Publications:

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HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD).

Biomedicines

A Di Costanzo, A Ronca, L D'Erasmo, M Manfredini, F Baratta, D Pastori, M Di Martino, F Ceci, F Angelico, M Del Ben, C Pavanello, M Turri, L Calabresi, E Favari, M Arca

Publication Date: 2020-12-18

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33352841

Variant Present in the following documents:

• Main text

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Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments.

Frontiers In Pharmacology

C Peng, AG Stewart, OL Woodman, RH Ritchie, CX Qin

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33343375

Variant Present in the following documents:

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Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease.

Frontiers In Oncology

D Suresh, AN Srinivas, DP Kumar

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33330100

Variant Present in the following documents:

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Modeling Non-Alcoholic Fatty Liver Disease (NAFLD) Using "Good-Fit" Genome-Editing Tools.

Cells

U Kim, N Kim, HY Shin

Publication Date: 2020-12-01

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33271878

Variant Present in the following documents:

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EZH2 as a Potential Target for NAFLD Therapy.

International Journal Of Molecular Sciences

HJ Lim, M Kim

Publication Date: 2020-11-16

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33207561

Variant Present in the following documents:

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Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.

International Journal Of Molecular Sciences

RC Stone, V Chen, J Burgess, S Pannu, M Tomic-Canic

Publication Date: 2020-11-14

Variant appearance in text: rs738409

PubMed Link: 33202590

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Nineteen-year prognosis in Japanese patients with biopsy-proven nonalcoholic fatty liver disease: Lean versus overweight patients.

Plos One

S Hirose, K Matsumoto, M Tatemichi, K Tsuruya, K Anzai, Y Arase, K Shiraishi, M Suzuki, S Ieda, T Kagawa

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33186403

Variant Present in the following documents:

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In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism.

Molecular Medicine Reports

S Liu, E Murakami, T Nakahara, K Ohya, Y Teraoka, GN Makokha, T Uchida, K Morio, H Fujino, A Ono, M Yamauchi, T Kawaoka, D Miki, M Tsuge, A Hiramatsu, H Abe-Chayama, NC Hayes, M Imamura, H Aikata, K Chayama

Publication Date: 2021-01

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33179077

Variant Present in the following documents:

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Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population.

Liver International : Official Journal Of The International Association For The Study Of The Liver

H Chen, Y Zhang, T Guo, F Yang, Y Mao, L Li, C Liu, H Gao, Y Jin, Y Che, Y Li, J Huang

Publication Date: 2020-09

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33151633

Variant Present in the following documents:

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Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease.

Bmc Gastroenterology

S Iritani, N Akuta, Y Kawamura, A Kajiwara, K Kasuya, S Fujiyama, H Sezaki, T Hosaka, M Kobayashi, M Kobayashi, S Saito, F Suzuki, Y Arase, K Ikeda, Y Suzuki, H Kumada

Publication Date: 2020-11-04

Variant appearance in text: rs738409

PubMed Link: 33148171

Variant Present in the following documents:

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A new model to predict response to direct-acting antiviral therapy in decompensated cirrhotics due to hepatitis C virus.

Clinical And Experimental Hepatology

P Debnath, S Chandnani, P Rathi, S Nair, P Junare, S Udgirkar, A Singh, Q Contractor

Publication Date: 2020-09

Variant appearance in text: rs738409

PubMed Link: 33145432

Variant Present in the following documents:

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Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers.

Disease Markers

O Khalifa, K Errafii, NS Al-Akl, A Arredouani

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33133304

Variant Present in the following documents:

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Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease.

World Journal Of Gastroenterology

A Campos-Murguía, A Ruiz-Margáin, JA González-Regueiro, RU Macías-Rodríguez

Publication Date: 2020-10-21

Variant appearance in text: rs738409

PubMed Link: 33132645

Variant Present in the following documents:

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Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease.

Pharmacogenomics And Personalized Medicine

C Cafiero, A Re, A Micera, R Palmirotta, D Monaco, F Romano, C Fabrizio, R Di Francia, A Cacciamani, PL Surico, G D'Amato, S Pisconti

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 33116761

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Current NAFLD guidelines for risk stratification in diabetic patients have poor diagnostic discrimination.

Scientific Reports

V Blank, D Petroff, S Beer, A Böhlig, M Heni, T Berg, Y Bausback, A Dietrich, A Tönjes, M Hollenbach, M Blüher, V Keim, J Wiegand, T Karlas

Publication Date: 2020-10-27

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33110165

Variant Present in the following documents:

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Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study.

Genes

L Castaldo, F Laguzzi, RJ Strawbridge, D Baldassarre, F Veglia, L Vigo, E Tremoli, U de Faire, P Eriksson, AJ Smit, J Aubrecht, K Leander, M Pirro, P Giral, A Ritieni, G Di Minno, A Mälarstig, B Gigante

Publication Date: 2020-10-22

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33105679

Variant Present in the following documents:

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Perspectives on youth-onset nonalcoholic fatty liver disease.

Endocrinology, Diabetes & Metabolism

E Castillo-Leon, CE Cioffi, MB Vos

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33102800

Variant Present in the following documents:

• Main text

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Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum.

Endocrinology, Diabetes & Metabolism

F Tavaglione, G Targher, L Valenti, S Romeo

Publication Date: 2020-10

Variant appearance in text: rs738409

PubMed Link: 33102799

Variant Present in the following documents:

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Diagnostic and interventional circulating biomarkers in nonalcoholic steatohepatitis.

Endocrinology, Diabetes & Metabolism

MA Tincopa

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33102798

Variant Present in the following documents:

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The metabolic basis of nonalcoholic steatohepatitis.

Endocrinology, Diabetes & Metabolism

MV Chakravarthy, BA Neuschwander-Tetri

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33102794

Variant Present in the following documents:

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Updating Phospholipase A2 Biology.

Biomolecules

M Murakami, H Sato, Y Taketomi

Publication Date: 2020-10-19

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33086624

Variant Present in the following documents:

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The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan.

Diagnostics (Basel, Switzerland)

Y Seko, K Yano, A Takahashi, S Okishio, S Kataoka, K Okuda, A Umemura, K Yamaguchi, M Moriguchi, S Tanaka, Y Itoh

Publication Date: 2020-10-19

Variant appearance in text: rs738409

PubMed Link: 33086582

Variant Present in the following documents:

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Genomics in Personalized Nutrition: Can You "Eat for Your Genes"?

Nutrients

VA Mullins, W Bresette, L Johnstone, B Hallmark, FH Chilton

Publication Date: 2020-10-13

Variant appearance in text: rs738409

PubMed Link: 33065985

Variant Present in the following documents:

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The association of genetic polymorphisms with nonalcoholic fatty liver disease in a longitudinal study.

Bmc Gastroenterology

GE Chung, E Shin, MS Kwak, J In Yang, JE Lee, EK Choe, JY Yim

Publication Date: 2020-10-15

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33059586

Variant Present in the following documents:

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Alcohol and hepatocarcinogenesis.

Clinical And Molecular Hepatology

M Taniai

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33053943

Variant Present in the following documents:

• Main text

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Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights.

Clinical And Molecular Hepatology

K Ikejima, K Kon, S Yamashina

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33053942

Variant Present in the following documents:

• Main text

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Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings.

Cells

BE Schwartz, V Rajagopal, C Smith, E Cohick, G Whissell, M Gamboa, R Pai, A Sigova, I Grossman, D Bumcrot, K Sasidharan, S Romeo, A Sehgal, P Pingitore

Publication Date: 2020-10-07

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33036387

Variant Present in the following documents:

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Playing Jekyll and Hyde-The Dual Role of Lipids in Fatty Liver Disease.

Cells

MR Molenaar, LC Penning, JB Helms

Publication Date: 2020-10-06

Variant appearance in text: PNPLA3: Ile148Met

PubMed Link: 33036257

Variant Present in the following documents:

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Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant.

World Journal Of Gastroenterology

A Di Sessa, GR Umano, G Cirillo, AP Passaro, V Verde, D Cozzolino, S Guarino, P Marzuillo, E Miraglia Del Giudice

Publication Date: 2020-09-28

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33024398

Variant Present in the following documents:

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A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B.

Microorganisms

H Hanif, MM Khan, MJ Ali, PA Shah, J Satiya, DTY Lau, A Aslam

Publication Date: 2020-10-04

Variant appearance in text: rs738409

PubMed Link: 33020450

Variant Present in the following documents:

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Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver.

Frontiers In Physiology

JA Valcin, US Udoh, TM Swain, KK Andringa, CR Patel, S Al Diffalha, PRS Baker, KL Gamble, SM Bailey

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M

PubMed Link: 33013449

Variant Present in the following documents:

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Dysregulated lipid metabolism links NAFLD to cardiovascular disease.

Molecular Metabolism

A Deprince, JT Haas, B Staels

Publication Date: 2020-12

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 33010471

Variant Present in the following documents:

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Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment.

Cancers

ML Martínez-Chantar, MA Avila, SC Lu

Publication Date: 2020-09-23

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32977536

Variant Present in the following documents:

• Main text

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Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.

International Journal Of Molecular Sciences

YA Nasykhova, ZN Tonyan, AA Mikhailova, MM Danilova, AS Glotov

Publication Date: 2020-09-18

Variant appearance in text: PNPLA3: Ile148Met; rs738409

PubMed Link: 32961860

Variant Present in the following documents:

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Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver.

Biomolecules

W Chamulitrat, C Jansakun, H Li, G Liebisch

Publication Date: 2020-09-17

Variant appearance in text: rs738409

PubMed Link: 32957701

Variant Present in the following documents:

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Racial disparities in nonalcoholic fatty liver disease clinical trial enrollment: A systematic review and meta-analysis.

World Journal Of Hepatology

P Patel, C Muller, S Paul

Publication Date: 2020-08-27

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32952877

Variant Present in the following documents:

• Main text

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Difference in lifestyle and metabolic profile of non-alcoholic fatty liver disease with raised alanine amino-transferases between obese and non-overweight subjects.

Scientific Reports

M Sharma, A Kulkarni, P Kumar, VB Nori, N Jagtap, R Gupta, DN Reddy, PN Rao

Publication Date: 2020-09-17

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32943747

Variant Present in the following documents:

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Abnormal metabolic processes involved in the pathogenesis of non-alcoholic fatty liver disease (Review).

Experimental And Therapeutic Medicine

M Shao, Z Ye, Y Qin, T Wu

Publication Date: 2020-11

Variant appearance in text: rs738409

PubMed Link: 32934691

Variant Present in the following documents:

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Fatty Liver Disease: Metabolic, Genetic, or Both?

Hepatology Communications

H Zoller, S Wagner, B Schaefer

Publication Date: 2020-09

Variant appearance in text: PNPLA3: Ile148Met; rs738409

PubMed Link: 32923830

Variant Present in the following documents:

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Racial Disparities in Diagnosis and Prognosis of Nonalcoholic Fatty Liver Disease.

Clinical Liver Disease

NS Samji, PD Snell, AK Singal, SK Satapathy

Publication Date: 2020-08

Variant appearance in text: rs738409

PubMed Link: 32922753

Variant Present in the following documents:

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Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology.

Clinical And Molecular Hepatology

S Sookoian, CJ Pirola

Publication Date: 2020-10

Variant appearance in text: rs738409

PubMed Link: 32906228

Variant Present in the following documents:

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Validating candidate biomarkers for different stages of non-alcoholic fatty liver disease.

Medicine

R Al-Qarni, M Iqbal, M Al-Otaibi, F Al-Saif, AA Alfadda, H Alkhalidi, F Bamehriz, M Hassanain

Publication Date: 2020-09-04

Variant appearance in text: rs738409

PubMed Link: 32898995

Variant Present in the following documents:

• Main text

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Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.

Pharmaceuticals (Basel, Switzerland)

R Jamwal, BJ Barlock

Publication Date: 2020-08-29

Variant appearance in text: rs738409

PubMed Link: 32872474

Variant Present in the following documents:

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Exploring the genetic basis of fatty liver development in geese.

Scientific Reports

Y Yang, H Wang, G Li, Y Liu, C Wang, D He

Publication Date: 2020-08-31

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32868783

Variant Present in the following documents:

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Too Much of a Good Thing? An Evolutionary Theory to Explain the Role of Ceramides in NAFLD.

Frontiers In Endocrinology

AM Poss, SA Summers

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32849291

Variant Present in the following documents:

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Pharmacogenomics as a Tool to Limit Acute and Long-Term Adverse Effects of Chemotherapeutics: An Update in Pediatric Oncology.

Frontiers In Pharmacology

EC Bernsen, MM Hagleitner, TW Kouwenberg, LM Hanff

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32848787

Variant Present in the following documents:

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Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.

Pharmacogenomics And Personalized Medicine

D Maamari, H El-Khoury, O Saifi, SA Muwakkit, NK Zgheib

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32848445

Variant Present in the following documents:

• Main text

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Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program.

Plos One

M Serper, M Vujkovic, DE Kaplan, RM Carr, KM Lee, Q Shao, DR Miller, PD Reaven, LS Phillips, CJ O'Donnell, JB Meigs, PWF Wilson, R Vickers-Smith, HR Kranzler, AC Justice, JM Gaziano, S Muralidhar, S Pyarajan, SL DuVall, TL Assimes, JS Lee, PS Tsao, DJ Rader, SM Damrauer, JA Lynch, D Saleheen, BF Voight, KM Chang,

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32841307

Variant Present in the following documents:

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56th EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.

Diabetologia

.

Publication Date: 2020-09

Variant appearance in text: rs738409

PubMed Link: 32840677

Variant Present in the following documents:

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Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies.

Journal Of Lipid And Atherosclerosis

SY Bu

Publication Date: 2019-09

Variant appearance in text: rs738409

PubMed Link: 32821703

Variant Present in the following documents:

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Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis.

Bmc Medical Genetics

S Tang, J Zhang, TT Mei, HQ Guo, XH Wei, WY Zhang, YL Liu, S Liang, ZP Fan, LX Ma, W Lin, YR Liu, LX Qiu, HB Yu

Publication Date: 2020-08-18

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32811452

Variant Present in the following documents:

• Main text

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Resection of NAFLD-Associated HCC: Patient Selection and Reported Outcomes.

Journal Of Hepatocellular Carcinoma

C Campani, C Bensi, S Milani, A Galli, M Tarocchi

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32802809

Variant Present in the following documents:

• Main text

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Genome-Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus.

Hepatology Communications

K Yoshida, K Yokota, Y Kutsuwada, K Nakayama, K Watanabe, A Matsumoto, H Miyashita, SS Khor, K Tokunaga, Y Kawai, M Nagasaki, S Iwamoto

Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32766473

Variant Present in the following documents:

• Main text

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Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study.

Hepatology Communications

SL Park, Y Li, X Sheng, V Hom, L Xia, K Zhao, L Pooler, VW Setiawan, U Lim, KR Monroe, LR Wilkens, BS Kristal, JW Lampe, M Hullar, J Shepherd, LLM Loo, T Ernst, AA Franke, M Tiirikainen, CA Haiman, DO Stram, L Le Marchand, I Cheng

Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32766472

Variant Present in the following documents:

• Main text

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The complement system in liver diseases: Evidence-based approach and therapeutic options.

Journal Of Translational Autoimmunity

T Lung, B Sakem, L Risch, R Würzner, G Colucci, A Cerny, U Nydegger

Publication Date: 2019-12

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32743505

Variant Present in the following documents:

• Main text

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The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis.

Saudi Journal Of Gastroenterology : Official Journal Of The Saudi Gastroenterology Association

J Tan, J Zhang, Z Zhao, J Zhang, M Dong, X Ma, S Liu, Y Xin

Publication Date: 2020-07-23

Variant appearance in text: rs738409

PubMed Link: 32719241

Variant Present in the following documents:

• Main text

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The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease.

Metabolism: Clinical And Experimental

N Perakakis, K Stefanakis, CS Mantzoros

Publication Date: 2020-10

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32712221

Variant Present in the following documents:

• Main text

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Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma.

Hepatoma Research

JN Benhammou, J Lin, SK Hussain, M El-Kabany

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32685690

Variant Present in the following documents:

• Main text

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NAFLD as a continuum: from obesity to metabolic syndrome and diabetes.

Diabetology & Metabolic Syndrome

AF Godoy-Matos, WS Silva Júnior, CM Valerio

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32684985

Variant Present in the following documents:

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Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis.

Bmc Gastroenterology

J Seeßle, H Gan-Schreier, M Kirchner, W Stremmel, W Chamulitrat, U Merle

Publication Date: 2020-07-17

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32680469

Variant Present in the following documents:

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Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases.

Nutrients

T Himoto, T Masaki

Publication Date: 2020-07-14

Variant appearance in text: rs738409

PubMed Link: 32674425

Variant Present in the following documents:

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A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.

The Journal Of Nutrition

MA Van Name, M Savoye, JM Chick, BT Galuppo, AE Feldstein, B Pierpont, C Johnson, V Shabanova, U Ekong, PL Valentino, G Kim, S Caprio, N Santoro

Publication Date: 2020-09-01

Variant appearance in text: rs738409

PubMed Link: 32652034

Variant Present in the following documents:

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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease.

Cells

A Fougerat, A Montagner, N Loiseau, H Guillou, W Wahli

Publication Date: 2020-07-08

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32650421

Variant Present in the following documents:

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Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation.

Translational Gastroenterology And Hepatology

BJ Maliakkal

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32632387

Variant Present in the following documents:

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MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.

Ebiomedicine

M Meroni, M Longo, AL Fracanzani, P Dongiovanni

Publication Date: 2020-07

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32629394

Variant Present in the following documents:

• Main text

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Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Middle East Journal Of Digestive Diseases

S Saki, N Saki, H Poustchi, R Malekzadeh

Publication Date: 2020-04

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32626560

Variant Present in the following documents:

• Main text

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Highlights From the AASLD/EASL ALD Endpoints Conference 2019.

Clinical Liver Disease

M Bertha, H Maddur

Publication Date: 2020-06

Variant appearance in text: rs738409

PubMed Link: 32617152

Variant Present in the following documents:

• Main text

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Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease.

Endocrinology And Metabolism (Seoul, Korea)

DH Lee

Publication Date: 2020-06

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409

PubMed Link: 32615709

Variant Present in the following documents:

• Main text

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Nonalcoholic fatty liver disease and cardiovascular disease phenotypes.

Sage Open Medicine

G Bisaccia, F Ricci, C Mantini, C Tana, GL Romani, C Schiavone, S Gallina

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32612827

Variant Present in the following documents:

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Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease.

Cancers

B Smeuninx, E Boslem, MA Febbraio

Publication Date: 2020-06-28

Variant appearance in text: rs738409

PubMed Link: 32605253

Variant Present in the following documents:

• Main text

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Epidemiology: Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan.

International Journal Of Molecular Sciences

Y Sumida, T Shima, Y Mitsumoto, T Katayama, A Umemura, K Yamaguchi, Y Itoh, M Yoneda, T Okanoue

Publication Date: 2020-06-18

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32570776

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• Main text

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Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth.

The Journal Of Clinical Endocrinology And Metabolism

A Monga Kravetz, T Testerman, B Galuppo, J Graf, B Pierpont, S Siebel, R Feinn, N Santoro

Publication Date: 2020-10-01

Variant appearance in text: rs738409

PubMed Link: 32561908

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Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients.

Plos One

O Aly, HH Zaki, MR Herzalla, A Fathy, N Raafat, MM Hafez

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32544194

Variant Present in the following documents:

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Nonalcoholic Fatty Liver Disease: An Important Consideration for Primary Care Providers in Hawai'i.

Hawai'I Journal Of Health & Social Welfare

RJ Pattison, JP Esteban, T Sempokuya, J Kewcharoen, S Kalathil, SK Kuwada

Publication Date: 2020-06-01

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32524096

Variant Present in the following documents:

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Association between non-alcoholic fatty liver disease and obstructive sleep apnea.

World Journal Of Gastroenterology

I Umbro, V Fabiani, M Fabiani, F Angelico, M Del Ben

Publication Date: 2020-05-28

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32523319

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Regional difference in the susceptibility of non-alcoholic fatty liver disease in China.

Bmj Open Diabetes Research & Care

M Xia, X Sun, L Zheng, Y Bi, Q Li, L Sun, F Di, H Li, D Zhu, Y Gao, Y Bao, Y Wang, L He, B Wu, S Wang, J Gao, X Gao, H Bian

Publication Date: 2020-06

Variant appearance in text: rs738409

PubMed Link: 32522731

Variant Present in the following documents:

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Combined alcoholic and non-alcoholic steatohepatitis.

Jhep Reports : Innovation In Hepatology

LC Ntandja Wandji, V Gnemmi, P Mathurin, A Louvet

Publication Date: 2020-06

Variant appearance in text: rs738409

PubMed Link: 32514497

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Non-alcoholic fatty liver disease (NAFLD) diagnosis and management-differentiating the essential from the ancillary and the present from the future.

Hepatobiliary Surgery And Nutrition

A Lonardo, S Lugari, F Nascimbeni

Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32509834

Variant Present in the following documents:

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PNPLA3 and nonalcoholic fatty liver disease: towards personalized medicine for fatty liver.

Hepatobiliary Surgery And Nutrition

L Yuan, NA Terrrault

Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32509828

Variant Present in the following documents:

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Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective?

Cancers

MC Plaz Torres, G Bodini, M Furnari, E Marabotto, P Zentilin, M Strazzabosco, EG Giannini

Publication Date: 2020-05-31

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32486355

Variant Present in the following documents:

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The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease.

International Journal Of Molecular Sciences

H Fujii, N Kawada, Japan Study Group Of Nafld Jsg-Nafld

Publication Date: 2020-05-29

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32485838

Variant Present in the following documents:

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Medical management of metabolic and cardiovascular complications after liver transplantation.

World Journal Of Gastroenterology

C Becchetti, M Dirchwolf, V Banz, JF Dufour

Publication Date: 2020-05-14

Variant appearance in text: rs738409

PubMed Link: 32476781

Variant Present in the following documents:

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Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease.

Clinical And Translational Gastroenterology

F Ferri, M Mischitelli, G Tozzi, E Messina, I Mignini, S Mazzuca, M Pellone, S Parisse, R Marrapodi, M Visentini, F Baratta, M Del Ben, D Pastori, R Perciballi, ML Attilia, M Carbone, A De Santis, F Violi, F Angelico, S Ginanni Corradini

Publication Date: 2020-02

Variant appearance in text: rs738409

PubMed Link: 32463622

Variant Present in the following documents:

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Unique insights from ClinicalTrials.gov by mining protein mutations and RSids in addition to applying the Human Phenotype Ontology.

Plos One

S Alag

Publication Date: 2020

Variant appearance in text: rs738409

PubMed Link: 32459809

Variant Present in the following documents:

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Lack of genetic evidence that fatty liver disease predisposes to COVID-19.

Journal Of Hepatology

L Valenti, O Jamialahmadi, S Romeo

Publication Date: 2020-09

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32445883

Variant Present in the following documents:

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Molecular Mechanisms Regulating Obesity-Associated Hepatocellular Carcinoma.

Cancers

Y Rajesh, D Sarkar

Publication Date: 2020-05-20

Variant appearance in text: PNPLA3: Ile148Met; rs738409

PubMed Link: 32443737

Variant Present in the following documents:

• Main text

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Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan.

International Journal Of Molecular Sciences

AM Raja, E Ciociola, IN Ahmad, FS Dar, SMS Naqvi, M Moaeen-Ud-Din, G Kaukab Raja, S Romeo, RM Mancina

Publication Date: 2020-05-18

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32443539

Variant Present in the following documents:

• Main text

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Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association.

Diabetes & Metabolism Journal

BW Lee, YH Lee, CY Park, EJ Rhee, WY Lee, NH Kim, KM Choi, KG Park, YK Choi, BS Cha, DH Lee,

Publication Date: 2020-06

Variant appearance in text: PNPLA3: 444C>G; I148M; rs738409

PubMed Link: 32431115

Variant Present in the following documents:

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Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.

Lipids In Health And Disease

A Medina-Urrutia, AR Lopez-Uribe, M El Hafidi, MDC González-Salazar, R Posadas-Sánchez, E Jorge-Galarza, L Del Valle-Mondragón, JG Juárez-Rojas

Publication Date: 2020-05-19

Variant appearance in text: rs738409

PubMed Link: 32430018

Variant Present in the following documents:

• Main text

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The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Frontiers In Pharmacology

JJ Martínez-Magaña, AD Genis-Mendoza, JA Villatoro Velázquez, B Camarena, R Martín Del Campo Sanchez, C Fleiz Bautista, M Bustos Gamiño, E Reséndiz, A Aguilar, ME Medina-Mora, H Nicolini

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32390825

Variant Present in the following documents:

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Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.

Alimentary Pharmacology & Therapeutics

B Carlsson, D Lindén, G Brolén, M Liljeblad, M Bjursell, S Romeo, R Loomba

Publication Date: 2020-06

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32383295

Variant Present in the following documents:

• Main text

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Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients.

Gastroenterology Research And Practice

C De Benedittis, M Bellan, M Crevola, E Boin, MN Barbaglia, VR Mallela, P Ravanini, E Ceriani, S Fangazio, PP Sainaghi, ME Burlone, R Minisini, M Pirisi

Publication Date: 2020

Variant appearance in text: PNPLA3: I148M; rs738409

PubMed Link: 32382265

Variant Present in the following documents:

• Main text

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Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease.

Nutrients

N Perez-Diaz-Del-Campo, I Abete, I Cantero, BA Marin-Alejandre, JI Monreal, M Elorz, JI Herrero, A Benito-Boillos, JI Riezu-Boj, FI Milagro, JA Tur, JA Martinez, MA Zulet

Publication Date: 2020-04-29

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32365683

Variant Present in the following documents:

• Main text

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High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD.

Hepatology Communications

S Lang, A Martin, F Farowski, H Wisplinghoff, MJGT Vehreschild, J Liu, M Krawczyk, A Nowag, A Kretzschmar, J Herweg, B Schnabl, XM Tu, F Lammert, T Goeser, F Tacke, K Heinzer, P Kasper, HM Steffen, M Demir

Publication Date: 2020-05

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32363319

Variant Present in the following documents:

• Main text

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Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD.

Hepatology Communications

G Ezaz, HD Trivedi, MA Connelly, C Filozof, K Howard, M L Parrish, M Kim, MA Herman, I Nasser, NH Afdhal, ZG Jiang, M Lai

Publication Date: 2020-05

Variant appearance in text: rs738409

PubMed Link: 32363318

Variant Present in the following documents:

• Main text

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Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.

Biochimica Et Biophysica Acta. Molecular And Cell Biology Of Lipids

C Wagner, V Hois, L Pajed, LM Pusch, H Wolinski, M Trauner, R Zimmermann, U Taschler, A Lass

Publication Date: 2020-08

Variant appearance in text: PNPLA3: I148M

PubMed Link: 32361002

Variant Present in the following documents:

• Main text

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Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.

World Journal Of Gastroenterology

J Zeng, RX Yang, C Sun, Q Pan, RN Zhang, GY Chen, Y Hu, JG Fan

Publication Date: 2020-04-21

Variant appearance in text: rs738409

PubMed Link: 32351294

Variant Present in the following documents:

• Main text

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Possible Relevance of PNPLA3 and TLL1 Gene Polymorphisms to the Efficacy of PEG-IFN Therapy for HBV-Infected Patients.

International Journal Of Molecular Sciences

H Enomoto, N Aizawa, K Hasegawa, N Ikeda, Y Sakai, K Yoh, R Takata, Y Yuri, K Kishino, Y Shimono, N Ishii, T Takashima, T Nishimura, H Nishikawa, Y Iwata, H Iijima, S Nishiguchi

Publication Date: 2020-04-27

Variant appearance in text: rs738409

PubMed Link: 32349377

Variant Present in the following documents:

• Main text

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Noninvasive Diagnosis of NAFLD and NASH.

Cells

VA Piazzolla, A Mangia

Publication Date: 2020-04-17

Variant appearance in text: rs738409

PubMed Link: 32316690

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Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.

Contemporary Clinical Trials Communications

JG Stine, I Schreibman, S Navabi, M Kang, J Dahmus, C Soriano, G Rivas, B Hummer, M Beyer, H Tressler, SR Kimball, AD Patterson, K Schmitz, C Sciamanna

Publication Date: 2020-06

Variant appearance in text: rs738409

PubMed Link: 32309672

Variant Present in the following documents:

• Main text

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000216180.3	c.444C>G	p.Ile148Met	missense_variant	3/9	-
ENST00000406117.2	c.*76C>G	-	3_prime_UTR_variant,NMD_transcript_variant	3/10	-
ENST00000423180.2	c.432C>G	p.Ile144Met	missense_variant	3/9	-
ENST00000478713.1	n.478C>G	-	non_coding_transcript_exon_variant	3/4	-
NM_025225.3	c.444C>G	p.Ile148Met	missense_variant	3/9	-