Publications:

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Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.

Scientific Reports

Petros, Zelalem Z; Habtewold, Abiy A; Makonnen, Eyasu E; Aklillu, Eleni E

Publication Date: 2022-06-11

Variant appearance in text: NR1I2: D163G

PubMed Link: 35690682

Variant Present in the following documents:

• Main text
• 41598_2022_Article_14032.pdf

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Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.

International Journal Of Biological Sciences

Niu, Xiaxia X; Wu, Ting T; Li, Gege G; Gu, Xinsheng X; Tian, Yanan Y; Cui, Hongmei H

Publication Date: 2022

Variant appearance in text: PXR: D163G

PubMed Link: 35002522

Variant Present in the following documents:

• Main text
• ijbsv18p0742.pdf

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: NR1I2: 488A>G; D163G; rs72551374

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

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Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

Obstetrics And Gynecology

Lazorwitz, Aaron A; Aquilante, Christina L CL; Oreschak, Kris K; Sheeder, Jeanelle J; Guiahi, Maryam M; Teal, Stephanie S

Publication Date: 2019-04

Variant appearance in text: rs72551374

PubMed Link: 30870275

Variant Present in the following documents:

• Main text

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: rs72551374

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

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Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.

Biochemical Pharmacology

Banerjee, Monimoy M; Chai, Sergio C SC; Wu, Jing J; Robbins, Delira D; Chen, Taosheng T

Publication Date: 2016-03-15

Variant appearance in text: PXR: D163G

PubMed Link: 26902414

Variant Present in the following documents:

• Main text

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs72551374

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs72551374

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

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Role of pregnane X receptor in chemotherapeutic treatment.

Cancer Chemotherapy And Pharmacology

Zhuo, Wei W; Hu, Lei L; Lv, Jinfeng J; Wang, Hongbing H; Zhou, Honghao H; Fan, Lan L

Publication Date: 2014-08

Variant appearance in text: PXR: D163G

PubMed Link: 24889719

Variant Present in the following documents:

• Main text

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Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.

Acta Pharmaceutica Sinica. B

Wang, Duan D; Wang, Hongbing H

Publication Date: 2012-04-01

Variant appearance in text: PXR: D163G

PubMed Link: 24349963

Variant Present in the following documents:

• Main text

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics

Klein, Kathrin K; Zanger, Ulrich M UM

Publication Date: 2013

Variant appearance in text: PXR: D163G

PubMed Link: 23444277

Variant Present in the following documents:

• Main text
• fgene-04-00012.pdf

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Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.

Mutation Research

Rusyn, Ivan I; Corton, J Christopher JC

Publication Date: 2012

Variant appearance in text: PXR: D163G

PubMed Link: 22198209

Variant Present in the following documents:

• Main text

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Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Frontiers In Pharmacology

Klein, Kathrin K; Winter, Stefan S; Turpeinen, Miia M; Schwab, Matthias M; Zanger, Ulrich M UM

Publication Date: 2010

Variant appearance in text: rs72551374

PubMed Link: 21918647

Variant Present in the following documents:

• Main text
• fphar-01-00129.pdf

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Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Current Pharmacogenomics And Personalized Medicine

Hernandez, J P JP; Mota, L C LC; Baldwin, W S WS

Publication Date: 2009-06-01

Variant appearance in text: PXR: D163G

PubMed Link: 20871735

Variant Present in the following documents:

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The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

Nuclear Receptor Signaling

Zhou, Changcheng C; Verma, Suman S; Blumberg, Bruce B

Publication Date: 2009

Variant appearance in text: SXR: D163G

PubMed Link: 19240808

Variant Present in the following documents:

• Main text
• nrs07001000.pdf

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Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.

British Journal Of Clinical Pharmacology

Wang, Xue-Ding XD; Li, Jia-Li JL; Su, Qi-Biao QB; Guan, Su S; Chen, Jie J; Du, Jun J; He, Yu-Wen YW; Zeng, Jun J; Zhang, Jin-Xin JX; Chen, Xiao X; Huang, Min M; Zhou, Shu-Feng SF

Publication Date: 2009-02

Variant appearance in text: NR1I2: D163G

PubMed Link: 19173680

Variant Present in the following documents:

• Main text

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Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

Nuclear Receptor

Krasowski, Matthew D MD; Yasuda, Kazuto K; Hagey, Lee R LR; Schuetz, Erin G EG

Publication Date: 2005-09-30

Variant appearance in text: PXR: D163G

PubMed Link: 16197547

Variant Present in the following documents:

• Main text

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