Publications:

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Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.

Scientific Reports

Petros, Zelalem Z; Habtewold, Abiy A; Makonnen, Eyasu E; Aklillu, Eleni E

Publication Date: 2022-06-11

Variant appearance in text: NR1I2: A370T

PubMed Link: 35690682

Variant Present in the following documents:

• Main text
• 41598_2022_Article_14032.pdf

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Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.

International Journal Of Biological Sciences

Niu, Xiaxia X; Wu, Ting T; Li, Gege G; Gu, Xinsheng X; Tian, Yanan Y; Cui, Hongmei H

Publication Date: 2022

Variant appearance in text: PXR: A370T

PubMed Link: 35002522

Variant Present in the following documents:

• Main text
• ijbsv18p0742.pdf

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: NR1I2: 1108G>A; A370T; rs35761343

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

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TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.

Nature Communications

Gomes, Carolina Cavalieri CC; Gayden, Tenzin T; Bajic, Andrea A; Harraz, Osama F OF; Pratt, Jonathan J; Nikbakht, Hamid H; Bareke, Eric E; Diniz, Marina Gonçalves MG; Castro, Wagner Henriques WH; St-Onge, Pascal P; Sinnett, Daniel D; Han, HyeRim H; Rivera, Barbara B; Mikael, Leonie G LG; De Jay, Nicolas N; Kleinman, Claudia L CL; Valera, Elvis Terci ET; Bassenden, Angelia V AV; Berghuis, Albert M AM; Majewski, Jacek J; Nelson, Mark T MT; Gomez, Ricardo Santiago RS; Jabado, Nada N

Publication Date: 2018-11-01

Variant appearance in text: NR1I2: A370T; rs35761343

PubMed Link: 30385747

Variant Present in the following documents:

• 41467_2018_6690_MOESM8_ESM.xlsx, sheet 1

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs35761343

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: NR1I2: A370T

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs35761343

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs35761343

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

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Role of pregnane X receptor in chemotherapeutic treatment.

Cancer Chemotherapy And Pharmacology

Zhuo, Wei W; Hu, Lei L; Lv, Jinfeng J; Wang, Hongbing H; Zhou, Honghao H; Fan, Lan L

Publication Date: 2014-08

Variant appearance in text: PXR: A370T

PubMed Link: 24889719

Variant Present in the following documents:

• Main text

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Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.

Acta Pharmaceutica Sinica. B

Wang, Duan D; Wang, Hongbing H

Publication Date: 2012-04-01

Variant appearance in text: PXR: A370T

PubMed Link: 24349963

Variant Present in the following documents:

• Main text

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics

Klein, Kathrin K; Zanger, Ulrich M UM

Publication Date: 2013

Variant appearance in text: PXR: A370T

PubMed Link: 23444277

Variant Present in the following documents:

• Main text
• fgene-04-00012.pdf

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Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.

Mutation Research

Rusyn, Ivan I; Corton, J Christopher JC

Publication Date: 2012

Variant appearance in text: PXR: A370T

PubMed Link: 22198209

Variant Present in the following documents:

• Main text

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Frequency of genetic polymorphisms of PXR gene in the Brazilian population.

Clinics (Sao Paulo, Brazil)

Moreira, Ricardo P P RP; Jorge, Alexander A L AA; Mendonca, Berenice B BB; Bachega, Tânia A S S TA

Publication Date: 2011

Variant appearance in text: PXR: Ala370Thr

PubMed Link: 21808872

Variant Present in the following documents:

• Main text
• cln-66-06-1041.pdf

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The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

Nuclear Receptor Signaling

Zhou, Changcheng C; Verma, Suman S; Blumberg, Bruce B

Publication Date: 2009

Variant appearance in text: SXR: A370T

PubMed Link: 19240808

Variant Present in the following documents:

• Main text
• nrs07001000.pdf

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Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.

British Journal Of Clinical Pharmacology

Wang, Xue-Ding XD; Li, Jia-Li JL; Su, Qi-Biao QB; Guan, Su S; Chen, Jie J; Du, Jun J; He, Yu-Wen YW; Zeng, Jun J; Zhang, Jin-Xin JX; Chen, Xiao X; Huang, Min M; Zhou, Shu-Feng SF

Publication Date: 2009-02

Variant appearance in text: NR1I2: A370T

PubMed Link: 19173680

Variant Present in the following documents:

• Main text

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Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

Nuclear Receptor

Krasowski, Matthew D MD; Yasuda, Kazuto K; Hagey, Lee R LR; Schuetz, Erin G EG

Publication Date: 2005-09-30

Variant appearance in text: PXR: A370T

PubMed Link: 16197547

Variant Present in the following documents:

• Main text

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