Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: GHRL: 269A>T; Gln90Leu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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Role of Leu72Met of GHRL and Gln223Arg of LEPR Variants on Food Intake, Subjective Appetite, and Hunger-Satiety Hormones.

Nutrients

Sanchez-Murguia, Tania T; Torres-Castillo, Nathaly N; Magaña-de la Vega, Lisset L; Rodríguez-Reyes, Saraí Citlalic SC; Campos-Pérez, Wendy W; Martínez-López, Erika E

Publication Date: 2022-05-18

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 35631243

Variant Present in the following documents:

• nutrients-14-02100.pdf

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Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice.

Frontiers In Endocrinology

Hassouna, Rim R; Fernandez, Gimena G; Lebrun, Nicolas N; Fiquet, Oriane O; Roelfsema, Ferdinand F; Labarthe, Alexandra A; Zizzari, Philippe P; Tomasetto, Catherine C; Epelbaum, Jacques J; Viltart, Odile O; Chauveau, Christophe C; Perello, Mario M; Tolle, Virginie V

Publication Date: 2021

Variant appearance in text: ghrelin: Q90L

PubMed Link: 34721302

Variant Present in the following documents:

• fendo-12-754522.pdf

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Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition.

Molecular & Cellular Proteomics : Mcp

Schmitt, Marisa M; Sinnberg, Tobias T; Bratl, Katrin K; Zittlau, Katharina K; Garbe, Claus C; Macek, Boris B; Nalpas, Nicolas C NC

Publication Date: 2021-10-19

Variant appearance in text: obestatin: Q90L; rs4684677

PubMed Link: 34673281

Variant Present in the following documents:

• mmc2.xlsx, sheet 11
• mmc2.xlsx, sheet 3

View BVdb publication page

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Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition.

Molecular & Cellular Proteomics : Mcp

Schmitt, Marisa M; Sinnberg, Tobias T; Bratl, Katrin K; Zittlau, Katharina K; Garbe, Claus C; Macek, Boris B; Nalpas, Nicolas C NC

Publication Date: 2021

Variant appearance in text: obestatin: Q90L; rs4684677

PubMed Link: 34673281

Variant Present in the following documents:

• mmc2.xlsx, sheet 11
• mmc2.xlsx, sheet 3

View BVdb publication page

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Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.

Bmc Cancer

Heft Neal, Molly E ME; Birkeland, Andrew C AC; Bhangale, Apurva D AD; Zhai, Jingyi J; Kulkarni, Aditi A; Foltin, Susan K SK; Jewell, Brittany M BM; Ludwig, Megan L ML; Pinatti, Lisa L; Jiang, Hui H; McHugh, Jonathan B JB; Marentette, Lawence L; McKean, Erin L EL; Brenner, J Chad JC

Publication Date: 2021-05-29

Variant appearance in text: GHRL: 269A>T; Gln90Leu; rs4684677

PubMed Link: 34051734

Variant Present in the following documents:

• 12885_2021_8370_MOESM15_ESM.xlsx, sheet 1

View BVdb publication page

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A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder.

Nutrients

Manfredi, Lucia L; Accoto, Alessandra A; Couyoumdjian, Alessandro A; Conversi, David D

Publication Date: 2021-03-05

Variant appearance in text: ghrelin: Gln90Leu; rs4684677

PubMed Link: 33807560

Variant Present in the following documents:

• Main text

View BVdb publication page

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Prioritization of candidate genes for a South African family with Parkinson's disease using in-silico tools.

Plos One

Sebate, Boiketlo B; Cuttler, Katelyn K; Cloete, Ruben R; Britz, Marcell M; Christoffels, Alan A; Williams, Monique M; Carr, Jonathan J; Bardien, Soraya S

Publication Date: 2021

Variant appearance in text: GHRL: 269A>T; Q90L; rs4684677

PubMed Link: 33770142

Variant Present in the following documents:

• pone.0249324.s003.xlsx, sheet 3

View BVdb publication page

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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells.

Npj Systems Biology And Applications

Immanuel, Selva Rupa Christinal SRC; Ghanate, Avinash D AD; Parmar, Dharmeshkumar S DS; Yadav, Ritu R; Uthup, Riya R; Panchagnula, Venkateswarlu V; Raghunathan, Anu A

Publication Date: 2021-01-08

Variant appearance in text: GHRL: Q90L; rs4684677

PubMed Link: 33420045

Variant Present in the following documents:

• 41540_2020_161_MOESM3_ESM.xlsx, sheet 4
• 41540_2020_161_MOESM3_ESM.xlsx, sheet 3
• 41540_2020_161_MOESM3_ESM.xlsx, sheet 2

View BVdb publication page

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GHRL Gene Leu72Met Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Involving 8,194 Participants.

Frontiers In Endocrinology

Li, Yan-Yan YY; Lu, Xin-Zheng XZ; Yang, Xin-Xing XX; Wang, Hui H; Geng, Hong-Yu HY; Gong, Ge G; Zhan, Yi-Yang YY; Kim, Hyun Jun HJ; Yang, Zhi-Jian ZJ

Publication Date: 2019

Variant appearance in text: GHRL: Gln90Leu

PubMed Link: 31440212

Variant Present in the following documents:

• Main text
• fendo-10-00559.pdf

View BVdb publication page

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Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis.

World Journal Of Gastroenterology

Koutouratsas, Tilemachos T; Kalli, Theodora T; Karamanolis, Georgios G; Gazouli, Maria M

Publication Date: 2019-02-07

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 30774270

Variant Present in the following documents:

• Main text
• WJG-25-539.pdf

View BVdb publication page

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Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis.

Frontiers In Genetics

Huang, Rong R; Tian, Sai S; Cai, Rongrong R; Sun, Jie J; Shen, Yanjue Y; Wang, Shaohua S

Publication Date: 2018

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 30487812

Variant Present in the following documents:

• Main text
• fgene-09-00541.pdf

View BVdb publication page

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The Role of Ghrelin in Anorexia Nervosa.

International Journal Of Molecular Sciences

Schalla, Martha A MA; Stengel, Andreas A

Publication Date: 2018-07-20

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 30037011

Variant Present in the following documents:

• Main text
• ijms-19-02117.pdf

View BVdb publication page

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Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation.

Plos One

Decourtye, Lyvianne L; Clemessy, Maud M; Mire, Erik E; Ledent, Tatiana T; Périn, Laurence L; Robinson, Iain C IC; Le Bouc, Yves Y; Kappeler, Laurent L

Publication Date: 2018

Variant appearance in text: obestatin: Q90L

PubMed Link: 29466413

Variant Present in the following documents:

• pone.0193196.pdf

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Combination of Selective Immunoassays and Mass Spectrometry to Characterize Preproghrelin-Derived Peptides in Mouse Tissues.

Frontiers In Neuroscience

Hassouna, Rim R; Grouselle, Dominique D; Chiappetta, Giovanni G; Lipecka, Joanna J; Fiquet, Oriane O; Tomasetto, Catherine C; Vinh, Joëlle J; Epelbaum, Jacques J; Tolle, Virginie V

Publication Date: 2017

Variant appearance in text: obestatin: Q90L

PubMed Link: 28473748

Variant Present in the following documents:

• fnins-11-00211.pdf

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Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients.

Oncotarget

Huang, Rong R; Han, Jing J; Tian, Sai S; Cai, Rongrong R; Sun, Jie J; Shen, Yanjue Y; Wang, Shaohua S

Publication Date: 2017-02-28

Variant appearance in text: ghrelin: Gln90Leu; rs4684677

PubMed Link: 28146431

Variant Present in the following documents:

• Main text

View BVdb publication page

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IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice.

Plos One

Decourtye, Lyvianne L; Mire, Erik E; Clemessy, Maud M; Heurtier, Victor V; Ledent, Tatiana T; Robinson, Iain C IC; Mollard, Patrice P; Epelbaum, Jacques J; Meaney, Michael J MJ; Garel, Sonia S; Le Bouc, Yves Y; Kappeler, Laurent L

Publication Date: 2017

Variant appearance in text: obestatin: Q90L

PubMed Link: 28076448

Variant Present in the following documents:

• pone.0170083.pdf

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New Insights in Anorexia Nervosa.

Frontiers In Neuroscience

Gorwood, Philip P; Blanchet-Collet, Corinne C; Chartrel, Nicolas N; Duclos, Jeanne J; Dechelotte, Pierre P; Hanachi, Mouna M; Fetissov, Serguei S; Godart, Nathalie N; Melchior, Jean-Claude JC; Ramoz, Nicolas N; Rovere-Jovene, Carole C; Tolle, Virginie V; Viltart, Odile O; Epelbaum, Jacques J

Publication Date: 2016

Variant appearance in text: obestatin: Q90L

PubMed Link: 27445651

Variant Present in the following documents:

• fnins-10-00256.pdf

View BVdb publication page

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Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes.

British Journal Of Pharmacology

Cowan, Elaine E; Burch, Kerry J KJ; Green, Brian D BD; Grieve, David J DJ

Publication Date: 2016-07

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 27111465

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetics and Epigenetics of Eating Disorders.

Advances In Genomics And Genetics

Yilmaz, Zeynep Z; Hardaway, J Andrew JA; Bulik, Cynthia M CM

Publication Date: 2015

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 27013903

Variant Present in the following documents:

• Main text

View BVdb publication page

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Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population.

Plos One

Mora, Mireia M; Adam, Victoria V; Palomera, Elisabet E; Blesa, Sebastian S; Díaz, Gonzalo G; Buquet, Xavier X; Serra-Prat, Mateu M; Martín-Escudero, Juan Carlos JC; Palanca, Ana A; Chaves, Javier Felipe JF; Puig-Domingo, Manuel M; ,

Publication Date: 2015

Variant appearance in text: ghrelin: Gln90Leu; rs4684677

PubMed Link: 26375586

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking.

Addiction Biology

Suchankova, Petra P; Nilsson, Staffan S; von der Pahlen, Bettina B; Santtila, Pekka P; Sandnabba, Kenneth K; Johansson, Ada A; Jern, Patrick P; Engel, Jörgen A JA; Jerlhag, Elisabet E

Publication Date: 2016-03

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 26059200

Variant Present in the following documents:

• Main text

View BVdb publication page

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Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan.

Journal Of Neurogastroenterology And Motility

Yamawaki, Hiroshi H; Futagami, Seiji S; Shimpuku, Mayumi M; Shindo, Tomotaka T; Maruki, Yuuta Y; Nagoya, Hiroyuki H; Kodaka, Yasuhiro Y; Sato, Hitomi H; Gudis, Katya K; Kawagoe, Tetsuro T; Sakamoto, Choitsu C

Publication Date: 2015-01-01

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 25540946

Variant Present in the following documents:

• Main text
• jnm-21-93.pdf

View BVdb publication page

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Whole-genome sequencing of the world's oldest people.

Plos One

Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK

Publication Date: 2014

Variant appearance in text: GHRL: Q90L; rs4684677

PubMed Link: 25390934

Variant Present in the following documents:

• pone.0112430.s004.xlsx, sheet 1

View BVdb publication page

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Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis.

Bmc Genetics

Pabalan, Noel A NA; Seim, Inge I; Jarjanazi, Hamdi H; Chopin, Lisa K LK

Publication Date: 2014-11-07

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 25376984

Variant Present in the following documents:

• Main text
• 12863_2014_Article_118.pdf

View BVdb publication page

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Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa.

Psychiatry Research

Holsen, Laura M LM; Lawson, Elizabeth A EA; Christensen, Kara K; Klibanski, Anne A; Goldstein, Jill M JM

Publication Date: 2014-08-30

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 24862390

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.

Plos One

Suchankova, Petra P; Jerlhag, Elisabet E; Jayaram-Lindström, Nitya N; Nilsson, Staffan S; Toren, Kjell K; Rosengren, Annika A; Engel, Jörgen A JA; Franck, Johan J

Publication Date: 2013

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 23579732

Variant Present in the following documents:

• Main text

View BVdb publication page

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A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

Plos One

Hassouna, Rim R; Zizzari, Philippe P; Viltart, Odile O; Yang, Seung-Kwon SK; Gardette, Robert R; Videau, Catherine C; Badoer, Emilio E; Epelbaum, Jacques J; Tolle, Virginie V

Publication Date: 2012

Variant appearance in text: obestatin: Q90L; rs4684677

PubMed Link: 23251435

Variant Present in the following documents:

• Main text
• pone.0051135.pdf

View BVdb publication page

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Ghrelin and eating disorders.

Progress In Neuro-Psychopharmacology & Biological Psychiatry

Atalayer, Deniz D; Gibson, Charlisa C; Konopacka, Alexandra A; Geliebter, Allan A

Publication Date: 2013-01-10

Variant appearance in text: ghrelin: Gln90Leu

PubMed Link: 22960103

Variant Present in the following documents:

• Main text

View BVdb publication page

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Ghrelin in diabetes and metabolic syndrome.

International Journal Of Peptides

Pulkkinen, Leena L; Ukkola, Olavi O; Kolehmainen, Marjukka M; Uusitupa, Matti M

Publication Date: 2010

Variant appearance in text: GHRL: Gln90Leu; rs4684677

PubMed Link: 20700400

Variant Present in the following documents:

• Main text
• IJPEP2010-248948.pdf

View BVdb publication page

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Molecular characterization of the ghrelin and ghrelin receptor genes and effects on fat deposition in chicken and duck.

Journal Of Biomedicine & Biotechnology

Nie, Q Q; Fang, M M; Xie, L L; Peng, X X; Xu, H H; Luo, C C; Zhang, D D; Zhang, X X

Publication Date: 2009

Variant appearance in text: GHRL: Gln90Leu

PubMed Link: 20145704

Variant Present in the following documents:

• Main text
• JBB2009-567120.pdf

View BVdb publication page

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Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.

Obesity Facts

Kring, Sofia Inez Iqbal SI; Larsen, Lesli Hingstrup LH; Holst, Claus C; Toubro, Søren S; Hansen, Torben T; Astrup, Arne A; Pedersen, Oluf O; Sørensen, Thorkild I A TI

Publication Date: 2008

Variant appearance in text: GHRL: Gln90Leu

PubMed Link: 20054173

Variant Present in the following documents:

• Main text

View BVdb publication page

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