Variant ID: 22-44324727-C-G

NM_025225.2(PNPLA3):c.444C>G;(p.Ile148Met)

This variant was identified in 822 publications




Publications:


The complement system in liver diseases: Evidence-based approach and therapeutic options.

Journal Of Translational Autoimmunity
T Lung, B Sakem, L Risch, R Würzner, G Colucci, A Cerny, U Nydegger
Publication Date: 2019-12

Variant appearance in text: PNPLA3: I148M
PMID: 32743505
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The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease.

Metabolism: Clinical And Experimental
N Perakakis, K Stefanakis, CS Mantzoros
Publication Date: 2020-07-23

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32712221
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Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma.

Hepatoma Research
JN Benhammou, J Lin, SK Hussain, M El-Kabany
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32685690
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NAFLD as a continuum: from obesity to metabolic syndrome and diabetes.

Diabetology & Metabolic Syndrome
AF Godoy-Matos, WS Silva Júnior, CM Valerio
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32684985
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Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis.

Bmc Gastroenterology
J Seeßle, H Gan-Schreier, M Kirchner, W Stremmel, W Chamulitrat, U Merle
Publication Date: 2020-07-17

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32680469
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Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases.

Nutrients
T Himoto, T Masaki
Publication Date: 2020-07-14

Variant appearance in text: rs738409
PMID: 32674425
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A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.

The Journal Of Nutrition
MA Van Name, M Savoye, JM Chick, BT Galuppo, AE Feldstein, B Pierpont, C Johnson, V Shabanova, U Ekong, PL Valentino, G Kim, S Caprio, N Santoro
Publication Date: 2020-07-11

Variant appearance in text: rs738409
PMID: 32652034
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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease.

Cells
A Fougerat, A Montagner, N Loiseau, H Guillou, W Wahli
Publication Date: 2020-07-08

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32650421
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MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.

Ebiomedicine
M Meroni, M Longo, AL Fracanzani, P Dongiovanni
Publication Date: 2020-07-03

Variant appearance in text: PNPLA3: I148M
PMID: 32629394
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Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Middle East Journal Of Digestive Diseases
S Saki, N Saki, H Poustchi, R Malekzadeh
Publication Date: 2020-04

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32626560
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Highlights From the AASLD/EASL ALD Endpoints Conference 2019.

Clinical Liver Disease
M Bertha, H Maddur
Publication Date: 2020-06

Variant appearance in text: rs738409
PMID: 32617152
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Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease.

Endocrinology And Metabolism (Seoul, Korea)
DH Lee
Publication Date: 2020-06

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PMID: 32615709
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Nonalcoholic fatty liver disease and cardiovascular disease phenotypes.

Sage Open Medicine
G Bisaccia, F Ricci, C Mantini, C Tana, GL Romani, C Schiavone, S Gallina
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32612827
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Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease.

Cancers
B Smeuninx, E Boslem, MA Febbraio
Publication Date: 2020-06-28

Variant appearance in text: rs738409
PMID: 32605253
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Epidemiology: Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan.

International Journal Of Molecular Sciences
Y Sumida, T Shima, Y Mitsumoto, T Katayama, A Umemura, K Yamaguchi, Y Itoh, M Yoneda, T Okanoue
Publication Date: 2020-06-18

Variant appearance in text: PNPLA3: I148M
PMID: 32570776
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Effect of gut microbiota and PNPLA3 rs738409 variant on non-alcoholic fatty liver disease (NAFLD) in obese youth.

The Journal Of Clinical Endocrinology And Metabolism
AM Kravetz, T Testerman, B Galuppo, J Graf, B Pierpont, S Siebel, R Feinn, N Santoro
Publication Date: 2020-06-19

Variant appearance in text: rs738409
PMID: 32561908
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Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients.

Plos One
O Aly, HH Zaki, MR Herzalla, A Fathy, N Raafat, MM Hafez
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32544194
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Nonalcoholic Fatty Liver Disease: An Important Consideration for Primary Care Providers in Hawai'i.

Hawai'I Journal Of Health & Social Welfare
RJ Pattison, JP Esteban, T Sempokuya, J Kewcharoen, S Kalathil, SK Kuwada
Publication Date: 2020-06-01

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32524096
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Association between non-alcoholic fatty liver disease and obstructive sleep apnea.

World Journal Of Gastroenterology
I Umbro, V Fabiani, M Fabiani, F Angelico, M Del Ben
Publication Date: 2020-05-28

Variant appearance in text: PNPLA3: I148M
PMID: 32523319
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Regional difference in the susceptibility of non-alcoholic fatty liver disease in China.

Bmj Open Diabetes Research & Care
M Xia, X Sun, L Zheng, Y Bi, Q Li, L Sun, F Di, H Li, D Zhu, Y Gao, Y Bao, Y Wang, L He, B Wu, S Wang, J Gao, X Gao, H Bian
Publication Date: 2020-06

Variant appearance in text: rs738409
PMID: 32522731
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Combined alcoholic and non-alcoholic steatohepatitis.

Jhep Reports : Innovation In Hepatology
LC Ntandja Wandji, V Gnemmi, P Mathurin, A Louvet
Publication Date: 2020-06

Variant appearance in text: rs738409
PMID: 32514497
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Non-alcoholic fatty liver disease (NAFLD) diagnosis and management-differentiating the essential from the ancillary and the present from the future.

Hepatobiliary Surgery And Nutrition
A Lonardo, S Lugari, F Nascimbeni
Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M
PMID: 32509834
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PNPLA3 and nonalcoholic fatty liver disease: towards personalized medicine for fatty liver.

Hepatobiliary Surgery And Nutrition
L Yuan, NA Terrrault
Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32509828
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Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective?

Cancers
MC Plaz Torres, G Bodini, M Furnari, E Marabotto, P Zentilin, M Strazzabosco, EG Giannini
Publication Date: 2020-05-31

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32486355
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The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease.

International Journal Of Molecular Sciences
H Fujii, N Kawada, Japan Study Group Of Nafld Jsg-Nafld
Publication Date: 2020-05-29

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32485838
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Medical management of metabolic and cardiovascular complications after liver transplantation.

World Journal Of Gastroenterology
C Becchetti, M Dirchwolf, V Banz, JF Dufour
Publication Date: 2020-05-14

Variant appearance in text: rs738409
PMID: 32476781
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Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease.

Clinical And Translational Gastroenterology
F Ferri, M Mischitelli, G Tozzi, E Messina, I Mignini, S Mazzuca, M Pellone, S Parisse, R Marrapodi, M Visentini, F Baratta, M Del Ben, D Pastori, R Perciballi, ML Attilia, M Carbone, A De Santis, F Violi, F Angelico, S Ginanni Corradini
Publication Date: 2020-02

Variant appearance in text: rs738409
PMID: 32463622
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Unique insights from ClinicalTrials.gov by mining protein mutations and RSids in addition to applying the Human Phenotype Ontology.

Plos One
S Alag
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32459809
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Lack of genetic evidence that fatty liver disease predisposes to COVID-19.

Journal Of Hepatology
L Valenti, O Jamialahmadi, S Romeo
Publication Date: 2020-05-20

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32445883
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Molecular Mechanisms Regulating Obesity-Associated Hepatocellular Carcinoma.

Cancers
Y Rajesh, D Sarkar
Publication Date: 2020-05-20

Variant appearance in text: PNPLA3: Ile148Met; rs738409
PMID: 32443737
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Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan.

International Journal Of Molecular Sciences
AM Raja, E Ciociola, IN Ahmad, FS Dar, SMS Naqvi, M Moaeen-Ud-Din, G Kaukab Raja, S Romeo, RM Mancina
Publication Date: 2020-05-18

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32443539
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Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association.

Diabetes & Metabolism Journal
BW Lee, YH Lee, CY Park, EJ Rhee, WY Lee, NH Kim, KM Choi, KG Park, YK Choi, BS Cha, DH Lee,
Publication Date: 2020-05-11

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PMID: 32431115
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Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.

Lipids In Health And Disease
A Medina-Urrutia, AR Lopez-Uribe, M El Hafidi, MDC González-Salazar, R Posadas-Sánchez, E Jorge-Galarza, L Del Valle-Mondragón, JG Juárez-Rojas
Publication Date: 2020-05-19

Variant appearance in text: rs738409
PMID: 32430018
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The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Frontiers In Pharmacology
JJ Martínez-Magaña, AD Genis-Mendoza, JA Villatoro Velázquez, B Camarena, R Martín Del Campo Sanchez, C Fleiz Bautista, M Bustos Gamiño, E Reséndiz, A Aguilar, ME Medina-Mora, H Nicolini
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32390825
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Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.

Alimentary Pharmacology & Therapeutics
B Carlsson, D Lindén, G Brolén, M Liljeblad, M Bjursell, S Romeo, R Loomba
Publication Date: 2020-05-07

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32383295
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Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients.

Gastroenterology Research And Practice
C De Benedittis, M Bellan, M Crevola, E Boin, MN Barbaglia, VR Mallela, P Ravanini, E Ceriani, S Fangazio, PP Sainaghi, ME Burlone, R Minisini, M Pirisi
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32382265
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Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease.

Nutrients
N Perez-Diaz-Del-Campo, I Abete, I Cantero, BA Marin-Alejandre, JI Monreal, M Elorz, JI Herrero, A Benito-Boillos, JI Riezu-Boj, FI Milagro, JA Tur, JA Martinez, MA Zulet
Publication Date: 2020-04-29

Variant appearance in text: PNPLA3: I148M
PMID: 32365683
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High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD.

Hepatology Communications
S Lang, A Martin, F Farowski, H Wisplinghoff, MJGT Vehreschild, J Liu, M Krawczyk, A Nowag, A Kretzschmar, J Herweg, B Schnabl, XM Tu, F Lammert, T Goeser, F Tacke, K Heinzer, P Kasper, HM Steffen, M Demir
Publication Date: 2020-05

Variant appearance in text: PNPLA3: I148M
PMID: 32363319
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Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD.

Hepatology Communications
G Ezaz, HD Trivedi, MA Connelly, C Filozof, K Howard, M L Parrish, M Kim, MA Herman, I Nasser, NH Afdhal, ZG Jiang, M Lai
Publication Date: 2020-05

Variant appearance in text: rs738409
PMID: 32363318
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Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.

Biochimica Et Biophysica Acta. Molecular And Cell Biology Of Lipids
C Wagner, V Hois, L Pajed, LM Pusch, H Wolinski, M Trauner, R Zimmermann, U Taschler, A Lass
Publication Date: 2020-04-30

Variant appearance in text: PNPLA3: I148M
PMID: 32361002
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Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.

World Journal Of Gastroenterology
J Zeng, RX Yang, C Sun, Q Pan, RN Zhang, GY Chen, Y Hu, JG Fan
Publication Date: 2020-04-21

Variant appearance in text: rs738409
PMID: 32351294
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Possible Relevance of PNPLA3 and TLL1 Gene Polymorphisms to the Efficacy of PEG-IFN Therapy for HBV-Infected Patients.

International Journal Of Molecular Sciences
H Enomoto, N Aizawa, K Hasegawa, N Ikeda, Y Sakai, K Yoh, R Takata, Y Yuri, K Kishino, Y Shimono, N Ishii, T Takashima, T Nishimura, H Nishikawa, Y Iwata, H Iijima, S Nishiguchi
Publication Date: 2020-04-27

Variant appearance in text: rs738409
PMID: 32349377
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Noninvasive Diagnosis of NAFLD and NASH.

Cells
VA Piazzolla, A Mangia
Publication Date: 2020-04-17

Variant appearance in text: rs738409
PMID: 32316690
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Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.

Contemporary Clinical Trials Communications
JG Stine, I Schreibman, S Navabi, M Kang, J Dahmus, C Soriano, G Rivas, B Hummer, M Beyer, H Tressler, SR Kimball, AD Patterson, K Schmitz, C Sciamanna
Publication Date: 2020-06

Variant appearance in text: rs738409
PMID: 32309672
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Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis.

Cells
T Hurrell, V Kastrinou-Lampou, A Fardellas, DFG Hendriks, Å Nordling, I Johansson, A Baze, C Parmentier, L Richert, M Ingelman-Sundberg
Publication Date: 2020-04-14

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32295224
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The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.

Metabolites
P Hofer, U Taschler, R Schreiber, P Kotzbeck, G Schoiswohl
Publication Date: 2020-04-10

Variant appearance in text: PNPLA3: I148M
PMID: 32290093
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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.

Plos Genetics
CA Emdin, ME Haas, AV Khera, K Aragam, M Chaffin, D Klarin, G Hindy, L Jiang, WQ Wei, Q Feng, J Karjalainen, A Havulinna, T Kiiskinen, A Bick, D Ardissino, JG Wilson, H Schunkert, R McPherson, H Watkins, R Elosua, MJ Bown, NJ Samani, U Baber, J Erdmann, N Gupta, J Danesh, D Saleheen, KM Chang, M Vujkovic, B Voight, S Damrauer, J Lynch, D Kaplan, M Serper, P Tsao, , J Mercader, C Hanis, M Daly, J Denny, S Gabriel, S Kathiresan
Publication Date: 2020-04-13

Variant appearance in text: rs738409
PMID: 32282858
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Non-alcoholic Fatty Liver Disease: Growing Burden, Adverse Outcomes and Associations.

Journal Of Clinical And Translational Hepatology
R Kumar, RN Priyadarshi, U Anand
Publication Date: 2020-03-28

Variant appearance in text: PNPLA3: I148M
PMID: 32274348
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Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia.

Frontiers In Pharmacology
M Cao, D Yin, Y Qin, F Liao, Y Su, X Xia, J Gao, Y Zhu, W Zhang, Y Shu, X Lu
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32265697
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Pathogenesis of Nonalcoholic Steatohepatitis: An Overview.

Hepatology Communications
G Parthasarathy, X Revelo, H Malhi
Publication Date: 2020-04

Variant appearance in text: PNPLA3: I148M
PMID: 32258944
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Inherited iron overload disorders.

Translational Gastroenterology And Hepatology
A Piperno, S Pelucchi, R Mariani
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32258529
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Importance of genetic polymorphisms in liver transplantation outcomes.

World Journal Of Gastroenterology
T Kelava, P Turcic, A Markotic, A Ostojic, D Sisl, A Mrzljak
Publication Date: 2020-03-28

Variant appearance in text: rs738409
PMID: 32256016
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Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Journal Of Hepatology
CA Parisinos, HR Wilman, EL Thomas, M Kelly, RC Nicholls, J McGonigle, S Neubauer, AD Hingorani, RS Patel, H Hemingway, JD Bell, R Banerjee, H Yaghootkar
Publication Date: 2020-04-02

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32247823
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Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China.

International Journal Of Environmental Research And Public Health
H Li, M Guo, Z An, J Meng, J Jiang, J Song, W Wu
Publication Date: 2020-03-11

Variant appearance in text: PNPLA3: I148M
PMID: 32168920
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Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations.

Scientific Reports
PT Williams
Publication Date: 2020-03-11

Variant appearance in text: rs738409
PMID: 32161301
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Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease.

Jci Insight
PK Luukkonen, T Tukiainen, A Juuti, H Sammalkorpi, PAN Haridas, O Niemelä, J Arola, M Orho-Melander, A Hakkarainen, PT Kovanen, O Dwivedi, L Groop, L Hodson, A Gastaldelli, T Hyötyläinen, M Orešič, H Yki-Järvinen
Publication Date: 2020-03-12

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32161197
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Sex Hormone-Binding Globulin Levels Are Inversely Associated With Nonalcoholic Fatty Liver Disease in HIV-Infected and -Uninfected Men.

Open Forum Infectious Diseases
JC Price, R Wang, EC Seaberg, TT Brown, MJ Budoff, LA Kingsley, FJ Palella, MD Witt, WS Post, JE Lake, CL Thio
Publication Date: 2019-12

Variant appearance in text: rs738409
PMID: 32128321
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Limitations of non-invasive tests for assessment of liver fibrosis.

Jhep Reports (Online)
K Patel, G Sebastiani
Publication Date: 2020-04

Variant appearance in text: rs738409
PMID: 32118201
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A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.

Diabetes, Metabolic Syndrome And Obesity : Targets And Therapy
N Muto, K Oniki, M Kudo, Y Obata, Y Sakamoto, N Tokumaru, T Izuka, T Watanabe, K Otake, Y Ogata, J Saruwatari
Publication Date: 2020

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PMID: 32104030
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Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma.

International Journal Of Molecular Sciences
T Kanda, T Goto, Y Hirotsu, R Masuzaki, M Moriyama, M Omata
Publication Date: 2020-02-23

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409
PMID: 32102237
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Independent and joint correlation of PNPLA3 I148M and TM6SF2 E167K variants with the risk of coronary heart disease in patients with non-alcoholic fatty liver disease.

Lipids In Health And Disease
JT Wu, SS Liu, XJ Xie, Q Liu, YN Xin, SY Xuan
Publication Date: 2020-02-24

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32093693
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

Ebiomedicine
M Meroni, P Dongiovanni, M Longo, F Carli, G Baselli, R Rametta, S Pelusi, S Badiali, M Maggioni, M Gaggini, AL Fracanzani, S Romeo, S Gatti, NO Davidson, A Gastaldelli, L Valenti
Publication Date: 2020-02-11

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32058943
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Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach.

Canadian Journal Of Gastroenterology & Hepatology
I Grgurevic, K Podrug, I Mikolasevic, M Kukla, A Madir, EA Tsochatzis
Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32051820
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NAFLD Preclinical Models: More than a Handful, Less of a Concern?

Biomedicines
Y Oligschlaeger, R Shiri-Sverdlov
Publication Date: 2020-02-08

Variant appearance in text: PNPLA3: I148M
PMID: 32046285
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The effect of liver enzymes on body composition: A Mendelian randomization study.

Plos One
J Liu, SL Au Yeung, MK Kwok, JYY Leung, LL Hui, GM Leung, CM Schooling
Publication Date: 2020

Variant appearance in text: rs738409
PMID: 32045441
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Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH.

Liver International : Official Journal Of The International Association For The Study Of The Liver
FV Bruschi, M Tardelli, M Herac, T Claudel, M Trauner
Publication Date: 2020-02-11

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32043752
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Lifestyle modification in NAFLD/NASH: Facts and figures.

Jhep Reports (Online)
K Hallsworth, LA Adams
Publication Date: 2019-12

Variant appearance in text: rs738409
PMID: 32039399
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Serum lipopolysaccharides predict advanced liver disease in the general population.

Jhep Reports (Online)
V Männistö, M Färkkilä, P Pussinen, A Jula, S Männistö, A Lundqvist, L Valsta, V Salomaa, M Perola, F Åberg
Publication Date: 2019-11

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32039385
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Non-alcoholic fatty liver disease in lean individuals.

Jhep Reports (Online)
S Albhaisi, A Chowdhury, AJ Sanyal
Publication Date: 2019-10

Variant appearance in text: rs738409
PMID: 32039383
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Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity.

Jhep Reports (Online)
B Sandhu, MC Perez Matos, S Tran, A Zhong, E Csizmadia, M Kim, MA Herman, I Nasser, M Lai, ZG Jiang
Publication Date: 2019-09

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 32039370
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Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy.

Metabolites
D Beyoğlu, JR Idle
Publication Date: 2020-01-28

Variant appearance in text: PNPLA3: I148M
PMID: 32012846
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Genetics of Non-Alcoholic Fatty Liver and Cardiovascular Disease: Implications for Therapy?

Frontiers In Pharmacology
K Chandrasekharan, W Alazawi
Publication Date: 2019

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 31969816
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Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C.

World Journal Of Gastroenterology
S Tanwar, F Rhodes, A Srivastava, PM Trembling, WM Rosenberg
Publication Date: 2020-01-14

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 31969775
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Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension.

Liver International : Official Journal Of The International Association For The Study Of The Liver
B Scheiner, AF Stättermayer, P Schwabl, T Bucsics, R Paternostro, D Bauer, B Simbrunner, R Schmidt, R Marculescu, A Ferlitsch, M Peck-Radosavljevic, M Pinter, M Trauner, T Reiberger, P Ferenci, M Mandorfer
Publication Date: 2020-02

Variant appearance in text: PNPLA3: I148M
PMID: 31967400
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The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease.

Liver International : Official Journal Of The International Association For The Study Of The Liver
N Simons, M Bijnen, KAM Wouters, SS Rensen, JWJ Beulens, MMJ van Greevenbroek, LM 't Hart, JWM Greve, CJH van der Kallen, NC Schaper, CG Schalkwijk, CDA Stehouwer, MCGJ Brouwers
Publication Date: 2020-01-20

Variant appearance in text: rs738409
PMID: 31960587
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The dawn of a new era for nonalcoholic fatty liver disease?

Hepatobiliary Surgery And Nutrition
A Mantovani, C Zusi
Publication Date: 2019-12

Variant appearance in text: rs738409
PMID: 31929991
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Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.

Bmc Research Notes
S Mohammadi, S Farajnia, M Shadmand, F Mohseni, R Baghban
Publication Date: 2020-01-10

Variant appearance in text: rs738409
PMID: 31924263
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PNPLA3-A Potential Therapeutic Target for Personalized Treatment of Chronic Liver Disease.

Frontiers In Medicine
XC Dong
Publication Date: 2019

Variant appearance in text: rs738409
PMID: 31921875
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Pathogenesis of Insulin Resistance and Atherogenic Dyslipidemia in Nonalcoholic Fatty Liver Disease.

Journal Of Clinical And Translational Hepatology
DH Akhtar, U Iqbal, LM Vazquez-Montesino, BB Dennis, A Ahmed
Publication Date: 2019-12-28

Variant appearance in text: rs738409
PMID: 31915606
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Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population.

Journal Of Clinical And Translational Hepatology
H Gao, S Liu, Z Zhao, X Yu, Q Liu, Y Xin, S Xuan
Publication Date: 2019-12-28

Variant appearance in text: rs738409
PMID: 31915598
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A Microphysiological System for Studying Nonalcoholic Steatohepatitis.

Hepatology Communications
T Kostrzewski, P Maraver, L Ouro-Gnao, A Levi, S Snow, A Miedzik, K Rombouts, D Hughes
Publication Date: 2020-01

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 31909357
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Circulating MicroRNA-122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD.

Hepatology Communications
N Akuta, Y Kawamura, Y Arase, S Saitoh, S Fujiyama, H Sezaki, T Hosaka, M Kobayashi, M Kobayashi, Y Suzuki, F Suzuki, K Ikeda, H Kumada
Publication Date: 2020-01

Variant appearance in text: rs738409
PMID: 31909356
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FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease.

International Journal Of Molecular Sciences
Y Seko, K Yano, A Takahashi, S Okishio, S Kataoka, K Okuda, N Mizuno, M Takemura, H Taketani, A Umemura, T Nishikawa, K Yamaguchi, M Moriguchi, T Okanoue, Y Itoh
Publication Date: 2019-12-25

Variant appearance in text: PNPLA3: I148M; rs738409
PMID: 31881781
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Anti-NASH Drug Development Hitches a Lift on PPAR Agonism.

Cells
J Boeckmans, A Natale, M Rombaut, K Buyl, V Rogiers, J De Kock, T Vanhaecke, R M Rodrigues
Publication Date: 2019-12-21

Variant appearance in text: rs738409
PMID: 31877771
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Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis.

Cells
O Khomich, AV Ivanov, B Bartosch
Publication Date: 2019-12-20

Variant appearance in text: PNPLA3: I148M
PMID: 31861818
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Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy.

Journal Of Clinical Medicine
G Tarantino, V Citro, D Capone
Publication Date: 2019-12-19

Variant appearance in text: PNPLA3: I148M
PMID: 31861591
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Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease.

Journal Of Clinical Medicine
MV Milaciu, ȘC Vesa, IC Bocșan, L Ciumărnean, D Sâmpelean, V Negrean, RM Pop, DM Matei, S Pașca, AL Răchișan, AD Buzoianu, M Acalovschi
Publication Date: 2019-12-13

Variant appearance in text: rs738409
PMID: 31847187
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000216180.3 c.444C>G p.Ile148Met missense_variant 3/9 -
ENST00000406117.2 c.*76C>G - 3_prime_UTR_variant,NMD_transcript_variant 3/10 -
ENST00000423180.2 c.432C>G p.Ile144Met missense_variant 3/9 -
ENST00000478713.1 n.478C>G - non_coding_transcript_exon_variant 3/4 -
NM_025225.3 c.444C>G p.Ile148Met missense_variant 3/9 -