Di D; Trynka, Gosia G; Raj, Towfique T; Terao, Chikashi C; Ikari, Katsunori K; Kochi, Yuta Y; Ohmura, Koichiro K; Suzuki, Akari A; Yoshida, Shinji S; Graham, Robert R RR; Manoharan, Arun A; Ortmann, Ward W; Bhangale, Tushar T; Denny, Joshua C JC; Carroll, Robert J RJ; Eyler, Anne E AE; Greenberg, Jeffrey D JD; Kremer, Joel M JM; Pappas, Dimitrios A DA; Jiang, Lei L; Yin, Jian J; Ye, Lingying L; Su, Ding-Feng DF; Yang, Jian J; Xie, Gang G; Keystone, Ed E; Westra, Harm-Jan HJ; Esko, Tõnu T; Metspalu, Andres A; Zhou, Xuezhong X; Gupta, Namrata N; Mirel, Daniel D; Stahl, Eli A EA; Diogo, Dorothée D; Cui, Jing J; Liao, Katherine K; Guo, Michael H MH; Myouzen, Keiko K; Kawaguchi, Takahisa T; Coenen, Marieke J H MJ; van Riel, Piet L C M PL; van de Laar, Mart A F J MA; Guchelaar, Henk-Jan HJ; Huizinga, Tom W J TW; Dieudé, Philippe P; Mariette, Xavier X; Bridges, S Louis SL; Zhernakova, Alexandra A; Toes, Rene E M RE; Tak, Paul P PP; Miceli-Richard, Corinne C; Bang, So-Young SY; Lee, Hye-Soon HS; Martin, Javier J; Gonzalez-Gay, Miguel A MA; Rodriguez-Rodriguez, Luis L; Rantapää-Dahlqvist, Solbritt S; Arlestig, Lisbeth L; Choi, Hyon K HK; Kamatani, Yoichiro Y; Galan, Pilar P; Lathrop, Mark M; , ; , ; Eyre, Steve S; Bowes, John J; Barton, Anne A; de Vries, Niek N; Moreland, Larry W LW; Criswell, Lindsey A LA; Karlson, Elizabeth W EW; Taniguchi, Atsuo A; Yamada, Ryo R; Kubo, Michiaki M; Liu, Jun S JS; Bae, Sang-Cheol SC; Worthington, Jane J; Padyukov, Leonid L; Klareskog, Lars L; Gregersen, Peter K PK; Raychaudhuri, Soumya S; Stranger, Barbara E BE; De Jager, Philip L PL; Franke, Lude L; Visscher, Peter M PM; Brown, Matthew A MA; Yamanaka, Hisashi H; Mimori, Tsuneyo T; Takahashi, Atsushi A; Xu, Huji H; Behrens, Timothy W TW; Siminovitch, Katherine A KA; Momohara, Shigeki S; Matsuda, Fumihiko F; Yamamoto, Kazuhiko K; Plenge, Robert M RM
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
Human Molecular Genetics
Juran, Brian D BD; Hirschfield, Gideon M GM; Invernizzi, Pietro P; Atkinson, Elizabeth J EJ; Li, Yafang Y; Xie, Gang G; Kosoy, Roman R; Ransom, Michael M; Sun, Ye Y; Bianchi, Ilaria I; Schlicht, Erik M EM; Lleo, Ana A; Coltescu, Catalina C; Bernuzzi, Francesca F; Podda, Mauro M; Lammert, Craig C; Shigeta, Russell R; Chan, Landon L LL; Balschun, Tobias T; Marconi, Maurizio M; Cusi, Daniele D; Heathcote, E Jenny EJ; Mason, Andrew L AL; Myers, Robert P RP; Milkiewicz, Piotr P; Odin, Joseph A JA; Luketic, Velimir A VA; Bacon, Bruce R BR; Bodenheimer, Henry C HC; Liakina, Valentina V; Vincent, Catherine C; Levy, Cynthia C; Franke, Andre A; Gregersen, Peter K PK; Bossa, Fabrizio F; Gershwin, M Eric ME; deAndrade, Mariza M; Amos, Christopher I CI; , ; Lazaridis, Konstantinos N KN; Seldin, Michael F MF; Siminovitch, Katherine A KA