Variant ID: 22-44324727-C-G

NM_025225.2(PNPLA3):c.444C>G;(p.Ile148Met)

This variant was identified in 895 publications


Data for the 100 most recent publications are displayed below.


Publications:


HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD).

Biomedicines
A Di Costanzo, A Ronca, L D'Erasmo, M Manfredini, F Baratta, D Pastori, M Di Martino, F Ceci, F Angelico, M Del Ben, C Pavanello, M Turri, L Calabresi, E Favari, M Arca
Publication Date: 2020-12-18

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33352841
Variant Present in the following documents:
  • Main text
View BVdb publication page



Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments.

Frontiers In Pharmacology
C Peng, AG Stewart, OL Woodman, RH Ritchie, CX Qin
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33343375
Variant Present in the following documents:
  • Main text
View BVdb publication page



Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease.

Frontiers In Oncology
D Suresh, AN Srinivas, DP Kumar
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33330100
Variant Present in the following documents:
  • Main text
View BVdb publication page



Modeling Non-Alcoholic Fatty Liver Disease (NAFLD) Using "Good-Fit" Genome-Editing Tools.

Cells
U Kim, N Kim, HY Shin
Publication Date: 2020-12-01

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33271878
Variant Present in the following documents:
  • Main text
View BVdb publication page



EZH2 as a Potential Target for NAFLD Therapy.

International Journal Of Molecular Sciences
HJ Lim, M Kim
Publication Date: 2020-11-16

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33207561
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.

International Journal Of Molecular Sciences
RC Stone, V Chen, J Burgess, S Pannu, M Tomic-Canic
Publication Date: 2020-11-14

Variant appearance in text: rs738409
PubMed Link: 33202590
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nineteen-year prognosis in Japanese patients with biopsy-proven nonalcoholic fatty liver disease: Lean versus overweight patients.

Plos One
S Hirose, K Matsumoto, M Tatemichi, K Tsuruya, K Anzai, Y Arase, K Shiraishi, M Suzuki, S Ieda, T Kagawa
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33186403
Variant Present in the following documents:
  • Main text
View BVdb publication page



In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism.

Molecular Medicine Reports
S Liu, E Murakami, T Nakahara, K Ohya, Y Teraoka, GN Makokha, T Uchida, K Morio, H Fujino, A Ono, M Yamauchi, T Kawaoka, D Miki, M Tsuge, A Hiramatsu, H Abe-Chayama, NC Hayes, M Imamura, H Aikata, K Chayama
Publication Date: 2021-01

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33179077
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population.

Liver International : Official Journal Of The International Association For The Study Of The Liver
H Chen, Y Zhang, T Guo, F Yang, Y Mao, L Li, C Liu, H Gao, Y Jin, Y Che, Y Li, J Huang
Publication Date: 2020-09

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33151633
Variant Present in the following documents:
  • Main text
View BVdb publication page



Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease.

Bmc Gastroenterology
S Iritani, N Akuta, Y Kawamura, A Kajiwara, K Kasuya, S Fujiyama, H Sezaki, T Hosaka, M Kobayashi, M Kobayashi, S Saito, F Suzuki, Y Arase, K Ikeda, Y Suzuki, H Kumada
Publication Date: 2020-11-04

Variant appearance in text: rs738409
PubMed Link: 33148171
Variant Present in the following documents:
  • Main text
View BVdb publication page



A new model to predict response to direct-acting antiviral therapy in decompensated cirrhotics due to hepatitis C virus.

Clinical And Experimental Hepatology
P Debnath, S Chandnani, P Rathi, S Nair, P Junare, S Udgirkar, A Singh, Q Contractor
Publication Date: 2020-09

Variant appearance in text: rs738409
PubMed Link: 33145432
Variant Present in the following documents:
  • Main text
View BVdb publication page



Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers.

Disease Markers
O Khalifa, K Errafii, NS Al-Akl, A Arredouani
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33133304
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease.

World Journal Of Gastroenterology
A Campos-Murguía, A Ruiz-Margáin, JA González-Regueiro, RU Macías-Rodríguez
Publication Date: 2020-10-21

Variant appearance in text: rs738409
PubMed Link: 33132645
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease.

Pharmacogenomics And Personalized Medicine
C Cafiero, A Re, A Micera, R Palmirotta, D Monaco, F Romano, C Fabrizio, R Di Francia, A Cacciamani, PL Surico, G D'Amato, S Pisconti
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 33116761
Variant Present in the following documents:
  • Main text
View BVdb publication page



Current NAFLD guidelines for risk stratification in diabetic patients have poor diagnostic discrimination.

Scientific Reports
V Blank, D Petroff, S Beer, A Böhlig, M Heni, T Berg, Y Bausback, A Dietrich, A Tönjes, M Hollenbach, M Blüher, V Keim, J Wiegand, T Karlas
Publication Date: 2020-10-27

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33110165
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study.

Genes
L Castaldo, F Laguzzi, RJ Strawbridge, D Baldassarre, F Veglia, L Vigo, E Tremoli, U de Faire, P Eriksson, AJ Smit, J Aubrecht, K Leander, M Pirro, P Giral, A Ritieni, G Di Minno, A Mälarstig, B Gigante
Publication Date: 2020-10-22

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33105679
Variant Present in the following documents:
  • Main text
View BVdb publication page



Perspectives on youth-onset nonalcoholic fatty liver disease.

Endocrinology, Diabetes & Metabolism
E Castillo-Leon, CE Cioffi, MB Vos
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33102800
Variant Present in the following documents:
  • Main text
View BVdb publication page



Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum.

Endocrinology, Diabetes & Metabolism
F Tavaglione, G Targher, L Valenti, S Romeo
Publication Date: 2020-10

Variant appearance in text: rs738409
PubMed Link: 33102799
Variant Present in the following documents:
  • Main text
View BVdb publication page



Diagnostic and interventional circulating biomarkers in nonalcoholic steatohepatitis.

Endocrinology, Diabetes & Metabolism
MA Tincopa
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33102798
Variant Present in the following documents:
  • Main text
View BVdb publication page



The metabolic basis of nonalcoholic steatohepatitis.

Endocrinology, Diabetes & Metabolism
MV Chakravarthy, BA Neuschwander-Tetri
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33102794
Variant Present in the following documents:
  • Main text
View BVdb publication page



Updating Phospholipase A2 Biology.

Biomolecules
M Murakami, H Sato, Y Taketomi
Publication Date: 2020-10-19

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33086624
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan.

Diagnostics (Basel, Switzerland)
Y Seko, K Yano, A Takahashi, S Okishio, S Kataoka, K Okuda, A Umemura, K Yamaguchi, M Moriguchi, S Tanaka, Y Itoh
Publication Date: 2020-10-19

Variant appearance in text: rs738409
PubMed Link: 33086582
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomics in Personalized Nutrition: Can You "Eat for Your Genes"?

Nutrients
VA Mullins, W Bresette, L Johnstone, B Hallmark, FH Chilton
Publication Date: 2020-10-13

Variant appearance in text: rs738409
PubMed Link: 33065985
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association of genetic polymorphisms with nonalcoholic fatty liver disease in a longitudinal study.

Bmc Gastroenterology
GE Chung, E Shin, MS Kwak, J In Yang, JE Lee, EK Choe, JY Yim
Publication Date: 2020-10-15

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33059586
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alcohol and hepatocarcinogenesis.

Clinical And Molecular Hepatology
M Taniai
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33053943
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights.

Clinical And Molecular Hepatology
K Ikejima, K Kon, S Yamashina
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33053942
Variant Present in the following documents:
  • Main text
View BVdb publication page



Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings.

Cells
BE Schwartz, V Rajagopal, C Smith, E Cohick, G Whissell, M Gamboa, R Pai, A Sigova, I Grossman, D Bumcrot, K Sasidharan, S Romeo, A Sehgal, P Pingitore
Publication Date: 2020-10-07

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33036387
Variant Present in the following documents:
  • Main text
View BVdb publication page



Playing Jekyll and Hyde-The Dual Role of Lipids in Fatty Liver Disease.

Cells
MR Molenaar, LC Penning, JB Helms
Publication Date: 2020-10-06

Variant appearance in text: PNPLA3: Ile148Met
PubMed Link: 33036257
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant.

World Journal Of Gastroenterology
A Di Sessa, GR Umano, G Cirillo, AP Passaro, V Verde, D Cozzolino, S Guarino, P Marzuillo, E Miraglia Del Giudice
Publication Date: 2020-09-28

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33024398
Variant Present in the following documents:
  • Main text
View BVdb publication page



A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B.

Microorganisms
H Hanif, MM Khan, MJ Ali, PA Shah, J Satiya, DTY Lau, A Aslam
Publication Date: 2020-10-04

Variant appearance in text: rs738409
PubMed Link: 33020450
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver.

Frontiers In Physiology
JA Valcin, US Udoh, TM Swain, KK Andringa, CR Patel, S Al Diffalha, PRS Baker, KL Gamble, SM Bailey
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M
PubMed Link: 33013449
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dysregulated lipid metabolism links NAFLD to cardiovascular disease.

Molecular Metabolism
A Deprince, JT Haas, B Staels
Publication Date: 2020-12

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 33010471
Variant Present in the following documents:
  • Main text
View BVdb publication page



Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment.

Cancers
ML Martínez-Chantar, MA Avila, SC Lu
Publication Date: 2020-09-23

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32977536
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.

International Journal Of Molecular Sciences
YA Nasykhova, ZN Tonyan, AA Mikhailova, MM Danilova, AS Glotov
Publication Date: 2020-09-18

Variant appearance in text: PNPLA3: Ile148Met; rs738409
PubMed Link: 32961860
Variant Present in the following documents:
  • Main text
View BVdb publication page



Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver.

Biomolecules
W Chamulitrat, C Jansakun, H Li, G Liebisch
Publication Date: 2020-09-17

Variant appearance in text: rs738409
PubMed Link: 32957701
Variant Present in the following documents:
  • Main text
View BVdb publication page



Racial disparities in nonalcoholic fatty liver disease clinical trial enrollment: A systematic review and meta-analysis.

World Journal Of Hepatology
P Patel, C Muller, S Paul
Publication Date: 2020-08-27

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32952877
Variant Present in the following documents:
  • Main text
View BVdb publication page



Difference in lifestyle and metabolic profile of non-alcoholic fatty liver disease with raised alanine amino-transferases between obese and non-overweight subjects.

Scientific Reports
M Sharma, A Kulkarni, P Kumar, VB Nori, N Jagtap, R Gupta, DN Reddy, PN Rao
Publication Date: 2020-09-17

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32943747
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abnormal metabolic processes involved in the pathogenesis of non-alcoholic fatty liver disease (Review).

Experimental And Therapeutic Medicine
M Shao, Z Ye, Y Qin, T Wu
Publication Date: 2020-11

Variant appearance in text: rs738409
PubMed Link: 32934691
Variant Present in the following documents:
  • Main text
View BVdb publication page



Fatty Liver Disease: Metabolic, Genetic, or Both?

Hepatology Communications
H Zoller, S Wagner, B Schaefer
Publication Date: 2020-09

Variant appearance in text: PNPLA3: Ile148Met; rs738409
PubMed Link: 32923830
Variant Present in the following documents:
  • Main text
View BVdb publication page



Racial Disparities in Diagnosis and Prognosis of Nonalcoholic Fatty Liver Disease.

Clinical Liver Disease
NS Samji, PD Snell, AK Singal, SK Satapathy
Publication Date: 2020-08

Variant appearance in text: rs738409
PubMed Link: 32922753
Variant Present in the following documents:
  • Main text
View BVdb publication page



Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology.

Clinical And Molecular Hepatology
S Sookoian, CJ Pirola
Publication Date: 2020-10

Variant appearance in text: rs738409
PubMed Link: 32906228
Variant Present in the following documents:
  • Main text
View BVdb publication page



Validating candidate biomarkers for different stages of non-alcoholic fatty liver disease.

Medicine
R Al-Qarni, M Iqbal, M Al-Otaibi, F Al-Saif, AA Alfadda, H Alkhalidi, F Bamehriz, M Hassanain
Publication Date: 2020-09-04

Variant appearance in text: rs738409
PubMed Link: 32898995
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.

Pharmaceuticals (Basel, Switzerland)
R Jamwal, BJ Barlock
Publication Date: 2020-08-29

Variant appearance in text: rs738409
PubMed Link: 32872474
Variant Present in the following documents:
  • Main text
View BVdb publication page



Exploring the genetic basis of fatty liver development in geese.

Scientific Reports
Y Yang, H Wang, G Li, Y Liu, C Wang, D He
Publication Date: 2020-08-31

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32868783
Variant Present in the following documents:
  • Main text
View BVdb publication page



Too Much of a Good Thing? An Evolutionary Theory to Explain the Role of Ceramides in NAFLD.

Frontiers In Endocrinology
AM Poss, SA Summers
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32849291
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics as a Tool to Limit Acute and Long-Term Adverse Effects of Chemotherapeutics: An Update in Pediatric Oncology.

Frontiers In Pharmacology
EC Bernsen, MM Hagleitner, TW Kouwenberg, LM Hanff
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32848787
Variant Present in the following documents:
  • Main text
View BVdb publication page



Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.

Pharmacogenomics And Personalized Medicine
D Maamari, H El-Khoury, O Saifi, SA Muwakkit, NK Zgheib
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32848445
Variant Present in the following documents:
  • Main text
View BVdb publication page



Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program.

Plos One
M Serper, M Vujkovic, DE Kaplan, RM Carr, KM Lee, Q Shao, DR Miller, PD Reaven, LS Phillips, CJ O'Donnell, JB Meigs, PWF Wilson, R Vickers-Smith, HR Kranzler, AC Justice, JM Gaziano, S Muralidhar, S Pyarajan, SL DuVall, TL Assimes, JS Lee, PS Tsao, DJ Rader, SM Damrauer, JA Lynch, D Saleheen, BF Voight, KM Chang,
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32841307
Variant Present in the following documents:
  • Main text
View BVdb publication page



56th EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.

Diabetologia
.
Publication Date: 2020-09

Variant appearance in text: rs738409
PubMed Link: 32840677
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies.

Journal Of Lipid And Atherosclerosis
SY Bu
Publication Date: 2019-09

Variant appearance in text: rs738409
PubMed Link: 32821703
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis.

Bmc Medical Genetics
S Tang, J Zhang, TT Mei, HQ Guo, XH Wei, WY Zhang, YL Liu, S Liang, ZP Fan, LX Ma, W Lin, YR Liu, LX Qiu, HB Yu
Publication Date: 2020-08-18

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32811452
Variant Present in the following documents:
  • Main text
View BVdb publication page



Resection of NAFLD-Associated HCC: Patient Selection and Reported Outcomes.

Journal Of Hepatocellular Carcinoma
C Campani, C Bensi, S Milani, A Galli, M Tarocchi
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32802809
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus.

Hepatology Communications
K Yoshida, K Yokota, Y Kutsuwada, K Nakayama, K Watanabe, A Matsumoto, H Miyashita, SS Khor, K Tokunaga, Y Kawai, M Nagasaki, S Iwamoto
Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32766473
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study.

Hepatology Communications
SL Park, Y Li, X Sheng, V Hom, L Xia, K Zhao, L Pooler, VW Setiawan, U Lim, KR Monroe, LR Wilkens, BS Kristal, JW Lampe, M Hullar, J Shepherd, LLM Loo, T Ernst, AA Franke, M Tiirikainen, CA Haiman, DO Stram, L Le Marchand, I Cheng
Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32766472
Variant Present in the following documents:
  • Main text
View BVdb publication page



The complement system in liver diseases: Evidence-based approach and therapeutic options.

Journal Of Translational Autoimmunity
T Lung, B Sakem, L Risch, R Würzner, G Colucci, A Cerny, U Nydegger
Publication Date: 2019-12

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32743505
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis.

Saudi Journal Of Gastroenterology : Official Journal Of The Saudi Gastroenterology Association
J Tan, J Zhang, Z Zhao, J Zhang, M Dong, X Ma, S Liu, Y Xin
Publication Date: 2020-07-23

Variant appearance in text: rs738409
PubMed Link: 32719241
Variant Present in the following documents:
  • Main text
View BVdb publication page



The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease.

Metabolism: Clinical And Experimental
N Perakakis, K Stefanakis, CS Mantzoros
Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32712221
Variant Present in the following documents:
  • Main text
View BVdb publication page



Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma.

Hepatoma Research
JN Benhammou, J Lin, SK Hussain, M El-Kabany
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32685690
Variant Present in the following documents:
  • Main text
View BVdb publication page



NAFLD as a continuum: from obesity to metabolic syndrome and diabetes.

Diabetology & Metabolic Syndrome
AF Godoy-Matos, WS Silva Júnior, CM Valerio
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32684985
Variant Present in the following documents:
  • Main text
View BVdb publication page



Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis.

Bmc Gastroenterology
J Seeßle, H Gan-Schreier, M Kirchner, W Stremmel, W Chamulitrat, U Merle
Publication Date: 2020-07-17

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32680469
Variant Present in the following documents:
  • Main text
View BVdb publication page



Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases.

Nutrients
T Himoto, T Masaki
Publication Date: 2020-07-14

Variant appearance in text: rs738409
PubMed Link: 32674425
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.

The Journal Of Nutrition
MA Van Name, M Savoye, JM Chick, BT Galuppo, AE Feldstein, B Pierpont, C Johnson, V Shabanova, U Ekong, PL Valentino, G Kim, S Caprio, N Santoro
Publication Date: 2020-09-01

Variant appearance in text: rs738409
PubMed Link: 32652034
Variant Present in the following documents:
  • Main text
View BVdb publication page



Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease.

Cells
A Fougerat, A Montagner, N Loiseau, H Guillou, W Wahli
Publication Date: 2020-07-08

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32650421
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation.

Translational Gastroenterology And Hepatology
BJ Maliakkal
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32632387
Variant Present in the following documents:
  • Main text
View BVdb publication page



MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.

Ebiomedicine
M Meroni, M Longo, AL Fracanzani, P Dongiovanni
Publication Date: 2020-07

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32629394
Variant Present in the following documents:
  • Main text
View BVdb publication page



Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Middle East Journal Of Digestive Diseases
S Saki, N Saki, H Poustchi, R Malekzadeh
Publication Date: 2020-04

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32626560
Variant Present in the following documents:
  • Main text
View BVdb publication page



Highlights From the AASLD/EASL ALD Endpoints Conference 2019.

Clinical Liver Disease
M Bertha, H Maddur
Publication Date: 2020-06

Variant appearance in text: rs738409
PubMed Link: 32617152
Variant Present in the following documents:
  • Main text
View BVdb publication page



Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease.

Endocrinology And Metabolism (Seoul, Korea)
DH Lee
Publication Date: 2020-06

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PubMed Link: 32615709
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nonalcoholic fatty liver disease and cardiovascular disease phenotypes.

Sage Open Medicine
G Bisaccia, F Ricci, C Mantini, C Tana, GL Romani, C Schiavone, S Gallina
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32612827
Variant Present in the following documents:
  • Main text
View BVdb publication page



Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease.

Cancers
B Smeuninx, E Boslem, MA Febbraio
Publication Date: 2020-06-28

Variant appearance in text: rs738409
PubMed Link: 32605253
Variant Present in the following documents:
  • Main text
View BVdb publication page



Epidemiology: Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan.

International Journal Of Molecular Sciences
Y Sumida, T Shima, Y Mitsumoto, T Katayama, A Umemura, K Yamaguchi, Y Itoh, M Yoneda, T Okanoue
Publication Date: 2020-06-18

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32570776
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth.

The Journal Of Clinical Endocrinology And Metabolism
A Monga Kravetz, T Testerman, B Galuppo, J Graf, B Pierpont, S Siebel, R Feinn, N Santoro
Publication Date: 2020-10-01

Variant appearance in text: rs738409
PubMed Link: 32561908
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients.

Plos One
O Aly, HH Zaki, MR Herzalla, A Fathy, N Raafat, MM Hafez
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32544194
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nonalcoholic Fatty Liver Disease: An Important Consideration for Primary Care Providers in Hawai'i.

Hawai'I Journal Of Health & Social Welfare
RJ Pattison, JP Esteban, T Sempokuya, J Kewcharoen, S Kalathil, SK Kuwada
Publication Date: 2020-06-01

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32524096
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between non-alcoholic fatty liver disease and obstructive sleep apnea.

World Journal Of Gastroenterology
I Umbro, V Fabiani, M Fabiani, F Angelico, M Del Ben
Publication Date: 2020-05-28

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32523319
Variant Present in the following documents:
  • Main text
View BVdb publication page



Regional difference in the susceptibility of non-alcoholic fatty liver disease in China.

Bmj Open Diabetes Research & Care
M Xia, X Sun, L Zheng, Y Bi, Q Li, L Sun, F Di, H Li, D Zhu, Y Gao, Y Bao, Y Wang, L He, B Wu, S Wang, J Gao, X Gao, H Bian
Publication Date: 2020-06

Variant appearance in text: rs738409
PubMed Link: 32522731
Variant Present in the following documents:
  • Main text
View BVdb publication page



Combined alcoholic and non-alcoholic steatohepatitis.

Jhep Reports : Innovation In Hepatology
LC Ntandja Wandji, V Gnemmi, P Mathurin, A Louvet
Publication Date: 2020-06

Variant appearance in text: rs738409
PubMed Link: 32514497
Variant Present in the following documents:
  • Main text
View BVdb publication page



Non-alcoholic fatty liver disease (NAFLD) diagnosis and management-differentiating the essential from the ancillary and the present from the future.

Hepatobiliary Surgery And Nutrition
A Lonardo, S Lugari, F Nascimbeni
Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32509834
Variant Present in the following documents:
  • Main text
View BVdb publication page



PNPLA3 and nonalcoholic fatty liver disease: towards personalized medicine for fatty liver.

Hepatobiliary Surgery And Nutrition
L Yuan, NA Terrrault
Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32509828
Variant Present in the following documents:
  • Main text
View BVdb publication page



Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective?

Cancers
MC Plaz Torres, G Bodini, M Furnari, E Marabotto, P Zentilin, M Strazzabosco, EG Giannini
Publication Date: 2020-05-31

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32486355
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease.

International Journal Of Molecular Sciences
H Fujii, N Kawada, Japan Study Group Of Nafld Jsg-Nafld
Publication Date: 2020-05-29

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32485838
Variant Present in the following documents:
  • Main text
View BVdb publication page



Medical management of metabolic and cardiovascular complications after liver transplantation.

World Journal Of Gastroenterology
C Becchetti, M Dirchwolf, V Banz, JF Dufour
Publication Date: 2020-05-14

Variant appearance in text: rs738409
PubMed Link: 32476781
Variant Present in the following documents:
  • Main text
View BVdb publication page



Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease.

Clinical And Translational Gastroenterology
F Ferri, M Mischitelli, G Tozzi, E Messina, I Mignini, S Mazzuca, M Pellone, S Parisse, R Marrapodi, M Visentini, F Baratta, M Del Ben, D Pastori, R Perciballi, ML Attilia, M Carbone, A De Santis, F Violi, F Angelico, S Ginanni Corradini
Publication Date: 2020-02

Variant appearance in text: rs738409
PubMed Link: 32463622
Variant Present in the following documents:
  • Main text
View BVdb publication page



Unique insights from ClinicalTrials.gov by mining protein mutations and RSids in addition to applying the Human Phenotype Ontology.

Plos One
S Alag
Publication Date: 2020

Variant appearance in text: rs738409
PubMed Link: 32459809
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lack of genetic evidence that fatty liver disease predisposes to COVID-19.

Journal Of Hepatology
L Valenti, O Jamialahmadi, S Romeo
Publication Date: 2020-09

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32445883
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular Mechanisms Regulating Obesity-Associated Hepatocellular Carcinoma.

Cancers
Y Rajesh, D Sarkar
Publication Date: 2020-05-20

Variant appearance in text: PNPLA3: Ile148Met; rs738409
PubMed Link: 32443737
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan.

International Journal Of Molecular Sciences
AM Raja, E Ciociola, IN Ahmad, FS Dar, SMS Naqvi, M Moaeen-Ud-Din, G Kaukab Raja, S Romeo, RM Mancina
Publication Date: 2020-05-18

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32443539
Variant Present in the following documents:
  • Main text
View BVdb publication page



Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association.

Diabetes & Metabolism Journal
BW Lee, YH Lee, CY Park, EJ Rhee, WY Lee, NH Kim, KM Choi, KG Park, YK Choi, BS Cha, DH Lee,
Publication Date: 2020-06

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PubMed Link: 32431115
Variant Present in the following documents:
  • Main text
View BVdb publication page



Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.

Lipids In Health And Disease
A Medina-Urrutia, AR Lopez-Uribe, M El Hafidi, MDC González-Salazar, R Posadas-Sánchez, E Jorge-Galarza, L Del Valle-Mondragón, JG Juárez-Rojas
Publication Date: 2020-05-19

Variant appearance in text: rs738409
PubMed Link: 32430018
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Frontiers In Pharmacology
JJ Martínez-Magaña, AD Genis-Mendoza, JA Villatoro Velázquez, B Camarena, R Martín Del Campo Sanchez, C Fleiz Bautista, M Bustos Gamiño, E Reséndiz, A Aguilar, ME Medina-Mora, H Nicolini
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32390825
Variant Present in the following documents:
  • Main text
View BVdb publication page



Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.

Alimentary Pharmacology & Therapeutics
B Carlsson, D Lindén, G Brolén, M Liljeblad, M Bjursell, S Romeo, R Loomba
Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32383295
Variant Present in the following documents:
  • Main text
View BVdb publication page



Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients.

Gastroenterology Research And Practice
C De Benedittis, M Bellan, M Crevola, E Boin, MN Barbaglia, VR Mallela, P Ravanini, E Ceriani, S Fangazio, PP Sainaghi, ME Burlone, R Minisini, M Pirisi
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 32382265
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease.

Nutrients
N Perez-Diaz-Del-Campo, I Abete, I Cantero, BA Marin-Alejandre, JI Monreal, M Elorz, JI Herrero, A Benito-Boillos, JI Riezu-Boj, FI Milagro, JA Tur, JA Martinez, MA Zulet
Publication Date: 2020-04-29

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32365683
Variant Present in the following documents:
  • Main text
View BVdb publication page



High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD.

Hepatology Communications
S Lang, A Martin, F Farowski, H Wisplinghoff, MJGT Vehreschild, J Liu, M Krawczyk, A Nowag, A Kretzschmar, J Herweg, B Schnabl, XM Tu, F Lammert, T Goeser, F Tacke, K Heinzer, P Kasper, HM Steffen, M Demir
Publication Date: 2020-05

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32363319
Variant Present in the following documents:
  • Main text
View BVdb publication page



Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD.

Hepatology Communications
G Ezaz, HD Trivedi, MA Connelly, C Filozof, K Howard, M L Parrish, M Kim, MA Herman, I Nasser, NH Afdhal, ZG Jiang, M Lai
Publication Date: 2020-05

Variant appearance in text: rs738409
PubMed Link: 32363318
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.

Biochimica Et Biophysica Acta. Molecular And Cell Biology Of Lipids
C Wagner, V Hois, L Pajed, LM Pusch, H Wolinski, M Trauner, R Zimmermann, U Taschler, A Lass
Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M
PubMed Link: 32361002
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.

World Journal Of Gastroenterology
J Zeng, RX Yang, C Sun, Q Pan, RN Zhang, GY Chen, Y Hu, JG Fan
Publication Date: 2020-04-21

Variant appearance in text: rs738409
PubMed Link: 32351294
Variant Present in the following documents:
  • Main text
View BVdb publication page



Possible Relevance of PNPLA3 and TLL1 Gene Polymorphisms to the Efficacy of PEG-IFN Therapy for HBV-Infected Patients.

International Journal Of Molecular Sciences
H Enomoto, N Aizawa, K Hasegawa, N Ikeda, Y Sakai, K Yoh, R Takata, Y Yuri, K Kishino, Y Shimono, N Ishii, T Takashima, T Nishimura, H Nishikawa, Y Iwata, H Iijima, S Nishiguchi
Publication Date: 2020-04-27

Variant appearance in text: rs738409
PubMed Link: 32349377
Variant Present in the following documents:
  • Main text
View BVdb publication page



Noninvasive Diagnosis of NAFLD and NASH.

Cells
VA Piazzolla, A Mangia
Publication Date: 2020-04-17

Variant appearance in text: rs738409
PubMed Link: 32316690
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.

Contemporary Clinical Trials Communications
JG Stine, I Schreibman, S Navabi, M Kang, J Dahmus, C Soriano, G Rivas, B Hummer, M Beyer, H Tressler, SR Kimball, AD Patterson, K Schmitz, C Sciamanna
Publication Date: 2020-06

Variant appearance in text: rs738409
PubMed Link: 32309672
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000216180.3 c.444C>G p.Ile148Met missense_variant 3/9 -
ENST00000406117.2 c.*76C>G - 3_prime_UTR_variant,NMD_transcript_variant 3/10 -
ENST00000423180.2 c.432C>G p.Ile144Met missense_variant 3/9 -
ENST00000478713.1 n.478C>G - non_coding_transcript_exon_variant 3/4 -
NM_025225.3 c.444C>G p.Ile148Met missense_variant 3/9 -