Publications:

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Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Frontiers In Pharmacology

Zhai, Qinglian Q; van der Lee, Maaike M; van Gelder, Teun T; Swen, Jesse J JJ

Publication Date: 2022

Variant appearance in text: rs7643645

PubMed Link: 35784699

Variant Present in the following documents:

• Main text
• fphar-13-912618.pdf

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Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer.

Endocrinology And Metabolism (Seoul, Korea)

Kasarla, Siva Swapna SS; Garikapati, Vannuruswamy V; Kumar, Yashwant Y; Dodoala, Sujatha S

Publication Date: 2022-06

Variant appearance in text: rs7643645

PubMed Link: 35654576

Variant Present in the following documents:

• enm-2021-1349.pdf

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Impact of polymorphisms of pharmacokinetics-related genes and the inflammatory response on the metabolism of voriconazole.

Pharmacology Research & Perspectives

Aiuchi, Naoya N; Nakagawa, Junichi J; Sakuraba, Hirotake H; Takahata, Takenori T; Kamata, Kosuke K; Saito, Norihiro N; Ueno, Kayo K; Ishiyama, Masahiro M; Yamagata, Kazufumi K; Kayaba, Hiroyuki H; Niioka, Takenori T

Publication Date: 2022-04

Variant appearance in text: rs7643645

PubMed Link: 35199485

Variant Present in the following documents:

• Main text
• PRP2-10-e00935.pdf

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The Nuclear Receptor PXR in Chronic Liver Disease.

Cells

Sayaf, Katia K; Zanotto, Ilaria I; Russo, Francesco Paolo FP; Gabbia, Daniela D; De Martin, Sara S

Publication Date: 2021-12-27

Variant appearance in text: rs7643645

PubMed Link: 35011625

Variant Present in the following documents:

• Main text
• cells-11-00061.pdf

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The Nuclear Receptor PXR in Chronic Liver Disease.

Cells

Sayaf, Katia K; Zanotto, Ilaria I; Russo, Francesco Paolo FP; Gabbia, Daniela D; De Martin, Sara S

Publication Date: 2021-12-27

Variant appearance in text: rs7643645

PubMed Link: 35011625

Variant Present in the following documents:

• Main text
• cells-11-00061.pdf

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Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment.

Biomolecules

Skandalaki, Aikaterini A; Sarantis, Panagiotis P; Theocharis, Stamatios S

Publication Date: 2021-08-02

Variant appearance in text: rs7643645

PubMed Link: 34439808

Variant Present in the following documents:

• Main text
• biomolecules-11-01142.pdf

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Clinical and Genetic Risk Factors of Recurrent Nonalcoholic Fatty Liver Disease After Liver Transplantation.

Clinical And Translational Gastroenterology

Satapathy, Sanjaya K SK; Tran, Quynh T QT; Kovalic, Alexander J AJ; Bontha, Sai Vineela SV; Jiang, Yu Y; Kedia, Satish S; Karri, Saradashri S; Mupparaju, Vamsee V; Podila, Pradeep S B PSB; Verma, Rajanshu R; Maluf, Daniel D; Mas, Valeria V; Nair, Satheesh S; Eason, James D JD; Bridges, Dave D; Kleiner, David E DE

Publication Date: 2021-02-05

Variant appearance in text: rs7643645

PubMed Link: 33555168

Variant Present in the following documents:

• Main text

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Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD).

Translational Gastroenterology And Hepatology

Choudhary, Narendra Singh NS; Duseja, Ajay A

Publication Date: 2021

Variant appearance in text: rs7643645

PubMed Link: 33409397

Variant Present in the following documents:

• Main text

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NR1I2 genetic polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity: A systematic review and meta-analysis.

Pharmacology Research & Perspectives

Yang, Miaomiao M; Qiu, Yunliang Y; Jin, Yanyu Y; Liu, Wenpei W; Wang, Qingliang Q; Yi, Honggang H; Tang, Shaowen S

Publication Date: 2020-12

Variant appearance in text: rs7643645

PubMed Link: 33300686

Variant Present in the following documents:

• Main text

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Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculosis drug-induced hepatotoxicity: A prospective study.

Journal Of Clinical Laboratory Analysis

Cheng, Yuhui Y; Jiao, Lin L; Li, Weixiu W; Wang, Jialing J; Lin, Zhangyu Z; Lai, Hongli H; Ying, Binwu B

Publication Date: 2021-02

Variant appearance in text: rs7643645

PubMed Link: 33296124

Variant Present in the following documents:

• Main text

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Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

British Journal Of Clinical Pharmacology

Yip, Vincent L M VLM; Pertinez, Henry H; Meng, Xiaoli X; Maggs, James L JL; Carr, Daniel F DF; Park, B Kevin BK; Marson, Anthony G AG; Pirmohamed, Munir M

Publication Date: 2021-06

Variant appearance in text: rs7643645

PubMed Link: 33217013

Variant Present in the following documents:

• Main text
• BCP-87-2572.pdf

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Pharmacogenomic Characterization in Bipolar Spectrum Disorders.

Pharmaceutics

Fortinguerra, Stefano S; Sorrenti, Vincenzo V; Giusti, Pietro P; Zusso, Morena M; Buriani, Alessandro A

Publication Date: 2019-12-21

Variant appearance in text: rs7643645

PubMed Link: 31877761

Variant Present in the following documents:

• Main text
• pharmaceutics-12-00013.pdf

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Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.

Plos One

Zhang, Jingwei J; Zhao, Zhenzhen Z; Bai, Hao H; Wang, Minjin M; Jiao, Lin L; Peng, Wu W; Wu, Tao T; Liu, Tangyuheng T; Chen, Hao H; Song, Xingbo X; Wu, Lijuan L; Hu, Xuejiao X; Wu, Qian Q; Zhou, Juan J; Song, Jiajia J; Lyv, Mengyuan M; Ying, Binwu B

Publication Date: 2019

Variant appearance in text: rs7643645

PubMed Link: 31490979

Variant Present in the following documents:

• Main text
• pone.0222033.pdf

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Impact of NR1I2, adenosine triphosphate-binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers.

Journal Of Ginseng Research

Zhou, Luping L; Chen, Lulu L; Wang, Yaqin Y; Huang, Jie J; Yang, Guoping G; Tan, Zhirong Z; Wang, Yicheng Y; Liao, Jianwei J; Zhou, Gan G; Hu, Kai K; Li, Zhenyu Z; Ouyang, Dongsheng D

Publication Date: 2019-07

Variant appearance in text: rs7643645

PubMed Link: 31308818

Variant Present in the following documents:

• Main text
• main.pdf

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Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

Obstetrics And Gynecology

Lazorwitz, Aaron A; Aquilante, Christina L CL; Oreschak, Kris K; Sheeder, Jeanelle J; Guiahi, Maryam M; Teal, Stephanie S

Publication Date: 2019-04

Variant appearance in text: rs7643645

PubMed Link: 30870275

Variant Present in the following documents:

• Main text

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Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity.

Scientific Reports

Wang, Yu Y; Xiang, Xi X; Huang, Wei-Wei WW; Sandford, Andrew J AJ; Wu, Shou-Quan SQ; Zhang, Miao-Miao MM; Wang, Ming-Gui MG; Chen, Guo G; He, Jian-Qing JQ

Publication Date: 2019-02-18

Variant appearance in text: rs7643645

PubMed Link: 30778091

Variant Present in the following documents:

• Main text
• 41598_2018_Article_38452.pdf

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Genetic Variations Associated with Anti-Tuberculosis Drug-Induced Liver Injury.

Current Pharmacology Reports

Bao, Yifan Y; Ma, Xiaochao X; Rasmussen, Theodore P TP; Zhong, Xiao-Bo XB

Publication Date: 2018-06

Variant appearance in text: rs7643645

PubMed Link: 30464886

Variant Present in the following documents:

• Main text

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Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal

Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL

Publication Date: 2019-04

Variant appearance in text: rs7643645

PubMed Link: 30214008

Variant Present in the following documents:

• NIHMS1503453-supplement-6.xlsx, sheet 1
• NIHMS1503453-supplement-3.xlsx, sheet 1

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Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients.

Frontiers In Pharmacology

De Mattia, Elena E; Cecchin, Erika E; Montico, Marcella M; Labriet, Adrien A; Guillemette, Chantal C; Dreussi, Eva E; Roncato, Rossana R; Bignucolo, Alessia A; Buonadonna, Angela A; D'Andrea, Mario M; Coppola, Luigi L; Lonardi, Sara S; Lévesque, Eric E; Jonker, Derek D; Couture, Félix F; Toffoli, Giuseppe G

Publication Date: 2018

Variant appearance in text: rs7643645

PubMed Link: 29706892

Variant Present in the following documents:

• Main text

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Association between PXR polymorphisms and cancer risk: a systematic review and meta-analysis.

Bioscience Reports

Wen, Jing J; Lv, Zhi Z; Ding, Hanxi H; Fang, Xinxin X; Sun, Mingjun M

Publication Date: 2018-06-29

Variant appearance in text: rs7643645

PubMed Link: 29654162

Variant Present in the following documents:

• Main text
• bsr-38-bsr20171614.pdf

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Targeting nuclear receptors for the treatment of fatty liver disease.

Pharmacology & Therapeutics

Tanaka, Naoki N; Aoyama, Toshifumi T; Kimura, Shioko S; Gonzalez, Frank J FJ

Publication Date: 2017-11

Variant appearance in text: rs7643645

PubMed Link: 28546081

Variant Present in the following documents:

• Main text

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Association of NR1I2 gene polymorphisms and time of progression to AIDS.

Memorias Do Instituto Oswaldo Cruz

Medeiros, Rúbia Marília de RM; Menti, Carolina Fialho CF; Benelli, Jéssica Louise JL; Matte, Maria Cristina Cotta MC; Melo, Marineide Gonçalves de MG; Almeida, Sabrina Esteves de Matos SE; Fiegenbaum, Marilu M

Publication Date: 2017-04

Variant appearance in text: rs7643645

PubMed Link: 28327790

Variant Present in the following documents:

• Main text
• 0074-0276-mioc-112-4-0269.pdf

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Molecular Pathogenesis of NASH.

International Journal Of Molecular Sciences

Caligiuri, Alessandra A; Gentilini, Alessandra A; Marra, Fabio F

Publication Date: 2016-09-20

Variant appearance in text: rs7643645

PubMed Link: 27657051

Variant Present in the following documents:

• Main text
• ijms-17-01575.pdf

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Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.

World Journal Of Gastroenterology

Severson, Tyler J TJ; Besur, Siddesh S; Bonkovsky, Herbert L HL

Publication Date: 2016-08-07

Variant appearance in text: rs7643645

PubMed Link: 27547017

Variant Present in the following documents:

• Main text

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Nuclear receptors and nonalcoholic fatty liver disease.

Biochimica Et Biophysica Acta

Cave, Matthew C MC; Clair, Heather B HB; Hardesty, Josiah E JE; Falkner, K Cameron KC; Feng, Wenke W; Clark, Barbara J BJ; Sidey, Jennifer J; Shi, Hongxue H; Aqel, Bashar A BA; McClain, Craig J CJ; Prough, Russell A RA

Publication Date: 2016-09

Variant appearance in text: rs7643645

PubMed Link: 26962021

Variant Present in the following documents:

• Main text

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Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population.

Molecular Genetics & Genomic Medicine

Edelman, Deborah D; Kalia, Harmit H; Delio, Maria M; Alani, Mustafa M; Krishnamurthy, Karthik K; Abd, Mortadha M; Auton, Adam A; Wang, Tao T; Wolkoff, Allan W AW; Morrow, Bernice E BE

Publication Date: 2015-11

Variant appearance in text: NR1I2: -22-579A>G; rs7643645

PubMed Link: 26740948

Variant Present in the following documents:

• Main text
• MGG3-3-558.pdf

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The pregnane X receptor in tuberculosis therapeutics.

Expert Opinion On Drug Metabolism & Toxicology

Shehu, Amina I AI; Li, Guangming G; Xie, Wen W; Ma, Xiaochao X

Publication Date: 2016

Variant appearance in text: rs7643645

PubMed Link: 26592418

Variant Present in the following documents:

• Main text

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Systematic review of genetic association studies involving histologically confirmed non-alcoholic fatty liver disease.

Bmj Open Gastroenterology

Wood, Kayleigh L KL; Miller, Michael H MH; Dillon, John F JF

Publication Date: 2015

Variant appearance in text: rs7643645

PubMed Link: 26462272

Variant Present in the following documents:

• Main text
• bmjgast-2014-000019supp_tables.pdf
• bmjgast-2014-000019.pdf

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Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus.

British Journal Of Clinical Pharmacology

Shu, Wenying W; Guan, Su S; Yang, Xiuyan X; Liang, Liuqin L; Li, Jiali J; Chen, Zhuojia Z; Zhang, Yu Y; Chen, Lingyan L; Wang, Xueding X; Huang, Min M

Publication Date: 2016-02

Variant appearance in text: rs7643645

PubMed Link: 26456622

Variant Present in the following documents:

• Main text

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Gender-Dimorphic Impact of PXR Genotype and Haplotype on Hepatotoxicity During Antituberculosis Treatment.

Medicine

Wang, Jann Yuan JY; Tsai, Ching Hui CH; Lee, Yungling Leo YL; Lee, Li Na LN; Hsu, Chia Lin CL; Chang, Hsiu Ching HC; Chen, Jong Ming JM; Hsu, Cheng An CA; Yu, Chong Jen CJ; Yang, Pan Chyr PC

Publication Date: 2015-06

Variant appearance in text: rs7643645

PubMed Link: 26091473

Variant Present in the following documents:

• Main text

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The PXR rs7643645 polymorphism is associated with the risk of higher prostate-specific antigen levels in prostate cancer patients.

Plos One

Reyes-Hernández, Octavio D OD; Vega, Libia L; Jiménez-Ríos, Miguel A MA; Martínez-Cervera, Pedro F PF; Lugo-García, Juan A JA; Hernández-Cadena, Leticia L; Ostrosky-Wegman, Patricia P; Orozco, Lorena L; Elizondo, Guillermo G

Publication Date: 2014

Variant appearance in text: rs7643645

PubMed Link: 24924803

Variant Present in the following documents:

• Main text
• pone.0099974.pdf

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Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance.

British Journal Of Clinical Pharmacology

Noetzli, Muriel M; Guidi, Monia M; Ebbing, Karsten K; Eyer, Stephan S; Wilhelm, Laurence L; Michon, Agnès A; Thomazic, Valérie V; Stancu, Ioana I; Alnawaqil, Abdel-Messieh AM; Bula, Christophe C; Zumbach, Serge S; Gaillard, Michel M; Giannakopoulos, Panteleimon P; von Gunten, Armin A; Csajka, Chantal C; Eap, Chin B CB

Publication Date: 2014-07

Variant appearance in text: rs7643645

PubMed Link: 24433464

Variant Present in the following documents:

• Main text

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Molecular Interactions between NAFLD and Xenobiotic Metabolism.

Frontiers In Genetics

Naik, Adviti A; Belič, Aleš A; Zanger, Ulrich M UM; Rozman, Damjana D

Publication Date: 2013

Variant appearance in text: rs7643645

PubMed Link: 23346097

Variant Present in the following documents:

• Main text
• fgene-04-00002.pdf

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Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

Pharmacogenomics

Puranik, Yogita Ghodke YG; Birnbaum, Angela K AK; Marino, Susan E SE; Ahmed, Ghada G; Cloyd, James C JC; Remmel, Rory P RP; Leppik, Ilo E IE; Lamba, Jatinder K JK

Publication Date: 2013-01

Variant appearance in text: rs7643645

PubMed Link: 23252947

Variant Present in the following documents:

• Main text

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Donor ABCB1 variant associates with increased risk for kidney allograft failure.

Journal Of The American Society Of Nephrology : Jasn

Moore, Jason J; McKnight, Amy Jayne AJ; Döhler, Bernd B; Simmonds, Matthew J MJ; Courtney, Aisling E AE; Brand, Oliver J OJ; Briggs, David D; Ball, Simon S; Cockwell, Paul P; Patterson, Christopher C CC; Maxwell, Alexander P AP; Gough, Stephen C L SC; Opelz, Gerhard G; Borrows, Richard R

Publication Date: 2012-11

Variant appearance in text: rs7643645

PubMed Link: 23064017

Variant Present in the following documents:

• Main text

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Nuclear receptor variants in liver disease.

Journal Of Lipids

Müllenbach, Roman R; Weber, Susanne N SN; Lammert, Frank F

Publication Date: 2012

Variant appearance in text: rs7643645

PubMed Link: 22523693

Variant Present in the following documents:

• Main text

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Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.

Antimicrobial Agents And Chemotherapy

Arab-Alameddine, Mona M; Fayet-Mello, Aurélie A; Lubomirov, Rubin R; Neely, Michael M; di Iulio, Julia J; Owen, Andrew A; Boffito, Marta M; Cavassini, Matthias M; Günthard, Huldrych F HF; Rentsch, Katharina K; Buclin, Thierry T; Aouri, Manel M; Telenti, Amalio A; Decosterd, Laurent Arthur LA; Rotger, Margalida M; Csajka, Chantal C; ,

Publication Date: 2012-06

Variant appearance in text: rs7643645

PubMed Link: 22371894

Variant Present in the following documents:

• Main text

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Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Frontiers In Pharmacology

Klein, Kathrin K; Winter, Stefan S; Turpeinen, Miia M; Schwab, Matthias M; Zanger, Ulrich M UM

Publication Date: 2010

Variant appearance in text: rs7643645

PubMed Link: 21918647

Variant Present in the following documents:

• Main text
• fphar-01-00129.pdf

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Association of warfarin dose with genes involved in its action and metabolism.

Human Genetics

Wadelius, Mia M; Chen, Leslie Y LY; Eriksson, Niclas N; Bumpstead, Suzannah S; Ghori, Jilur J; Wadelius, Claes C; Bentley, David D; McGinnis, Ralph R; Deloukas, Panos P

Publication Date: 2007-03

Variant appearance in text: rs7643645

PubMed Link: 17048007

Variant Present in the following documents:

• Main text
• 439_2006_Article_260.pdf

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Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis.

Gut

Ho, G-T GT; Soranzo, N N; Tate, S K SK; Drummond, H H; Nimmo, E R ER; Tenesa, A A; Arnott, I D ID; Satsangi, J J

Publication Date: 2006-11

Variant appearance in text: rs7643645

PubMed Link: 17047126

Variant Present in the following documents:

• Main text

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